| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S E File, N Andrews, P Y Wu, A Zharkovsky, H Zangross. Modification of chlordiazepoxide's behavioural and neurochemical effects by handling and plus-maze experience. European journal of pharmacology. vol 218. issue 1. 1992-11-20. PMID:1397035. |
the effects of chlordiazepoxide on k(+)-evoked [3h]5-ht release from the hippocampus depended on both prior handling and plus-maze experience and could be predicted from the undrugged level of evoked release; when this was low, chlordiazepoxide increased it, when it was high, chlordiazepoxide reduced it. |
1992-11-20 |
2023-08-11 |
rat |
| C S Biggs, B R Pearce, L J Fowler, P S Whitto. Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine, and their metabolites in the rat brain: an in vivo microdialysis study. Journal of neurochemistry. vol 59. issue 5. 1992-11-20. PMID:1402915. |
on ventral hippocampal and anterior caudate putamen extracellular levels of dopamine (da) and 5-hydroxytryptamine (5-ht) were examined using in vivo microdialysis. |
1992-11-20 |
2023-08-11 |
rat |
| C S Biggs, B R Pearce, L J Fowler, P S Whitto. Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine, and their metabolites in the rat brain: an in vivo microdialysis study. Journal of neurochemistry. vol 59. issue 5. 1992-11-20. PMID:1402915. |
vpa induced dose-related increases in dialysate da, 3,4-dihydroxyphenylacetic acid, and 5-ht in the ventral hippocampus. |
1992-11-20 |
2023-08-11 |
rat |
| A P Zis, G G Nomikos, E E Brown, G Damsma, H C Fibige. Neurochemical effects of electrically and chemically induced seizures: an in vivo microdialysis study in the rat hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 7. issue 3. 1992-11-19. PMID:1382432. |
this study examined the effects of electroconvulsive shock (ecs) on interstitial concentrations of serotonin (5-ht), its metabolite 5-hydroxyindoleacetic acid (5-hiaa), acetylcholine and choline, and the dopamine metabolite homovanillic acid (hva) in the hippocampus of freely moving rats using online brain microdialysis. |
1992-11-19 |
2023-08-11 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383883. |
effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis. |
1992-11-06 |
2023-08-11 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383883. |
the purpose of the present study is to clarify the effect of clonidine on the release of serotonin from the rat hippocampus in vivo. |
1992-11-06 |
2023-08-11 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383883. |
potassium-evoked serotonin release from the hippocampus of freely moving rats was significantly inhibited when clonidine (10(-5) m) was added to the perfusion solution, while the 5-hydroxyindoleacetic acid output remained unchanged. |
1992-11-06 |
2023-08-11 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383883. |
in catecholaminergically denervated rats, clonidine (10(-5) m) also inhibited the potassium-evoked serotonin release from the hippocampus and the 5-hydroxyindoleacetic acid output was unaffected by clonidine. |
1992-11-06 |
2023-08-11 |
rat |
| M Yoshioka, M Matsumoto, H Togashi, C B Smith, H Sait. Effect of clonidine on the release of serotonin from the rat hippocampus as measured by microdialysis. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383883. |
these results suggest that the inhibitory effect of clonidine on serotonin release from the hippocampus might reflect the activation of alpha 2-adrenoceptors which are localized on the serotonergic nerve terminals. |
1992-11-06 |
2023-08-11 |
rat |
| A Manfridi, A Clavenna, M G De Simon. Serotonin uptake inhibition: in vivo effect of sertraline in rats. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1383885. |
sertraline (11 mg/kg) lowered extracellular 5-hydroxyindolacetic acid (5-hiaa), measured in rat hippocampus by in vivo voltammetry, for about 3 h. the interaction between sertraline and drugs known to interfere with the release or uptake of serotonin (l-5-hydroxytryptophan (5-htp), d-norfenfluramine and tianeptine) was then studied. |
1992-11-06 |
2023-08-11 |
rat |
| J Donnerer, C Humpel, A Sari. Effect of noradrenergic denervation by neonatal DSP-4 on peptide neurotransmitter systems in the rat brain. Neuropeptides. vol 22. issue 2. 1992-10-26. PMID:1357578. |
