| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Ueda, L J Willmor. Hippocampal gamma-aminobutyric acid transporter alterations following focal epileptogenesis induced in rat amygdala. Brain research bulletin. vol 52. issue 5. 2000-09-14. PMID:10922514. |
we used western blotting to measure alterations in the expression of hippocampal gaba transporter proteins gat-1 and gat-3. |
2000-09-14 |
2023-08-12 |
rat |
| R M Law, A Stafford, M W Quic. Functional regulation of gamma-aminobutyric acid transporters by direct tyrosine phosphorylation. The Journal of biological chemistry. vol 275. issue 31. 2000-09-07. PMID:10816599. |
to test the hypothesis that tyrosine phosphorylation affects transporter function and to determine its mechanism of action, we examined the regulation of the rat brain gamma-aminobutyric acid (gaba) transporter gat1 expressed endogenously in hippocampal neurons and expressed heterologously in chinese hamster ovary cells. |
2000-09-07 |
2023-08-12 |
rat |
| D L Pettit, G J Augustin. Distribution of functional glutamate and GABA receptors on hippocampal pyramidal cells and interneurons. Journal of neurophysiology. vol 84. issue 1. 2000-09-07. PMID:10899180. |
to map the location of functional glutamate and gaba receptors on individual hippocampal neurons, we photolyzed "caged" glutamate and gaba while measuring the electrical currents resulting from activation of these receptors. |
2000-09-07 |
2023-08-12 |
Not clear |
| J E Coelho, A de Mendonça, J A Ribeir. Presynaptic inhibitory receptors mediate the depression of synaptic transmission upon hypoxia in rat hippocampal slices. Brain research. vol 869. issue 1-2. 2000-08-25. PMID:10865070. |
we tested the hypothesis that activation of heterosynaptic inhibitory receptors localized in glutamatergic presynaptic terminals in the hippocampus, namely gamma-aminobutyric acid subtype b (gaba(b)) receptors, alpha(2)-adrenergic receptors, and muscarinic receptors might contribute to the hypoxia-induced depression of synaptic transmission. |
2000-08-25 |
2023-08-12 |
rat |
| P Lorente, A Lacampagne, Y Pouzeratte, S Richards, B Malitschek, R Kuhn, B Bettler, G Vassor. gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 15. 2000-08-24. PMID:10900022. |
gamma-hydroxybutyrate (ghb), an anesthetic adjuvant analog of gamma-aminobutyrate (gaba), depresses cell excitability in hippocampal neurons by inducing hyperpolarization through the activation of a prominent inwardly rectifying k(+) (kir3) conductance. |
2000-08-24 |
2023-08-12 |
rat |
| S C Steffensen, Z Nie, J R Criado, G R Siggin. Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900243. |
we have previously demonstrated that gaba(b) receptor blockade uncovers ethanol enhancement of gaba(a) responses in the hippocampus. |
2000-08-24 |
2023-08-12 |
Not clear |
| S C Steffensen, Z Nie, J R Criado, G R Siggin. Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900243. |
therefore, we evaluated in vivo and in vitro the role of gaba(b) receptors in ethanol-induced inhibition of neuronal activity as well as nmda responses in the hippocampus, ventral tegmental area (vta), and nucleus accumbens (nacc), three brain areas with known sensitivity to low doses of ethanol. |
2000-08-24 |
2023-08-12 |
Not clear |
| S C Steffensen, Z Nie, J R Criado, G R Siggin. Ethanol inhibition of N-methyl-D-aspartate responses involves presynaptic gamma-aminobutyric acid(B) receptors. The Journal of pharmacology and experimental therapeutics. vol 294. issue 2. 2000-08-24. PMID:10900243. |
the gaba(b) antagonist cgp35348 blocked baclofen- and ethanol-induced, but not muscimol-induced, reduction of nmda-activated firing of hippocampal hilar mossy cells, hilar interneurons, and vta gaba neurons, as well as ethanol inhibition of nmda receptor-sensitive, amygdala-driven nacc neurons. |
2000-08-24 |
2023-08-12 |
Not clear |
| S SanMartín, L Menéndez, M Gutiérrez, A Hidalgo, A Baamond. Effects of DAGO on the rodent hippocampal evoked potentials using different perfusion solutions. Acta neurobiologiae experimentalis. vol 60. issue 2. 2000-08-24. PMID:10909174. |
opioid receptor agonists exert excitatory effects in the hippocampus by inhibiting gaba release. |
2000-08-24 |
2023-08-12 |
mouse |
| J Ai, X Wang, H Wahe, Z T Fomum, O Sterner, M Nielsen, M R Wit. 2-Oxo-2H-Pyrimido[2,1-b]benzothiazoles inhibit brain benzodiazepine receptor binding in vitro. Pharmacology. vol 60. issue 4. 2000-08-22. PMID:10828741. |
the most potent compound, 2-oxo-4-phenyl-2h-pyrimido[2,1-b]- benzothiazole showed a similar potency to inhibit (3)h-ro 15-1788 binding to membrane preparations of rat brain cortex, cerebellum and hippocampus as well as to various subunit combinations of recombinant human gamma-aminobutyric acid(a)/benzodiazepine receptors. |
