| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvie L Lesuis, Paul M Kaplick, Paul J Lucassen, Harm J Kruger. Treatment with the glutamate modulator riluzole prevents early life stress-induced cognitive deficits and impairments in synaptic plasticity in APPswe/PS1dE9 mice. Neuropharmacology. vol 150. 2020-01-21. PMID:30794835. |
excess glutamate has been proposed as a possible mediator underlying these effects in the hippocampus, a vulnerable brain region implicated in learning and memory. |
2020-01-21 |
2023-08-13 |
mouse |
| Guendalina Olivero, Matteo Vergassola, Francesca Cisani, Cesare Usai, Anna Pittalug. Immuno-Pharmacological Characterization of Presynaptic GluN3A-Containing NMDA Autoreceptors: Relevance to Anti-NMDA Receptor Autoimmune Diseases. Molecular neurobiology. vol 56. issue 9. 2020-01-09. PMID:30734226. |
the presence of glun1, glun2a, glun2b, and glun3a subunits in hippocampal vesicular glutamate transporter type 1-positive synaptosomes was confirmed with confocal microscopy. |
2020-01-09 |
2023-08-13 |
mouse |
| Xuming Yu, Juan Wu, Mingbai Hu, Jinhua Wu, Quanfei Zhu, Zheqiong Yang, Xianfei Xie, Yu-Qi Feng, Jiang Yu. Glutamate affects the CYP1B1- and CYP2U1-mediated hydroxylation of arachidonic acid metabolism via astrocytic mGlu5 receptor. The international journal of biochemistry & cell biology. vol 110. 2020-01-08. PMID:30858141. |
the mrna levels of cyp1b1 and cyp2u1 were increased in the cortex, hippocampus, and cerebellum from adult rats that received a subcutaneous injection of monosodium l-glutamate at 1, 3, 5, and 7 days of age; meanwhile, the protein levels of cyp1b1 and cyp2u1 in the astrocytes were induced by glutamate. |
2020-01-08 |
2023-08-13 |
human |
| Yan Zheng, Aiyi Liu, Zi-Jun Wang, Qing Cao, Wei Wang, Lin Lin, Kaijie Ma, Freddy Zhang, Jing Wei, Emmanuel Matas, Jia Cheng, Guo-Jun Chen, Xiaomin Wang, Zhen Ya. Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease. Brain : a journal of neurology. vol 142. issue 3. 2020-01-06. PMID:30668640. |
treatment of fad mice with specific ehmt1/2 inhibitors reversed histone hyper-methylation and led to the recovery of glutamate receptor expression and excitatory synaptic function in prefrontal cortex and hippocampus. |
2020-01-06 |
2023-08-13 |
mouse |
| Ting Yang Hsieh, Yi Chang, Su Jane Wan. Piperine-mediated suppression of voltage-dependent Ca Food & function. vol 10. issue 5. 2020-01-02. PMID:31033966. |
because inhibition of glutamatergic excitatory neurotransmission is a possible mechanism involved in neuroprotection, we investigated the effect of piperine on the 4-aminopyridine (4-ap)-evoked release of glutamate from rat hippocampal synaptosomes. |
2020-01-02 |
2023-08-13 |
rat |
| Ting Yang Hsieh, Yi Chang, Su Jane Wan. Piperine-mediated suppression of voltage-dependent Ca Food & function. vol 10. issue 5. 2020-01-02. PMID:31033966. |
these results suggest that piperine inhibits glutamate release from rat hippocampal nerve terminals by reducing ca2+ influx through n- and p/q-type ca2+ channels and that the activation of presynaptic 5-ht1a receptors and the g protein βγ subunit is involved in this effect. |
2020-01-02 |
2023-08-13 |
rat |
| Shohei Yokoyama, Ichiro Nakagawa, Yoichi Ogawa, Yudai Morisaki, Yasushi Motoyama, Young Su Park, Yasuhiko Saito, Hiroyuki Nakas. Ischemic postconditioning prevents surge of presynaptic glutamate release by activating mitochondrial ATP-dependent potassium channels in the mouse hippocampus. PloS one. vol 14. issue 4. 2019-12-30. PMID:30978206. |
ischemic postconditioning prevents surge of presynaptic glutamate release by activating mitochondrial atp-dependent potassium channels in the mouse hippocampus. |
