| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Boris Sakic, Susan Lacosta, Judah A Denburg, Henry Szechtma. Altered neurotransmission in brains of autoimmune mice: pharmacological and neurochemical evidence. Journal of neuroimmunology. vol 129. issue 1-2. 2002-09-27. PMID:12161024. |
in particular, mrl-lpr brains showed increased dopamine (da) levels in the paraventricular nucleus (pvn) and median eminence (me), decreased concentrations of serotonin in the pvn and enhanced levels in the hippocampus, as well as decreased norepinephrine (ne) levels in the prefrontal cortex. |
2002-09-27 |
2023-08-12 |
mouse |
| B Bjorvatn, J Grønli, F Hamre, E Sørensen, E Fiske, A A Bjørkum, C M Portas, R Ursi. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Neuroscience. vol 113. issue 2. 2002-09-26. PMID:12127089. |
effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. |
2002-09-26 |
2023-08-12 |
rat |
| B Bjorvatn, J Grønli, F Hamre, E Sørensen, E Fiske, A A Bjørkum, C M Portas, R Ursi. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Neuroscience. vol 113. issue 2. 2002-09-26. PMID:12127089. |
in this study, we used in vivo microdialysis to monitor extracellular serotonin in the hippocampus and the frontal cortex of rats during an 8 h sleep deprivation period. |
2002-09-26 |
2023-08-12 |
rat |
| B Bjorvatn, J Grønli, F Hamre, E Sørensen, E Fiske, A A Bjørkum, C M Portas, R Ursi. Effects of sleep deprivation on extracellular serotonin in hippocampus and frontal cortex of the rat. Neuroscience. vol 113. issue 2. 2002-09-26. PMID:12127089. |
sleep deprivation produced a gradual decline in extracellular serotonin levels, both in the hippocampus and in the frontal cortex. |
2002-09-26 |
2023-08-12 |
rat |
| Gonzalo Viana Di Prisco, Zimbul Albo, Robert P Vertes, Bernat Kocsi. Discharge properties of neurons of the median raphe nucleus during hippocampal theta rhythm in the rat. Experimental brain research. vol 145. issue 3. 2002-09-26. PMID:12136388. |
the serotonin (5-ht)-containing median raphe nucleus has been shown to be critically involved in the control of desynchronized (non theta) states of the hippocampal electroencephalogram (eeg). |
2002-09-26 |
2023-08-12 |
rat |
| Gonzalo Viana Di Prisco, Zimbul Albo, Robert P Vertes, Bernat Kocsi. Discharge properties of neurons of the median raphe nucleus during hippocampal theta rhythm in the rat. Experimental brain research. vol 145. issue 3. 2002-09-26. PMID:12136388. |
an activation of local serotonergic and gabaergic theta-on cells would inhibit 5-ht slow- or moderate-firing theta-off projection cells to release or generate theta, whereas the suppression of serotonergic- or gabaergic theta-on cells would disinhibit 5-ht theta-off cells, resulting in a blockade of theta or a desynchronization of the hippocampal eeg. |
2002-09-26 |
2023-08-12 |
rat |
| Michelle E Page, John F Cryan, Arthur Sullivan, Ashutosh Dalvi, Berangere Saucy, David R Manning, Irwin Luck. Behavioral and neurochemical effects of 5-(4-[4-(5-Cyano-3-indolyl)-butyl)-butyl]-1-piperazinyl)-benzofuran-2-carboxamide (EMD 68843): a combined selective inhibitor of serotonin reuptake and 5-hydroxytryptamine(1A) receptor partial agonist. The Journal of pharmacology and experimental therapeutics. vol 302. issue 3. 2002-09-18. PMID:12183683. |
acute, systemic administration of emd 68843 produced a larger maximal increase of extracellular 5-ht than the ssri fluoxetine in both the ventral hippocampus (hpv) (558 versus 274%) and the frontal cortex (fc) (527 versus 165%). |
2002-09-18 |
2023-08-12 |
mouse |
| M N Subhash, B N Srinivas, K Y Vino. Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain. Life sciences. vol 71. issue 13. 2002-09-12. PMID:12127910. |
the chronic administration of trazodone (10 mg/kg body wt, 40 days) resulted in a significant downregulation of [(3)h]5-ht binding sites and 5-ht(1a) receptors in cortex and hippocampus. |
2002-09-12 |
2023-08-12 |
rat |
| M N Subhash, B N Srinivas, K Y Vino. Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain. Life sciences. vol 71. issue 13. 2002-09-12. PMID:12127910. |
trazodone significantly (p < 0.0001) decreased the density of [(3)h]5-ht binding sites in cortex (42.6 +/- 3.6 fmol/mg protein, 65%) and hippocampus (12.6 +/- 1.6 fmol/mg protein, 87%) when compared to control values of 121.9 +/- 5.4 and 99.3 +/- 7.5 fmol/mg protein in these regions, respectively. |
2002-09-12 |
2023-08-12 |
rat |
| M N Subhash, B N Srinivas, K Y Vino. Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain. Life sciences. vol 71. issue 13. 2002-09-12. PMID:12127910. |
