| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhi Chen, Tingting Li, Linke Zhang, Huan Wang, Fan H. Bisphenol A exposure remodels cognition of male rats attributable to excitatory alterations in the hippocampus and visual cortex. Toxicology. vol 410. 2019-05-01. PMID:30312744. |
our results showed that male but not female juvenile rats had a marked decline in spatial memory after 0.4 mg/kg/day bpa exposure, which accompanied with downregulation of glutamate receptor (nr2) expression in their hippocampus and primary visual cortex (v1). |
2019-05-01 |
2023-08-13 |
human |
| Zhi Chen, Tingting Li, Linke Zhang, Huan Wang, Fan H. Bisphenol A exposure remodels cognition of male rats attributable to excitatory alterations in the hippocampus and visual cortex. Toxicology. vol 410. 2019-05-01. PMID:30312744. |
additionally, those rats had a significant decline in spine density of pyramidal neurons and a decreased expression of glutamate receptor subtypes (nr2 and glur1) in the hippocampus. |
2019-05-01 |
2023-08-13 |
human |
| Zhi Chen, Tingting Li, Linke Zhang, Huan Wang, Fan H. Bisphenol A exposure remodels cognition of male rats attributable to excitatory alterations in the hippocampus and visual cortex. Toxicology. vol 410. 2019-05-01. PMID:30312744. |
importantly, such impairments in the hippocampus of male rats were associated with a decrease of glutamate receptor (nr2) expression in the v1, which could perturb the visual information inputs. |
2019-05-01 |
2023-08-13 |
human |
| Diana Y Sakae, Lauriane Ramet, Annabelle Henrion, Odile Poirel, Stéphane Jamain, Salah El Mestikawy, Stéphanie Dauma. Differential expression of VGLUT3 in laboratory mouse strains: Impact on drug-induced hyperlocomotion and anxiety-related behaviors. Genes, brain, and behavior. vol 18. issue 3. 2019-05-01. PMID:30324647. |
the atypical vesicular glutamate transporter vglut3 is present in subpopulations of gabaergic interneurons in the cortex and the hippocampus, in subgroups of serotoninergic neurons in raphe nuclei, and in cholinergic interneurons in the striatum. |
2019-05-01 |
2023-08-13 |
mouse |
| Xiao-Peng Wang, Pin Ye, Jiao Lv, Lei Zhou, Zhong-Yi Qian, Yong-Jie Huang, Zhi-Hao Mu, Xie Wang, Xin-Jie Liu, Qi Wan, Zhi-Hong Yang, Fang Wang, Ying-Ying Zo. Expression Changes of NMDA and AMPA Receptor Subunits in the Hippocampus in rats with Diabetes Induced by Streptozotocin Coupled with Memory Impairment. Neurochemical research. vol 44. issue 4. 2019-04-26. PMID:30747310. |
here, we sought to determine the cognitive changes and aim to correlate this with the expression changes of nmdar and ampar of glutamate signaling pathways in the rat hippocampus from early phase of dm and in the course of the disease progression. |
2019-04-26 |
2023-08-13 |
rat |
| Ester Francija, Zorica Petrovic, Zeljka Brkic, Milos Mitic, Jelena Radulovic, Miroslav Adzi. Disruption of the NMDA receptor GluN2A subunit abolishes inflammation-induced depression. Behavioural brain research. vol 359. 2019-04-23. PMID:30296532. |
this was accompanied by unaltered levels of il-6 and significant changes in neuroplasticity markers and glutamate receptor subunits composition in pfc and hippocampus. |
2019-04-23 |
2023-08-13 |
mouse |
| Hayato Akimoto, Shinji Oshima, Tomoaki Sugiyama, Akio Negishi, Tadashi Nemoto, Daisuke Kobayash. Changes in brain metabolites related to stress resilience: Metabolomic analysis of the hippocampus in a rat model of depression. Behavioural brain research. vol 359. 2019-04-23. PMID:30447240. |
cms model rats showed an increase in the levels of n-acetylaspartate and glutamate, and a decrease in the levels of aspartate and γ-aminobutyric acid in the hippocampus. |
2019-04-23 |
2023-08-13 |
rat |
| Bin Wang, Qiong Wu, Lei Lei, Hailun Sun, Ntim Michael, Xuan Zhang, Ying Wang, Yue Zhang, Biying Ge, Xuefei Wu, Yue Wang, Yi Xin, Jie Zhao, Shao L. Long-term social isolation inhibits autophagy activation, induces postsynaptic dysfunctions and impairs spatial memory. Experimental neurology. vol 311. 2019-04-10. PMID:30219732. |