2019-12-30 |
2023-08-13 |
mouse |
| Yun Zhou, Bjørnar Hassel, Tore Eid, Niels Christian Danbol. Axon-terminals expressing EAAT2 (GLT-1; Slc1a2) are common in the forebrain and not limited to the hippocampus. Neurochemistry international. vol 123. 2019-12-26. PMID:29530756. |
although synapsin 1-cre mediated gene deletion only reduced the forebrain tissue content of eaat2 protein to 95.5 ± 3.4% of wild-type (littermate) controls, the glutamate accumulation in homogenates of neocortex, hippocampus, striatum and thalamus were nevertheless diminished to, respectively, 54 ± 4, 46 ± 3, 46 ± 2 and 65 ± 7% of controls (average ± sem, n = 3 pairs of littermates). |
2019-12-26 |
2023-08-13 |
mouse |
| Robert B Laprairie, Geraldine T Petr, Yan Sun, Kathryn D Fischer, Eileen M Denovan-Wright, Paul A Rosenber. Huntington's disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1. Neurochemistry international. vol 123. 2019-12-26. PMID:29709465. |
glt-1 is the major glutamate transporter in the brain, and is expressed in astrocytes and in axon terminals in the hippocampus, cortex, and striatum. |
2019-12-26 |
2023-08-13 |
Not clear |
| Jingdian Zhang, Jiachun Feng, Di Ma, Feng Wang, Yumeng Wang, Chunxiao Li, Xu Wang, Xiang Yin, Ming Zhang, Ruben K Dagda, Ying Zhan. Neuroprotective Mitochondrial Remodeling by AKAP121/PKA Protects HT22 Cell from Glutamate-Induced Oxidative Stress. Molecular neurobiology. vol 56. issue 8. 2019-12-17. PMID:30652267. |
unexpectedly, treating mouse hippocampal progenitor neuronal ht22 cells with an acute dose or chronic exposure of glutamate robustly elevates pka signaling, a beneficial compensatory response that is phenocopied in ht22 cells conditioned to thrive in the presence of excess glutamate but not in parental ht22 cells. |
2019-12-17 |
2023-08-13 |
mouse |
| Bin Luo, Qian Pang, Qingsong Jian. Tooth loss causes spatial cognitive impairment in rats through decreased cerebral blood flow and increased glutamate. Archives of oral biology. vol 102. 2019-12-17. PMID:31079020. |
this study aimed to investigate the changes in cbf, glutamate concentration, the expression of neuronal apoptosis-relatedbax/bcl-2 and caspase-3 mrna and pyramidal cells in the hippocampus, as well as behavioral changes after tooth loss in rats. |
2019-12-17 |
2023-08-13 |
rat |
| Megumi Taket. Metabotropic glutamate receptor 1-mediated calcium mobilization in the neonatal hippocampal marginal zone. The European journal of neuroscience. vol 48. issue 11. 2019-12-12. PMID:30304574. |
metabotropic glutamate receptor 1-mediated calcium mobilization in the neonatal hippocampal marginal zone. |
2019-12-12 |
2023-08-13 |
Not clear |
| Berger, Jensen, Hossmann, Pasche. Effect of mild hypothermia during and after transient in vitro ischemia on metabolic disturbances in hippocampal slices at different stages of development Brain research. Developmental brain research. vol 105. issue 1. 2019-11-20. PMID:9473592. |
effect of mild hypothermia during and after transient in vitro ischemia on metabolic disturbances in hippocampal slices at different stages of development in the present study the neuroprotective effect of mild hypothermia (decrease of temperature from 37degreesc to 33degreesc) during and after transient ischemia in brain tissue at different stages of development was tested in vitro by measuring energy metabolism, glutamate release and protein biosynthesis rate (psr) in hippocampal slices. |
2019-11-20 |
2023-08-12 |
Not clear |
| Rafiki, Chevassus-au-Louis, Ben-Ari, Khrestchatisky, Repres. Glutamate receptors in dysplasic cortex: an in situ hybridization and immunohistochemistry study in rats with prenatal treatment with methylazoxymethanol Brain research. vol 782. issue 1-2. 2019-11-20. PMID:9526068. |