similarly there was a significant (p < 0.0001) decrease in the density of 5-ht(1a) receptors in both cortex (7.2 +/- 0.5 fmol/mg protein, 70%) and hippocampus (6.3 +/- 1.2 fmol/mg protein, 79%) when compared to control values of 24.2 +/- 2.1 and 30.6 +/- 3.7 fmol/mg protein, in these regions respectively. |
2002-09-12 |
2023-08-12 |
rat |
| M N Subhash, B N Srinivas, K Y Vino. Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain. Life sciences. vol 71. issue 13. 2002-09-12. PMID:12127910. |
the basal ac activity did not alter in treated rats, where as, the inhibition of forskolin-stimulated ac activity by 5-ht (10 microm) was significantly (p < 0.0001) decreased both in cortex (43%) and hippocampus (40%) when compared to control levels. |
2002-09-12 |
2023-08-12 |
rat |
| M N Subhash, B N Srinivas, K Y Vino. Alterations in 5-HT(1A) receptors and adenylyl cyclase response by trazodone in regions of rat brain. Life sciences. vol 71. issue 13. 2002-09-12. PMID:12127910. |
in conclusion, chronic treatment with trazodone results in downregulation of 5-ht(1a) receptors in cortex and hippocampus along with concomitant increased ac response, suggesting the involvement of 5-ht(1a) receptor-mediated ac response in the mechanism of action of trazodone. |
2002-09-12 |
2023-08-12 |
rat |
| Milena Koprowska, Maria Krotewicz, Andrzej Romaniuk, Magdalena Strzelczuk, Marek Wieczore. Fear behavior and regional brain monoamines distribution after R(+)-8-OHDPAT and R(+)-UH-301 injections into the dorsal raphe nucleus in rats. Acta neurobiologiae experimentalis. vol 62. issue 2. 2002-09-12. PMID:12201034. |
the effects of 8-ohdpat and uh-301 injection into the dorsal raphe nucleus (drn) on fear behavior of the light-dark transitions test and regional brain monoamines (na, da, 5-ht) and their metabolites (mhpg, dopac, 5-hiaa) in the hypothalamus (hpt), midbrain central gray matter (mid), amygdala (amy), hippocampus (hip) and pons (po) were examined. |
2002-09-12 |
2023-08-12 |
rat |
| Pallab Seth, Survjit Cheeta, Sonia Tucci, Sandra E Fil. Nicotinic--serotonergic interactions in brain and behaviour. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888570. |
nicotine increases 5-hydroxytryptamine (5-ht) release in the cortex, striatum, hippocampus, dorsal raphé nucleus (drn), hypothalamus, and spinal cord. |
2002-09-11 |
2023-08-12 |
Not clear |
| Pallab Seth, Survjit Cheeta, Sonia Tucci, Sandra E Fil. Nicotinic--serotonergic interactions in brain and behaviour. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888570. |
the effects in the cortex, hippocampus, and drn involve stimulation of 5-ht(1a) receptors, and in the striatum, 5-ht(3) receptors. |
2002-09-11 |
2023-08-12 |
Not clear |
| Pallab Seth, Survjit Cheeta, Sonia Tucci, Sandra E Fil. Nicotinic--serotonergic interactions in brain and behaviour. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888570. |
the 5-ht(1a) receptors in the drn play a role in mediating the anxiolytic effects of nicotine and the 5-ht(1a) receptors in the dorsal hippocampus and lateral septum mediate its anxiogenic effects. |
2002-09-11 |
2023-08-12 |
Not clear |
| Eva Hajós-Korcsok, Trevor Shar. Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888571. |
both drn and mrn stimulations enhanced extracellular 5-ht levels in the lc and previous studies have demonstrated that extracellular 5-ht also increases in the hippocampus. |
2002-09-11 |
2023-08-12 |
rat |
| Eva Hajós-Korcsok, Trevor Shar. Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888571. |
however, the increase in hippocampal noradrenaline evoked by drn stimulation was not altered by 5-ht neuronal lesions, which reduced 5-ht metabolite levels by 90%. |
2002-09-11 |
2023-08-12 |
rat |
| Eva Hajós-Korcsok, Trevor Shar. Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888571. |
in conclusion, electrical stimulation of the midbrain raphe increases extracellular noradrenaline in the hippocampus, however, experiments in 5-ht-lesioned animals suggest that this response is not mediated by 5-ht. |
2002-09-11 |
2023-08-12 |
rat |
| Kevin C F Fone, Ian A Topha. Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats. Pharmacology, biochemistry, and behavior. vol 71. issue 4. 2002-09-11. PMID:11888572. |
the flat body posture, reciprocal forepaw treading, elevated corticosterone, hyperglycaemia, hypothermia and reduced hippocampal 5-ht induced by the 5-ht(1a) agonist 8-ohdpat (0.3 mg/kg ip) were all significantly attenuated by the corticosterone implant. |
2002-09-11 |
2023-08-12 |
rat |