| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kirstan Gimse, Ryan C Gorzek, Andrew Olin, Sue Osting, Corinna Burge. Hippocampal Homer1b/c is necessary for contextual fear conditioning and group I metabotropic glutamate receptor mediated long-term depression. Neurobiology of learning and memory. vol 156. 2019-09-16. PMID:30336208. |
we have previously found that overexpression of hippocampal homer1c is sufficient to rescue learning and memory ability in aged learning impaired rats and in homer1 knockout (ko) mice, and to rescue group i metabotropic glutamate receptor (mglur1/5) mediated long-term potentiation in ko mice. |
2019-09-16 |
2023-08-13 |
mouse |
| Yi Chang, Cheng Wei Lu, Yi Jing Chen, Tzu Yu Lin, Shu Kuei Huang, Su Jane Wan. Astaxanthin protects against kainic acid-induced seizures and pathological consequences. Neurochemistry international. vol 116. 2019-09-10. PMID:29475038. |
the results revealed that ka induced seizures, increased the hippocampal glutamate levels, caused considerable neuronal death and microglial activation in the hippocampal ca3 regions, and increased the production of proinflammatory cytokines. |
2019-09-10 |
2023-08-13 |
rat |
| Vitor Rocco Torrez, Eduardo R Zimmer, Eduardo Kalinine, Clarissa Branco Haas, Kamila Cagliari Zenki, Alexandre Pastoris Muller, Diogo Onofre de Souza, Luis Valmor Portel. Memantine mediates astrocytic activity in response to excitotoxicity induced by PP2A inhibition. Neuroscience letters. vol 696. 2019-09-02. PMID:30586637. |
mn decreased glutamate uptake in the hippocampus and increased the release of s100b protein in the csf in response to oka neurotoxicity, which indicates a possible neurons-astrocyte coupling protective mechanism. |
2019-09-02 |
2023-08-13 |
rat |
| Penghui Song, Jing Hu, Xijin Liu, Xuejun Den. Increased expression of the P2X7 receptor in temporal lobe epilepsy: Animal models and clinical evidence. Molecular medicine reports. vol 19. issue 6. 2019-08-29. PMID:31059094. |
the aim of the present study was to assess the expression of p2x7r, glutamate (glu) and glial fibrillary acidic protein (gfap) in the temporal neocortex and hippocampus of rats with lithium‑pilocarpine‑induced epilepsy as well as in patients with intractable tle. |
2019-08-29 |
2023-08-13 |
rat |
| Fei Gao, Xuntao Yin, Richard A E Edden, Alan C Evans, Junhai Xu, Guanmei Cao, Honghao Li, Muwei Li, Bin Zhao, Jian Wang, Guangbin Wan. Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis. Hippocampus. vol 28. issue 11. 2019-08-26. PMID:30069963. |
altered hippocampal gaba and glutamate levels and uncoupling from functional connectivity in multiple sclerosis. |
2019-08-26 |
2023-08-13 |
Not clear |
| Fei Gao, Xuntao Yin, Richard A E Edden, Alan C Evans, Junhai Xu, Guanmei Cao, Honghao Li, Muwei Li, Bin Zhao, Jian Wang, Guangbin Wan. Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis. Hippocampus. vol 28. issue 11. 2019-08-26. PMID:30069963. |
however, researchers have not clearly determined whether changes in hippocampal gaba and glutamate (glu) levels are associated with cognitive impairment and aberrant neural activity in patients with ms. we used magnetic resonance spectroscopy to measure gaba+ and glu levels in the left hippocampal region of 29 patients with relapsing-remitting ms and 29 healthy controls (hcs). |
2019-08-26 |
2023-08-13 |
Not clear |
| E Sherwood Brown, Nasreen Sayed, Changho Choi, Nicholas Tustison, Jared Roberts, Michael A Yassa, Erin Van Enkevort, Alyson Nakamura, Elena I Ivleva, Prabha Sunderajan, David A Khan, Miguel Vazquez, Bruce McEwen, Alexandra Kulikova, Alan B Frol, Traci Holme. A randomized, double-blind, placebo-controlled trial of lamotrigine for prescription corticosteroid effects on the human hippocampus. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 29. issue 3. 2019-08-26. PMID:30612854. |