glutamate receptors in dysplasic cortex: an in situ hybridization and immunohistochemistry study in rats with prenatal treatment with methylazoxymethanol injection of the antimitotic drug methylazoxymethanol (mam) in the pregnant rat at e14 leads in the offsprings to a severe malformation with microcephaly and cortical heterotopiae in the white matter and in the ca1 field of the hippocampus. |
2019-11-20 |
2023-08-12 |
rat |
| Rafiki, Chevassus-au-Louis, Ben-Ari, Khrestchatisky, Repres. Glutamate receptors in dysplasic cortex: an in situ hybridization and immunohistochemistry study in rats with prenatal treatment with methylazoxymethanol Brain research. vol 782. issue 1-2. 2019-11-20. PMID:9526068. |
immunostaining for glur2/3, nr1 or nr2 showed, in both mam and control animals, that glutamate receptors were mainly concentrated in the soma and dendrites of neocortical and hippocampal pyramidal cells, including in heterotopiae, and in the apical dendrites of hippocampal granule cells. |
2019-11-20 |
2023-08-12 |
rat |
| McBai. A short-term mechanism of plasticity for interneurones? The Journal of physiology. vol 511 (Pt 2). 2019-11-20. PMID:9706013. |
in contrast, some hippocampal and neocortical local circuit gabaergic inhibitory interneurones possess glutamate receptors with inwardly rectifying current-voltage (i-v) relationships and appreciable ca2+ permeability. |
2019-11-20 |
2023-08-12 |
spider |
| M. Bianchin, R.C. Da Silva, P.K. Schmitz, J.H. Medina, I. Izquierd. Memory of inhibitory avoidance in the rat is regulated by glutamate metabotropic receptors in the hippocampus. Behavioural pharmacology. vol 5. issue 3. 2019-11-20. PMID:11224286. |
memory of inhibitory avoidance in the rat is regulated by glutamate metabotropic receptors in the hippocampus. |
2019-11-20 |
2023-08-12 |
rat |
| Hideo Yamamoto, Noboru Kitamura, Xian-Hao Lin, Youji Ikeuchi, Takeshi Hashimoto, Osamu Shirakawa, Kiyoshi Maed. Differential changes in glutamatergic transmission via N-methyl-D-aspartate receptors in the hippocampus and striatum of rats behaviourally sensitized to methamphetamine. The international journal of neuropsychopharmacology. vol 2. issue 3. 2019-11-20. PMID:11281984. |
seven days after the challenge test, we examined glutamate (glu) release from hippocampal and striatal slices evoked by 30 mm kcl, and nmda-evoked dopamine (da) release from striatal slices. |
2019-11-20 |
2023-08-12 |
rat |
| P.-W. Gean, F.-C. Chang, P.-L. Yi, J.-H. Lin, J.-J. Tsa. Activation of Metabotropic Glutamate Receptors in Conjunction with Postsynaptic Depolarization Triggers a Long-Term Depression of the N-Methyl-D-Aspartate Receptor-Mediated Synaptic Potential in the Rat Hippocampus. Journal of biomedical science. vol 2. issue 2. 2019-11-20. PMID:11725053. |
activation of metabotropic glutamate receptors in conjunction with postsynaptic depolarization triggers a long-term depression of the n-methyl-d-aspartate receptor-mediated synaptic potential in the rat hippocampus. |
2019-11-20 |
2023-08-12 |
human |
| Sylvain Williams, Jean-Claude Lacaill. Bicuculline- and Phaclofen-Resistant Hyperpolarizations Evoked by Glutamate Applications to Stratum Lacunosum-Moleculare in CA1 Pyramidal Cells of the Rat Hippocampus In Vitro. The European journal of neuroscience. vol 2. issue 11. 2019-11-20. PMID:12106087. |
bicuculline- and phaclofen-resistant hyperpolarizations evoked by glutamate applications to stratum lacunosum-moleculare in ca1 pyramidal cells of the rat hippocampus in vitro. |
2019-11-20 |
2023-08-12 |
rat |