| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hualong Wang, Kaoqi Lian, Bing Han, Yanyong Wang, Sheng-Han Kuo, Yuan Geng, Jing Qiang, Meiyu Sun, Mingwei Wan. Age-related alterations in the metabolic profile in the hippocampus of the senescence-accelerated mouse prone 8: a spontaneous Alzheimer's disease mouse model. Journal of Alzheimer's disease : JAD. vol 39. issue 4. 2014-10-30. PMID:24284365. |
alterations in 17 metabolites were detected in mature and aged mice compared to young mice (13 decreased and 4 increased metabolites), including metabolites related to dysfunctional lipid metabolism (significantly increased cholesterol, oleic acid, and phosphoglyceride levels), decreased amino acid (alanine, serine, glycine, aspartic acid, glutamate, and gamma-aminobutyric acid), and energy-related metabolite levels (malic acid, butanedioic acid, fumaric acid, and citric acid), and other altered metabolites (increased n-acetyl-aspartic acid and decreased pyroglutamic acid, urea, and lactic acid) in the hippocampus. |
2014-10-30 |
2023-08-12 |
mouse |
| Melissa A Herman, Frauke Ackermann, Thorsten Trimbuch, Christian Rosenmun. Vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 35. 2014-10-17. PMID:25164673. |
vesicular glutamate transporter expression level affects synaptic vesicle release probability at hippocampal synapses in culture. |
2014-10-17 |
2023-08-13 |
mouse |
| Gonzalo Viana Di Prisco, Wei Huang, Shelly A Buffington, Chih-Chun Hsu, Penelope E Bonnen, Andon N Placzek, Carmela Sidrauski, Krešimir Krnjević, Randal J Kaufman, Peter Walter, Mauro Costa-Mattiol. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nature neuroscience. vol 17. issue 8. 2014-10-15. PMID:24974795. |
at hippocampal synapses, activation of group i metabotropic glutamate receptors (mglurs) induces long-term depression (ltd), which requires new protein synthesis. |
2014-10-15 |
2023-08-13 |
mouse |
| Sean D Kelly, Constance S Harrell, Gretchen N Neig. Chronic stress modulates regional cerebral glucose transporter expression in an age-specific and sexually-dimorphic manner. Physiology & behavior. vol 126. 2014-10-14. PMID:24382486. |
the data indicated that sex differences in glut expression were most profound in the hypothalamus, and the transition from adolescence to adulthood had the most profound effect on glut expression in the hippocampus. |
2014-10-14 |
2023-08-12 |
rat |
| Sachie Sasaki-Hamada, Keita Tamaki, Hayuma Otsuka, Tatsuto Ueno, Hiroaki Sacai, Yimin Niu, Kinzo Matsumoto, Junichiro Ok. Chotosan, a Kampo formula, ameliorates hippocampal LTD and cognitive deficits in juvenile-onset diabetes rats. Journal of pharmacological sciences. vol 124. issue 2. 2014-10-13. PMID:24476927. |
the expression level of nr2b glutamate receptor subunits, but not other glutamate receptor subunits was enhanced in the hippocampus of jdm rats, and repeated treatment with cts reversed these changes. |
2014-10-13 |
2023-08-12 |
rat |
| Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wan. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PloS one. vol 9. issue 2. 2014-10-13. PMID:24520409. |
the effect of acacetin on endogenous glutamate release in rat hippocampal nerve terminals (synaptosomes) was also investigated. |
2014-10-13 |
2023-08-12 |
rat |
| Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wan. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PloS one. vol 9. issue 2. 2014-10-13. PMID:24520409. |
the results indicated that acacetin inhibited depolarization-evoked glutamate release and cytosolic free ca(2+) concentration ([ca(2+)]c) in the hippocampal nerve terminals. |
2014-10-13 |
2023-08-12 |
rat |
| Tzu-Yu Lin, Wei-Jan Huang, Chia-Chan Wu, Cheng-Wei Lu, Su-Jane Wan. Acacetin inhibits glutamate release and prevents kainic acid-induced neurotoxicity in rats. PloS one. vol 9. issue 2. 2014-10-13. PMID:24520409. |
the present study demonstrates that the natural compound, acacetin, inhibits glutamate release from hippocampal synaptosomes by attenuating voltage-dependent ca(2+) entry and effectively prevents ka-induced in vivo excitotoxicity. |
2014-10-13 |
2023-08-12 |
rat |
| Alessia Salamone, Elisa Mura, Stefania Zappettini, Massimo Grilli, Guendalina Olivero, Stefania Preda, Stefano Govoni, Mario March. Inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution. European journal of pharmacology. vol 723. 2014-10-07. PMID:24275353. |
inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution. |
2014-10-07 |
2023-08-12 |
rat |
| Alessia Salamone, Elisa Mura, Stefania Zappettini, Massimo Grilli, Guendalina Olivero, Stefania Preda, Stefano Govoni, Mario March. Inhibitory effects of beta-amyloid on the nicotinic receptors which stimulate glutamate release in rat hippocampus: the glial contribution. European journal of pharmacology. vol 723. 2014-10-07. PMID:24275353. |
we investigated on the neuronal nicotinic acetylcholine receptor subtypes involved in the cholinergic control of in vivo hippocampal glutamate (glu), aspartate (asp) and inhibitory γ-aminobutyric acid (gaba) overflow. |
2014-10-07 |
2023-08-12 |
rat |
