| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malika El Yacoubi, Saoussen Bouali, Daniela Popa, Laurent Naudon, Isabelle Leroux-Nicollet, Michel Hamon, Jean Costentin, Joëlle Adrien, Jean-Marie Vaugeoi. Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 10. 2003-07-01. PMID:12732720. |
compared with "nonhelpless" mice, they display higher basal seric corticosterone levels and lower serotonin metabolism index in the hippocampus. |
2003-07-01 |
2023-08-12 |
mouse |
| Charalambos Tsoukalas, Ioannis Pirmettis, George Patsis, Maria Pelecanou, Katalin Bodo, Catherine P Raptopoulou, Aris Terzis, Minas Papadopoulos, Efstratios Chiotelli. Novel oxorhenium and oxotechnetium MO(NS)(S)2 complexes in the development of 5-HT1A receptor imaging agents. Journal of inorganic biochemistry. vol 93. issue 3-4. 2003-06-24. PMID:12576284. |
the binding affinity of the oxorhenium complex 1 for the 5-ht(1a) receptor subtype was determined in rat brain hippocampal preparations (ic(50)=106 nm). |
2003-06-24 |
2023-08-12 |
rat |
| A L Mize, L J Young, R H Alpe. Uncoupling of 5-HT1A receptors in the brain by estrogens: regional variations in antagonism by ICI 182,780. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668044. |
ici 182,780 (1 microm) blocked the ability of tamoxifen to decrease 5-ht(1a) receptor coupling in the hippocampus, but not in the frontal cortex. |
2003-06-23 |
2023-08-12 |
rat |
| A L Mize, L J Young, R H Alpe. Uncoupling of 5-HT1A receptors in the brain by estrogens: regional variations in antagonism by ICI 182,780. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668044. |
taken together, these data support the existence of a pharmacologically distinct er in hippocampus vs. frontal cortex that might be responsible for rapid uncoupling of 5-ht(1a) receptors. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
serotonin1a-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
we have previously reported that the 5-ht(1a)-receptor antagonist way 100635 blocked cocaine-induced hyperactivity, while potentiating cocaine-induced 5-ht increases in the hippocampus and the nac. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
in order to further investigate the relationship between extracellular 5-ht concentration and cocaine-induced behaviour, we used in vivo microdialysis to measure the effects of the 5-ht(1a)-receptor agonist 8-oh-dpat on cocaine-induced changes in the extracellular 5-ht concentration in the hippocampus and the nac and on behavioural activity. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
we found that the 5-ht(1a)-receptor agonist 8-oh-dpat attenuated the cocaine-induced increases in 5-ht in the hippocampus and the nac, but potentiated cocaine-induced hyperlocomotion. |
2003-06-23 |
2023-08-12 |
rat |
| C P Müller, R J Carey, J B Salloum, J P Husto. Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study. Neuropharmacology. vol 44. issue 5. 2003-06-23. PMID:12668045. |
altogether, these observations support an important role of the 5-ht(1a)-receptor in the hippocampus and nac in the modulation of cocaine stimulant effects. |
2003-06-23 |
2023-08-12 |
rat |
| Amy L Mize, Richard H Alpe. Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C. Neuroendocrinology. vol 76. issue 6. 2003-06-16. PMID:12566941. |
rapid uncoupling of serotonin-1a receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases a and c. 17beta-estradiol decreases r(+)8-oh-dpat-stimulated [(35)s]gtpgammas binding [an index of serotonin-1a (5-ht(1a)) receptor coupling] through the activation of estrogen receptors. |
2003-06-16 |
2023-08-12 |
rat |
| Amy L Mize, Richard H Alpe. Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C. Neuroendocrinology. vol 76. issue 6. 2003-06-16. PMID:12566941. |
incubation of hippocampus with 17beta-estradiol (50 nm, 60 min) caused the phosphorylation of a protein consistent with the 5-ht(1a) receptor. |
2003-06-16 |
2023-08-12 |
rat |
| Amy L Mize, Richard H Alpe. Rapid uncoupling of serotonin-1A receptors in rat hippocampus by 17beta-estradiol in vitro requires protein kinases A and C. Neuroendocrinology. vol 76. issue 6. 2003-06-16. PMID:12566941. |
