| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eric P M Prinssen, Marie-Bernadette Assié, Wouter Koek, Mark S Kleve. Depletion of 5-HT disrupts prepulse inhibition in rats: dependence on the magnitude of depletion, and reversal by a 5-HT precursor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 3. 2002-04-02. PMID:11850148. |
repeated treatment with the 5-ht synthesis inhibitor p-chlorophenylalanine methyl ester (pcpa; 160 mg/kg) produced a small, but significant, attenuation of ppi, and a large decrease in extracellular 5-ht levels in the hippocampus, as measured in independent microdialysis experiments. |
2002-04-02 |
2023-08-12 |
rat |
| W J Riedel, T Klaassen, E Griez, A Honig, P P C A Menheere, H M van Praa. Dissociable hormonal, cognitive and mood responses to neuroendocrine challenge: evidence for receptor-specific serotonergic dysregulation in depressed mood. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 26. issue 3. 2002-04-02. PMID:11850150. |
the results support the evidence for both hypothalamic and possibly hippocampal 5-ht(1a) receptor desensitisation and non-hypothalamic, 5-ht(2c) receptor sensitisation, probably fronto-cortical, in patients with major depression and dysthymia. |
2002-04-02 |
2023-08-12 |
Not clear |
| Yoshiaki Miyamoto, Kiyofumi Yamada, Yukihiro Noda, Hisashi Mori, Masayoshi Mishina, Toshitaka Nabeshim. Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 6. 2002-03-27. PMID:11896172. |
a postmortem examination in glurepsilon4 mutant mice revealed that tissue contents of norepinephrine, dopamine, serotonin, and their metabolites were reduced in the hippocampus and that dopamine, as well as serotonin, metabolism was upregulated in the frontal cortex, striatum, hippocampus, and thalamus. |
2002-03-27 |
2023-08-12 |
mouse |
| Vita Birzniece, Inga-Maj Johansson, Ming-De Wang, Torbjörn Bäckström, Tommy Olsso. Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats. Neuroscience letters. vol 319. issue 3. 2002-03-26. PMID:11834317. |
ovarian hormone effects on 5-hydroxytryptamine(2a) and 5-hydroxytryptamine(2c) receptor mrna expression in the ventral hippocampus and frontal cortex of female rats. |
2002-03-26 |
2023-08-12 |
rat |
| Vita Birzniece, Inga-Maj Johansson, Ming-De Wang, Torbjörn Bäckström, Tommy Olsso. Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats. Neuroscience letters. vol 319. issue 3. 2002-03-26. PMID:11834317. |
the aim of the present study was to determine influences of chronic gonadal hormone supplementation on 5-ht(2a) and 5-ht(2c) receptor mrna levels in the ventral hippocampus and the frontal cerebral cortex. |
2002-03-26 |
2023-08-12 |
rat |
| Vita Birzniece, Inga-Maj Johansson, Ming-De Wang, Torbjörn Bäckström, Tommy Olsso. Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats. Neuroscience letters. vol 319. issue 3. 2002-03-26. PMID:11834317. |
serotonin receptor mrna levels were analyzed by in situ hybridization in the ventral hippocampus and 5-ht(2a) receptor mrna also in the frontal cortex. |
2002-03-26 |
2023-08-12 |
rat |
| Vita Birzniece, Inga-Maj Johansson, Ming-De Wang, Torbjörn Bäckström, Tommy Olsso. Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats. Neuroscience letters. vol 319. issue 3. 2002-03-26. PMID:11834317. |
estradiol treatment in combination with low-dose progesterone increased 5-ht(2a) receptor mrna by 43% in the ca2 region of the ventral hippocampus, while estradiol combined with high-dose progesterone increased the expression of this gene by 84% in ventral ca1. |
2002-03-26 |
2023-08-12 |
rat |
| Vita Birzniece, Inga-Maj Johansson, Ming-De Wang, Torbjörn Bäckström, Tommy Olsso. Ovarian hormone effects on 5-hydroxytryptamine(2A) and 5-hydroxytryptamine(2C) receptor mRNA expression in the ventral hippocampus and frontal cortex of female rats. Neuroscience letters. vol 319. issue 3. 2002-03-26. PMID:11834317. |
5-ht(2c) receptor gene expression was in the ventral hippocampus decreased in the ca2, ventral ca1 and the subiculum subregions by high-dose estradiol treatment (8-20% decreases). |
2002-03-26 |
2023-08-12 |
rat |
| S Aznar, G M Knudse. Serotonin induces a decrease of 5-HT(1A) immunoreactivity in organotypic hippocampal cultures. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742209. |
serotonin induces a decrease of 5-ht(1a) immunoreactivity in organotypic hippocampal cultures. |
2002-03-18 |
2023-08-12 |
Not clear |
| S Aznar, G M Knudse. Serotonin induces a decrease of 5-HT(1A) immunoreactivity in organotypic hippocampal cultures. Neuroreport. vol 12. issue 18. 2002-03-18. PMID:11742209. |
different concentrations of serotonin (0.5, 1, 10, 50 and 100 microm) were added to organotypic hippocampal cultures and incubated for 1 week. |
2002-03-18 |
2023-08-12 |
Not clear |
