| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Minchao He, Jun Liu, Shaowu Cheng, Yigang Xing, William Z Su. Differentiation renders susceptibility to excitotoxicity in HT22 neurons. Neural regeneration research. vol 8. issue 14. 2014-09-10. PMID:25206424. |
ht22 is an immortalized mouse hippocampal neuronal cell line that does not express cholinergic and glutamate receptors like mature hippocampal neurons in vivo. |
2014-09-10 |
2023-08-13 |
mouse |
| Jing Ge, Jun Wang, Dan Xue, Zhengsheng Zhu, Zhenyu Chen, Xiaoqiu Li, Dongfeng Su, Juan D. Why does a high-fat diet induce preeclampsia-like symptoms in pregnant rats. Neural regeneration research. vol 8. issue 20. 2014-09-10. PMID:25206496. |
simultaneously, metabotropic glutamate receptor 1 mrna and protein expressions were upregulated in the rat hippocampus. |
2014-09-10 |
2023-08-13 |
rat |
| Zhiqiang Li, Qingming Shu, Lingzhi Li, Maolin Ge, Yongliang Zhan. Sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury. Neural regeneration research. vol 9. issue 9. 2014-09-10. PMID:25206921. |
sequential expression of cyclooxygenase-2, glutamate receptor-2, and platelet activating factor receptor in rat hippocampal neurons after fluid percussion injury. |
2014-09-10 |
2023-08-13 |
rat |
| Jobran M Al-Qahtani, Basel A Abdel-Wahab, Samy M Abd El-Azi. Long-term moderate dose exogenous erythropoietin treatment protects from intermittent hypoxia-induced spatial learning deficits and hippocampal oxidative stress in young rats. Neurochemical research. vol 39. issue 1. 2014-09-09. PMID:24248862. |
moreover, the effect on hippocampal glutamate and oxidative stress were assessed. |
2014-09-09 |
2023-08-12 |
rat |
| Jobran M Al-Qahtani, Basel A Abdel-Wahab, Samy M Abd El-Azi. Long-term moderate dose exogenous erythropoietin treatment protects from intermittent hypoxia-induced spatial learning deficits and hippocampal oxidative stress in young rats. Neurochemical research. vol 39. issue 1. 2014-09-09. PMID:24248862. |
moreover, hippocampal glutamate and thiobarbituric acid reactive substances (tbars) increased while antioxidant defenses (gsh and gsh-px) decreased. |
2014-09-09 |
2023-08-12 |
rat |
| Jobran M Al-Qahtani, Basel A Abdel-Wahab, Samy M Abd El-Azi. Long-term moderate dose exogenous erythropoietin treatment protects from intermittent hypoxia-induced spatial learning deficits and hippocampal oxidative stress in young rats. Neurochemical research. vol 39. issue 1. 2014-09-09. PMID:24248862. |
epo in the tested doses significantly reduced the ih-induced spatial learning deficits in both mwm and epm tests and dose-dependently antagonized the effects of ih on hippocampal glutamate, tbars, gsh levels, and gsh-px activity. |
2014-09-09 |
2023-08-12 |
rat |
| Lorena C L R Santana, Maria R M Brito, George L S Oliveira, Antônia M G L Citó, Clayton Q Alves, Juceni P David, Jorge M David, Rivelilson M de Freita. Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-09-09. PMID:25202336. |
this extract demonstrated anxiolytic effects, which may be mediated by gabaergic system, and was able to increase gaba levels and reduce of glutamate and aspartate concentrations in mice hippocampus, which can directly and/or indirectly assist in their anxiolytic effect. |
2014-09-09 |
2023-08-13 |
mouse |
| Julie Lalande, Hélène Halley, Stéphane Balayssac, Véronique Gilard, Sébastien Déjean, Robert Martino, Bernard Francés, Jean-Michel Lassalle, Myriam Malet-Martin. 1H NMR metabolomic signatures in five brain regions of the AβPPswe Tg2576 mouse model of Alzheimer's disease at four ages. Journal of Alzheimer's disease : JAD. vol 39. issue 1. 2014-09-03. PMID:24145382. |
metabolic perturbations were already detected in the hippocampus and the rhinal cortex of transgenic mice as early as 1 month of age with decreased concentrations of glutamate (glu) and n-acetylaspartate (naa) compared to those in wild-type animals. |
2014-09-03 |
2023-08-12 |
mouse |
| S A Shah, H Y Lee, R A Bressan, D J Yun, M O Ki. Novel osmotin attenuates glutamate-induced synaptic dysfunction and neurodegeneration via the JNK/PI3K/Akt pathway in postnatal rat brain. Cell death & disease. vol 5. 2014-09-02. PMID:24481440. |
the results indicated that glutamate treatment induced excitotoxicity by overactivating glutamate receptors, causing synaptic dysfunction and neuronal apoptosis after 4 h in the cortex and hippocampus of the postnatal brain. |
2014-09-02 |
2023-08-12 |
rat |
| Xinkun Wang, Nilam D Patel, Dongwei Hui, Ranu Pal, Mohamed M Hafez, Mohamed M Sayed-Ahmed, Abdulaziz A Al-Yahya, Elias K Michaeli. Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice. BMC neuroscience. vol 15. 2014-08-27. PMID:24593767. |
gene expression patterns in the hippocampus during the development and aging of glud1 (glutamate dehydrogenase 1) transgenic and wild type mice. |
2014-08-27 |
2023-08-12 |
mouse |
| Fabio Tescarollo, Luciene Covolan, Luc Pelleri. Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neurons. Frontiers in neuroscience. vol 8. 2014-08-27. PMID:25161606. |
