| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Blaabjerg, B W Kristensen, C Bonde, J Zimme. The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. Brain research. vol 898. issue 1. 2001-07-19. PMID:11292452. |
we conclude that, stimulation of metabotropic glutamate receptors with acpd at concentrations of 2 mm or higher induces a distinct subfield-related and time and concentration dependent pattern of hippocampal degeneration, and that acpd at subtoxic concentrations modulates nmda-induced excitotoxicity through the mglur5 receptor in a time dependent way. |
2001-07-19 |
2023-08-12 |
Not clear |
| N Kasai, Y Jimbo, O Niwa, T Matsue, K Torimits. Real-time multisite observation of glutamate release in rat hippocampal slices. Neuroscience letters. vol 304. issue 1-2. 2001-07-19. PMID:11335067. |
real-time multisite observation of glutamate release in rat hippocampal slices. |
2001-07-19 |
2023-08-12 |
rat |
| N Janssens, A S Lesag. Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. Journal of neurochemistry. vol 77. issue 6. 2001-07-19. PMID:11413230. |
we report on the expression of ionotropic glutamate receptor subunits in primary neuronal cultures from rat cortex, hippocampus and cerebellum and of metabotropic glutamate (mglu) receptor subtypes in these neuronal cultures as well as in cortical astroglial cultures. |
2001-07-19 |
2023-08-12 |
rat |
| X Lu, M Wyszynski, M Sheng, M Baudr. Proteolysis of glutamate receptor-interacting protein by calpain in rat brain: implications for synaptic plasticity. Journal of neurochemistry. vol 77. issue 6. 2001-07-19. PMID:11413238. |
here we report that glutamate receptor-interacting protein (grip) is a substrate of calpain, as calpain-mediated grip degradation was demonstrated using three different approaches: (i) purified calpain i digestion of synaptic membranes, (ii) calcium treatment of frozen-thawed brain sections, and (iii) nmda-stimulated organotypic hippocampal slice cultures. |
2001-07-19 |
2023-08-12 |
rat |
| C Lu, W Fu, M P Mattso. Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative disorders. Neurobiology of disease. vol 8. issue 2. 2001-07-12. PMID:11300717. |
caspase-mediated suppression of glutamate (ampa) receptor channel activity in hippocampal neurons in response to dna damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative disorders. |
2001-07-12 |
2023-08-12 |
Not clear |
| G M Khan, I Smolders, G Ebinger, Y Michott. 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. Neuropharmacology. vol 40. issue 5. 2001-07-12. PMID:11311893. |
however, pilocarpine-evoked elevation of hippocampal glutamate overflow was significantly attenuated by ccpa irrespective of the mode of administration. |
2001-07-12 |
2023-08-12 |
rat |
| G M Khan, I Smolders, G Ebinger, Y Michott. 2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats. Neuropharmacology. vol 40. issue 5. 2001-07-12. PMID:11311893. |
intrahippocampal ccpa markedly reduced basal hippocampal dopamine efflux but not gaba or glutamate and considerably attenuated the pilocarpine-evoked elevation in dopamine levels. |
2001-07-12 |
2023-08-12 |
rat |
| S M Sequeira, J O Malva, A P Carvalho, C M Carvalh. Presynaptic N-methyl-D-aspartate receptor activation inhibits neurotransmitter release through nitric oxide formation in rat hippocampal nerve terminals. Brain research. Molecular brain research. vol 89. issue 1-2. 2001-07-12. PMID:11311981. |
n-methyl-d-aspartate dose-dependently inhibited the release of glutamate evoked by 4-aminopyridine (ic(50)=155 microm), and this effect was reversed by the n-methyl-d-aspartate receptor antagonist d-(-)-2-amino-5-phosphopentanoic acid and by the nitric oxide synthase inhibitor, l-nitroarginine, in synaptosomes isolated from whole hippocampus, ca3 and ca1 areas, but not from the dentate gyrus. |
2001-07-12 |
2023-08-12 |
rat |
| T Okada, N Yamada, W Kakegawa, K Tsuzuki, M Kawamura, H Nawa, M Iino, S Ozaw. Sindbis viral-mediated expression of Ca2+-permeable AMPA receptors at hippocampal CA1 synapses and induction of NMDA receptor-independent long-term potentiation. The European journal of neuroscience. vol 13. issue 8. 2001-07-12. PMID:11328357. |