these studies demonstrate that 17beta-estradiol acts on estrogen receptors locally within the hippocampus through nongenomic mechanisms to activate pka and pkc, phosphorylate 5-ht(1a) receptors and uncouple them from their g proteins. |
2003-06-16 |
2023-08-12 |
rat |
| Monica De la Fuente, Angel Hernanz, Sonia Medina, Noelia Guayerbas, Beatriz Fernández, Maria Paz Vivero. Characterization of monoaminergic systems in brain regions of prematurely ageing mice. Neurochemistry international. vol 43. issue 2. 2003-06-13. PMID:12620285. |
pam also showed decreased serotonine (5-ht) levels in hypothalamus, striatum and midbrain, as well as increased 5-hydroxyindol-3-acetic acid (5-hiaa)/5-ht ratios in hypothalamus and hippocampus. |
2003-06-13 |
2023-08-12 |
mouse |
| Mihály Hajós, William E Hoffmann, Deborah D Robinson, Jen H Yu, Eva Hajós-Korcso. Norepinephrine but not serotonin reuptake inhibitors enhance theta and gamma activity of the septo-hippocampal system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 5. 2003-06-11. PMID:12637957. |
under the same experimental conditions, reboxetine induced a two-fold increase in extracellular ne (but not serotonin) levels in the hippocampus as revealed by microdialysis. |
2003-06-11 |
2023-08-12 |
human |
| G F Molodtsov. Differences in serotonin and dopamine metabolism in the rat brain in latent inhibition. Neuroscience and behavioral physiology. vol 33. issue 3. 2003-06-11. PMID:12762587. |
monoamine oxidase activity during deamination of serotonin and dopamine in the amygdaloid complex, hippocampus, striatum and prefrontal cortex of the brain was studied at different stages in the formation of latent inhibition, acquired by rats on the basis of a conditioned passive avoidance reaction. |
2003-06-11 |
2023-08-12 |
rat |
| G F Molodtsov. Differences in serotonin and dopamine metabolism in the rat brain in latent inhibition. Neuroscience and behavioral physiology. vol 33. issue 3. 2003-06-11. PMID:12762587. |
at the stage of preliminary repeated presentation of the conditioned stimulus, serotonin metabolism was seen to change in the amygdaloid complex and striatum, while dopamine metabolism changed in the amygdaloid complex and hippocampus. |
2003-06-11 |
2023-08-12 |
rat |
| L E Gonzalez, M A Parada, S Tucci, L Teneud, D H Overstreet, L Hernande. A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 2. 2003-06-10. PMID:12563529. |
in the present microdialysis study we observed that basal 5-ht concentrations in the prefrontal cortex and dorsal hippocampus did not differ significantly between hds and lds rats. |
2003-06-10 |
2023-08-12 |
rat |
| L E Gonzalez, M A Parada, S Tucci, L Teneud, D H Overstreet, L Hernande. A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 2. 2003-06-10. PMID:12563529. |
the administration of (+/-)-fenfluramine (10 mg/kg) induced a greater increase in hippocampal 5-ht levels in hds rats (500%) as compared with lds (248%) or rds (243%) rats (p<0.0001). |
2003-06-10 |
2023-08-12 |
rat |
| L E Gonzalez, M A Parada, S Tucci, L Teneud, D H Overstreet, L Hernande. A brain microdialysis study on 5-HT release in freely moving rat lines selectively bred for differential 5-HT1A receptor function. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 36. issue 2. 2003-06-10. PMID:12563529. |
this differential response to fenfluramine may be due to functional alterations of hippocampal 5-ht reuptake sites in the hds line. |
2003-06-10 |
2023-08-12 |
rat |
| Takeshi Inoue, Yuji Kitaichi, Tsukasa Koyam. [Treatment strategy of refractory depression and its presynaptic mechanism of action]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 23. issue 1. 2003-06-10. PMID:12690637. |
although there are only a few studies concerning the mechanism of action of augmentation therapy, recent studies demonstrated that subchronic lithium treatment increases basal concentrations of extracellular serotonin in the frontal cortex and hippocampus. |
2003-06-10 |
2023-08-12 |
Not clear |