| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D J Heal, S A Butler, M R Prow, W R Bucket. Quantification of presynaptic alpha 2-adrenoceptors in rat brain after short-term DSP-4 lesioning. European journal of pharmacology. vol 249. issue 1. 1994-02-14. PMID:7506666. |
at the 3 day time-point, dsp-4 treatment produced marked reductions in the noradrenaline content of the cortex (93%), hippocampus (89%), hypothalamus (83%) and cerebellum (92%) with no change in the levels of dopamine or 5-ht. |
1994-02-14 |
2023-08-12 |
rat |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
acute administration of the 5-ht1a receptor agonists buspirone (0.1-5 mg/kg s.c.) and ipsapirone (0.03-3 mg/kg s.c.) caused a dose-dependent decrease in 5-ht output in ventral hippocampus of the chloral hydrate anaesthetized rat. |
1994-02-04 |
2023-08-12 |
rat |
| T Sharp, R McQuade, S Bramwell, S Hjort. Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology. vol 348. issue 4. 1994-02-04. PMID:7904048. |
the effect of an acute challenge of buspirone (0.5 mg/kg s.c.) on 5-ht output in ventral hippocampus was not attenuated in rats treated twice daily for 14 days with 0.5 or 5 mg/kg s.c. buspirone compared to saline-injected controls. |
1994-02-04 |
2023-08-12 |
rat |
| M Nakamura, Y Wada, H Hasegawa, N Yamaguch. [Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin]. No to shinkei = Brain and nerve. vol 45. issue 10. 1994-02-01. PMID:8268033. |
based on our previous findings that a serotonin (5-ht) precursor l-5-hydroxytryptophan and a 5-ht1 a receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin can suppress seizures kindled from the feline hippocampus (hip), we have suggested that 5-ht1 a receptors play an inhibitory role in hip seizure generation. |
1994-02-01 |
2023-08-12 |
Not clear |
| C N Theron, A S de Villiers, J J Taljaar. Effects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration. Neurochemical research. vol 18. issue 12. 1994-01-28. PMID:7505893. |
effects of dsp-4 on noradrenaline (na), 3-methoxy-4-hydroxyphenyl glycol (mhpg), serotonin (5-ht) and 5-hydroxyindole acetic acid (5-hiaa) levels and on beta adrenoceptor binding kinetics (bmax and kd) in rat hippocampus, cortex and hypothalamus were studied between 24 hours and 14 days after systemic administration. |
1994-01-28 |
2023-08-12 |
rat |
| C N Theron, A S de Villiers, J J Taljaar. Effects of DSP-4 on monoamine and monoamine metabolite levels and on beta adrenoceptor binding kinetics in rat brain at different times after administration. Neurochemical research. vol 18. issue 12. 1994-01-28. PMID:7505893. |
in cortex and hippocampus 5-ht levels were slightly, but significantly decreased after dsp-4. |
1994-01-28 |
2023-08-12 |
rat |
| R G Johnson, D Fiorella, R A Rabi. Effects of chronic cocaine administration on the serotonergic system in the rat brain. Pharmacology, biochemistry, and behavior. vol 46. issue 2. 1994-01-27. PMID:7505454. |
the chronic cocaine treatment caused an increase in the levels of serotonin [5-hydroxytryptamine (5-ht)] and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the hippocampus. |
1994-01-27 |
2023-08-12 |
rat |
| A M Andrews, D L Murph. 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263805. |
2'-nh2-mptp in swiss webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission. |
1994-01-27 |
2023-08-12 |
mouse |
| A M Andrews, D L Murph. 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263805. |
administration of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-nh2-mptp; 4 x 20 mg/kg) to swiss webster mice caused substantial decreases in cortical and hippocampal 5-hydroxytryptamine (5-ht), 5-hydroxyindoleacetic acid and norepinephrine (ne) measured 1 week post-treatment. |
1994-01-27 |
2023-08-12 |
mouse |
| A M Andrews, D L Murph. 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263805. |
a long-term study showed that cortical and hippocampal 5-ht, 5-hydroxyindoleacetic acid and ne were still decreased 40% to 50% 6 months after treatment. |
1994-01-27 |
2023-08-12 |
mouse |
| A M Andrews, D L Murph. 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 267. issue 3. 1994-01-27. PMID:8263805. |
pretreatment with the 5-ht-selective uptake inhibitors, fluoxetine or paroxetine, or with the ne-selective uptake inhibitor, desipramine, prevented decreases in cortical and hippocampal 5-ht and ne, respectively, 3 weeks after 2'-nh2-mptp (4 x 20 mg/kg). |