in this study, we expressed the gene encoding the unedited glur2 (glur-b) subunit of the ampa-type glutamate receptor that forms inwardly rectifying and ca2+-permeable channels, in rat ca1 hippocampal neurons in slice cultures using sindbis viral vectors. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
here we show that chronic treatment of rats with the anti-epileptic drug sodium valproate (200 mg or 400 mg/kg bodyweight, twice per day for 90 days) leads to a dose-dependent increase in hippocampal glutamate uptake capacity as measured by uptake of [(3)h]glutamate into proteoliposomes. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
the level of glutamate transporters eaat1 and eaat2 in hippocampus also increased dose-dependently. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
the hippocampal levels of glial fibrillary acidic protein and glutamine synthetase were unaffected by valproate treatment, whereas the levels of synapsin i and phosphate-activated glutaminase were reduced by valproate treatment, suggesting that the increase in glutamate transporters was not caused by astrocytosis or increased synaptogenesis. |
2001-07-12 |
2023-08-12 |
rat |
| B Hassel, E G Iversen, L Gjerstad, E Taubøl. Up-regulation of hippocampal glutamate transport during chronic treatment with sodium valproate. Journal of neurochemistry. vol 77. issue 5. 2001-07-12. PMID:11389179. |
the results show that hippocampal glutamate transport is an accessible target for pharmacological intervention and that sodium valproate may have a role in the treatment of excitotoxic states in the hippocampus. |
2001-07-12 |
2023-08-12 |
rat |
| C E Gee, G Woodhall, J C Lacaill. Synaptically activated calcium responses in dendrites of hippocampal oriens-alveus interneurons. Journal of neurophysiology. vol 85. issue 4. 2001-07-05. PMID:11287484. |
activation of metabotropic glutamate receptors (mglurs) by agonists increases intracellular calcium levels ([ca(2+)](i)) in interneurons of stratum oriens/alveus (oa) of the hippocampus. |
2001-07-05 |
2023-08-12 |
rat |
| S M Lasley, M C Green, M E Gilber. Rat hippocampal NMDA receptor binding as a function of chronic lead exposure level. Neurotoxicology and teratology. vol 23. issue 2. 2001-07-05. PMID:11348836. |
a crude membrane fraction was prepared from hippocampal tissue, and scatchard analysis conducted in the presence of saturating concentrations of glutamate and glycine. |
2001-07-05 |
2023-08-12 |
rat |
| S M Lasley, M C Green, M E Gilber. Rat hippocampal NMDA receptor binding as a function of chronic lead exposure level. Neurotoxicology and teratology. vol 23. issue 2. 2001-07-05. PMID:11348836. |
these findings are an approximate reflection of analogous relationships reported for hippocampal ltp and glutamate release, suggesting that the diminished glutamate release is one cause of the receptor up-regulation. |
2001-07-05 |
2023-08-12 |
rat |
| M Shapir. Plasticity, hippocampal place cells, and cognitive maps. Archives of neurology. vol 58. issue 6. 2001-07-05. PMID:11405801. |
n-methyl d-aspartate (nmda) receptors, a subtype of glutamate receptor, are crucial for inducing these plastic changes, and blocking these receptors reduces plasticity and impairs learning in tasks that require the hippocampus. |
2001-07-05 |
2023-08-12 |
mouse |
| S Uchino, T Nakamura, K Nakamura, S Nakajima-Iijima, M Mishina, S Kohsaka, Y Kud. Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices. The European journal of neuroscience. vol 13. issue 4. 2001-06-28. PMID:11207802. |
real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices. |
2001-06-28 |
2023-08-12 |
rat |
| C Culmsee, S Bondada, M P Mattso. Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain research. Molecular brain research. vol 87. issue 2. 2001-06-28. PMID:11245929. |
we now report that cultured hippocampal neurons from severe combined immunodeficient (scid) mice which lack dna-pk activity are hypersensitive to apoptosis induced by exposure to topoisomerase inhibitors, amyloid beta peptide (a beta) and glutamate. |
2001-06-28 |
2023-08-12 |
mouse |