| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Félix Matos-Ocasio, Anixa Hernández-López, Kenira J Thompso. Ceftriaxone, a GLT-1 transporter activator, disrupts hippocampal learning in rats. Pharmacology, biochemistry, and behavior. vol 122. 2015-01-26. PMID:24650590. |
our results further support the notion that glutamate transporters provide an essential regulatory role in hippocampal learning and memory. |
2015-01-26 |
2023-08-12 |
rat |
| Wolfgang Kelsch, Zhijun Li, Sebastian Wieland, Oleg Senkov, Anne Herb, Christina Göngrich, Hannah Monye. GluN2B-containing NMDA receptors promote glutamate synapse development in hippocampal interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 48. 2015-01-26. PMID:25429143. |
glun2b-containing nmda receptors promote glutamate synapse development in hippocampal interneurons. |
2015-01-26 |
2023-08-13 |
mouse |
| Angela Neitz, Evanthia Mergia, Barbara Imbrosci, Elisabeth Petrasch-Parwez, Ulf T Eysel, Doris Koesling, Thomas Mittman. Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 7. 2015-01-23. PMID:23448871. |
recently, we showed that the no-gc1 isoform is located presynaptically in glutamatergic neurons and increases the glutamate release via hyperpolarization-activated cyclic nucleotide (hcn)-gated channels in the hippocampus. |
2015-01-23 |
2023-08-12 |
mouse |
| Ella Zeldich, Ci-Di Chen, Teresa A Colvin, Erin A Bove-Fenderson, Jennifer Liang, Tracey B Tucker Zhou, David A Harris, Carmela R Abraha. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. The Journal of biological chemistry. vol 289. issue 35. 2015-01-22. PMID:25037225. |
pretreatment of rat primary hippocampal neurons and mouse hippocampal neuronal cell line ht22 with recombinant klotho protected these cells from glutamate and oligomeric amyloid β (oaβ)-induced cytotoxicity. |
2015-01-22 |
2023-08-13 |
mouse |
| Ella Zeldich, Ci-Di Chen, Teresa A Colvin, Erin A Bove-Fenderson, Jennifer Liang, Tracey B Tucker Zhou, David A Harris, Carmela R Abraha. The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. The Journal of biological chemistry. vol 289. issue 35. 2015-01-22. PMID:25037225. |
in addition, primary hippocampal neurons obtained from klotho-overexpressing mouse embryos were more resistant to both cytotoxic insults, glutamate and oaβ, compared with neurons from wild-type littermates. |
2015-01-22 |
2023-08-13 |
mouse |
| Amajad Iqbal Kazi, Anna Oomme. Chronic noise stress-induced alterations of glutamate and gamma-aminobutyric acid and their metabolism in the rat brain. Noise & health. vol 16. issue 73. 2015-01-22. PMID:25387529. |
glutamate levels increased 10% in the hippocampus, 28% in striatum and glutaminase activity 15% in striatum. |
2015-01-22 |
2023-08-13 |
rat |
| Amajad Iqbal Kazi, Anna Oomme. Chronic noise stress-induced alterations of glutamate and gamma-aminobutyric acid and their metabolism in the rat brain. Noise & health. vol 16. issue 73. 2015-01-22. PMID:25387529. |
noise stress-increased gaba levels and glutamate alpha decarboxylase activity 20% and 45% in the cortex, 13% and 28% in the hippocampus respectively. |
2015-01-22 |
2023-08-13 |
rat |
| Carolyn Graybeal, Caryl Kiselycznyk, Andrew Holme. Stress-induced deficits in cognition and emotionality: a role of glutamate. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22261703. |
stress can alter glutamate transmission in the prefrontal cortex, hippocampus and amygdala and altered glutamate transmission has been linked to neuronal morphological changes. |
2015-01-20 |
2023-08-12 |
Not clear |
| Yun Zhou, Xiaoyu Wang, Anastasios V Tzingounis, Niels C Danbolt, H Peter Larsso. EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 40. 2015-01-20. PMID:25274824. |
the eaat2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. |
2015-01-20 |
2023-08-13 |
mouse |
| Angela Bisio, Ernesto Fedele, Anna Pittaluga, Guendalina Olivero, Massimo Grilli, Jiayang Chen, Giacomo Mele, Nicola Malafronte, Nunziatina De Tommasi, Fabio Leddae, Renata Manconi, Roberto Pronzato, Mario March. Isolation of hydroxyoctaprenyl-1',4'-hydroquinone, a new octaprenylhydroquinone from the marine sponge Sarcotragus spinosulus and evaluation of its pharmacological activity on acetylcholine and glutamate release in the rat central nervous system. Natural product communications. vol 9. issue 11. 2015-01-20. PMID:25532286. |
our findings indicate that the compounds isolated from s. spinosulus can significantly modulate the release of glutamate and acetylcholine in the rat hippocampus and cortex and might, therefore, represent the prototype of a new class of drugs regulating glutamatergic and cholinergic transmission in the mammalian central nervous system. |
2015-01-20 |
2023-08-13 |
rat |
| Pishan Chang, Alexandra M E Zuckermann, Sophie Williams, Adam J Close, Marife Cano-Jaimez, James P McEvoy, John Spencer, Matthew C Walker, Robin S B William. Seizure control by derivatives of medium chain fatty acids associated with the ketogenic diet show novel branching-point structure for enhanced potency. The Journal of pharmacology and experimental therapeutics. vol 352. issue 1. 2015-01-19. PMID:25326131. |
