| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Tao, S B Auerbac. Increased extracellular serotonin in rat brain after systemic or intraraphe administration of morphine. Journal of neurochemistry. vol 63. issue 2. 1994-08-12. PMID:7518500. |
systemic morphine also produced significant increases in extracellular 5-ht in the striatum and hippocampus during uptake inhibition. |
1994-08-12 |
2023-08-12 |
rat |
| U Staubli, N Otak. Serotonin controls the magnitude of LTP induced by theta bursts via an action on NMDA-receptor-mediated responses. Brain research. vol 643. issue 1-2. 1994-08-12. PMID:7913394. |
these results are discussed in terms of the known effects of serotonin on hippocampal physiology and how these might interact with the machinery whereby theta stimulation activates nmda receptor mediated currents. |
1994-08-12 |
2023-08-12 |
Not clear |
| S Haj-Dahmane, T Jolas, A M Laporte, H Gozlan, A J Farré, M Hamon, L Lanfume. Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. European journal of pharmacology. vol 255. issue 1-3. 1994-08-08. PMID:8026543. |
as expected of a full agonist at postsynaptic 5-ht1a receptors, lesopitron (ic50 = 125 nm) inhibited forskolin-stimulated adenylate cyclase activity in rat hippocampal membranes to the same extent as 5-ht, and this effect was preventable by potent 5-ht1a receptor antagonists such as (-)-tertatolol, (-)-propranolol and n-tert-butyl-3,4-(2-methoxyphenyl)piperazin-1-yl-2-phenyl- propanamide ((+)-way 100135). |
1994-08-08 |
2023-08-12 |
mouse |
| S Watabe, K Taniguchi, H Kojim. Improvement of impaired brain monoamine metabolism by the cognition-enhancing agent nefiracetam after microsphere-induced cerebral embolism in rats. Arzneimittel-Forschung. vol 44. issue 2A. 1994-07-27. PMID:7517140. |
5-ht contents in the control group significantly decreased from normal levels in the cortex and hippocampus, on which nefiracetam at various doses had no effect. |
1994-07-27 |
2023-08-12 |
rat |
| T De Boer, F Nefkens, A Van Helvoir. The alpha 2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo. European journal of pharmacology. vol 253. issue 1-2. 1994-07-26. PMID:7912194. |
on-line microdialysis studies in freely moving rats showed org 3770 (2 mg/kg s.c.) to increase hippocampal 5-ht (5-hydroxytryptamine) and dihydroxyphenyl acetic acid (dopac)--a measure of noradrenergic activity--by approximately 80%. |
1994-07-26 |
2023-08-12 |
rat |
| R Mongeau, C de Montigny, P Blie. Effects of long-term alpha-2 adrenergic antagonists and electroconvulsive treatments on the alpha-2 adrenoceptors modulating serotonin neurotransmission. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:7912278. |
the aim of the present study was to determine whether the alpha-2 adrenergic antagonists idazoxan (10 mg/kg/day x 21 days s.c.) and mianserin (5 mg/kg/day x 21 days s.c.), or electroconvulsive shocks (6 or 7 over a 2-week period) would also affect the alpha-2 adrenoceptors modulating 5-ht neurotransmission in the rat hippocampus. |
1994-07-26 |
2023-08-12 |
rat |
| E H Lee, Y L Yang, L G Chia, J S Ku. Interactions among deprenyl, clorgyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on catecholamines in mice. Neuroscience letters. vol 165. issue 1-2. 1994-07-26. PMID:7912414. |
the interactive effects of clorgyline, deprenyl and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on striatal dopamine (da), serotonin (5ht) and hippocampal norepinephrine (ne) were examined in the present study. |
1994-07-26 |
2023-08-12 |
mouse |
| E H Lee, Y L Yang, L G Chia, J S Ku. Interactions among deprenyl, clorgyline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on catecholamines in mice. Neuroscience letters. vol 165. issue 1-2. 1994-07-26. PMID:7912414. |
on the other hand, in all clorgyline-treated groups, there was a significant increase of 5ht in both the striatum and the hippocampus. |
1994-07-26 |
2023-08-12 |
mouse |
| L Cervo, C Bendotti, G Tarizzo, A Cagnotto, M Skorupska, T Mennini, R Samani. Potential antidepressant properties of SR 57746A, a novel compound with selectivity and high affinity for 5-HT1A receptors. European journal of pharmacology. vol 253. issue 1-2. 1994-07-26. PMID:8013540. |
the compound showed a high affinity for 5-ht1a specific binding sites in the rat hippocampus (ic50 3 nm), moderate affinity (10(-7)-10(-6) m) for dopamine d2 receptor, 5-ht uptake, 5-ht2 and alpha 1-adrenoceptor binding sites and practically no effect on binding sites of monoamine, gabaa, benzodiazepine and histamine receptors. |
