| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D W Bonhaus, D N Loury, L B Jakeman, Z To, A DeSouza, R M Eglen, E H Won. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:8246171. |
]oct-3-yl)- 2,3-dihydro-3-ethyl-2-oxo-1h-benzimidazole-1-carboxamide hydrochloride ([3h]bimu-1) a benzimidazolone with high affinity for 5-hydroxytryptamine (5-ht)3 and 4 5-ht3 and 5-ht4 receptors, was characterized in ng-108 cells and guinea pig hippocampus. |
1994-01-06 |
2023-08-12 |
Not clear |
| D W Bonhaus, D N Loury, L B Jakeman, Z To, A DeSouza, R M Eglen, E H Won. [3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus. The Journal of pharmacology and experimental therapeutics. vol 267. issue 2. 1994-01-06. PMID:8246171. |
in guinea pig hippocampal membranes [3h]bimu-1 binding was insensitive to serotonin but was displaced by haloperidol, and 1,3-di-o-tolyl-guanidine with affinities appropriate for the labeling of a sigma binding site (ki of 6.3 and 31 nm, respectively). |
1994-01-06 |
2023-08-12 |
Not clear |
| C Bendotti, G Tarizzo, F Fumagalli, S Baldessari, R Samani. Increased expression of preproneuropeptide Y and preprosomatostatin mRNA in striatum after selective serotoninergic lesions in rats. Neuroscience letters. vol 160. issue 2. 1994-01-04. PMID:7902549. |
it thus appears that serotonin has an inhibitory effect on the biosynthesis of neuropeptide y and somatostatin in striatum whereas it probably acts by stimulating the release of these peptides in hippocampus and frontal cortex. |
1994-01-04 |
2023-08-12 |
rat |
| R F Cox, E Meller, B L Waszcza. Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-HT1A agonists. Synapse (New York, N.Y.). vol 14. issue 4. 1994-01-03. PMID:8248853. |
pharmacol., 37:231-237] have shown that a large receptor reserve exists for the inhibition of serotonin synthesis in rat cortex and hippocampus by the 5-ht1a agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-oh-dpat), whereas little or no reserve exists for the lower efficacy agonists ipsapirone and bmy 7378. |
1994-01-03 |
2023-08-12 |
rat |
| P H Silverstone, C Done, T Shar. In vivo monoamine release during naloxone-precipitated morphine withdrawal. Neuroreport. vol 4. issue 8. 1993-12-27. PMID:8241461. |
here we demonstrate, using in vivo microdialysis, that whilst there is a considerable increase (300%) in release of na in hippocampus precipitated by naloxone in morphine-dependent rats, there is no change in the release of either 5-ht (in hippocampus) or da (in nucleus accumbens). |
1993-12-27 |
2023-08-12 |
rat |
| G Richter-Levin, M Sega. Age-related cognitive deficits in rats are associated with a combined loss of cholinergic and serotonergic functions. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239292. |
we found that restoration of the serotonergic innervation in the hippocampus of serotonin depleted rats, using tissue transplants, can restore impaired behavior. |
1993-12-10 |
2023-08-12 |
rat |
| G Richter-Levin, M Sega. Age-related cognitive deficits in rats are associated with a combined loss of cholinergic and serotonergic functions. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239292. |
we have localized a memory-related interaction between serotonin and acetylcholine in the hippocampus and are in the process of identifying a physiological function which may underly this interaction. |
1993-12-10 |
2023-08-12 |
rat |
| C Routledge, J Gurling, I K Wright, C T Douris. Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223894. |
the neurochemical profile of the selective 5-ht1a receptor antagonist way100135 [n-tert-butyl 3-4-(2-methoxyphenyl) piperazin-1-yl-2-phenylpropanamide dihydrochloride] and its enantiomers at the somatodendritic 5-ht1a receptor was determined by studying the effects of these compounds on 5-ht (5-hydroxytryptamine, serotonin) release in the rat hippocampus using in vivo microdialysis. |
1993-12-01 |
2023-08-12 |
rat |
| C Routledge, J Gurling, I K Wright, C T Douris. Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223894. |
(+/-)-way100135, (+)-way100135 and (-)-way100135 (all at 10 mg/kg s.c.) had no significant effect on extracellular levels of 5-ht in the hippocampus demonstrating that these compounds are devoid of 5-ht1a receptor agonist properties. |
1993-12-01 |
2023-08-12 |
rat |
| C Routledge, J Gurling, I K Wright, C T Douris. Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study. European journal of pharmacology. vol 239. issue 1-3. 1993-12-01. PMID:8223894. |
in contrast, the 5-ht1a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-oh-dpat) (0.1 mg/kg s.c.) and the partial agonists bmy 7378 (1.0 mg/kg s.c.) and buspirone (5 mg/kg s.c.) significantly decreased hippocampal 5-ht. |
1993-12-01 |
2023-08-12 |
rat |
