| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ulf Bickmeyer, Martin Heine, Till Manzke, Diethelm W Richte. Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons. The European journal of neuroscience. vol 16. issue 2. 2002-11-06. PMID:12169103. |
ca1 pyramidal neurons of the hippocampus express various types of serotonin (5-ht) receptors, such as 5-ht(1a), 5-ht(4) and 5-ht(7) receptors, which couple to galpha(i) or galpha(s) proteins and operate on different intracellular signalling pathways. |
2002-11-06 |
2023-08-12 |
mouse |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
we used intracerebral microdialysis to study the role of raphe and presynaptic serotonin (5-ht) autoreceptors in the effect of the selective 5-ht reuptake inhibitor, paroxetine, on 5-ht release from ventral hippocampus of anaesthetised rats. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
in addition, we have tested the ability of pindolol, a non-selective beta-adrenergic/5-ht(1a) receptor antagonist, to alter the response of hippocampal 5-ht to paroxetine. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
doses of paroxetine with maximal effects were near to three-fold less effective when administered systemically than after local infusion at increasing extracellular 5-ht in ventral hippocampus. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
moreover, systemic paroxetine treatment resulted in a marked decrease of the extracellular 5-ht in the hippocampus when 5-ht reuptake was blocked with paroxetine 3 microm applied locally, thereby evidencing that systemic treatment induced a decrease of 5-ht release in the neuronal terminal. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
racemic (+/-)-pindolol (10 mg/kg, s.c.) completely blocked the paroxetine-induced decrease in 5-ht release from rat hippocampus. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
in addition, the infusion into median raphe of (-)-pindolol, the isoform with highest antagonist activity, at concentrations of 10 microm and 100 microm was able to partially block the decrease of hippocampal 5-ht release after systemic paroxetine. |
2002-11-04 |
2023-08-12 |
rat |
| Jesús M Míguez, Lucinda Paz-Valiñas, Isabel Míguez, Manuel Aldegund. Somatodendritic action of pindolol to attenuate the paroxetine-induced decrease in serotonin release from the rat ventral hippocampus: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology. vol 365. issue 5. 2002-11-04. PMID:12012024. |
however, perfusion of (-)-pindolol into the hippocampus was without effect on local 5-ht release. |
2002-11-04 |
2023-08-12 |
rat |
| A E Umriukhin, R Landgra. [Serotonin in brain regions of rats differing in their inborn locomotor activity]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 52. issue 3. 2002-10-24. PMID:12125406. |
serotonin contents in the paraventricular hypothalamic nucleus (pvn) and dorsal hippocampus of rats with different levels of inborn motor activity were studied by microdialysis in basal and stimulated conditions. |
2002-10-24 |
2023-08-12 |
rat |
| A E Umriukhin, R Landgra. [Serotonin in brain regions of rats differing in their inborn locomotor activity]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 52. issue 3. 2002-10-24. PMID:12125406. |
in basal conditions, differences in serotonin contents between rats with different levels of inborn motor activity were found neither in hippocampus nor in pvn. |
2002-10-24 |
2023-08-12 |
rat |
| A E Umriukhin, R Landgra. [Serotonin in brain regions of rats differing in their inborn locomotor activity]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 52. issue 3. 2002-10-24. PMID:12125406. |
in both kinds of stress conditions, serotonin content in hippocampus increased only in rats with higher level of inborn motor activity. |
2002-10-24 |
2023-08-12 |
rat |
| G Roglic, D Andric, S Kostic-Rajacic, S Dukic, V Soski. Introduction of a methyl group in alpha- or beta-position of 1-heteroarylethyl-4-phenylpiperazines affects their dopaminergic/serotonergic properties. Archiv der Pharmazie. vol 334. issue 12. 2002-10-22. PMID:11852532. |
