| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Invernizzi, M Bramante, R Samani. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574685. |
citalopram, 1 and 10 mg/kg i.p., that in a previous study using identical treatment and dialysis conditions had little or no effect on dialysate serotonin (5-ht) in the frontal cortex, dose-dependently raised the extracellular concentrations of 5-ht in the dorsal hippocampus, by 70% and 205% respectively at the peak. |
1996-03-14 |
2023-08-12 |
rat |
| R Invernizzi, M Bramante, R Samani. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574685. |
in animals given 10 mg/kg citalopram twice daily for 14 days, intraperitoneal doses of 1 and 10 mg/kg or infusion of 10(-8) - 10(-6) m through the hippocampal probe raised dialysate 5-ht in the dorsal hippocampus similarly in animals treated chronically with citalopram or saline. |
1996-03-14 |
2023-08-12 |
rat |
| R Invernizzi, M Bramante, R Samani. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574685. |
a dose of 100 micrograms/kg 8-hydroxy-2-(di-n-propylamino)tetralin (8-oh-dpat), an agonist at 5-ht1a receptors, reduced hippocampal extracellular 5-ht concentrations to the same extent in rats repeatedly given saline or citalopram. |
1996-03-14 |
2023-08-12 |
rat |
| R Invernizzi, M Bramante, R Samani. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574685. |
the effect of citalopram and the sensitivity of autoreceptors controlling 5-ht release in the dorsal hippocampus were unaffected by a chronic treatment known to facilitate the drug's effect on dialysate 5-ht and to reduce the sensitivity of 5-ht1a receptors controlling 5-ht release in the frontal cortex. |
1996-03-14 |
2023-08-12 |
rat |
| R Invernizzi, M Bramante, R Samani. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain research. vol 696. issue 1-2. 1996-03-14. PMID:8574685. |
the effects of acute and chronic treatment with citalopram on dialysate 5-ht in the rat brain thus appear to differ in at least two brain regions: the frontal cortex and the dorsal hippocampus. |
1996-03-14 |
2023-08-12 |
rat |
| J M Monti, H Jantos, R Silveira, M Reyes-Parada, C Scorz. Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone. Pharmacology, biochemistry, and behavior. vol 52. issue 2. 1996-03-11. PMID:8577795. |
5,7-dht-treated animals showed a marked and significant serotonin and 5-hiaa depletion in the raphe regions of the pons and upper brain stem, cerebral cortex, hippocampus, and striatum. |
1996-03-11 |
2023-08-12 |
rat |
| M I Colado, A R Gree. The spin trap reagent alpha-phenyl-N-tert-butyl nitrone prevents 'ecstasy'-induced neurodegeneration of 5-hydroxytryptamine neurones. European journal of pharmacology. vol 280. issue 3. 1996-03-07. PMID:8566105. |
of 3,4-methylenedioxy-methamphetamine (mdma or 'ecstasy') produced a 40% loss of 5-hydroxytryptamine (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in cortex and hippocampus of dark agouti rats 7 days later. |
1996-03-07 |
2023-08-12 |
rat |
| L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570030. |
serotonin turnover rate, [3h]paroxetine binding sites, and 5-ht1a receptors in the hippocampus of rats subchronically treated with clonazepam. |
1996-03-04 |
2023-08-12 |
rat |
| L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570030. |
in order to further study the effect of this benzodiazepine on serotonin turnover rate, rats received clonazepam, 10 mg/kg for 10 days, and the concentrations of serotonin and 5-hydroxyindoleacetic acid were determined in the hippocampus after inhibition of monoamineoxidase with pargyline. |
1996-03-04 |
2023-08-12 |
rat |
| L Lima, E Trejo, M Urbin. Serotonin turnover rate, [3H]paroxetine binding sites, and 5-HT1A receptors in the hippocampus of rats subchronically treated with clonazepam. Neuropharmacology. vol 34. issue 10. 1996-03-04. PMID:8570030. |
the present observations indicate that clonazepam produces a reduction of serotonin turnover rate in the hippocampus of the rat concomitant with a down-regulation of 5-ht1a binding sites, probably by an effect at the forebrain projections. |
1996-03-04 |
2023-08-12 |
rat |
| M Asikainen, T Deboer, T Porkka-Heiskanen, D Stenberg, I Toble. Sleep deprivation increases brain serotonin turnover in the Djungarian hamster. Neuroscience letters. vol 198. issue 1. 1996-03-01. PMID:8570087. |
