| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M C Walker, A Ruiz, D M Kullman. Monosynaptic GABAergic signaling from dentate to CA3 with a pharmacological and physiological profile typical of mossy fiber synapses. Neuron. vol 29. issue 3. 2001-04-26. PMID:11301029. |
mossy fibers are the sole excitatory projection from dentate gyrus granule cells to the hippocampus, where they release glutamate, dynorphin, and zinc. |
2001-04-26 |
2023-08-12 |
Not clear |
| D D Savage, R Galindo, S A Queen, L L Paxton, A M Alla. Characterization of electrically evoked [3H]-D-aspartate release from hippocampal slices. Neurochemistry international. vol 38. issue 3. 2001-04-19. PMID:11099785. |
we demonstrate here that [3h]-d-aspartate (d-asp) release can be detected from hippocampal slices at lower stimulation intensities in the presence of a glutamate reuptake inhibitor. |
2001-04-19 |
2023-08-12 |
Not clear |
| B Hassel, E Taubøll, L Gjersta. Chronic lamotrigine treatment increases rat hippocampal GABA shunt activity and elevates cerebral taurine levels. Epilepsy research. vol 43. issue 2. 2001-04-19. PMID:11164704. |
the hippocampal level of gaba increased 25%, and the activities of glutamate decarboxylase and succinic semialdehyde/gaba transaminase increased 12 and 21% (p< 0.05), respectively, indicating increased gaba turnover. |
2001-04-19 |
2023-08-12 |
rat |
| b' V Erakovi\\xc4\\x87, G Zupan, J Varljen, J Laginja, A Simoni\\xc4\\x8. Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol--induced seizures. Epilepsy research. vol 43. issue 2. 2001-04-19. PMID:11164705.' |
glutamate dehydrogenase, aspartate-aminotransferase (ast), alanine-aminotransferase, gamma-glutamyltransferase, alkaline phosphatase (alp), lactate dehydrogenase (ldh) and creatine kinase (ck) were determined in the frontal cortex, cerebellum, hippocampus and pons-medulla regions of hannover-wistar rats. |
2001-04-19 |
2023-08-12 |
rat |
| R J Cormier, S Mennerick, H Melbostad, C F Zorumsk. Basal levels of adenosine modulate mGluR5 on rat hippocampal astrocytes. Glia. vol 33. issue 1. 2001-04-12. PMID:11169789. |
on cultured hippocampal microislands containing only astrocytes, activation of metabotropic glutamate receptors (mglurs) with the specific agonist 1s,3r-acpd triggers ca2+ elevations that are potentiated by adenosine a1 receptor activation. |
2001-04-12 |
2023-08-12 |
rat |
| P Saransaari, S S Oj. Taurine and neural cell damage. Amino acids. vol 19. issue 3-4. 2001-04-05. PMID:11140356. |
excitotoxic concentrations of glutamate also potentiate taurine release in mouse hippocampal slices. |
2001-04-05 |
2023-08-12 |
mouse |
| J Hada, T Kaku, M H Jiang, K Morimoto, Y Hayashi, K Naga. Sodium nitroprusside-induced seizure and taurine release from rat hippocampus. Amino acids. vol 19. issue 3-4. 2001-04-05. PMID:11140358. |
we have recently reported that the nitric oxide (no) donor, sodium nitroprusside (snp), induces seizures which are associated with an increase in the basal release of aspartate and glutamate from rat hippocampus (kaku et al., 1998). |
2001-04-05 |
2023-08-12 |
rat |
| V Gundersen, F Fonnum, O P Ottersen, J Storm-Mathise. Redistribution of neuroactive amino acids in hippocampus and striatum during hypoglycemia: a quantitative immunogold study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 1. 2001-04-05. PMID:11149667. |
postembedding immunocytochemistry was used to localize aspartate, glutamate, gamma-aminobutyric acid (gaba), and glutamine in hippocampus and striatum during normo- and hypoglycemia in rat. |
2001-04-05 |
2023-08-12 |
rat |
| H Manev, T Uz, T Q. 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113602. |
5-lipoxygenase and cyclooxygenase mrna expression in rat hippocampus:early response to glutamate receptor activation by kainate. |
2001-03-29 |
2023-08-12 |
rat |
| H Manev, T Uz, T Q. 5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate. Experimental gerontology. vol 35. issue 9-10. 2001-03-29. PMID:11113602. |
our results indicate that hippocampal expression of both 5lox and cox2 increases rather promptly when glutamate receptors are stimulated by kainate. |
2001-03-29 |
2023-08-12 |
rat |
| Y Odagaki, N Nishi, T Koyam. Stimulation of high-affinity GTPase activity through group II metabotropic glutamate receptors in rat hippocampal and striatal membranes. Japanese journal of pharmacology. vol 84. issue 4. 2001-03-22. PMID:11202611. |