glutamate reduces glucose utilization while concomitantly enhancing aqp9 and mct2 expression in cultured rat hippocampal neurons. |
2014-08-27 |
2023-08-13 |
rat |
| Fabio Tescarollo, Luciene Covolan, Luc Pelleri. Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neurons. Frontiers in neuroscience. vol 8. 2014-08-27. PMID:25161606. |
using primary cultures of rat hippocampal neurons, we observed that glutamate reduces glucose utilization in this cell type, suggesting alteration in mitochondrial oxidative metabolism. |
2014-08-27 |
2023-08-13 |
rat |
| Fabio Tescarollo, Luciene Covolan, Luc Pelleri. Glutamate reduces glucose utilization while concomitantly enhancing AQP9 and MCT2 expression in cultured rat hippocampal neurons. Frontiers in neuroscience. vol 8. 2014-08-27. PMID:25161606. |
exposure of cultured hippocampal neurons to glutamate 100 μm for 1 h led to enhanced expression of both aqp9 and mct2 at the protein level without any significant change at the mrna level. |
2014-08-27 |
2023-08-13 |
rat |
| Sina Oppermann, Florian C Schrader, Katharina Elsässer, Amalia M Dolga, Anna Lena Kraus, Nunzianna Doti, Christof Wegscheid-Gerlach, Martin Schlitzer, Carsten Culmse. Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity. The Journal of pharmacology and experimental therapeutics. vol 350. issue 2. 2014-08-26. PMID:24849923. |
the new compounds 6, 7, and 16 were identified as highly protective by extensive screening in a model of glutamate toxicity in immortalized mouse hippocampal neurons (ht-22 cells). |
2014-08-26 |
2023-08-13 |
mouse |
| Madeleine V King, Nisha Kurian, Si Qin, Nektaria Papadopoulou, Ben H C Westerink, Thomas I Cremers, Mark P Epping-Jordan, Emmanuel Le Poul, David E Ray, Kevin C F Fone, David A Kendall, Charles A Marsden, Tyson V Shar. Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:24037344. |
lentiviral delivery of a vesicular glutamate transporter 1 (vglut1)-targeting short hairpin rna vector into the mouse hippocampus impairs cognition. |
2014-08-21 |
2023-08-12 |
mouse |
| Madeleine V King, Nisha Kurian, Si Qin, Nektaria Papadopoulou, Ben H C Westerink, Thomas I Cremers, Mark P Epping-Jordan, Emmanuel Le Poul, David E Ray, Kevin C F Fone, David A Kendall, Charles A Marsden, Tyson V Shar. Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:24037344. |
this study utilized novel lentiviral short hairpin rna (shrna) vectors to target expression of the vesicular glutamate transporter 1 (vglut1) following injection into the dorsal hippocampus of adult mice, as partial reductions in vglut1 expression should attenuate glutamatergic signaling and similar reductions have been reported in schizophrenia. |
2014-08-21 |
2023-08-12 |
mouse |
| Madeleine V King, Nisha Kurian, Si Qin, Nektaria Papadopoulou, Ben H C Westerink, Thomas I Cremers, Mark P Epping-Jordan, Emmanuel Le Poul, David E Ray, Kevin C F Fone, David A Kendall, Charles A Marsden, Tyson V Shar. Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 2. 2014-08-21. PMID:24037344. |
the vglut1-targeting vector attenuated tonic glutamate release in the dorsal hippocampus without affecting gaba, and selectively impaired novel object discrimination (nod) and retention (but not acquisition) in the morris water maze, without influencing contextual fear-motivated learning or causing any adverse locomotor or central immune effects. |
2014-08-21 |
2023-08-12 |
mouse |
| B D Harvey, C J Siok, T Kiss, D Volfson, S Grimwood, C L Shaffer, M Hajó. Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors. Neuropharmacology. vol 75. 2014-08-19. PMID:23831682. |
the group i metabotropic glutamate receptor subtype 5 (mglur5) is widely distributed in the brain with dense expression in the cerebral cortex, hippocampus, and basal ganglia. |
2014-08-19 |
2023-08-12 |
rat |
| Jun Yang, Ming-Xing Li, Yi Luo, Tao Chen, Jing Liu, Peng Fang, Bo Jiang, Zhuang-Li Hu, You Jin, Jian-Guo Chen, Fang Wan. Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1. Neuropharmacology. vol 75. 2014-08-19. PMID:23973312. |
besides its important role in water transport across the blood-brain barrier, our present study demonstrated that aqp4 deficiency impaired hippocampal long-term potentiation (ltp) and hippocampus-dependent memory formation, accompanied by the increase in extracellular glutamate concentration and n-methyl-d-aspartate (nmda) receptor-mediated currents in hippocampal dentate gyrus (dg) region. |
2014-08-19 |
2023-08-12 |
mouse |
| Holly M Brothers, Isabelle Bardou, Sarah C Hopp, Roxanne M Kaercher, Angela W Corona, Ashley M Fenn, Jonathan P Godbout, Gary L Wen. Riluzole partially rescues age-associated, but not LPS-induced, loss of glutamate transporters and spatial memory. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 5. 2014-08-18. PMID:23709339. |
glt1 is the primary excitatory amino acid transporter responsible for regulating extracellular glutamate levels in the hippocampus. |
2014-08-18 |
2023-08-12 |
rat |