| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L D Partridge, C F Valenzuel. Neurosteroid-induced enhancement of glutamate transmission in rat hippocampal slices. Neuroscience letters. vol 301. issue 2. 2001-05-24. PMID:11248433. |
thus, we propose a novel mechanism of action of neurosteroids in hippocampal neurons that involves the modulation of glutamate release. |
2001-05-24 |
2023-08-12 |
rat |
| A F Ambrósio, A P Silva, J O Malva, P Soares-da-Silva, A P Carvalho, C M Carvalh. Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels. Biochemical pharmacology. vol 61. issue 10. 2001-05-24. PMID:11322931. |
we investigated the mechanism(s) of action of two new putative antiepileptic drugs (aeds), (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide (bia 2-093) and 10,11-dihydro-10-hydroxyimino-5h-dibenz[b,f]azepine-5-carboxamide (bia 2-024), by comparing their effects on the release of endogenous glutamate in hippocampal synaptosomes, with those of carbamazepine (cbz) and oxcarbazepine (oxc). |
2001-05-24 |
2023-08-12 |
Not clear |
| J P Hodgkiss, J S Kell. Effect of FK960, a putative cognitive enhancer, on synaptic transmission in CA1 neurons of rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 297. issue 2. 2001-05-21. PMID:11303051. |
it is concluded that fk960 increases the quantal release of glutamate from schaffer collateral-commissural nerve terminals in area ca1 of the hippocampus either by changing the ambient level of acetylcholine or by positively modulating the activity of alpha 7nachrs located on glutamatergic nerve terminals. |
2001-05-21 |
2023-08-12 |
rat |
| M Penkowa, A Molinero, J Carrasco, J Hidalg. Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures. Neuroscience. vol 102. issue 4. 2001-05-17. PMID:11182244. |
the role of interleukin-6 in hippocampal tissue damage after injection with kainic acid, a rigid glutamate analogue inducing epileptic seizures, has been studied by means of interleukin-6 null mice. |
2001-05-17 |
2023-08-12 |
mouse |
| M P Flavin, G Zha. Tissue plasminogen activator protects hippocampal neurons from oxygen-glucose deprivation injury. Journal of neuroscience research. vol 63. issue 5. 2001-05-17. PMID:11223913. |
whereas glutamate receptor-mediated events are important in cerebral ischemia and tpa has previously been shown to enhance excitotoxicity in hippocampus, we hypothesized that tpa would exaggerate oxygen glucose deprivation (ogd) injury in cultures of hippocampal neurons. |
2001-05-17 |
2023-08-12 |
human |
| P L Chazo. CP-101606 Pfizer Inc. Current opinion in investigational drugs (London, England : 2000). vol 1. issue 3. 2001-05-17. PMID:11249721. |
cp-101606 prevents glutamate-induced toxicity in cultured hippocampal neurons when given during or immediately after glutamate perfusion, (ic50 = 11 and 35 nm, respectively). |
2001-05-17 |
2023-08-12 |
Not clear |
| S Eliasof, H B McIlvain, R E Petroski, A C Foster, J Dunlo. Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. Journal of neurochemistry. vol 77. issue 2. 2001-05-17. PMID:11299317. |
finally, t3mg acts as a poor ionotropic glutamate receptor agonist in cultured hippocampal neurons: concentrations greater than 100 microm t3mg were required to elicit significant nmda receptor-mediated currents. |
2001-05-17 |
2023-08-12 |
xenopus_laevis |
| C Culmsee, Y Zhu, J Krieglstein, M P Mattso. Evidence for the involvement of Par-4 in ischemic neuron cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 21. issue 4. 2001-05-17. PMID:11323519. |
the authors recently identified prostate apoptosis response-4 (par-4) as a protein that participates in the death of cultured hippocampal neurons induced by trophic factor withdrawal and exposure to glutamate. |
2001-05-17 |
2023-08-12 |
mouse |
| B J Xue, Z A Wang, R R He, S Y H. [Inhibitory effects of nitric oxide on glutamate-induced neuronal activity of CA1 area in rat hippocampal slices]. Sheng li xue bao : [Acta physiologica Sinica]. vol 50. issue 1. 2001-05-17. PMID:11324518. |
taken together, it is likely that glutamate binding with nmda receptors in hippocampal neurons not only induces an increase in discharge, but also activates the l-arg: no pathway to generate no responsible for neuroprotection via negative feedback mechanisms. |
2001-05-17 |
2023-08-12 |
rat |
| O Vergun, A I Sobolevsky, M V Yelshansky, J Keelan, B I Khodorov, M R Duche. Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. The Journal of physiology. vol 531. issue Pt 1. 2001-05-10. PMID:11179399. |
exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. |
2001-05-10 |
2023-08-12 |
rat |
| O Vergun, A I Sobolevsky, M V Yelshansky, J Keelan, B I Khodorov, M R Duche. Exploration of the role of reactive oxygen species in glutamate neurotoxicity in rat hippocampal neurones in culture. The Journal of physiology. vol 531. issue Pt 1. 2001-05-10. PMID:11179399. |
