| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Czyrak, Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Fijał, Anna Gadek-Michalska, Krzysztof Wedzon. 8-OHDPAT-induced disruption of prepulse inhibition in rats is attenuated by prolonged corticosterone treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12700680. |
however, 5-ht(1a) receptor binding in the ventral hippocampus and entorhinal cortex but not in the raphe nuclei was decreased after chronic corticosterone treatment. |
2003-09-02 |
2023-08-12 |
rat |
| Anna Czyrak, Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Fijał, Anna Gadek-Michalska, Krzysztof Wedzon. 8-OHDPAT-induced disruption of prepulse inhibition in rats is attenuated by prolonged corticosterone treatment. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12700680. |
it is concluded that chronically elevated corticosterone level is capable of inducing functional desensitization of 5-ht(1a) receptors which is paralleled by decreases in the 5-ht(1a) receptor binding in the ventral hippocampus and entorhinal cortex, the brain structures shown to be engaged in the regulation of ppi. |
2003-09-02 |
2023-08-12 |
rat |
| Axel Becker, Brigitte Peters, Helmut Schroeder, Tobias Mann, Gerald Huether, Gisela Grecksc. Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia. Progress in neuro-psychopharmacology & biological psychiatry. vol 27. issue 4. 2003-08-29. PMID:12787858. |
the density of 5-ht transporters was increased in the striatum, the hippocampus, and the frontal cortex. |
2003-08-29 |
2023-08-12 |
rat |
| Mihaly Hajos, William E Hoffmann, Royal J Weave. Regulation of septo-hippocampal activity by 5-hydroxytryptamine(2C) receptors. The Journal of pharmacology and experimental therapeutics. vol 306. issue 2. 2003-08-28. PMID:12734389. |
inhibition of serotonin neurons leads to theta oscillation of septal neurons and theta wave activity in the hippocampus, indicating a tonic regulation of the septo-hippocampal system by serotonin neurons. |
2003-08-28 |
2023-08-12 |
rat |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
the role of serotonin (5-ht)1b receptors in the mechanism of action of selective serotonin re-uptake inhibitors (ssri) was studied by using intracerebral in vivo microdialysis in conscious, freely moving wild-type and 5-ht1b receptor knockout (ko 5-ht1b) mice in order to compare the effects of chronic administration of paroxetine via osmotic minipumps (1 mg per kg per day for 14 days) on extracellular 5-ht levels ([5-ht]ext) in the medial prefrontal cortex and ventral hippocampus. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
basal [5-ht]ext values in the medial prefrontal cortex and ventral hippocampus, approximately 20 h after removing the minipump, were not altered by chronic paroxetine treatment in both genotypes. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
to avoid the interaction with raphe 5-ht1a autoreceptors, 1 micro m paroxetine was perfused locally through the dialysis probe implanted in the ventral hippocampus; similar increases in hippocampal [5-ht]ext were found in acutely or chronically treated wild-type mice. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
systemic administration of the mixed 5-ht1b/1d receptor antagonist gr 127935 (4 mg/kg) in chronically treated wild-type mice potentiated the effect of a paroxetine challenge dose on [5-ht]ext in the ventral hippocampus, whereas systemic administration of the selective 5-ht1a receptor antagonist way 100635 did not. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
by using the zero net flux method of quantitative microdialysis in the medial prefrontal cortex and ventral hippocampus of wild-type and ko 5-ht1b mice, we found that basal [5-ht]ext and the extraction fraction of 5-ht were similar in the medial prefrontal cortex and ventral hippocampus of both genotypes, suggesting that no compensatory response to the constitutive deletion of the 5-ht1b receptor involving changes in 5-ht uptake capacity occurred in vivo. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
as steady-state brain concentrations of paroxetine at day 14 were similar in both genotypes, it is unlikely that differences in the effects of a paroxetine challenge on hippocampal [5-ht]ext are due to alterations of the drug's pharmacokinetic properties in mutants. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
these data suggest that there are differences between the ventral hippocampus and medial prefrontal cortex in activation of terminal 5-ht1b autoreceptors and their role in regulating dialysate 5-ht levels. |