1994-07-26 |
2023-08-12 |
rat |
| D S Kreiss, I Luck. Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014870. |
differential regulation of serotonin (5-ht) release in the striatum and hippocampus by 5-ht1a autoreceptors of the dorsal and median raphe nuclei. |
1994-07-26 |
2023-08-12 |
rat |
| D S Kreiss, I Luck. Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014870. |
5-ht release was measured simultaneously in the striatum and ventral hippocampus by using in vivo microdialysis in rats maintained under chloral hydrate anesthesia. |
1994-07-26 |
2023-08-12 |
rat |
| D S Kreiss, I Luck. Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014870. |
local administration of 8-oh-dpat into the striatum or hippocampus through the microdialysis probe did not alter 5-ht release. |
1994-07-26 |
2023-08-12 |
rat |
| D S Kreiss, I Luck. Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014870. |
local administration of 8-oh-dpat into the dorsal raphe nucleus reduced 5-ht release in the striatum, but not in the hippocampus. |
1994-07-26 |
2023-08-12 |
rat |
| D S Kreiss, I Luck. Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014870. |
conversely, administration of 8-oh-dpat into the median raphe nucleus reduced 5-ht release in the hippocampus, but not in the striatum. |
1994-07-26 |
2023-08-12 |
rat |
| D S Kreiss, I Luck. Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. The Journal of pharmacology and experimental therapeutics. vol 269. issue 3. 1994-07-26. PMID:8014870. |
the effects of systemic 8-oh-dpat on striatal 5-ht release were selectively blocked by concurrent administration of (-)-propranolol into the dorsal raphe nucleus, whereas effects of systemic 8-oh-dpat on hippocampal 5-ht release were selectively blocked by concurrent administration of (-)-propranolol into the median raphe nucleus. |
1994-07-26 |
2023-08-12 |
rat |
| M I Colado, A R Gree. A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:7516800. |
resulted in a 50% loss of cortical and hippocampal 5-ht and 5-hydroxyindole acetic acid (5-hiaa) 4 days later. |
1994-07-25 |
2023-08-12 |
rat |
| M I Colado, A R Gree. A study of the mechanism of MDMA ('ecstasy')-induced neurotoxicity of 5-HT neurones using chlormethiazole, dizocilpine and other protective compounds. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:7516800. |
resulted in a greater than 80% depletion of 5-ht in hippocampus and cortex 4 h later, reflecting the initial rapid release that had occurred. |
1994-07-25 |
2023-08-12 |
rat |
| D J Leishman, P H Boeijinga, M Galva. Differential effects of centrally-active antihypertensives on 5-HT1A receptors in rat dorso-lateral septum, rat hippocampus and guinea-pig hippocampus. British journal of pharmacology. vol 111. issue 1. 1994-07-25. PMID:8012713. |
the relative efficacies (5-ht = 1) of dp-5-ct, 8-oh-dpat, flesinoxan and 5-methyl-urapidil at the three sites were: rat hippocampus, 1.09, 0.7, 0.5 and 0.24; rat septum, 0.88, 0.69, 0.82 and 0.7; guinea-pig hippocampus, 1.0, 0.69, 0.89 and 0, respectively. |
1994-07-25 |
2023-08-12 |
rat |
| C Nyakas, B Buwalda, R J Kramers, J Traber, P G Luite. Postnatal development of hippocampal and neocortical cholinergic and serotonergic innervation in rat: effects of nitrite-induced prenatal hypoxia and nimodipine treatment. Neuroscience. vol 59. issue 3. 1994-07-21. PMID:8008208. |
postnatal development of ingrowing cholinergic and serotonergic fiber patterns were studied in the rat hippocampus and parietal cortex employing a histochemical procedure for acetylcholinesterase as a cholinergic fiber marker, and immunocytochemistry of serotonin for serotonergic fiber staining. |
1994-07-21 |
2023-08-12 |
rat |
| P W Burnet, D Michelson, M A Smith, P W Gold, E M Sternber. The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundances of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat. Brain research. vol 638. issue 1-2. 1994-07-07. PMID:8199869. |
to further characterize these strains, we investigated the effect of chronic (8 wk) imipramine administration (5 mg/kg/day) on 5-ht1a and 5-ht2 receptor densities and mrna in the cortex and hippocampus and 5-ht transporter mrna in the dorsal raphe of lew/n, hsd, and f344/n rats, using quantitative autoradiography and in situ hybridization histochemistry. |
1994-07-07 |
2023-08-12 |
rat |