| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Philip Heiser, Eva Schulte, Christiane Hausmann, Ralf Becker, Helmut Remschmidt, Jürgen-Christian Krieg, Helmut Vedde. Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro. Progress in neuro-psychopharmacology & biological psychiatry. vol 28. issue 2. 2004-05-28. PMID:14751426. |
the goal of the present study was to determine the effects of clozapine (cloz) and its metabolites norclozapine (norcloz) and clozapine-n-oxide (cloz-n-oxide) on the 5-ht(2) receptor system on the levels of protein and gene expression in in vitro systems of primary cortical cells of the rat and human hippocampal shs5y5 neuroblastoma cells. |
2004-05-28 |
2023-08-12 |
human |
| Junzo Kamei, Yasuhiro Matsunawa, Shigeo Miyata, Shun-ichi Tanaka, Akiyoshi Saito. Effects of nociceptin on the exploratory behavior of mice in the hole-board test. European journal of pharmacology. vol 489. issue 1-2. 2004-05-26. PMID:15063158. |
of nociceptin significantly increased the rate of serotonin (5-hyroxytryptamine, 5-ht) turnover in the hippocampus, a high dose (5 nmol, i.c.v.) |
2004-05-26 |
2023-08-12 |
mouse |
| Junzo Kamei, Yasuhiro Matsunawa, Shigeo Miyata, Shun-ichi Tanaka, Akiyoshi Saito. Effects of nociceptin on the exploratory behavior of mice in the hole-board test. European journal of pharmacology. vol 489. issue 1-2. 2004-05-26. PMID:15063158. |
the present results also suggest that a low dose of nociceptin has an anxiolytic effect via the activation of 5-ht ergic function in the hippocampus, while a high dose of nociceptin has an anxiogenic effect via the inhibition of 5-ht ergic function in the amygdala. |
2004-05-26 |
2023-08-12 |
mouse |
| Marcus H Andrews, Alice Kostaki, Elaine Setiawan, Lucy McCabe, Stephen G Matthew. Developmental regulation of 5-HT1A receptor mRNA in the fetal limbic system: response to antenatal glucocorticoid. Brain research. Developmental brain research. vol 149. issue 1. 2004-05-24. PMID:15013627. |
because fetal exposure to glucocorticoids programs hypothalamo-pituitary-adrenal (hpa) function, and hippocampal serotonin is known to influence glucocorticoid receptor (gr) expression, the glucocorticoid-mediated changes in 5-ht1a receptor mrna may play a role in the programming of hpa function. |
2004-05-24 |
2023-08-12 |
Not clear |
| Amanda J Roberts, Thomas Krucker, Coree L Levy, Kristen A Slanina, J Gregor Sutcliffe, Peter B Hedlun. Mice lacking 5-HT receptors show specific impairments in contextual learning. The European journal of neuroscience. vol 19. issue 7. 2004-05-24. PMID:15078565. |
in addition, we demonstrate that 5-ht(7) receptor knockout mice display decreased long-term synaptic plasticity within the ca1 region of the hippocampus. |
2004-05-24 |
2023-08-12 |
mouse |
| Amanda J Roberts, Thomas Krucker, Coree L Levy, Kristen A Slanina, J Gregor Sutcliffe, Peter B Hedlun. Mice lacking 5-HT receptors show specific impairments in contextual learning. The European journal of neuroscience. vol 19. issue 7. 2004-05-24. PMID:15078565. |
the results indicate an important role for the 5-ht(7) receptor in contextual hippocampal-dependent learning and suggest a possible neuronal correlate for such a role is present within the ca1 region of the hippocampus. |
2004-05-24 |
2023-08-12 |
mouse |
| Ercem Kodas, Laurent Galineau, Sylvie Bodard, Sylvie Vancassel, Denis Guilloteau, Jean-Claude Besnard, Sylvie Chalo. Serotoninergic neurotransmission is affected by n-3 polyunsaturated fatty acids in the rat. Journal of neurochemistry. vol 89. issue 3. 2004-05-19. PMID:15086526. |
in vivo synaptic serotonin (5-ht) levels were studied in basal and pharmacologically stimulated conditions using intracerebral microdialysis in the hippocampus of awake 2-month-old rats. |
2004-05-19 |
2023-08-12 |
rat |
| David R Thomas, Jim J Haga. 5-HT7 receptors. Current drug targets. CNS and neurological disorders. vol 3. issue 1. 2004-05-11. PMID:14965246. |
studies utilising these compounds suggest that the 5-ht(7) receptor modulates neuronal function in a number of brain areas including the hippocampus and thalamus. |
2004-05-11 |
2023-08-12 |
Not clear |
| James B Koprich, Nicholas G Campbell, Jack W Lipto. Neonatal 3,4-methylenedioxymethamphetamine (ecstasy) alters dopamine and serotonin neurochemistry and increases brain-derived neurotrophic factor in the forebrain and brainstem of the rat. Brain research. Developmental brain research. vol 147. issue 1-2. 2004-05-03. PMID:14741762. |
all forebrain structures examined (frontal cortex, hippocampus, and striatum) showed significant mdma-induced reductions in 5-ht and its metabolite, 5-hiaa, and significant increases in the da metabolite, hva, as well as da turnover (hva/da). |
2004-05-03 |
2023-08-12 |
rat |
| R Mössner, A Schmitt, T Hennig, J Benninghoff, M Gerlach, P Riederer, J Deckert, K P Lesc. Quantitation of 5HT3 receptors in forebrain of serotonin transporter deficient mice. Journal of neural transmission (Vienna, Austria : 1996). vol 111. issue 1. 2004-04-30. PMID:14714213. |