using low magnesium conditions to induce glutamate excitotoxicity in rat primary hippocampal neuronal cultures for the assessment of neuroprotection, we also show a structural dependence identical to that for seizure control, suggesting a related mechanism of action for these compounds in both seizure control and neuroprotection. |
2015-01-19 |
2023-08-13 |
rat |
| Ryo Okada, Kinzo Matsumoto, Ryohei Tsushima, Hironori Fujiwara, Koichi Tsuneyam. Social isolation stress-induced fear memory deficit is mediated by down-regulated neuro-signaling system and Egr-1 expression in the brain. Neurochemical research. vol 39. issue 5. 2015-01-16. PMID:24647971. |
moreover, in the si group, phosphorylated levels of synaptic plasticity-related signaling proteins in the hippocampus, nr1 subunit of n-methyl-d-aspartate receptor, glutamate receptor 1, and calmodulin-dependent kinase ii but not cyclic amp-responsive element binding protein were significantly down-regulated compared with those levels in gh animals, whereas non-phosphorylated levels of these proteins were not affected by si. |
2015-01-16 |
2023-08-12 |
mouse |
| Hayley A Mattison, Dina Popovkina, Joseph P Y Kao, Scott M Thompso. The role of glutamate in the morphological and physiological development of dendritic spines. The European journal of neuroscience. vol 39. issue 11. 2015-01-16. PMID:24661419. |
we used microphotolysis of caged glutamate to stimulate individual dendritic processes in young hippocampal slice cultures while recording their morphological and physiological responses. |
2015-01-16 |
2023-08-12 |
Not clear |
| I O Logvinov, T A Antipova, T A Gudasheva, A V Tarasiuk, P I Antipov, S B Seredeni. Neuroprotective effects of dipeptide analogue of brain-derived neurotrophic factor GSB-106 in in vitro experiments. Bulletin of experimental biology and medicine. vol 155. issue 3. 2015-01-12. PMID:24137599. |
dimeric dipeptide gsb-106, a novel structural analogue of neurotrophin bdnf, in doses from 10(-5) to 10(-8) m protected cultured immortalized mouse hippocampal ht-22 neurons from h2o2 or glutamate damage. |
2015-01-12 |
2023-08-12 |
mouse |
| Yan Lin, Jianli Yao, Yaowen Chen, Li Pang, Haihong Li, Zhen Cao, Kezeng You, Haiyang Dai, Renhua W. Hippocampal neurochemical changes in senescent mice induced with chronic injection of D-galactose and NaNO₂: an in vitro high-resolution NMR spectroscopy study at 9.4T. PloS one. vol 9. issue 2. 2015-01-09. PMID:24533108. |
consistent with previously published in vivo ¹h mrs findings in human ad patients and ad transgenic mice, our in vitro ¹h mrs on the perchloric acid extractions of hippocampus in senescent mice observed significant decreases of n-acetylaspartate (naa) and glutamate (glu) but an increase in myo-inositol (mins). |
2015-01-09 |
2023-08-12 |
mouse |
| Smita Thakker-Varia, Joseph Behnke, David Doobin, Vidhi Dalal, Keya Thakkar, Farah Khadim, Elizabeth Wilson, Alicia Palmieri, Hanna Antila, Tomi Rantamaki, Janet Alde. VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling. Stem cell research. vol 12. issue 3. 2015-01-09. PMID:24747217. |
vgf (tlqp-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and bdnf signaling. |
2015-01-09 |
2023-08-13 |
mouse |
| Stephen H Braren, Damian Drapala, Ingrid K Tulloch, Peter A Serran. Methamphetamine-induced short-term increase and long-term decrease in spatial working memory affects protein Kinase M zeta (PKMζ), dopamine, and glutamate receptors. Frontiers in behavioral neuroscience. vol 8. 2015-01-08. PMID:25566006. |
the hippocampus and dorsal striatum were assessed for expression of glutamate receptors subunits, glua2 and glun2b; dopamine markers, dopamine 1 receptor (d1), dopamine transporter (dat) and tyrosine hydroxylase (th); and memory markers, protein kinase m zeta (pkmζ) and protein kinase c zeta (pkcζ). |
2015-01-08 |
2023-08-13 |
mouse |
| Helena Domin, Krystyna Gołembiowska, Danuta Jantas, Katarzyna Kamińska, Barbara Zięba, Maria Smiałowsk. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotoxicity research. vol 26. issue 1. 2015-01-06. PMID:24402869. |
moreover, in vivo microdialysis studies in the rat hippocampus showed that acpt-i (200 μm) given simultaneously with ka (50 μm) significantly diminished the ka-induced glutamate release in the hippocampus. |
2015-01-06 |
2023-08-12 |
rat |
| Soroush G Sadeghi, Sonja J Pyott, Zhou Yu, Elisabeth Glowatzk. Glutamatergic signaling at the vestibular hair cell calyx synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 44. 2015-01-06. PMID:25355208. |
we propose that similar to other brain areas, such as the cerebellum and hippocampus, glutamate spillover may play a role in gain control of calyx afferents and contribute to their high-pass properties. |
2015-01-06 |
2023-08-13 |
rat |
| Jianxue Gong, Shujuan Gong, Min Zhang, Lianwei Zhang, Yuyan Hu, Yixian Liu, Wenbin L. Cerebral ischemic preconditioning reduces glutamate excitotoxicity by up-regulating the uptake activity of GLT-1 in rats. Amino acids. vol 46. issue 6. 2015-01-05. PMID:24643365. |
the results showed that a significant pulse of glutamate concentration reached the peak value of sevenfold of the basal level after lethal ischemic insult, which was associated with delayed neuronal death in the ca1 hippocampus. |
2015-01-05 |
2023-08-12 |
rat |