| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anja Birthelmer, Theresa Schweizer, Hélène Jeltsch, Rolf Jackisch, Jean-Christophe Casse. 5,7-Dihydroxytryptamine lesions enhance and serotonergic grafts normalize the evoked overflow of acetylcholine in rat hippocampal slices. The European journal of neuroscience. vol 16. issue 10. 2003-03-05. PMID:12453047. |
about 11 months later, we assessed baseline and electrically evoked release of tritium ([3h]) in hippocampal slices, preloaded with tritiated ([3h])choline or [3h]serotonin (5-ht), in the presence or absence of the 5-ht1b receptor agonist cp-93,129 and the 5-ht receptor antagonist methiothepine. |
2003-03-05 |
2023-08-12 |
rat |
| Vaishali A Kulkarni, Shanker Jha, Vidita A Vaidy. Depletion of norepinephrine decreases the proliferation, but does not influence the survival and differentiation, of granule cell progenitors in the adult rat hippocampus. The European journal of neuroscience. vol 16. issue 10. 2003-03-05. PMID:12453065. |
a few studies have examined the neurotransmitter regulation of adult hippocampal neurogenesis and have shown that this process is regulated by serotonin and glutamate. |
2003-03-05 |
2023-08-12 |
rat |
| Janusz Szyndler, Paulina Rok, Piotr Maciejak, Jerzy Walkowiak, Agnieszka I Członkowska, Halina Sienkiewicz-Jarosz, Aleksandra Wisłowska, Małgorzata Zienowicz, Małgorzata Lehner, Andrzej Bidziński, Wojciech Kostowski, Adam Plazni. Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems. Pharmacology, biochemistry, and behavior. vol 73. issue 4. 2003-03-04. PMID:12213531. |
simultaneously, ptz kindling decreased the concentration of homovanillic acid (hva) and 5-hydroxyindoleacetic acid (5-hiaa) in the prefrontal cortex, decreased the da (hva/da ratio) turnover rate in the striatum, and inhibited the serotonin (5-ht) metabolism (5-hiaa/5-ht ratio) in the hippocampus and the prefrontal cortex. |
2003-03-04 |
2023-08-12 |
rat |
| Janusz Szyndler, Paulina Rok, Piotr Maciejak, Jerzy Walkowiak, Agnieszka I Członkowska, Halina Sienkiewicz-Jarosz, Aleksandra Wisłowska, Małgorzata Zienowicz, Małgorzata Lehner, Andrzej Bidziński, Wojciech Kostowski, Adam Plazni. Effects of pentylenetetrazol-induced kindling of seizures on rat emotional behavior and brain monoaminergic systems. Pharmacology, biochemistry, and behavior. vol 73. issue 4. 2003-03-04. PMID:12213531. |
the hypothesis is put forward that ptz kindling-induced inhibition of the serotonergic innervation may lead to the compensatory increase in 5-ht(1a) receptors in the dentate gyrus of the hippocampus, thus evoking the anxiolytic-like changes in animal behavior. |
2003-03-04 |
2023-08-12 |
rat |
| Naoko Narita, Michiko Kato, Mami Tazoe, Kaoru Miyazaki, Masaaki Narita, Nobuo Okad. Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. Pediatric research. vol 52. issue 4. 2003-03-04. PMID:12357053. |
of the groups exposed to thalidomide on embryonic day (e)2, e4, e7, e9, and e11, a significant increase of hippocampal serotonin was only observed in the group exposed on e9. |
2003-03-04 |
2023-08-12 |
human |
| Naoko Narita, Michiko Kato, Mami Tazoe, Kaoru Miyazaki, Masaaki Narita, Nobuo Okad. Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. Pediatric research. vol 52. issue 4. 2003-03-04. PMID:12357053. |
furthermore, e9 thalidomide and valproic acid exposure both resulted in an increase of hippocampal serotonin, frontal cortex dopamine, and hyperserotonemia. |
2003-03-04 |
2023-08-12 |
human |
| Masakazu Fujio, Shinji Nagata, Kazunori Kawamura, Naoki Sugiyama, Hiroshi Tanaka, Kimiichi Uno, Kiichi Ishiwat. Synthesis and evaluation of (11)C-labeled (S)-N-[[1-(2-phenylethyl) pyrrolidin-2-yl]methyl]-3-methylthiobenzamide as a PET 5-HT(1A) receptor ligand. Nuclear medicine and biology. vol 29. issue 6. 2003-03-03. PMID:12234590. |
both radioligands showed similar brain distribution in mice with relatively higher affinity for the hippocampus being rich in 5-ht(1a) receptors than for other brain regions. |
2003-03-03 |
2023-08-12 |
mouse |
| Theresa Schweizer, Anja Birthelmer, Hélène Jeltsch, Jean-Christophe Cassel, Rolf Jackisc. Raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors. Neuroreport. vol 13. issue 15. 2003-02-07. PMID:12395082. |
raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-ht1a autoreceptors. |
2003-02-07 |
2023-08-12 |
rat |
| Theresa Schweizer, Anja Birthelmer, Hélène Jeltsch, Jean-Christophe Cassel, Rolf Jackisc. Raphé grafts and 3,4-diaminopyridine-evoked overflow of serotonin in the rat hippocampus after 5,7-dihydroxytryptamine lesions: evidence for 5-HT1A autoreceptors. Neuroreport. vol 13. issue 15. 2003-02-07. PMID:12395082. |
a first experiment verified that the overflow of 5-ht evoked by 75 microm 3,4-diaminopyridine in superfused hippocampal slices was calcium-dependent, tetrodotoxin-sensitive and modulable by drugs acting on 5-ht autoreceptors. |
2003-02-07 |
2023-08-12 |
rat |
| Jonathan C Gewirtz, Andrew C Chen, Rose Terwilliger, Ronald C Duman, Gerard J Mare. Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors. Pharmacology, biochemistry, and behavior. vol 73. issue 2. 2003-02-05. PMID:12117585. |