| Delia M Vázquez, Ramin Eskandari, Carrie A Zimmer, Seymour Levine, Juan F Lópe. Brain 5-HT receptor system in the stressed infant rat: implications for vulnerability to substance abuse. Psychoneuroendocrinology. vol 27. issue 1-2. 2002-03-18. PMID:11750782. |
maternally deprived animals also showed a decrease in corticosteroid receptors and an increase in 5-ht 1a and 1b receptors restricted to the ca1 region of the hippocampus. |
2002-03-18 |
2023-08-12 |
rat |
| A J Thomas, B O Erokwu, B K Yamamoto, P Ernsberger, O Bishara, K P Stroh. Alterations in respiratory behavior, brain neurochemistry and receptor density induced by pharmacologic suppression of sleep in the neonatal period. Brain research. Developmental brain research. vol 120. issue 2. 2002-03-14. PMID:10775770. |
on p21 (14 days after the end of drug exposure), pups from each condition were sacrificed and punch biopsies of the frontal cortex, hypothalamus, and hippocampus were examined for hydroxytryptophan (5-ht), and norepinepherine (ne) by hplc. |
2002-03-14 |
2023-08-12 |
rat |
| Alexander Kulla, Denise Manahan-Vaugha. Modulation by serotonin 5-HT(4) receptors of long-term potentiation and depotentiation in the dentate gyrus of freely moving rats. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 2. 2002-03-14. PMID:11739263. |
5-ht(4) receptors are expressed in the hippocampus and are suggested to be involved in hippocampus-dependent cognitive processes. |
2002-03-14 |
2023-08-12 |
rat |
| Alexander Kulla, Denise Manahan-Vaugha. Modulation by serotonin 5-HT(4) receptors of long-term potentiation and depotentiation in the dentate gyrus of freely moving rats. Cerebral cortex (New York, N.Y. : 1991). vol 12. issue 2. 2002-03-14. PMID:11739263. |
these results strongly support a role for 5-ht(4) receptors in hippocampal synaptic plasticity and provide an important link to findings with regard to the involvement of 5-ht in processes related to learning and memory. |
2002-03-14 |
2023-08-12 |
rat |
| N Okado, M Narita, N Narit. A biogenic amine-synapse mechanism for mental retardation and developmental disabilities. Brain & development. vol 23 Suppl 1. 2002-03-13. PMID:11738835. |
in fact, maternal stress has been shown to decrease the levels of serotonin and the density of synapses in the hippocampus of the offspring, and they showed developmental disabilities in the spatial learning and memory. |
2002-03-13 |
2023-08-12 |
Not clear |
| T G Amstislavskaia, N K Popov. [Serotonin metabolism in the brain during sexual motivation and activation of the murine hypothalamo-hypophyseal-testicular system]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 51. issue 5. 2002-03-08. PMID:11764518. |
longer sexual activation of male rats (for 20 min) resulted in an increase in the content of serotonin and 5-hiaa in the amygdala and olfactory bubs, while in the hippocampus only the level of 5-hiaa increased. |
2002-03-08 |
2023-08-12 |
mouse |
| W P Daugherty, K C Corley, T H Phan, M C Boadle-Bibe. Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743977. |
the present study reveals that this activation also occurs in serotonin projection areas, in hippocampus, nucleus accumbens and cortex but not in caudate nucleus. |
2002-03-05 |
2023-08-12 |
rat |
| W P Daugherty, K C Corley, T H Phan, M C Boadle-Bibe. Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743977. |
two approaches are used in sprague-dawley rat to measure the activation of serotonergic neurons: (1) determination ex vivo of accumulation of 5-hydroxytryptophan (5-htp) in tissue from the dorsal and median raphe nuclei, hippocampus, cortex, caudate nucleus, and nucleus accumbens following in vivo inhibition of aromatic amino acid decarboxylase; and (2) measurement of extracellular serotonin levels in hippocampus, caudate nucleus, and nucleus accumbens. |
2002-03-05 |
2023-08-12 |
rat |
| W P Daugherty, K C Corley, T H Phan, M C Boadle-Bibe. Further studies on the activation of rat median raphe serotonergic neurons by inescapable sound stress. Brain research. vol 923. issue 1-2. 2002-03-05. PMID:11743977. |
sound stress also enhances extracellular serotonin levels in hippocampus and nucleus accumbens, but not caudate nucleus. |
2002-03-05 |
2023-08-12 |
rat |
| P Kehoe, K Mallinson, J Bronzino, C M McCormic. Effects of prenatal protein malnutrition and neonatal stress on CNS responsiveness. Brain research. Developmental brain research. vol 132. issue 1. 2002-03-05. PMID:11744104. |
specifically, we assessed the levels of plasma corticosterone, as well as dopamine, serotonin and their metabolites in both the hypothalamus and hippocampus in rat pups that had been prenatally malnourished (6% casein diet) and isolated from nest, dam, and siblings for 1 h daily during postnatal days (pnd) 2 through 8. |
2002-03-05 |
2023-08-12 |
rat |