| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Pocivavsek, Greg I Elmer, Robert Schwarc. Inhibition of kynurenine aminotransferase II attenuates hippocampus-dependent memory deficit in adult rats treated prenatally with kynurenine. Hippocampus. vol 29. issue 2. 2020-05-20. PMID:30311334. |
ekyn treatment resulted in increased extracellular kyna and reduced extracellular glutamate in the hippocampus, measured by in vivo microdialysis, and caused impairments in hippocampus-dependent learning in adult rats. |
2020-05-20 |
2023-08-13 |
rat |
| Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang, Shu Kuei Huan. Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. European journal of pharmacology. vol 865. 2020-05-20. PMID:31706856. |
asiatic acid, an active substance of centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. |
2020-05-20 |
2023-08-13 |
rat |
| Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang, Shu Kuei Huan. Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. European journal of pharmacology. vol 865. 2020-05-20. PMID:31706856. |
in this study, by using isolated nerve terminal (synaptosome) and slice preparations, we investigated the effect of asiatic acid, a triterpene isolated from centella asiatica with antiepileptic activity, on glutamate release in the hippocampus of rats. |
2020-05-20 |
2023-08-13 |
rat |
| Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang, Shu Kuei Huan. Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. European journal of pharmacology. vol 865. 2020-05-20. PMID:31706856. |
in hippocampal synaptosomes, application of asiatic acid resulted in a concentration-dependent inhibition of 4-aminopyridine-evoked glutamate release. |
2020-05-20 |
2023-08-13 |
rat |
| Cheng Wei Lu, Tzu Yu Lin, Su Jane Wang, Shu Kuei Huan. Asiatic acid, an active substance of Centella asiatica, presynaptically depresses glutamate release in the rat hippocampus. European journal of pharmacology. vol 865. 2020-05-20. PMID:31706856. |
these data suggest that, in rat hippocampal nerve terminals, asiatic acid attenuates the calcium influx via n- and p/q-type calcium channels, subsequently suppressing protein kinase c activity and decreasing glutamate release. |
2020-05-20 |
2023-08-13 |
rat |
| Jordan M Adkins, Joseph F Lynch, Payton Hagerdorn, Monique Esterhuizen, Aaron M Jasno. Anterior cingulate cortex and dorsal hippocampal glutamate receptors mediate generalized fear in female rats. Psychoneuroendocrinology. vol 107. 2020-05-18. PMID:31125757. |
anterior cingulate cortex and dorsal hippocampal glutamate receptors mediate generalized fear in female rats. |
2020-05-18 |
2023-08-13 |
rat |
| Giti Garthwaite, John Garthwait. Mechanisms of AMPA Neurotoxicity in Rat Brain Slices. The European journal of neuroscience. vol 3. issue 8. 2020-05-11. PMID:12106459. |
the mechanisms underlying the neurodegenerative effects of the glutamate receptor agonist, ampa (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate), were studied using brain slice preparations of young rat (8 - 9 days old) cerebellum and hippocampus. |
2020-05-11 |
2023-08-12 |
rat |
| Kuan-Ming Chiu, Tzu-Yu Lin, Ming-Yi Lee, Cheng-Wei Lu, Ming-Jiuh Wang, Su-Jane Wan. Dexmedetomidine protects neurons from kainic acid-induced excitotoxicity by activating BDNF signaling. Neurochemistry international. vol 129. 2020-05-11. PMID:31220473. |
the results suggest that dexmedetomidine protected rat brains from ka-induced excitotoxic damage by reducing glutamate levels, suppressing caspase-3 activation and mapks phosphorylation, and enhancing bcl-2, nrf2, bdnf and trkb expression in the hippocampus. |
2020-05-11 |
2023-08-13 |
rat |
| Han-A Park, Nelli Mnatsakanyan, Katheryn Broman, Abigail U Davis, Jordan May, Pawel Licznerski, Kristi M Crowe-White, Kimberly H Lackey, Elizabeth A Jona. Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. International journal of molecular sciences. vol 21. issue 1. 2020-05-11. PMID:31905614. |
primary hippocampal neurons were treated with α-tct, glutamate, or a combination of both. |
2020-05-11 |
2023-08-13 |
Not clear |
| Caio H Mazucanti, Elisa M Kawamoto, Mark P Mattson, Cristoforo Scavone, Simonetta Camandol. Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 8. 2020-05-08. PMID:29493420. |
here, we show that cultured hippocampal neurons respond to insulin and glutamate stimulation by elevating klotho protein levels. |
2020-05-08 |
2023-08-13 |
Not clear |
| Chihiro Nakamoto, Meiko Kawamura, Ena Nakatsukasa, Rie Natsume, Keizo Takao, Masahiko Watanabe, Manabu Abe, Tomonori Takeuchi, Kenji Sakimur. GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior. PloS one. vol 15. issue 2. 2020-05-08. PMID:32078638. |