in animals, stress and corticosteroid excess are associated with decreases in memory performance and hippocampal volume that may be prevented with agents that decrease glutamate release. |
2019-08-26 |
2023-08-13 |
human |
| Ricardo Martín, José Javier Ferrero, Andrea Collado-Alsina, Carolina Aguado, Rafael Luján, Magdalena Torres, José Sánchez-Priet. Bidirectional modulation of glutamatergic synaptic transmission by metabotropic glutamate type 7 receptors at Schaffer collateral-CA1 hippocampal synapses. The Journal of physiology. vol 596. issue 5. 2019-08-19. PMID:29280494. |
bidirectional modulation of glutamatergic synaptic transmission by metabotropic glutamate type 7 receptors at schaffer collateral-ca1 hippocampal synapses. |
2019-08-19 |
2023-08-13 |
Not clear |
| Regina U Hegemann, Wickliffe C Abraha. Electrophysiological Investigation of Metabotropic Glutamate Receptor-Dependent Metaplasticity in the Hippocampus. Methods in molecular biology (Clifton, N.J.). vol 1941. 2019-08-19. PMID:30707429. |
electrophysiological investigation of metabotropic glutamate receptor-dependent metaplasticity in the hippocampus. |
2019-08-19 |
2023-08-13 |
Not clear |
| Kirstan E Gimse, Kenneth O'Riordan, Corinna Burge. Induction of Metabotropic Glutamate Receptor-Mediated Long-Term Depression in the Hippocampal Schaffer Collateral Pathway of Aging Rats. Methods in molecular biology (Clifton, N.J.). vol 1941. 2019-08-19. PMID:30707430. |
induction of metabotropic glutamate receptor-mediated long-term depression in the hippocampal schaffer collateral pathway of aging rats. |
2019-08-19 |
2023-08-13 |
rat |
| Kirstan E Gimse, Kenneth O'Riordan, Corinna Burge. Induction of Metabotropic Glutamate Receptor-Mediated Long-Term Depression in the Hippocampal Schaffer Collateral Pathway of Aging Rats. Methods in molecular biology (Clifton, N.J.). vol 1941. 2019-08-19. PMID:30707430. |
the technique described in this chapter outlines the procedure for measuring metabotropic glutamate receptor-mediated long-term depression in hippocampal slices using extracellular field recordings and includes specific details for the application of this technique in the study of neuronal aging. |
2019-08-19 |
2023-08-13 |
rat |
| Ji Hoon Song, Changyeol Lee, Dahae Lee, Soonok Kim, Sunghee Bang, Myoung-Sook Shin, Jun Lee, Ki Sung Kang, Sang Hee Shi. Neuroprotective Compound from an Endophytic Fungus, Colletotrichum sp. JS-0367. Journal of natural products. vol 81. issue 6. 2019-08-14. PMID:29790746. |
therefore, the neuroprotective effects of these compounds were determined against murine hippocampal ht22 cell death induced by glutamate. |
2019-08-14 |
2023-08-13 |
Not clear |
| Caroline Zanotto, Fernanda Hansen, Fabiana Galland, Cristiane Batassini, Bárbara Carolina Federhen, Vanessa Fernanda da Silva, Marina Concli Leite, Patrícia Nardin, Carlos-Alberto Gonçalve. Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4. Molecular neurobiology. vol 56. issue 5. 2019-08-13. PMID:30145785. |
we found a decrease in glutamate uptake and glun1 content in the hippocampus of diabetic rats; ex-4 was able to revert these parameters, but had no effect on the other parameters evaluated (glycemia, c-peptide, age levels, rage, and glyoxalase 1). |
2019-08-13 |
2023-08-13 |
rat |
| Caroline Zanotto, Fernanda Hansen, Fabiana Galland, Cristiane Batassini, Bárbara Carolina Federhen, Vanessa Fernanda da Silva, Marina Concli Leite, Patrícia Nardin, Carlos-Alberto Gonçalve. Glutamatergic Alterations in STZ-Induced Diabetic Rats Are Reversed by Exendin-4. Molecular neurobiology. vol 56. issue 5. 2019-08-13. PMID:30145785. |
ex-4 abrogated the decrease in glutamate uptake and glun1 content caused by methylglyoxal (mg) in hippocampal slices, in addition to leading to an increase in glutamate uptake in astrocyte culture cells and hippocampal slices under basal conditions. |
