| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Caccia, M Anelli, C Fracasso, E Frittoli, P Giorcelli, M Gobbi, C Taddei, S Garattini, T Mennin. Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 3. 1993-05-27. PMID:8479546. |
however, the brain concentrations of the metabolite required to reduce food intake after synthetic d-nf were more than twice those after d-f, indicating that d-nf contributes to but does not completely explain the anorectic effect of d-f. at this dose d-f did not appreciably modify the serotonin (5-ht) and 5-hydroxyindoleacetic (5-hiaa) contents of the brain regions examined, except for a slight enhancement of 5-hiaa in hippocampus. |
1993-05-27 |
2023-08-12 |
marmoset |
| O Adeola, R O Ball, J D House, P J O'Brie. Regional brain neurotransmitter concentrations in stress-susceptible pigs. Journal of animal science. vol 71. issue 4. 1993-05-21. PMID:8097511. |
hippocampal serotonin and norepinephrine were lower (p < .05) in nn than in nn pigs. |
1993-05-21 |
2023-08-12 |
Not clear |
| O Adeola, R O Ball, J D House, P J O'Brie. Regional brain neurotransmitter concentrations in stress-susceptible pigs. Journal of animal science. vol 71. issue 4. 1993-05-21. PMID:8097511. |
in the third experiment, serotonin was the only neurotransmitter that was lower in the hippocampus of nn (n = 5) than of nn (n = 6) pigs; concentrations of all other neurotransmitters in the three brain regions were similar between nn and nn pigs. |
1993-05-21 |
2023-08-12 |
Not clear |
| P Banerjee, E Berry-Kravis, D Bonafede-Chhabra, G Dawso. Heterologous expression of the serotonin 5-HT1A receptor in neural and non-neural cell lines. Biochemical and biophysical research communications. vol 192. issue 1. 1993-05-20. PMID:8476411. |
following electroporation assisted transfer of a construct containing the hippocampal serotonin 5-ht1a receptor (5-ht1ar) dna, one neural cell line, ng-108-15 (murine neuroblastoma x c6 glioma), failed to express the transfected activity, while three others as well as the non-neural cho (chinese hamster ovary) cells expressed high levels of the receptor. |
1993-05-20 |
2023-08-12 |
human |
| A Adell, A Carceller, F Artiga. In vivo brain dialysis study of the somatodendritic release of serotonin in the Raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. Journal of neurochemistry. vol 60. issue 5. 1993-05-18. PMID:7682600. |
in animals bearing two probes (raphe nuclei and ventral hippocampus), only the 10 mm dose of 8-oh-dpat perfused into the raphe decreased the hippocampal output of 5-ht and 5-hiaa. |
1993-05-18 |
2023-08-12 |
rat |
| A Adell, A Carceller, F Artiga. In vivo brain dialysis study of the somatodendritic release of serotonin in the Raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. Journal of neurochemistry. vol 60. issue 5. 1993-05-18. PMID:7682600. |
the systemic injection of 0.1 mg/kg 8-oh-dpat decreased dialysate 5-ht and 5-hiaa in the raphe and hippocampus. |
1993-05-18 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474003. |
such in situ injection of either toxin in the dorsal hippocampus decreased by about 90% the responsiveness of ca3 pyramidal neurons to microiontophoretic applications onto their cell body of 5-ht and 8-oh-dpat, but not of gaba. |
1993-05-18 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474003. |
in the ca3 region of the hippocampus, there would be two subsets of postsynaptic 5-ht1a receptors on the pyramidal neurons: those apposed to 5-ht terminals on their dendritic tree (denoted intrasynaptic) and those located on their cell body (denoted extrasynaptic). |
1993-05-18 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474032. |
in contrast, the same dose of spiperone did not alter the responsiveness to microiontophoretic applications of 5-ht and 8-oh-dpat of pyramidal neurons in the ca3 region of the hippocampus, therefore indicating that spiperone does not act as a classical antagonist at these postsynaptic 5-ht1a receptors. |
1993-05-18 |
2023-08-12 |
rat |
| P Blier, A Lista, C De Montign. Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. The Journal of pharmacology and experimental therapeutics. vol 265. issue 1. 1993-05-18. PMID:8474032. |