exposure of hippocampal neurones to glutamate at toxic levels is associated with a profound collapse of mitochondrial potential and deregulation of calcium homeostasis. |
2001-05-10 |
2023-08-12 |
rat |
| J P Ren, H L Xia, J S Chen. [The relation between changes of nitric oxide synthase in hippocampus and activities of excitatory amino acid receptor during epilepsy]. Sheng li xue bao : [Acta physiologica Sinica]. vol 50. issue 4. 2001-05-10. PMID:11324544. |
the time course of alteration in neuronal nitric oxide synthase (nnos) and the influence of glutamate receptor antagonists on immunoreactivity of nnos were investigated immunohistochemically in rat hippocampus during penicillin-induced epilepsy. |
2001-05-10 |
2023-08-12 |
rat |
| L H Wang, P Zhao, Y L Huang, J S Chen. [Changes of intracellular calcium level in hippocampal slice neurons: a confocal laser scanning microscopic study]. Sheng li xue bao : [Acta physiologica Sinica]. vol 50. issue 3. 2001-05-10. PMID:11324580. |
with this improvement of labeling and the use of the confocal laser scanning microscope (leica lasetechnik gmbh), changes of calcium fluorescence intensity in ca1 pyramidal cells of rat hippocampal slices on the models of mimic epilepsy (induced by penicillin or glutamate) or hypoglycemia/hypoxia were studied in vitro. |
2001-05-10 |
2023-08-12 |
rat |
| S V Vellucci, R F Parrot. Hippocampal gene expression in the pig: upregulation of corticotrophin releasing hormone mRNA following central administration of the peptide. Neuropeptides. vol 34. issue 3-4. 2001-05-03. PMID:11021984. |
in this study, mrna for crh and selected ionotropic glutamate receptor (iglur) subunits (nr1, glur2, glur3) was quantified in the hippocampus of pigs in which stress was simulated by central administration of crh (100 microg). |
2001-05-03 |
2023-08-12 |
rat |
| J B McCarthy, S T Lim, N B Elkind, J S Trimmer, R M Duvoisin, E Rodriguez-Boulan, M J Capla. The C-terminal tail of the metabotropic glutamate receptor subtype 7 is necessary but not sufficient for cell surface delivery and polarized targeting in neurons and epithelia. The Journal of biological chemistry. vol 276. issue 12. 2001-05-03. PMID:11106656. |
here we report that metabotropic glutamate receptor subtype 7a (mglur7a) is polarized at the basolateral surface when expressed in madin-darby canine kidney (mdck) epithelial cells but is not polarized when expressed in cultured hippocampal neurons. |
2001-05-03 |
2023-08-12 |
human |
| H P Chang, Y L Ma, F J Wan, L Y Tsai, F P Lindberg, E H Le. Functional blocking of integrin-associated protein impairs memory retention and decreases glutamate release from the hippocampus. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166115. |
functional blocking of integrin-associated protein impairs memory retention and decreases glutamate release from the hippocampus. |
2001-05-03 |
2023-08-12 |
mouse |
| H P Chang, Y L Ma, F J Wan, L Y Tsai, F P Lindberg, E H Le. Functional blocking of integrin-associated protein impairs memory retention and decreases glutamate release from the hippocampus. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166115. |
at a dose that effectively impairs both memory retention and long-term potentiation, integrin-associated protein monoclonal antibody also significantly blocks potassium chloride-induced glutamate release from the hippocampus in vivo. |
2001-05-03 |
2023-08-12 |
mouse |
| H P Chang, Y L Ma, F J Wan, L Y Tsai, F P Lindberg, E H Le. Functional blocking of integrin-associated protein impairs memory retention and decreases glutamate release from the hippocampus. Neuroscience. vol 102. issue 2. 2001-05-03. PMID:11166115. |
from these results we suggest that integrin-associated protein monoclonal antibody may impair synaptic plasticity and behavioral plasticity in mice through blockade of granular cell attachment to extracellular matrix protein and the subsequent signal transduction, and through inhibition of glutamate release from the hippocampus. |
2001-05-03 |
2023-08-12 |
mouse |
| G Segovia, A Porras, A Del Arco, F Mor. Glutamatergic neurotransmission in aging: a critical perspective. Mechanisms of ageing and development. vol 122. issue 1. 2001-04-26. PMID:11163621. |
first, an age-related decrease of glutamate content in tissue from cerebral cortex and hippocampus has been reported, although it may be mainly a consequence of changes in metabolic activity rather than glutamatergic neurotransmission. |
2001-04-26 |
2023-08-12 |
rat |
| K Abe, N Matsuk. Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT. Neuroscience research. vol 38. issue 4. 2001-04-26. PMID:11164558. |
this method was successfully applied for evaluating t-butyl hydroperoxide toxicity in cultured rat cortical astrocytes and glutamate toxicity in cultured rat hippocampal neurons. |
2001-04-26 |
2023-08-12 |
rat |