2019-08-13 |
2023-08-13 |
rat |
| J A Lieberman, R R Girgis, G Brucato, H Moore, F Provenzano, L Kegeles, D Javitt, J Kantrowitz, M M Wall, C M Corcoran, S A Schobel, S A Smal. Hippocampal dysfunction in the pathophysiology of schizophrenia: a selective review and hypothesis for early detection and intervention. Molecular psychiatry. vol 23. issue 8. 2019-08-12. PMID:29311665. |
in this context, we have developed a hypothesis that describes the evolution of schizophrenia-from the premorbid through the prodromal stages to syndromal psychosis-and posits dysregulation of glutamate neurotransmission beginning in the ca1 region of the hippocampus as inducing attenuated psychotic symptoms and initiating the transition to syndromal psychosis. |
2019-08-12 |
2023-08-13 |
Not clear |
| Francesca L Gues. Early Detection and Treatment of Patients with Alzheimer's Disease: Future Perspectives. Advances in experimental medicine and biology. vol 1118. 2019-08-02. PMID:30747429. |
as the disease progresses, it is accompanied by accumulation of amyloid plaques and neurofibrillary tangles in key areas of the brain, leading to a loss of neurogenesis and synaptic plasticity in the hippocampus, along with changes in the levels of essential neurotransmitters such as acetylcholine and glutamate. |
2019-08-02 |
2023-08-13 |
Not clear |
| Sawsan Aboul-Fotouh, Mohamed Habib, Tarek Asaad, Samar K Kassim, Mohamed H Ghane. Behavioral effects of toll-like receptor-4 antagonist 'eritoran' in an experimental model of depression: role of prefrontal and hippocampal neurogenesis and γ-aminobutyric acid/glutamate balance. Behavioural pharmacology. vol 29. issue 5. 2019-07-31. PMID:29561292. |
long-term administration of eri ameliorated crs-induced depressive-like symptoms and hypothalamic-pituitary-adrenal axis hyperactivity alongside reducing levels of hippocampal and pfc inflammatory cytokines, restoring gaba and glutamate balance, and enhancing pfc and hippocampal neurogenesis, by increasing bdnf gene and protein expression in a dose-dependent manner. |
2019-07-31 |
2023-08-13 |
rat |
| Wei-Yu Zhu, Xia Feng, Jin Wang, Yu-Pan Lu, Xian-Zhe Dong, Ping Li. [Effect of Dingzhi Xiaowan on miR-16 expression and 5-HT reuptake]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 17. 2019-07-29. PMID:30347920. |
the effects of dz (10, 100, 200, 500 mg·l⁻¹) on the expression of mir-16 and sert mrna in the cell model induced by mir-16 silencing and corticosterone or glutamate injury were observed in primary cultured hippocampal neurons of rats in vitro. |
2019-07-29 |
2023-08-13 |
rat |
| Wei-Yu Zhu, Xia Feng, Jin Wang, Yu-Pan Lu, Xian-Zhe Dong, Ping Li. [Effect of Dingzhi Xiaowan on miR-16 expression and 5-HT reuptake]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 17. 2019-07-29. PMID:30347920. |
at the same time, in primary cultured hippocampal neurons, 100, 200, 500 mg·l⁻¹ of dz could significantly increase the expression level of mir-16 in mir-16 silencing and corticosterone or glutamate injury cell model, and decrease the expression level of sert significantly. |
2019-07-29 |
2023-08-13 |
rat |
| Binika Hada, Mrigendra Bir Karmacharya, So R Park, Byung H Cho. Low-Intensity Ultrasound Decreases Ischemia-Induced Edema by Inhibiting N-Methyl-d-Aspartic Acid Receptors. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. vol 45. issue 6. 2019-07-18. PMID:30430968. |
we have previously shown that low-intensity ultrasound (lius), a noninvasive mechanical stimulus, inhibits brain edema formation induced by oxygen and glucose deprivation (ogd) or treatment with glutamate, a mediator of ogd-induced edema, in acute rat hippocampal slice model in vitro. |
2019-07-18 |
2023-08-13 |
rat |