| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saju Balakrishnan, Sergej L Mirono. Regenerative glutamate release in the hippocampus of Rett syndrome model mice. PloS one. vol 13. issue 9. 2019-02-19. PMID:30256804. |
we propose that pervasive spontaneous glutamate release is a hallmark of mecp2-/y hippocampus, stemming from and modulating the hyperexcitability of neurons. |
2019-02-19 |
2023-08-13 |
mouse |
| Valentyna Dubovyk, Denise Manahan-Vaugha. Less means more: The magnitude of synaptic plasticity along the hippocampal dorso-ventral axis is inversely related to the expression levels of plasticity-related neurotransmitter receptors. Hippocampus. vol 28. issue 2. 2019-02-13. PMID:29171922. |
a similar distribution gradient (dh< ih< vh) was evident in the hippocampus for glun1, the metabotropic glutamate receptors mglu1 and mglu2/3, gaba |
2019-02-13 |
2023-08-13 |
Not clear |
| Giulia Albertini, Lauren Deneyer, Sigrid Ottestad-Hansen, Yun Zhou, Gamze Ates, Laura Walrave, Thomas Demuyser, Eduard Bentea, Hideyo Sato, Dimitri De Bundel, Niels C Danbolt, Ann Massie, Ilse Smolder. Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice. Glia. vol 66. issue 9. 2019-02-12. PMID:29693305. |
this cystine-glutamate antiporter, with xct as specific subunit, represents the main glial provider of extracellular glutamate in mouse hippocampus. |
2019-02-12 |
2023-08-13 |
mouse |
| Damek Homiack, Emma O'Cinneide, Sema Hajmurad, Gary P Dohanich, Laura A Schrade. Effect of acute alarm odor exposure and biological sex on generalized avoidance and glutamatergic signaling in the hippocampus of Wistar rats. Stress (Amsterdam, Netherlands). vol 21. issue 4. 2019-02-11. PMID:29916754. |
moreover, tmt exposure dampened glutamate uptake and affected expression of the glutamate transporter, glt-1 in the hippocampus. |
2019-02-11 |
2023-08-13 |
rat |
| Cheng Wei Lu, Hsi Lung Hsieh, Tzu Yu Lin, Ting Yang Hsieh, Shu Kuei Huang, Su Jane Wan. Echinacoside, an Active Constituent of Cistanche Herba, Exerts a Neuroprotective Effect in a Kainic Acid Rat Model by Inhibiting Inflammatory Processes and Activating the Akt/GSK3β Pathway. Biological & pharmaceutical bulletin. vol 41. issue 11. 2019-02-11. PMID:30197410. |
the results showed that kainic acid induced seizure-like behavioral patterns, increased glutamate concentrations, caused neuronal loss and microglial activation, and stimulated proinflammatory cytokine gene expression in the hippocampus. |
2019-02-11 |
2023-08-13 |
rat |
| Giulia Orteca, Francesco Tavanti, Zuzana Bednarikova, Zuzana Gazova, Giovanna Rigillo, Carol Imbriano, Valentina Basile, Mattia Asti, Luca Rigamonti, Monica Saladini, Erika Ferrari, Maria Cristina Menzian. Curcumin derivatives and Aβ-fibrillar aggregates: An interactions' study for diagnostic/therapeutic purposes in neurodegenerative diseases. Bioorganic & medicinal chemistry. vol 26. issue 14. 2019-02-04. PMID:30031653. |
significantly, in vitro results on hippocampal cells pointed out protection against glutamate toxicity and safety when administered at low concentrations (1 μm). |
2019-02-04 |
2023-08-13 |
mouse |
| Zhen Liu, Rui Li, Cheng Jiang, Sha Zhao, Weishan Li, Xiaobo Tan. The neuroprotective effect of lithium chloride on cognitive impairment through glycogen synthase kinase-3β inhibition in intracerebral hemorrhage rats. European journal of pharmacology. vol 840. 2019-01-22. PMID:30336136. |
since neurons that contain glutamate play crucial roles in psychological functions, such as learning and memory, the glutamate-mediated excitotoxicity and consequent neuronal death and cognitive impairment in hippocampus may co-determine the clinical course of intracerebral hemorrhage. |
2019-01-22 |
2023-08-13 |
rat |
| Yun Pei, Zhexiao Jiao, Wanting Dong, Linguo Pei, Xia He, Hui Wang, Dan X. Excitotoxicity and compensatory upregulation of GAD67 in fetal rat hippocampus caused by prenatal nicotine exposure are associated with inhibition of the BDNF pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 123. 2019-01-15. PMID:30389584. |
rat fetal hippocampal h19-7/igf1r cell lines were treated with different concentrations of nicotine (1, 10 and 100 μm) for 3 days, the extracellular fluid glutamate (glu) level increased and similar effects were observed as in vivo. |
2019-01-15 |
2023-08-13 |
rat |
| Ilham A Muslimov, Taesun Eom, Anna Iacoangeli, Shih-Chieh Chuang, Renate K Hukema, Rob Willemsen, Dimitre G Stefanov, Robert K S Wong, Henri Tiedg. BC RNA Mislocalization in the Fragile X Premutation. eNeuro. vol 5. issue 2. 2019-01-11. PMID:29766042. |
in ca3 hippocampal neurons of such animals, synaptic release of glutamate elicits neuronal hyperexcitability in the form of group i metabotropic glutamate receptor-dependent prolonged epileptiform discharges. |
2019-01-11 |
2023-08-13 |
mouse |
| Mei Huang, Sunoh Kwon, Lakshmi Rajagopal, Wenqi He, Herbert Y Meltze. 5-HT Psychopharmacology. vol 235. issue 10. 2018-12-31. PMID:30066135. |
5-ht the effect of atypical antipsychotic drugs (aapds), e.g., lurasidone, to improve cognitive impairment associated with schizophrenia (cias), has been suggested to be due, in part, to enhancing release of dopamine (da), acetylcholine (ach), and glutamate (glu) in cortex and hippocampus. |