1994-01-27 |
2023-08-12 |
mouse |
| Y Wada, M Nakamura, H Hasegawa, N Yamaguch. Intra-hippocampal injection of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) inhibits partial and generalized seizures induced by kindling stimulation in cats. Neuroscience letters. vol 159. issue 1-2. 1994-01-25. PMID:8264964. |
this study assessed the effects of microinjections of a serotonin (5-ht) 1a agonist, 8-oh-dpat, into the feline hippocampus (hip) on seizure response induced by electrical stimulation of this region. |
1994-01-25 |
2023-08-12 |
Not clear |
| M Y Chung, D G Kim, K J Yoo, S S Hon. Regional differences in the levels of biogenic amines and their metabolites in rat brain after tricyclic antidepressant treatments. Yonsei medical journal. vol 34. issue 3. 1994-01-14. PMID:8259704. |
it is noteworthy that chronic treatment with both desipramine and imipramine caused altered hippocampal concentrations of norepinephrine and/or 5-ht and its metabolites. |
1994-01-14 |
2023-08-12 |
rat |
| M Y Chung, D G Kim, K J Yoo, S S Hon. Regional differences in the levels of biogenic amines and their metabolites in rat brain after tricyclic antidepressant treatments. Yonsei medical journal. vol 34. issue 3. 1994-01-14. PMID:8259704. |
these results suggest that tricyclic antidepressants altered neurotransmission according to the brain region, and the hippocampal norepinephrine and 5-ht and/or the striatal dopamine may have a significant role for the expression of antidepressant action of tricyclic antidepressants. |
1994-01-14 |
2023-08-12 |
rat |
| F Molina-Holgado, E Molina-Holgado, M L Leret, M I González, T A Reade. Distribution of indoleamines and [3H]paroxetine binding in rat brain regions following acute or perinatal delta 9-tetrahydrocannabinol treatments. Neurochemical research. vol 18. issue 11. 1994-01-13. PMID:7504790. |
following acute treatment (5 mg/kg), the 5-ht content increased in dorsal hippocampus (+35%), substantia nigra (+61%) and neostriatum (+62%) but remained unchanged in cingulate cortex, raphe nuclei, locus coeruleus and anterior hypothalamus. |
1994-01-13 |
2023-08-12 |
rat |
| Y Cui, T F Lee, L I Kramarova, L C Wan. The modulatory effects of mu and kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels. Life sciences. vol 53. issue 26. 1994-01-11. PMID:8255158. |
the modulatory effects of mu and kappa opioid agonists on 5-ht release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels. |
1994-01-11 |
2023-08-12 |
Not clear |
| Y Cui, T F Lee, L I Kramarova, L C Wan. The modulatory effects of mu and kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels. Life sciences. vol 53. issue 26. 1994-01-11. PMID:8255158. |
dago ([d-ala2,n-me-phe4,gly-ol5]-enkephalin), a specific mu agonist, evoked a significant dose-dependent (10(-7)-10(-5) m) inhibition of k(+)-stimulated 5-ht release from hippocampal slices of the non-hibernating squirrels. |
1994-01-11 |
2023-08-12 |
Not clear |
| Y Cui, T F Lee, L I Kramarova, L C Wan. The modulatory effects of mu and kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels. Life sciences. vol 53. issue 26. 1994-01-11. PMID:8255158. |
in contrast, kappa agonist u50488 (10(-5) m) exerted a significant enhancement of k(+)-stimulated 5-ht release from hippocampal slices of the non-hibernating squirrels. |
1994-01-11 |
2023-08-12 |
Not clear |
| S Aspley, K C Fon. Galanin fails to alter both acquisition of a two trial per day water maze task and neurochemical markers of cholinergic or serotonergic neurones in adult rats. Brain research. vol 622. issue 1-2. 1994-01-06. PMID:7694768. |
following behavioural acquisition, five days of galanin administration did not alter choline acetyltransferase activity, thyrotrophin-releasing hormone-like immunoreactivity or 5-hydroxytryptamine levels or turnover in the frontal cortex, hippocampus or septum, although dopamine levels were significantly elevated in the frontal cortex. |
1994-01-06 |
2023-08-12 |
rat |
| T Mennini, C Taddei, A Codegoni, M Gobbi, S Garattin. Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine. European journal of pharmacology. vol 241. issue 2-3. 1994-01-06. PMID:8243560. |
acute noise stress decreased [3h]5-hydroxytryptamine ([3h]5-ht) uptake in synaptosomes from rat hypothalamus, hippocampus and cerebral cortex. |
1994-01-06 |
2023-08-12 |
rat |