the 5-hydroxyindoleacetic acid/5-hydroxytryptamine (5-hiaa/5-ht) ratio was significantly increased after sd in the hippocampus, hypothalamus and brain stem, indicating increased serotonin (5-ht) turnover in those areas, while no changes were found in the frontal cortex and olfactory bulb. |
1996-03-01 |
2023-08-12 |
Not clear |
| U Oh, Y K Ho, D Ki. Modulation of the serotonin-activated K+ channel by G protein subunits and nucleotides in rat hippocampal neurons. The Journal of membrane biology. vol 147. issue 3. 1996-02-27. PMID:8558590. |
in hippocampal neurons, 5-hydroxytryptamine (5-ht) activates an inwardly rectifying k+ current via g protein. |
1996-02-27 |
2023-08-12 |
rat |
| U Oh, Y K Ho, D Ki. Modulation of the serotonin-activated K+ channel by G protein subunits and nucleotides in rat hippocampal neurons. The Journal of membrane biology. vol 147. issue 3. 1996-02-27. PMID:8558590. |
we identified the k+ channel activated by 5-ht (k5-ht channel) and studied the effects of g protein subunits and nucleotides on the k+ channel kinetics in adult rat hippocampal neurons. |
1996-02-27 |
2023-08-12 |
rat |
| R M Salimov, I I Poletaeva, G I Kovalev, N B Salimova, R R Gaĭnetdino. [Interstrain differences in extrapolation capacity and exploration of a cruciform maze correlate with various indices of monoamine metabolism in the brain]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 45. issue 5. 1996-02-23. PMID:8560938. |
the pattern of interstrain differences in noradrenaline level in the cortex and serotonin turnover indices in the hippocampus correlated with differences in extrapolation ability, while exploration strategies in the plus-maze correlated with differences in dopamine level and its turnover rate in the neocortex and striatum. |
1996-02-23 |
2023-08-12 |
mouse |
| D L Frederick, S F Ali, W Slikker, M P Gillam, R R Allen, M G Paul. Behavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys. Neurotoxicology and teratology. vol 17. issue 5. 1996-02-22. PMID:8551999. |
hippocampal 5-hiaa concentration, 5-ht uptake sites, and turnover of 5-ht of mdma-treated monkeys were significantly lower than control values. |
1996-02-22 |
2023-08-12 |
monkey |
| D L Frederick, S F Ali, W Slikker, M P Gillam, R R Allen, M G Paul. Behavioral and neurochemical effects of chronic methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys. Neurotoxicology and teratology. vol 17. issue 5. 1996-02-22. PMID:8551999. |
it is uncertain, however, if such tolerance is related to the observed decreases in uptake sites and turnover of 5-ht in the hippocampus of these monkeys. |
1996-02-22 |
2023-08-12 |
monkey |
| Y Takada, T Urano, H Ihara, A Takad. Changes in the central and peripheral serotonergic system in rats exposed to water-immersion restrained stress and nicotine administration. Neuroscience research. vol 23. issue 3. 1996-02-14. PMID:8545079. |
serotonin (5-ht) levels increased in the hypothalamus, hippocampus, cortex and cerebellum following the administration of nicotine. |
1996-02-14 |
2023-08-12 |
rat |
| Y Takada, T Urano, H Ihara, A Takad. Changes in the central and peripheral serotonergic system in rats exposed to water-immersion restrained stress and nicotine administration. Neuroscience research. vol 23. issue 3. 1996-02-14. PMID:8545079. |
nicotine decreased stress-induced increased levels of 5-ht in the hippocampus and cerebellum. |
1996-02-14 |
2023-08-12 |
rat |
| M G McNamara, J P Kelly, B E Leonar. Some behavioural and neurochemical aspects of subacute (+/-)3,4-methylenedioxymethamphetamine administration in rats. Pharmacology, biochemistry, and behavior. vol 52. issue 3. 1996-02-14. PMID:8545462. |
mdma caused a significant depletion of both 5-ht and 5-hydroxyindoleacetic acid (5-hiaa) in the frontal cortex and amygdala and a significant elevation of dopamine and noradrenaline in the hippocampus. |
1996-02-14 |
2023-08-12 |
rat |
| R McQuade, T Shar. Release of cerebral 5-hydroxytryptamine evoked by electrical stimulation of the dorsal and median raphe nuclei: effect of a neurotoxic amphetamine. Neuroscience. vol 68. issue 4. 1996-02-12. PMID:8544983. |
brain microdialysis was used to monitor extracellular 5-hydroxytryptamine in the hippocampus (dorsal and median raphe innervation) and frontal cortex (preferential dorsal raphe innervation) of the anaesthetized rat. |
1996-02-12 |
2023-08-12 |
rat |