when applied concomitantly with a 5-hydroxytryptamine uptake blocker, neonatal dsp-4 induced a selective depletion of noradrenaline (na) in cortex, hippocampus and amygdala. |
1992-10-26 |
2023-08-11 |
rat |
| J C Cassel, C Kelche, B Neufang, B E Will, G Hertting, R Jackisc. Graft-derived cholinergic reinnervation of the hippocampus prevents a lasting increase of hippocampal noradrenaline concentration induced by septohippocampal damage in rats. Neuroscience letters. vol 138. issue 1. 1992-10-26. PMID:1407663. |
between 9.5 and 10.5 months after grafting surgery, we found the lesions to decrease choline acetyltransferase activity (chat), high affinity synaptosomal uptake of [3h]choline (hacu) and serotonin concentration ([5-ht]), as well as to increase the noradrenaline concentration ([na]) in the dorsal hippocampus. |
1992-10-26 |
2023-08-11 |
rat |
| R Andrad. Whole-cell and perforated-patch recording of serotonin responses in the rat hippocampus. Journal of chemical neuroanatomy. vol 5. issue 4. 1992-10-22. PMID:1524720. |
whole-cell and perforated-patch recording of serotonin responses in the rat hippocampus. |
1992-10-22 |
2023-08-11 |
rat |
| A R Lumia, M H Teicher, F Salchli, E Ayers, B Possident. Olfactory bulbectomy as a model for agitated hyposerotonergic depression. Brain research. vol 587. issue 2. 1992-10-22. PMID:1525654. |
olfactory bulbectomy also altered serotonin metabolism (5-hiaa/5-ht ratio) in the frontal cortex, nucleus accumbens, hippocampus and corpus striatum. |
1992-10-22 |
2023-08-11 |
rat |
| M G van Luijtelaar, J A Tonnaer, H W Steinbusc. Aging of the serotonergic system in the rat forebrain: an immunocytochemical and neurochemical study. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1355858. |
5-hydroxytryptamine levels were increased in the frontoparietal cortex, hippocampus, hypothalamus and the mesencephalic raphe region but remained unchanged in the caudate-putamen complex. |
1992-10-13 |
2023-08-11 |
rat |
| M Shimizu-Sasamata, M Yamamoto, M Okada, T Yamaguchi, A Tamur. Effects of indeloxazine hydrochloride on behavioral and biochemical changes in the chronic phase of focal cerebral ischemia in rats. Archives internationales de pharmacodynamie et de therapie. vol 314. 1992-10-13. PMID:1824190. |
significant decreases in the content of serotonin and norepinephrine in the frontal cortex, of norepinephrine and 3-methoxy-4-hydroxy-phenylethylglycol in the hippocampus, and of 3-methoxy-4-hydroxy-phenylethylglycol in the corpus striatum on the occluded side were observed on day 14 after surgery. |
1992-10-13 |
2023-08-11 |
rat |
| M Shimizu-Sasamata, M Yamamoto, M Okada, T Yamaguchi, A Tamur. Effects of indeloxazine hydrochloride on behavioral and biochemical changes in the chronic phase of focal cerebral ischemia in rats. Archives internationales de pharmacodynamie et de therapie. vol 314. 1992-10-13. PMID:1824190. |
indeloxazine (10 or 30 mg/kg) caused significant increases in serotonin and decreases of 5-hydroxy-indoleacetic acid in the bilateral frontal cortex and hippocampus and contralateral corpus striatum. |
1992-10-13 |
2023-08-11 |
rat |
| A R Green, R J De Souza, J L Williams, T K Murray, A J Cros. The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole. Neuropharmacology. vol 31. issue 4. 1992-10-09. PMID:1381816. |
at 3 hr intervals resulted in a 75% loss of striatal dopamine 3 days later and a similar loss of 5-ht and 5-hiaa in cortex and hippocampus. |
1992-10-09 |
2023-08-11 |
mouse |
| S Caccia, C Fracasso, S Garattini, G Guiso, S Sarat. Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain. Neuropharmacology. vol 31. issue 4. 1992-10-09. PMID:1381817. |
on day 1 fluoxetine did not change the content of serotonin (5-ht) but reduced the concentrations of 5-hydroxyindolacetic acid (5-hiaa) in the hippocampus and cortex, compatible with the action of a blocker of the uptake of 5-ht. |
1992-10-09 |
2023-08-11 |
rat |
| S Caccia, C Fracasso, S Garattini, G Guiso, S Sarat. Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain. Neuropharmacology. vol 31. issue 4. 1992-10-09. PMID:1381817. |
continued injections of fluoxetine, however, significantly reduced 5-ht in the brain of the rat, the depletion being significant on days 7 and 21 in the hippocampus and cortex, respectively. |
1992-10-09 |
2023-08-11 |
rat |