| F Passarelli, F Orz. Effect of electroconvulsive shock treatment on the opioid-mediated inhibition of serotonin release in rat hippocampal slices. Neuroreport. vol 4. issue 9. 1993-11-29. PMID:8219035. |
effect of electroconvulsive shock treatment on the opioid-mediated inhibition of serotonin release in rat hippocampal slices. |
1993-11-29 |
2023-08-12 |
rat |
| F Passarelli, F Orz. Effect of electroconvulsive shock treatment on the opioid-mediated inhibition of serotonin release in rat hippocampal slices. Neuroreport. vol 4. issue 9. 1993-11-29. PMID:8219035. |
the overflow of [3h]serotonin elicited by high potassium (30 mm) in superfused slices of rat hippocampus was significantly inhibited in the presence of two agonists, mu-selective [d-ala2,n-methyl-phe4,gly5ol]enkephalin (dago) and delta-selective [d-pen2,d-pen5]enkephalin (dpdpe) in control animals. |
1993-11-29 |
2023-08-12 |
rat |
| S Hjorth, G Pettersso. 5-HT1A autoreceptor-mediated effects of the amperozide congeners, FG5865 and FG5893, on rat brain 5-hydroxytryptamine neurochemistry in vivo. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:7691622. |
in in vivo microdialysis experiments, both fg5865 (0.1-3.0 mg/kg, s.c.) and fg5893 (0.03-1.0 mg/kg, s.c.) caused a marked and dose-dependent decrease of 5-ht release in the ventral hippocampus. |
1993-11-09 |
2023-08-12 |
rat |
| S Hjorth, G Pettersso. 5-HT1A autoreceptor-mediated effects of the amperozide congeners, FG5865 and FG5893, on rat brain 5-hydroxytryptamine neurochemistry in vivo. European journal of pharmacology. vol 238. issue 2-3. 1993-11-09. PMID:7691622. |
local infusion of fg5865 into the ventral hippocampus (10 microm, 20-min pulse) resulted in a rapid and transient elevation of the 5-ht output, an effect that was independent of extracellular ca2+. |
1993-11-09 |
2023-08-12 |
rat |
| C Bendotti, S Baldessari, M Ehret, G Tarizzo, R Samani. Effect of d-fenfluramine and 5,7-dihydroxytryptamine on the levels of tryptophan hydroxylase and its mRNA in rat brain. Brain research. Molecular brain research. vol 19. issue 3. 1993-11-03. PMID:8412572. |
twice daily for 4 days) markedly reduced serotonin (5-ht) concentrations in the hippocampus and striatum of rat brain up to 1 month after treatment, while tryptophan hydroxylase (tph) levels were reduced only in the hippocampus 5 days after injection. |
1993-11-03 |
2023-08-12 |
rat |
| H Sommermeyer, R Schreiber, J M Greuel, J De Vry, T Glase. Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates. European journal of pharmacology. vol 240. issue 1. 1993-11-02. PMID:7691626. |
in the hippocampus, one of the projection areas of the serotonergic dorsal raphe neurons, systemic application of ipsapirone resulted in a dose- and time-dependent reduction in serotonergic neurotransmission, measured as a reduced serotonin output in microdialysis experiments with freely moving rats. |
1993-11-02 |
2023-08-12 |
rat |
| M Gobbi, E Frittoli, A Uslenghi, T Mennin. Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes. European journal of pharmacology. vol 238. issue 1. 1993-10-26. PMID:8405087. |
evidence of an exocytotic-like release of [3h]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes. |
1993-10-26 |
2023-08-12 |
rat |
| M Gobbi, E Frittoli, A Uslenghi, T Mennin. Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes. European journal of pharmacology. vol 238. issue 1. 1993-10-26. PMID:8405087. |
d-fenfluramine (0.5 microm) induced only [3h]5-hydroxytryptamine ([3h]5-ht) release from hippocampal synaptosomes whereas 10 microm also induced some overflow from hippocampal synaptosomes preloaded with [3h]noradrenaline or from striatal synaptosomes preloaded with [3h]dopamine, although the overflow was much lower than from 5-htergic synaptosomes. |
1993-10-26 |
2023-08-12 |
rat |
| M Gobbi, E Frittoli, A Uslenghi, T Mennin. Evidence of an exocytotic-like release of [3H]5-hydroxytryptamine induced by d-fenfluramine in rat hippocampal synaptosomes. European journal of pharmacology. vol 238. issue 1. 1993-10-26. PMID:8405087. |
by measuring [3h]5-ht uptake into rat hippocampal synaptosomes we confirmed that ca(2+)-ions are not required for the function of the 5-ht uptake carrier or for its interaction with d-fenfluramine. |
1993-10-26 |
2023-08-12 |
rat |
| S E File, H Zangrossi, N Andrew. Novel environment and cat odor change GABA and 5-HT release and uptake in the rat. Pharmacology, biochemistry, and behavior. vol 45. issue 4. 1993-10-26. PMID:8415833. |
in rats killed immediately after the 5-min exposure, there was decreased hippocampal [3h]5-ht uptake and higher hippocampal basal release, whereas in rats killed 30 min later there was increased [3h]5-ht uptake and lower basal release in both hippocampal and cortical slices. |
1993-10-26 |
2023-08-12 |
rat |