2018-12-31 |
2023-08-13 |
Not clear |
| Sakineh Alijanpour, Ameneh Arabi-Shirazi, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Khadijeh-Alsadat Sharif. The dorsal hippocampal group III metabotropic glutamate receptors are involved in morphine effect on memory formation in male mice. European journal of pharmacology. vol 836. 2018-12-27. PMID:30125564. |
the dorsal hippocampal group iii metabotropic glutamate receptors are involved in morphine effect on memory formation in male mice. |
2018-12-27 |
2023-08-13 |
mouse |
| Sakineh Alijanpour, Ameneh Arabi-Shirazi, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Khadijeh-Alsadat Sharif. The dorsal hippocampal group III metabotropic glutamate receptors are involved in morphine effect on memory formation in male mice. European journal of pharmacology. vol 836. 2018-12-27. PMID:30125564. |
this study investigated the role of dorsal hippocampal (ca1) group iii metabotropic glutamate (mglu) receptors in impairment of memory formation and state-dependent memory induced by morphine. |
2018-12-27 |
2023-08-13 |
mouse |
| Sakineh Alijanpour, Ameneh Arabi-Shirazi, Fatemeh Khakpai, Mohammad-Reza Zarrindast, Khadijeh-Alsadat Sharif. The dorsal hippocampal group III metabotropic glutamate receptors are involved in morphine effect on memory formation in male mice. European journal of pharmacology. vol 836. 2018-12-27. PMID:30125564. |
taken together, our results suggested that morphine effects on memory formation might be mediated via the activity of dorsal hippocampal metabotropic glutamate receptors. |
2018-12-27 |
2023-08-13 |
mouse |
| Badrah Saeed Ali Alghamd. Possible prophylactic anti-excitotoxic and anti-oxidant effects of virgin coconut oil on aluminium chloride-induced Alzheimer's in rat models. Journal of integrative neuroscience. vol 17. issue 3-4. 2018-12-26. PMID:30010139. |
alzheimer was induced by intraperitoneal injections of aluminium chloride (alcl3) for 45 days (40 ml/kg per day), and our results showed that oral administration of vco (5 ml per day for 30 days) prior to the administration of alcl3 significantly reduced the glutamate level in both the hippocampus and prefrontal cortex compared to an vco non-administrated ad group. |
2018-12-26 |
2023-08-13 |
rat |
| Josiane Budni, Simone Molz, Tharine Dal-Cim, Maria Dolores Martín-de-Saavedra, Javier Egea, Manuela G Lopéz, Carla Ines Tasca, Ana Lúcia Severo Rodrigue. Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28185129. |
considering that excitotoxicity and cell death induced by glutamate are involved in many disorders, the potential protective effect of folic acid on glutamate-induced cell damage in rat hippocampal slices and the possible intracellular signaling pathway involved in such effect were investigated. |
2018-12-21 |
2023-08-13 |
rat |
| Josiane Budni, Simone Molz, Tharine Dal-Cim, Maria Dolores Martín-de-Saavedra, Javier Egea, Manuela G Lopéz, Carla Ines Tasca, Ana Lúcia Severo Rodrigue. Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS. Molecular neurobiology. vol 55. issue 2. 2018-12-21. PMID:28185129. |
the treatment of hippocampal slices with folic acid (100 μm) significantly abrogated glutamate (1 mm)-induced reduction of cell viability measured by mtt reduction assay and inhibited glutamate-induced d-[ |
2018-12-21 |
2023-08-13 |
rat |
| Yukihiko Shirayama, Michio Takahashi, Fumio Osone, Akira Hara, Toshiyuki Okub. Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2018-12-19. PMID:29560915. |
myo-inositol, glutamate, and glutamine in the prefrontal cortex, hippocampus, and amygdala in major depression. |
2018-12-19 |
2023-08-13 |
Not clear |
| Yukihiko Shirayama, Michio Takahashi, Fumio Osone, Akira Hara, Toshiyuki Okub. Myo-inositol, Glutamate, and Glutamine in the Prefrontal Cortex, Hippocampus, and Amygdala in Major Depression. Biological psychiatry. Cognitive neuroscience and neuroimaging. vol 2. issue 2. 2018-12-19. PMID:29560915. |
our a priori hypothesis was that myo-inositol and glutamate were downregulated in the hippocampus and amygdala in depression. |
2018-12-19 |
2023-08-13 |
Not clear |
| Emily A Brown, Jonathan D Lautz, Tessa R Davis, Edward P Gniffke, Alison A W VanSchoiack, Steven C Neier, Noah Tashbook, Chiara Nicolini, Margaret Fahnestock, Adam G Schrum, Stephen E P Smit. Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models. Molecular autism. vol 9. 2018-12-18. PMID:30237867. |
clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models. |
2018-12-18 |
2023-08-13 |
mouse |
| Xiang Li, Hong-Jian Zhang, Qing Wang, Dian-Wen Zhang, Di Wu, Wei Li, Zhe-Shan Qua. Current Study of the Mechanism of Action of the Potential Anti-Epileptic Agent Q808. Molecules (Basel, Switzerland). vol 22. issue 7. 2018-12-11. PMID:28686214. |
results obtained with high-performance liquid chromatography (hplc) suggest that q808 may affect neurotransmitter content in the brain, by specifically increasing gaba content in the rat hippocampus at doses of 40 mg/kg and 80 mg/kg, and by reducing the content of glutamate and glutamine in the rat thalamus at a dose of 80 mg/kg. |
2018-12-11 |
2023-08-13 |
rat |