2000-08-22 |
2023-08-12 |
human |
| M Serra, M G Pisu, M Littera, G Papi, E Sanna, F Tuveri, L Usala, R H Purdy, G Biggi. Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain. Journal of neurochemistry. vol 75. issue 2. 2000-08-17. PMID:10899949. |
whereas the amplitude of gaba-induced cl(-) currents did not differ significantly between group-housed and isolated animals, the potentiation of these currents by diazepam was reduced at cortical or hippocampal gaba(a) receptors from isolated rats compared with that apparent at receptors from group-housed animals. |
2000-08-17 |
2023-08-12 |
rat |
| R A Cunha, J A Ribeir. Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals. Neuropharmacology. vol 39. issue 7. 2000-08-15. PMID:10760359. |
purinergic modulation of [(3)h]gaba release from rat hippocampal nerve terminals. |
2000-08-15 |
2023-08-12 |
rat |
| R A Cunha, J A Ribeir. Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals. Neuropharmacology. vol 39. issue 7. 2000-08-15. PMID:10760359. |
we have now confirmed that neither adenosine a(1) and a(3) receptor nor nucleotide p(2) or p(4) receptor activation modified the k(+)-evoked [(3)h]gaba release from hippocampal synaptosomes. |
2000-08-15 |
2023-08-12 |
rat |
| R A Cunha, J A Ribeir. Purinergic modulation of [(3)H]GABA release from rat hippocampal nerve terminals. Neuropharmacology. vol 39. issue 7. 2000-08-15. PMID:10760359. |
thus, the adenosine a(2a) receptor system appears to be one of the first presynaptic neuromodulatory systems able to enhance the evoked release of gaba from hippocampal nerve terminals. |
2000-08-15 |
2023-08-12 |
rat |
| M Mladinic, F Didelon, E Cherubini, A Bradbur. 'Specific' oligonucleotides often recognize more than one gene: the limits of in situ hybridization applied to GABA receptors. Journal of neuroscience methods. vol 98. issue 1. 2000-08-15. PMID:10837868. |
in studying the gaba receptor subunits in the neonatal hippocampus we have used oligonucleotide probes in in situ hybridization and cloning techniques. |
2000-08-15 |
2023-08-12 |
Not clear |
| M Alkondon, M F Braga, E F Pereira, A Maelicke, E X Albuquerqu. alpha7 nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus. European journal of pharmacology. vol 393. issue 1-3. 2000-08-11. PMID:10770998. |
the present report provides new findings regarding modulation of gamma-aminobutyric acid (gaba) transmission by alpha7 nicotinic receptor activity in ca1 interneurons of rat hippocampal slices. |
2000-08-11 |
2023-08-12 |
rat |
| D Ruano, F Araujo, E Revilla, J Vela, O Bergis, J Vitoric. GABAA and alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate receptors are differentially affected by aging in the rat hippocampus. The Journal of biological chemistry. vol 275. issue 26. 2000-08-10. PMID:10751391. |
we have investigated the age-dependent modifications in the expression of eight different subunits of the gamma-aminobutyric acid, type a (gaba(a)) receptor (alpha1, alpha2, alpha3, alpha5, beta2, beta3, gamma2s, and gamma2l) and all four subunits of the alpha-amino-3-hydroxy-5-methylsoxazole-4-propionate (ampa) receptor (glur1-4) in the hippocampus of 24-month-old rats. |
2000-08-10 |
2023-08-12 |
rat |
| J Ma, L S Leun. Relation between hippocampal gamma waves and behavioral disturbances induced by phencyclidine and methamphetamine. Behavioural brain research. vol 111. issue 1-2. 2000-08-10. PMID:10840127. |
inactivation of the medial septum with muscimol, a gamma-aminobutyric acid receptor a agonist, 15 min prior to injection of pcp, suppressed both hippocampal gamma waves and locomotor activity. |
2000-08-10 |
2023-08-12 |
rat |
| J A White, M I Banks, R A Pearce, N J Kopel. Networks of interneurons with fast and slow gamma-aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10869419. |
for example, region ca1 of the hippocampus contains a slower class of gaba(a) (gaba(a,slow)) synapses, believed to be generated by a distinct group of interneurons. |
2000-08-10 |
2023-08-12 |
Not clear |
| J A White, M I Banks, R A Pearce, N J Kopel. Networks of interneurons with fast and slow gamma-aminobutyric acid type A (GABAA) kinetics provide substrate for mixed gamma-theta rhythm. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 14. 2000-08-10. PMID:10869419. |
recent evidence indicates that these gaba(a,slow) interneurons project to the gaba(a, fast) interneurons that contribute to hippocampal gamma rhythms. |
2000-08-10 |
2023-08-12 |
Not clear |