2003-08-26 |
2023-08-12 |
mouse |
| A M Gardier, D J David, G Jego, C Przybylski, C Jacquot, S Durier, B Gruwez, E Douvier, P Beauverie, N Poisson, R Hen, M Bouri. Effects of chronic paroxetine treatment on dialysate serotonin in 5-HT1B receptor knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807420. |
these presynaptic receptors retain their capacity to limit 5-ht release mainly in the ventral hippocampus following chronic paroxetine treatment in mice. |
2003-08-26 |
2023-08-12 |
mouse |
| Sylvia Montañez, W Anthony Owens, Georgianna G Gould, Dennis L Murphy, Lynette C Daw. Exaggerated effect of fluvoxamine in heterozygote serotonin transporter knockout mice. Journal of neurochemistry. vol 86. issue 1. 2003-08-26. PMID:12807440. |
in this study, the rate of clearance of exogenously applied 5-ht was measured in the ca3 region of the hippocampus of anesthetized mice using high-speed chronoamperometry. |
2003-08-26 |
2023-08-12 |
mouse |
| L V Devoino, E L Al'perina, E K Podgornaya, O V Polyakov, G V Idova, R Yu Il'yucheno. Nature of the distribution of serotonin and a serotonin metabolite in brain structures and the development of immunosuppression in submissive mice. Neuroscience and behavioral physiology. vol 33. issue 5. 2003-08-26. PMID:12921178. |
studies of c57bl/6j mice with acquired submissive behavior in a sensory contact model demonstrated increases in serotonin (5-ht) levels in the amygdaloid complex, hippocampus, the dopaminergic nuclei a11, a10, and a9, and in the caudate nucleus and hypothalamus, compared with controls, after 10 and 20 days of confrontations. |
2003-08-26 |
2023-08-12 |
mouse |
| Mario Carta, Andrea M Allan, L Donald Partridge, C Fernando Valenzuel. Cocaine inhibits 5-HT3 receptor function in neurons from transgenic mice overexpressing the receptor. European journal of pharmacology. vol 459. issue 2-3. 2003-08-25. PMID:12524142. |
we examined the effect of cocaine on 5-ht(3) receptor function in cultured hippocampal neurons from transgenic mice overexpressing the receptor. |
2003-08-25 |
2023-08-12 |
mouse |
| Tatyana Adayev, Indrani Ray, Rachna Sondhi, Tomasz Sobocki, Probal Banerje. The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha. Biochimica et biophysica acta. vol 1640. issue 1. 2003-08-21. PMID:12676358. |
the 5-ht(1a) agonist 8-hydroxy-2 (di-n-propylamino) tetralin (8-oh-dpat) causes inhibition of caspase-3 and apoptosis via the extracellular signal-regulated kinases (erk1/2) in hippocampal hn2-5 cells. |
2003-08-21 |
2023-08-12 |
Not clear |
| Yotam Sagi, Marta Weinstock, Moussa B H Youdi. Attenuation of MPTP-induced dopaminergic neurotoxicity by TV3326, a cholinesterase-monoamine oxidase inhibitor. Journal of neurochemistry. vol 86. issue 2. 2003-08-21. PMID:12871570. |
inhibition of brain mao-a and -b by tv3326 resulted in significant elevations of dopamine, noradrenaline and serotonin in the striatum and hippocampus. |
2003-08-21 |
2023-08-12 |
mouse |
| Richard De La Garza, Gregory M Asni. The non-steroidal anti-inflammatory drug diclofenac sodium attenuates IFN-alpha induced alterations to monoamine turnover in prefrontal cortex and hippocampus. Brain research. vol 977. issue 1. 2003-08-14. PMID:12788515. |
the data show that acute ifn-alpha increased serotonin turnover in prefrontal cortex and increased dopamine turnover in hippocampus, while pre-treatment with diclofenac completely prevented these neurochemical responses. |
2003-08-14 |
2023-08-12 |
rat |
| Marja Van Kampen, E Ronald De Kloet, Gabriele Flügge, Eberhard Fuch. Blockade of glucocorticoid receptors with ORG 34116 does not normalize stress-induced symptoms in male tree shrews. European journal of pharmacology. vol 457. issue 2-3. 2003-08-08. PMID:12464368. |
post mortem analysis of 5-ht(1a) receptors revealed a decreased affinity of 3[h]-8-oh-dpat (3[h]-8-hydroxy-2-[di-n-propylamino]tetralin) binding sites in the hippocampus of animals treated with the glucocorticoid receptor antagonist. |
2003-08-08 |
2023-08-12 |
Not clear |
| Nadja Schröder, Steven J O'Dell, John F Marshal. Neurotoxic methamphetamine regimen severely impairs recognition memory in rats. Synapse (New York, N.Y.). vol 49. issue 2. 2003-08-08. PMID:12740864. |
damage to monoamine terminals was confirmed by significant 30-40% losses of [(125)i]rti-55 binding to striatal dopamine transporter and hippocampal serotonin transporter sites at both 1 and 3 weeks after mamph treatments. |
2003-08-08 |
2023-08-12 |
rat |