stimulation of high-affinity gtpase activity through group ii metabotropic glutamate receptors in rat hippocampal and striatal membranes. |
2001-03-22 |
2023-08-12 |
rat |
| Y Odagaki, N Nishi, T Koyam. Stimulation of high-affinity GTPase activity through group II metabotropic glutamate receptors in rat hippocampal and striatal membranes. Japanese journal of pharmacology. vol 84. issue 4. 2001-03-22. PMID:11202611. |
the stimulation of high-affinity gtpase activity through metabotropic glutamate receptors (mglurs) was pharmacologically characterized with the use of a series of agonists for mglurs in rat hippocampal and striatal membranes. |
2001-03-22 |
2023-08-12 |
rat |
| Y Ueda, T Doi, J Tokumaru, H Yokoyama, A Nakajima, Y Mitsuyama, H Ohya-Nishiguchi, H Kamada, L J Willmor. Collapse of extracellular glutamate regulation during epileptogenesis: down-regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid. Journal of neurochemistry. vol 76. issue 3. 2001-03-15. PMID:11158261. |
we used northern and western blotting to measure the quantity of glutamate and gaba transporters mrna and their proteins within the hippocampal tissue of rats with epileptogenesis. |
2001-03-15 |
2023-08-12 |
rat |
| T Ohnuma, S Tessler, H Arai, R L Faull, P J McKenna, P C Emso. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Brain research. Molecular brain research. vol 85. issue 1-2. 2001-03-08. PMID:11146103. |
gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. |
2001-03-08 |
2023-08-12 |
human |
| T Ohnuma, S Tessler, H Arai, R L Faull, P J McKenna, P C Emso. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Brain research. Molecular brain research. vol 85. issue 1-2. 2001-03-08. PMID:11146103. |
a disturbance in glutamatergic transmission has been suggested to contribute to the pathophysiology of schizophrenia and recent studies on ionotropic glutamate receptors are consistent with altered glutamatergic function in the hippocampus of schizophrenics. |
2001-03-08 |
2023-08-12 |
human |
| T Ohnuma, S Tessler, H Arai, R L Faull, P J McKenna, P C Emso. Gene expression of metabotropic glutamate receptor 5 and excitatory amino acid transporter 2 in the schizophrenic hippocampus. Brain research. Molecular brain research. vol 85. issue 1-2. 2001-03-08. PMID:11146103. |
in order to investigate this hypothesis further, the expression of two 'glutamatergic' markers, the mrnas of metabotropic glutamate receptor 5 (mglur5) and human excitatory amino acid transporter (eaat2) were compared in the hippocampus of control subjects and schizophrenics. |
2001-03-08 |
2023-08-12 |
human |
| T Nishizaki, T Nomura, T Matuoka, T Kondoh, G Enikolopov, G Enikolopo, K Sumikawa, S Watabe, T Shiotani, M Yoshi. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Brain research. Molecular brain research. vol 80. issue 1. 2001-03-01. PMID:11039729. |
in addition, the drug caused a marked increase in the glutamate release from electrically stimulated guinea pig hippocampal slices, and the effect was abolished by the nicotinic ach receptor antagonists, alpha-bungarotoxin and mecamylamine. |
2001-03-01 |
2023-08-12 |
rat |
| T Nishizaki, T Nomura, T Matuoka, T Kondoh, G Enikolopov, G Enikolopo, K Sumikawa, S Watabe, T Shiotani, M Yoshi. The anti-dementia drug nefiracetam facilitates hippocampal synaptic transmission by functionally targeting presynaptic nicotinic ACh receptors. Brain research. Molecular brain research. vol 80. issue 1. 2001-03-01. PMID:11039729. |
the results of the present study, thus, suggest that nefiracetam enhances activity of nicotinic ach receptors by interacting with a pkc pathway, thereby increasing glutamate release from presynaptic terminals, and then leading to a sustained facilitation of hippocampal neurotransmission. |
2001-03-01 |
2023-08-12 |
rat |
| F Peña, R Tapi. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113304. |
infusion of the k(+) channel blocker 4-aminopyridine in the hippocampus induces the release of glutamate, as well as seizures and neurodegeneration. |
2001-03-01 |
2023-08-12 |
rat |
| F Peña, R Tapi. Seizures and neurodegeneration induced by 4-aminopyridine in rat hippocampus in vivo: role of glutamate- and GABA-mediated neurotransmission and of ion channels. Neuroscience. vol 101. issue 3. 2001-03-01. PMID:11113304. |
tetrodotoxin largely prevented the increase of extracellular glutamate, the electroencephalographic epileptic discharges and the neuronal death in the ca1 and ca3 hippocampal regions. |
2001-03-01 |
2023-08-12 |
rat |