they were evaluated for in vitro binding affinity at the d1 and d2 dopamine and 5-ht1a serotonin receptors using synaptosomal membranes of the bovine caudate nucleus and hippocampus, respectively, as a source of the corresponding receptors. |
2002-10-22 |
2023-08-12 |
cattle |
| Mikhail V Pletnikov, Steven A Rubin, Michael W Vogel, Timothy H Moran, Kathryn M Carbon. Effects of genetic background on neonatal Borna disease virus infection-induced neurodevelopmental damage. II. Neurochemical alterations and responses to pharmacological treatments. Brain research. vol 944. issue 1-2. 2002-10-11. PMID:12106671. |
neonatal bdv infection also induced upregulation of hippocampal 5-ht(1a) and cortical 5-ht(2a) receptors in lewis rats and downregulation of cortical 5-ht(2a) receptors in fisher344 rats. |
2002-10-11 |
2023-08-12 |
human |
| C Shen, H Li, E Melle. Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTP gamma S binding in rat brain regions. Neuropharmacology. vol 42. issue 8. 2002-10-11. PMID:12128004. |
three brain regions rich in 5-ht(1a) receptors were examined: the dorsal raphe (somatodendritic), the dorsal hippocampus (postsynaptic) and the lateral septum (postsynaptic). |
2002-10-11 |
2023-08-12 |
rat |
| C Shen, H Li, E Melle. Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTP gamma S binding in rat brain regions. Neuropharmacology. vol 42. issue 8. 2002-10-11. PMID:12128004. |
these results generally support the concept of a net enhancement of hippocampal 5-ht neurotransmission via one or more 5-ht receptor subtypes. |
2002-10-11 |
2023-08-12 |
rat |
| Rosa M Tordera, Antonio Monge, Joaquín Del Río, Berta Lashera. Antidepressant-like activity of VN2222, a serotonin reuptake inhibitor with high affinity at 5-HT1A receptors. European journal of pharmacology. vol 442. issue 1-2. 2002-10-08. PMID:12020683. |
in keeping with the binding affinity at the 5-ht transporter, vn2222 inhibited 5-ht uptake in vitro both in rat cortical synaptosomes and in mesencephalic cultures and also in vivo when administered locally into the rat ventral hippocampus. |
2002-10-08 |
2023-08-12 |
mouse |
| Luc Zimmer, André Luxen, Fabrice Giacomelli, Jean-François Pujo. Short- and long-term effects of p-ethynylphenylalanine on brain serotonin levels. Neurochemical research. vol 27. issue 4. 2002-10-04. PMID:11958527. |
changes in tissue and extracellular serotonin (5-ht) in raphe dorsalis, raphe medialis and in their main projections areas (hippocampus, striatum and frontal cortex) were investigated at short and long-term times after single injection (5 mg/kg ip) of a novel tryptophan hydroxylase inhibitor, p-ethynylphenylalanine (p-epa). |
2002-10-04 |
2023-08-12 |
Not clear |
| Luc Zimmer, André Luxen, Fabrice Giacomelli, Jean-François Pujo. Short- and long-term effects of p-ethynylphenylalanine on brain serotonin levels. Neurochemical research. vol 27. issue 4. 2002-10-04. PMID:11958527. |
moreover, in the projection areas, the extracellular 5-ht levels decreased rapidly, 90, 40 and 30 min after p-epa injection, in hippocampus, striatum and frontal cortex, respectively. |
2002-10-04 |
2023-08-12 |
Not clear |
| Lara Orús, Silvia Pérez-Silanes, Ana-M Oficialdegui, Javier Martínez-Esparza, Juan-C Del Castillo, Marisa Mourelle, Thierry Langer, Salvatore Guccione, Giuseppina Donzella, Eva M Krovat, Konstantin Poptodorov, Berta Lasheras, Santiago Ballaz, Isabel Hervías, Rosa Tordera, Joaquín Del Río, Antonio Mong. Synthesis and molecular modeling of new 1-aryl-3-[4-arylpiperazin-1-yl]-1-propane derivatives with high affinity at the serotonin transporter and at 5-HT(1A) receptors. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213056. |
the compounds showing the higher affinity at both the 5-ht transporter (k(i) < 50 nm) and the 5-ht(1a) receptors (k(i) < 20 nm) were further explored for their ability to stimulate [(35)s]gtpgammas binding or to antagonize 8-hydroxy-2-di-n-propylamino-tetralin (8-oh-dpat)-stimulated [(35)]gtpgammas binding to rat hippocampal membranes, an index of agonist/antagonist action at 5-ht(1a) receptors, respectively. |
2002-10-01 |
2023-08-12 |
mouse |