the results further showed that the l-pwsi significantly decreased the protein expression levels of psd-95, glua1, nr1 and nr2b in the hippocampus, and no significant changes in the extracellular release of glutamate and the protein expression levels of synaptophysin, synapsin i, gap-43, nr2a and gaba |
2019-04-10 |
2023-08-13 |
mouse |
| Yuanyuan Liu, Zhongying Liu, Mengying Wei, Mingxin Hu, Kexin Yue, Rongbing Bi, Shan Zhai, Zifeng Pi, Fengrui Song, Zhiqiang Li. Pharmacodynamic and urinary metabolomics studies on the mechanism of Schisandra polysaccharide in the treatment of Alzheimer's disease. Food & function. vol 10. issue 1. 2019-04-09. PMID:30623955. |
in the hippocampus of the model rats, the contents of γ-aminobutyric acid, acetylcholine, glycine, norepinephrine, taurine, serotonin and dopamine were significantly decreased and the contents of glutamate and aspartic acid were increased significantly. |
2019-04-09 |
2023-08-13 |
rat |
| Nina María Mónaco, Mariana Bartos, Sergio Dominguez, Cristina Gallegos, Cristina Bras, María Del Carmen Esandi, Cecilia Bouzat, Leda Giannuzzi, Alejandra Minetti, Fernanda Gumila. Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of α7 nicotinic receptor, glutamate and oxidative stress. Neurotoxicology. vol 67. 2019-04-08. PMID:29678590. |
this behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nachr expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (cat) activity. |
2019-04-08 |
2023-08-13 |
rat |
| Zhong-Ren Sun, Xiao-Lin Lü, Hong-Na Yin, Ji-Shun Hao, Xiang-Xin Zeng, Zhu-Xin L. [Progress of Researches on Mechanisms of Acupuncture Therapy in Regulating Brain Plasticity]. Zhen ci yan jiu = Acupuncture research. vol 43. issue 10. 2019-04-08. PMID:30365266. |
from 1) regulating synaptic plasticity (up-regulating the proportion of hippocampal synapses, increasing synaptic curvature, post-synaptic density, and numerical density, areal density, and lowering synaptic cleft); 2) increasing hippocampal post-synaptic potential slop, peak and peak area of population spikes to evoke long-term potentiation (ltp) by regulating the expression of glutamate n-methyl-d-aspartate (nmda) and alpha amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (ampa) receptors, and growth associated protein (gap-43); 3) down-regulating the expression of glial fibrillary acidic protein (gfap) to suppress the activity of astrocytes in the ischemic cerebral area and hippocampus in cerebral ischemia rats, and in the spinal cord dorsal horns of bone cancer rats, etc. |
2019-04-08 |
2023-08-13 |
rat |
| Shuai Li, Jie Tan, Hong Zhang, Gui-Lan Huang, Duo-Xi Deng, Kui-Kui Guo, Jia-Qing Liu, Tong-Yan Liu, Yun-Yun W. [Effect of Catgut Implantation on Spatial Learning-memory Ability, Expression of Hippocampal Protein Kinase C Interacting Protein 1 and GluR 2 and Ca Zhen ci yan jiu = Acupuncture research. vol 43. issue 6. 2019-04-05. PMID:30091539. |
on learning-memory ability, expression of hippocampal protein kinase c interacting protein 1 (pick 1) and glutamate receptor 2 (glur 2) proteins and level of calcium ions, so as to explore its mechanism underlying improvement of vascular cognitive impairment. |
2019-04-05 |
2023-08-13 |
Not clear |
| Amy Ross, Nicolette Barnett, Alexa Faulkner, Reilly Hannapel, Marise B Paren. Sucrose ingestion induces glutamate AMPA receptor phosphorylation in dorsal hippocampal neurons: Increased sucrose experience prevents this effect. Behavioural brain research. vol 359. 2019-04-03. PMID:30076854. |
sucrose ingestion induces glutamate ampa receptor phosphorylation in dorsal hippocampal neurons: increased sucrose experience prevents this effect. |
2019-04-03 |
2023-08-13 |
Not clear |