previous studies have shown that 5-hydroxytryptamine(2a) (5-ht(2a)) receptor activation induces changes in the pattern of brain-derived neurotrophic factor (bdnf) mrna expression in the neocortex and hippocampus, and that 5-ht(2a) receptor blockade interferes with the induction of bdnf mrna by stress. |
2003-02-05 |
2023-08-12 |
Not clear |
| Suparporn Muchimapura, Robert Mason, Charles A Marsde. Effect of isolation rearing on pre- and post-synaptic serotonergic function in the rat dorsal hippocampus. Synapse (New York, N.Y.). vol 47. issue 3. 2003-02-04. PMID:12494403. |
an in vitro electrophysiological study investigated the effect of isolation rearing on postsynaptic 5-ht(1a) function on ca1 hippocampal neurones activated with the muscarinic agonist carbachol and found no change in the sensitivity of these postsynaptic receptors between the groups. |
2003-02-04 |
2023-08-12 |
human |
| Suparporn Muchimapura, Robert Mason, Charles A Marsde. Effect of isolation rearing on pre- and post-synaptic serotonergic function in the rat dorsal hippocampus. Synapse (New York, N.Y.). vol 47. issue 3. 2003-02-04. PMID:12494403. |
the selective 5-ht(1b) antagonist cp-294253 (1 microm), increased endogenous 5-ht release from hippocampal slices in vitro and this effect was greater (p < 0.001) in group compared to isolation-reared rats. |
2003-02-04 |
2023-08-12 |
human |
| Suparporn Muchimapura, Robert Mason, Charles A Marsde. Effect of isolation rearing on pre- and post-synaptic serotonergic function in the rat dorsal hippocampus. Synapse (New York, N.Y.). vol 47. issue 3. 2003-02-04. PMID:12494403. |
in summary, the present study showed that isolation rearing alters presynaptic 5-ht(1b) but not postsynaptic 5-ht(1a) receptor activity in the hippocampus. |
2003-02-04 |
2023-08-12 |
human |
| F Béquet, D Gomez-Merino, M Berthelot, C Y Guezenne. Evidence that brain glucose availability influences exercise-enhanced extracellular 5-HT level in hippocampus: a microdialysis study in exercising rats. Acta physiologica Scandinavica. vol 176. issue 1. 2003-01-31. PMID:12193220. |
evidence that brain glucose availability influences exercise-enhanced extracellular 5-ht level in hippocampus: a microdialysis study in exercising rats. |
2003-01-31 |
2023-08-12 |
rat |
| F Béquet, D Gomez-Merino, M Berthelot, C Y Guezenne. Evidence that brain glucose availability influences exercise-enhanced extracellular 5-HT level in hippocampus: a microdialysis study in exercising rats. Acta physiologica Scandinavica. vol 176. issue 1. 2003-01-31. PMID:12193220. |
in order to determine whether or not brain glucose could influence the brain 5-hydroxytryptamine (5-ht) system, we have monitored in microdialysis the effects of a direct injection of glucose in rat brain hippocampus on serotonergic metabolism [i.e. |
2003-01-31 |
2023-08-12 |
rat |
| Sylvia Montañez, Lynette C Daws, Georgianna G Gould, Greg A Gerhardt, Alan Fraze. Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region. Brain research. vol 955. issue 1-2. 2003-01-31. PMID:12419542. |
this was achieved by comparing the clearance of exogenously applied serotonin (5-ht) from the extracellular fluid (ecf) of the drn to that in the ca3 region of the hippocampus, an area with lower sert density. |
2003-01-31 |
2023-08-12 |
rat |
| Agnieszka Zahorodna, Krzysztof Tokarski, Maria Bija. Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors. European journal of pharmacology. vol 443. issue 1-3. 2003-01-27. PMID:12044792. |
imipramine but not 5-ht(1a) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-ht(1a) and 5-ht(4) receptors. |
2003-01-27 |
2023-08-12 |
rat |
| Agnieszka Zahorodna, Krzysztof Tokarski, Maria Bija. Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors. European journal of pharmacology. vol 443. issue 1-3. 2003-01-27. PMID:12044792. |
it has been reported that the treatment with a tricyclic antidepressant imipramine induces an increase in the sensitivity of 5-ht(1a) receptors and a decrease in the sensitivity of 5-ht(4) receptors in the rat hippocampus. |
2003-01-27 |
2023-08-12 |
rat |
| Agnieszka Zahorodna, Krzysztof Tokarski, Maria Bija. Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors. European journal of pharmacology. vol 443. issue 1-3. 2003-01-27. PMID:12044792. |
5-ht(1a) receptor agonists and neuroleptics also affect 5-ht(1a) receptors in different brain areas; therefore, it was of interest to compare their effects on hippocampal 5-ht receptors with the influence of the well-established antidepressant imipramine. |
2003-01-27 |
2023-08-12 |
rat |
| Agnieszka Zahorodna, Krzysztof Tokarski, Maria Bija. Imipramine but not 5-HT(1A) receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT(1A) and 5-HT(4) receptors. European journal of pharmacology. vol 443. issue 1-3. 2003-01-27. PMID:12044792. |
these findings indicate that adaptive changes in the sensitivity of hippocampal neurons to 5-ht(1a) and 5-ht(4) receptors agonists are specific to imipramine and may thus-at least partly-mediate its effects. |
2003-01-27 |
2023-08-12 |
rat |