| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Y Ng, S Bertrand, R Sullivan, N Ethier, J Wang, J Yergey, M Belley, L Trimble, K Bateman, L Alder, A Smith, R McKernan, K Metters, G P O'Neill, J C Lacaille, T E Héber. Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Molecular pharmacology. vol 59. issue 1. 2001-01-25. PMID:11125035. |
in ca1 pyramidal neurons of rat hippocampal slices, gabapentin activated postsynaptic k+ currents, probably via the gb1a-gb2 heterodimer coupled to inward rectifiers, but did not presynaptically depress monosynaptic gaba(a) inhibitory postsynaptic currents. |
2001-01-25 |
2023-08-12 |
human |
| G Y Ng, S Bertrand, R Sullivan, N Ethier, J Wang, J Yergey, M Belley, L Trimble, K Bateman, L Alder, A Smith, R McKernan, K Metters, G P O'Neill, J C Lacaille, T E Héber. Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action. Molecular pharmacology. vol 59. issue 1. 2001-01-25. PMID:11125035. |
this selective agonism of postsynaptic gaba(b) receptor subtypes by gabapentin in hippocampal neurons may be its key therapeutic advantage as an anticonvulsant. |
2001-01-25 |
2023-08-12 |
human |
| I Katona, B Sperlágh, Z Maglóczky, E Sántha, A Köfalvi, S Czirják, K Mackie, E S Vizi, T F Freun. GABAergic interneurons are the targets of cannabinoid actions in the human hippocampus. Neuroscience. vol 100. issue 4. 2001-01-18. PMID:11036213. |
this unique expression pattern and the presynaptic modulation of gaba release suggests a conserved role for cb1 receptors in controlling inhibitory networks of the hippocampus that are responsible for the generation and maintenance of fast and slow oscillatory patterns. |
2001-01-18 |
2023-08-12 |
human |
| D A Montoya, A M White, C L Williams, J K Blusztajn, W H Meck, H S Swartzwelde. Prenatal choline exposure alters hippocampal responsiveness to cholinergic stimulation in adulthood. Brain research. Developmental brain research. vol 123. issue 1. 2001-01-09. PMID:11020547. |
these results suggest that gaba receptor-mediated inhibition remains intact after prenatal choline manipulations, and that enhancement of the excitatory responsiveness of hippocampal circuits in slices from prenatally choline supplemented rats may be related in part to an increase in cholinergic tone within the ca1 circuit. |
2001-01-09 |
2023-08-12 |
rat |
| Z Q Xiong, J L Stringe. Effects of postsynaptic GABA(B) receptor activation on epileptiform activity in hippocampal slices. Neuropharmacology. vol 40. issue 1. 2001-01-09. PMID:11077079. |
effects of postsynaptic gaba(b) receptor activation on epileptiform activity in hippocampal slices. |
2001-01-09 |
2023-08-12 |
Not clear |
| R B Nehring, H P Horikawa, O El Far, M Kneussel, J H Brandstätter, S Stamm, E Wischmeyer, H Betz, A Karschi. The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. The Journal of biological chemistry. vol 275. issue 45. 2001-01-04. PMID:10924501. |
confocal fluorescence microscopy shows that gaba(b)r and atf-4 are strongly coclustered in the soma and at the dendritic membrane surface of both cultured hippocampal neurons as well as retinal amacrine cells in vivo. |
2001-01-04 |
2023-08-12 |
rat |
| E X Albuquerque, E F Pereira, A Mike, H M Eisenberg, A Maelicke, M Alkondo. Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance. Behavioural brain research. vol 113. issue 1-2. 2001-01-03. PMID:10942040. |
evidence is provided that functional alpha7- and alpha4beta2-like nachrs are present on somatodendritic and/or preterminal/terminal regions of interneurons in the ca1 field of the rat hippocampus and in the human cerebral cortex and that activation of the different nachr subtypes present in the preterminal/terminal areas of the interneurons triggers the tetrodotoxin-sensitive release of gaba. |