| Gang Du, Hui Tu, Xiaojing Li, Aijie Pei, Jing Chen, Zhigang Miao, Jizhen Li, Chen Wang, Hong Xie, Xingshun Xu, Heqing Zha. Daphnetin, a natural coumarin derivative, provides the neuroprotection against glutamate-induced toxicity in HT22 cells and ischemic brain injury. Neurochemical research. vol 39. issue 2. 2014-10-07. PMID:24343531. |
to explore its neuroprotective mechanisms of dap, we examined the protection of dap on glutamate toxicity-induced cell death in hippocampal ht-22 cells. |
2014-10-07 |
2023-08-12 |
mouse |
| Shan-Xue Jin, Christopher Bartolome, Junko A Arai, Laurel Hoffman, B Gizem Uzturk, Rajendra Kumar-Singh, M Neal Waxham, Larry A Fei. Domain contributions to signaling specificity differences between Ras-guanine nucleotide releasing factor (Ras-GRF) 1 and Ras-GRF2. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24755227. |
although both grf proteins transduce calcium signals emanating from nmda-type glutamate receptors in the ca1 region of the hippocampus, grf1 promotes ltd, whereas grf2 promotes θ-burst stimulation-induced ltp (tbs-ltp). |
2014-10-07 |
2023-08-13 |
mouse |
| Cho Rong Kim, Hye Lyun Jeon, Suk Kyung Shin, Hyun Jeong Kim, Chang-Won Ahn, Sung Ug Jung, Soo-Hyun Park, Mee Ree Ki. Neuroprotective action of deer bone extract against glutamate or Aβ₁₋₄₂-induced oxidative stress in mouse hippocampal cells. Journal of medicinal food. vol 17. issue 2. 2014-10-06. PMID:24460377. |
neuroprotective action of deer bone extract against glutamate or aβ₁₋₄₂-induced oxidative stress in mouse hippocampal cells. |
2014-10-06 |
2023-08-12 |
mouse |
| Shuzhen Kong, Zhihua Cheng, Jianhui Liu, Yun Wan. Downregulated GABA and BDNF-TrkB pathway in chronic cyclothiazide seizure model. Neural plasticity. vol 2014. 2014-10-06. PMID:24757570. |
cyclothiazide (ctz) has been reported to simultaneously enhance glutamate receptor excitation and inhibit gabaa receptor inhibition, and in turn it evokes epileptiform activities in hippocampal neurons. |
2014-10-06 |
2023-08-13 |
rat |
| Daniel Ortuño-Sahagún, Raúl Montes González, Ester Verdaguer, Verónica Chaparro Huerta, Blanca M Torres-Mendoza, Lourdes Lemus, Martha Catalina Rivera-Cervantes, A Camins, C Beas Zárat. Glutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of rat hippocampal neurons in vivo. Journal of molecular neuroscience : MN. vol 52. issue 3. 2014-09-30. PMID:24190281. |
glutamate excitotoxicity activates the mapk/erk signaling pathway and induces the survival of rat hippocampal neurons in vivo. |
2014-09-30 |
2023-08-12 |
human |
| Garry R Smith, Douglas E Brenneman, Yan Zhang, Yanming Du, Allen B Reit. Small-molecule anticonvulsant agents with potent in vitro neuroprotection and favorable drug-like properties. Journal of molecular neuroscience : MN. vol 52. issue 3. 2014-09-30. PMID:24277343. |
utilizing phenotypic screening of hippocampal cultures with nutrient medium depleted of antioxidants as a disease model, cell death and decreased neuronal viability produced by acute treatment with glutamate or hydrogen peroxide were prevented. |
2014-09-30 |
2023-08-12 |
rat |
| Yu-Wei Wu, Xiaofang Tang, Misa Arizono, Hiroko Bannai, Pei-Yu Shih, Yulia Dembitskaya, Victor Kazantsev, Mika Tanaka, Shigeyoshi Itohara, Katsuhiko Mikoshiba, Alexey Semyano. Spatiotemporal calcium dynamics in single astrocytes and its modulation by neuronal activity. Cell calcium. vol 55. issue 2. 2014-09-29. PMID:24484772. |
the power law exponent (α) was decreased by activation of metabotropic glutamate receptors (mglurs) either by specific receptor agonist or by low frequency stimulation of glutamatergic fibers in hippocampal slices. |
2014-09-29 |
2023-08-12 |
Not clear |
| Taku Naga. [Perinatal innate immune activation and neuropsychological development]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 33. issue 4. 2014-09-25. PMID:25069250. |
neonatal treatment of mice with polyi:c, an inducer of innate immune responses via toll-like receptor 3, caused a significant increase in interferon-induced transmembrane protein 3 (ifitm3) levels in the astrocytes of the hippocampus, which resulted in long-lasting brain dysfunction, including cognitive and emotional impairments as well as a deficit in depolarization-evoked glutamate release in the hippocampus in adulthood. |
2014-09-25 |
2023-08-13 |
mouse |
| Rendong Tang, Jiapei Da. Spatiotemporal imaging of glutamate-induced biophotonic activities and transmission in neural circuits. PloS one. vol 9. issue 1. 2014-09-21. PMID:24454909. |
furthermore, the application of glutamate in the hippocampal dentate gyrus results in increased biophotonic activities in its intrahippocampal projection areas. |
2014-09-21 |
2023-08-12 |
mouse |
| Caterina Michetti, Emilia Romano, Luisa Altabella, Angela Caruso, Paolo Castelluccio, Gaurav Bedse, Silvana Gaetani, Rossella Canese, Giovanni Laviola, Maria Luisa Scatton. Mapping pathological phenotypes in reelin mutant mice. Frontiers in pediatrics. vol 2. 2014-09-19. PMID:25237666. |
low levels of dopamine in cortex and high levels of glutamate and taurine in hippocampus were detected in het mice, in line with clinical data collected on asd children. |
2014-09-19 |
2023-08-13 |
mouse |