haloperidol and ketanserin (5 mg/kg, i.p., 24 h before the experiment) were ineffective in blocking the responsiveness of ca3 pyramidal neurons to 5-ht, thereby demonstrating that the dopamine d2 and 5-ht2 properties of spiperone could not account for the attenuated responsiveness of the hippocampus neurons to 5-ht. |
1993-05-18 |
2023-08-12 |
rat |
| S E File, H Zangrossi, N Andrew. Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474617. |
changes in release and uptake of [3h]5-ht and [14c]gaba were compared in slices taken from the hippocampus and frontal cortex of rats, left undisturbed in their home-cages, or exposed for 5 min to the elevated plus-maze or social interaction tests of anxiety. |
1993-05-17 |
2023-08-12 |
rat |
| S E File, H Zangrossi, N Andrew. Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474617. |
exposure to the plus-maze decreased cortical gaba function (shown by decreased release) and increased hippocampal 5-ht function (shown by increased k(+)-evoked release but more markedly by decreased uptake). |
1993-05-17 |
2023-08-12 |
rat |
| S E File, H Zangrossi, N Andrew. Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474617. |
compared with undisturbed home cage controls, only the high light, familiar condition of the social interaction test resulted in a significant increase in k(+)-evoked release of both [3h]5-ht and [14c]gaba from the hippocampus. |
1993-05-17 |
2023-08-12 |
rat |
| S E File, H Zangrossi, N Andrew. Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474617. |
analysing the two factors manipulated in the social interaction test, unfamiliarity with the test arena resulted in increased uptake of hippocampal [3h]5-ht and decreased cortical [14c]gaba, whereas an increase in the level of light decreased the cortical uptake of [14c]gaba. |
1993-05-17 |
2023-08-12 |
rat |
| S E File, H Zangrossi, N Andrew. Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology. vol 32. issue 3. 1993-05-17. PMID:8474617. |
however, only the increased hippocampal release of 5-ht is likely to be causally linked to anxiety and the results show that this cannot be the sole explanation. |
1993-05-17 |
2023-08-12 |
rat |
| M I Colado, T K Murray, A R Gree. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. British journal of pharmacology. vol 108. issue 3. 1993-05-13. PMID:7682129. |
the present study has investigated whether the neurotoxic effects of the relatively selective 5-hydroxytryptamine (5-ht) neurotoxins, 3,4-methylenedioxymethamphetamine (mdma or 'ecstasy'), p-chloroamphetamine (pca) and fenfluramine on hippocampal and cortical 5-ht terminals in rat brain could be prevented by administration of either chlormethiazole or dizocilpine. |
1993-05-13 |
2023-08-12 |
rat |
| M I Colado, T K Murray, A R Gree. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. British journal of pharmacology. vol 108. issue 3. 1993-05-13. PMID:7682129. |
resulted in an approximate 30% loss of cortical and hippocampal 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) content 4 days later. |
1993-05-13 |
2023-08-12 |
rat |
| M I Colado, T K Murray, A R Gree. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. British journal of pharmacology. vol 108. issue 3. 1993-05-13. PMID:7682129. |
resulted in a 70% loss of 5-ht and 5-hiaa content in hippocampus and cortex 4 days later. |
1993-05-13 |
2023-08-12 |
rat |
| M I Colado, T K Murray, A R Gree. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. British journal of pharmacology. vol 108. issue 3. 1993-05-13. PMID:7682129. |
neither chlormethiazole nor dizocilpine prevented the neurotoxic loss of hippocampal or cortical 5-ht neurones measured 4 days following administration of fenfluramine (25 mg kg-1, i.p.).6. |
1993-05-13 |
2023-08-12 |
rat |
| H A Baldwin, M I Colado, T K Murray, R J De Souza, A R Gree. Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine. British journal of pharmacology. vol 108. issue 3. 1993-05-13. PMID:8467354. |
every 2 h to a total of 4 doses resulted in a neurotoxic loss of striatal dopamine of 36% and of 5-hydroxytryptamine (5-ht) in the cortex (43%) and hippocampus (47%) 3 days later. |
1993-05-13 |
2023-08-12 |
rat |