| Rebeca Vidal, Emilio Garro-Martínez, Álvaro Díaz, Elena Castro, Eva Florensa-Zanuy, Makoto M Taketo, Ángel Pazos, Fuencisla Pilar-Cuélla. Targeting β-Catenin in GLAST-Expressing Cells: Impact on Anxiety and Depression-Related Behavior and Hippocampal Proliferation. Molecular neurobiology. vol 56. issue 1. 2019-04-01. PMID:29737454. |
to further understand the role of β-catenin in depression and anxiety, we generated two conditional transgenic mice in which β-catenin was either inactivated or stabilized in cells expressing creert under the control of the astrocyte-specific glutamate transporter (glast) promoter inducible by tamoxifen, which presents high expression levels on the subgranular zone of the hippocampus. |
2019-04-01 |
2023-08-13 |
mouse |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
the present work hypothesizes that ketosis associated to insulin resistance could interfere with the normal activity of vglut1 and its role in the release of glutamate in the hippocampus, which might ultimately lead to cognitive deficits. |
2019-03-28 |
2023-08-13 |
rat |
| Manuel Rodriguez-Perdigon, Maite Solas, Maria Jesús Moreno-Aliaga, Maria Javier Ramire. Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1862. issue 4. 2019-03-28. PMID:26769360. |
altogether, the present results suggest that hfd induced alterations in central insulin signalling could switch metabolism to produce ketone bodies, which in turn, in the hippocampus, might lead to a decreased expression of vglut1, and therefore to a decreased release of glutamate and hence, to the glutamatergic deficit described in ad. |
2019-03-28 |
2023-08-13 |
rat |
| Adel A Gomaa, Rania M Makboul, Mohamed A Al-Mokhtar, Mariam A Nicol. Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-03-25. PMID:30396086. |
moreover, bs extract enhanced significantly the suppressed hippocampal level of gsh, sod and glutamate receptor expression (glur, nr1, nr2 a, and nr2b). |
2019-03-25 |
2023-08-13 |
rat |
| Marzia Soligo, Sonia Piccinin, Virginia Protto, Francesca Gelfo, Maria Egle De Stefano, Fulvio Florenzano, Erica Berretta, Laura Petrosini, Robert Nisticò, Luigi Mann. Recovery of hippocampal functions and modulation of muscarinic response by electroacupuncture in young diabetic rats. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28831054. |
here we demonstrate, in a rat model of early type-1 diabetes, that a physical therapy, the electroacupuncture, counteracts the diabetes-induced deleterious effects on hippocampal physiology by ameliorating hippocampal-related memory functions; recovering the impaired long-term potentiation at the dentate gyrus (dg-ltp) and the lowered expression of the vesicular glutamate transporter 1; normalizing the activity-dependent release of prongf in diabetic rat hippocampus. |
2019-03-21 |
2023-08-13 |
rat |
| Connor Thelen, Emily Flaherty, Joseph Saurine, Jonathon Sens, Sara Mohamed, Pothitos M Pitychouti. Sex Differences in the Temporal Neuromolecular and Synaptogenic Effects of the Rapid-acting Antidepressant Drug Ketamine in the Mouse Brain. Neuroscience. vol 398. 2019-03-18. PMID:30537521. |
herein, we assessed the neurobiological effects of a single ketamine dose (10 mg/kg; previously shown to induce rapid and sustained antidepressant-like effects in mice of both sexes), on glutamate release in the mpfc, as well as on the expression of synaptic plasticity markers, and spine density in the mpfc and the hipp of c57bl/6j mice. |
2019-03-18 |
2023-08-13 |
mouse |
| Ainhoa Bilbao, Claudia Falfán-Melgoza, Sarah Leixner, Robert Becker, Sathish Kumar Singaravelu, Markus Sack, Alexander Sartorius, Rainer Spanagel, Wolfgang Weber-Fah. Longitudinal Structural and Functional Brain Network Alterations in a Mouse Model of Neuropathic Pain. Neuroscience. vol 387. 2019-03-14. PMID:29694917. |
these changes in connectivity were accompanied by enhanced glutamate levels in the hippocampus, but not in the prefrontal cortex. |
2019-03-14 |
2023-08-13 |
mouse |