in addition, biochemical analysis revealed no significant difference in protein expression levels, such as other glutamate receptors in the synaptosome and postsynaptic densities prepared from the frontal cortex and the hippocampus. |
2020-05-08 |
2023-08-13 |
mouse |
| Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand, Moslem Mohammad. Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system. Neurotoxicology and teratology. vol 71. 2020-05-04. PMID:30576762. |
protein expression of glutamate transporters has also been measured in hippocampus and prefrontal cortex. |
2020-05-04 |
2023-08-13 |
rat |
| Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand, Moslem Mohammad. Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system. Neurotoxicology and teratology. vol 71. 2020-05-04. PMID:30576762. |
there was an increase in both astrocytic glutamate transporter proteins (glast and glt-1) in the hippocampus of animals treated with 0.7 and 1 mg/kg of paraoxon. |
2020-05-04 |
2023-08-13 |
rat |
| Zohreh Zare, Mohsen Tehrani, Noorollah Rezaei, Babak Dana Ghalebarzand, Moslem Mohammad. Anxiolytic activity of paraoxon is associated with alterations in rat brain glutamatergic system. Neurotoxicology and teratology. vol 71. 2020-05-04. PMID:30576762. |
this effect may be attributed to alterations of glutamate transporter proteins in the rat hippocampus and prefrontal cortex. |
2020-05-04 |
2023-08-13 |
rat |
| Dalila Mango, Alessandra Caruso, Amira Saidi, Robert Nisticò, Sergio Scaccianoc. The positive allosteric modulator at mGlu2 receptors, LY487379, reverses the effects of chronic stress-induced behavioral maladaptation and synaptic dysfunction in the adulthood. Synapse (New York, N.Y.). vol 73. issue 9. 2020-04-29. PMID:30964565. |
the reduced availability of these receptors would enhance glutamate overflow in the hippocampus, supporting the hypothesis that hippocampal glutamatergic neurotransmission plays a key etiopathological determinant in stress-induced neuropsychiatric disorders. |
2020-04-29 |
2023-08-13 |
mouse |
| L K Friedman, N Osei-Tutu, B Zhan. Exposing immature hippocampal neurons to excitotoxins reveals distinct transcriptome and protein regulation with induction of common survival signaling pathways. Molecular and cellular neurosciences. vol 98. 2020-04-21. PMID:31085233. |
to determine which genes and pathways are most likely involved in specific adaptive effects, immature hippocampal cultures were exposed to a single high dose of glutamate (250 μm), nmda (100 μm), or ka (300 μm) for 48 h (5-7 div) based on our prior "two hit" in vitro model of preconditioning. |
2020-04-21 |
2023-08-13 |
Not clear |
| Martin Lackinger, A Özge Sungur, Reetu Daswani, Michael Soutschek, Silvia Bicker, Lea Stemmler, Tatjana Wüst, Roberto Fiore, Christoph Dieterich, Rainer Kw Schwarting, Markus Wöhr, Gerhard Schrat. A placental mammal-specific microRNA cluster acts as a natural brake for sociability in mice. EMBO reports. vol 20. issue 2. 2020-04-20. PMID:30552145. |
here, we show that deletion of the placental mammal-specific mir379-410 cluster in mice leads to hypersocial behaviour, which is accompanied by increased excitatory synaptic transmission, and exaggerated expression of ionotropic glutamate receptor complexes in the hippocampus. |
2020-04-20 |
2023-08-13 |
mouse |
| Ana Lúcia Bertarello Zeni, Anderson Camargo, Ana Paula Dalmagr. Lutein prevents corticosterone-induced depressive-like behavior in mice with the involvement of antioxidant and neuroprotective activities. Pharmacology, biochemistry, and behavior. vol 179. 2020-04-20. PMID:30786251. |
and the neuroprotection against glutamate was developed through prefrontal cortex and hippocampal slices. |
2020-04-20 |
2023-08-13 |
mouse |
| Thomas M Sanderson, John Georgiou, Patrick Tidball, Graham L Collingridg. The Hippocampus Is the Place to Be: Opioid Receptors and LTP. Cell reports. vol 28. issue 5. 2020-04-17. PMID:31365856. |
these receptors trigger a mechanism involving metabotropic glutamate receptors to enhance hippocampal long-term potentiation, linking the conditioning to the location. |
2020-04-17 |
2023-08-13 |
Not clear |
| Bartosz Pomierny, Weronika Krzyżanowska, Żaneta Broniowska, Beata Strach, Beata Bystrowska, Beata Starek-Świechowicz, Alicja Maciejska, Alicja Skórkowska, Julita Wesołowska, Maria Walczak, Bogusława Budziszewsk. Benzophenone-3 passes through the blood-brain barrier, increases the level of extracellular glutamate and induces apoptotic processes in the hippocampus and frontal cortex of rats. Toxicological sciences : an official journal of the Society of Toxicology. 2020-04-17. PMID:31368502. |
benzophenone-3 passes through the blood-brain barrier, increases the level of extracellular glutamate and induces apoptotic processes in the hippocampus and frontal cortex of rats. |
2020-04-17 |
2023-08-13 |
rat |