using quantitative autoradiography, we found that 5ht3 receptors are upregulated in frontal cortex (+46%), parietal cortex (+42%), and in stratum oriens of the ca3 region of the hippocampus (+18%) of 5htt knockout mice. |
2004-04-30 |
2023-08-12 |
mouse |
| H Miura, H Qiao, T Kitagami, T Oht. Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin in the mouse hippocampus. Neuropharmacology. vol 46. issue 3. 2004-04-21. PMID:14975689. |
fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin in the mouse hippocampus. |
2004-04-21 |
2023-08-12 |
mouse |
| Luc Zimmer, Guy Fournet, Joseph Benoît, Gérald Guillaumet, Didier Le Bar. Carbon-11 labelling of 8[[3-[4-(2-[(11)C]methoxyphenyl)piperazin-1-yl]-2-hydroxypropyl]oxy]thiochroman, a presynaptic 5-HT(1A) receptor agonist, and its in vivo evaluation in anaesthetised rat and in awake cat. Nuclear medicine and biology. vol 30. issue 5. 2004-04-20. PMID:12831993. |
in both in vivo techniques, the new ligand did not reveal any specific binding in hippocampus indicating that this radiotracer is not suitable for mapping 5ht(1a) receptors using positron emission tomography. |
2004-04-20 |
2023-08-12 |
rat |
| Takashi Yoshitake, Jan Keh. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life sciences. vol 74. issue 23. 2004-04-20. PMID:15050424. |
differential effects of (r)-, (r, s)- and (s)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. |
2004-04-20 |
2023-08-12 |
rat |
| Takashi Yoshitake, Jan Keh. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life sciences. vol 74. issue 23. 2004-04-20. PMID:15050424. |
the effects of (r)- and (s)-optical isomers of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-oh-dpat) and of the racemate (r,s)-8-oh-dpat on serotonin (5-ht) release in the ventral hippocampus of awake rats and on induction of the whole-body hypothermia were studied. |
2004-04-20 |
2023-08-12 |
rat |
| Takashi Yoshitake, Jan Keh. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life sciences. vol 74. issue 23. 2004-04-20. PMID:15050424. |
the reduction of hippocampal 5-ht levels induced by subcutaneous (s.c.) administration of (r,s)-8-oh-dpat (0.3 mg/kg) was significantly attenuated by the presence of 5-ht reuptake inhibitor citalopram in ringer solution only at its peak value at 40 min (maximal reduction to 60% compared to 46% of control values in ringer-perfused rats), whereas the overall effects were comparable at both experimental conditions. |
2004-04-20 |
2023-08-12 |
rat |
| Takashi Yoshitake, Jan Keh. Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life sciences. vol 74. issue 23. 2004-04-20. PMID:15050424. |
it is concluded that the acute systemic dose of (r)-, (s)- and (r,s)-8-oh-dpat enantiomers exerted enantiomer-specific effects on 5-ht(1a) receptor-mediated function both at the presynaptic and postsynaptic sites as revealed by monitoring hippocampal 5-ht levels and body temperature. |
2004-04-20 |
2023-08-12 |
rat |
| Shigeo Miyata, Shoko Hirano, Junzo Kame. Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 3. 2004-04-14. PMID:14628002. |
long-lasting increases in 5-ht turnover rates were observed in the diabetic mouse midbrain and frontal cortex, but not in the hippocampus. |
2004-04-14 |
2023-08-12 |
mouse |
| Mounira Banasr, Micheline Hery, Richard Printemps, Annie Daszut. Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 3. 2004-04-14. PMID:14872203. |
in addition to the influence of 5-ht1b autoreceptors on 5-ht terminals in the hippocampus and ventricles, 5-ht1b heteroreceptors also regulate cell proliferation in the sgl. |
2004-04-14 |
2023-08-12 |
Not clear |
| Amani E Khalif. Zuclopenthixol facilitates memory retrieval in rats: possible involvement of noradrenergic and serotonergic mechanisms. Pharmacology, biochemistry, and behavior. vol 75. issue 4. 2004-04-13. PMID:12957216. |
on the other hand, the lower dose of zuclopenthixol elevated cortical norepinephrine (ne) level, while the higher dose elevated both cortical and hippocampal ne level together with hippocampal serotonin (5-ht) level. |
2004-04-13 |
2023-08-12 |
rat |
| Veronika Butterweck, Kirsten Simbrey, Shujiro Seo, Tsutomu Sasaki, Sansei Nishib. Long-term effects of an Apocynum venetum extract on brain monoamine levels and beta-AR density in rats. Pharmacology, biochemistry, and behavior. vol 75. issue 3. 2004-04-08. PMID:12895673. |
to evaluate biochemical changes, we used a high-performance liquid chromatography system to examine the effects of short-term (2 weeks) and long-term (8 weeks) administration of imipramine (15 mg/kg po) and an av-extract (15, 60 and 250 mg/kg) on regional levels of serotonin (5-ht), norepinephrine (ne), dopamine (da) and their metabolites in the rat hypothalamus, striatum and hippocampus. |
2004-04-08 |
2023-08-12 |
rat |