2001-01-03 |
2023-08-12 |
human |
| Y Ueda, L J Willmor. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Experimental brain research. vol 133. issue 3. 2000-12-28. PMID:10958523. |
molecular regulation of glutamate and gaba transporter proteins by valproic acid in rat hippocampus during epileptogenesis. |
2000-12-28 |
2023-08-12 |
rat |
| Y Ueda, L J Willmor. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Experimental brain research. vol 133. issue 3. 2000-12-28. PMID:10958523. |
regions of the hippocampus were assayed for glutamate and gaba transporters by western blot. |
2000-12-28 |
2023-08-12 |
rat |
| Y Ueda, L J Willmor. Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis. Experimental brain research. vol 133. issue 3. 2000-12-28. PMID:10958523. |
gaba transporters gat-1 and gat-3 in the hippocampus were upregulated by fecl3 injection into the amygdala. |
2000-12-28 |
2023-08-12 |
rat |
| S M Lilly, E I Tiet. Chronic cocaine differentially affects diazepam's anxiolytic and anticonvulsant actions. Relationship to GABA(A) receptor subunit expression. Brain research. vol 882. issue 1-2. 2000-12-28. PMID:11056193. |
quantitative immunohistochemistry of gaba(a) receptor subunit protein demonstrated significant regulation of alpha2 (-10%) and beta3 (+9%) subunits in the hippocampal dentate gyrus and ca1 regions, respectively. |
2000-12-28 |
2023-08-12 |
rat |
| G Zhu, M Okada, T Murakami, A Kamata, Y Kawata, K Wada, S Kanek. Dysfunction of M-channel enhances propagation of neuronal excitability in rat hippocampus monitored by multielectrode dish and microdialysis systems. Neuroscience letters. vol 294. issue 1. 2000-12-22. PMID:11044585. |
to explore the pathogenesis of benign familial neonatal convulsions (bfnc), we determined effects of kcnq-related m-channels (kcnq-channels) on hippocampal glutamate (glu) and gamma-aminobutyric acid (gaba) releases using microdialysis, and propagation of evoked field-potentials (fp) using multielectrode (64-ch)-dish system as two-dimensional monitoring. |
2000-12-22 |
2023-08-12 |
rat |
| G Zhu, M Okada, T Murakami, A Kamata, Y Kawata, K Wada, S Kanek. Dysfunction of M-channel enhances propagation of neuronal excitability in rat hippocampus monitored by multielectrode dish and microdialysis systems. Neuroscience letters. vol 294. issue 1. 2000-12-22. PMID:11044585. |
kcnq-channel inhibitor, dup996, enhanced hippocampal k(+)-evoked glu and gaba releases without affecting basal releases of them. |
2000-12-22 |
2023-08-12 |
rat |
| F Didelon, M Mladinic', E Cherubini, A Bradbur. Early expression of GABA(A) receptor delta subunit in the neonatal rat hippocampus. Journal of neuroscience research. vol 62. issue 5. 2000-12-22. PMID:11104502. |
early expression of gaba(a) receptor delta subunit in the neonatal rat hippocampus. |
2000-12-22 |
2023-08-12 |
rat |
| F Didelon, M Mladinic', E Cherubini, A Bradbur. Early expression of GABA(A) receptor delta subunit in the neonatal rat hippocampus. Journal of neuroscience research. vol 62. issue 5. 2000-12-22. PMID:11104502. |
the cdna library screening strategy was used to identify the genes encoding for gaba(a) receptor subunits in the rat hippocampus during development. |
2000-12-22 |
2023-08-12 |
rat |
| F Didelon, M Mladinic', E Cherubini, A Bradbur. Early expression of GABA(A) receptor delta subunit in the neonatal rat hippocampus. Journal of neuroscience research. vol 62. issue 5. 2000-12-22. PMID:11104502. |
in situ hybridization experiments, using digoxigenin-labeled crna probes, confirmed that the delta subunit was expressed in the neonatal as well as in the adult hippocampus, and is likely to form functional receptors in association with other subunits of the gaba(a) receptor. |
2000-12-22 |
2023-08-12 |
rat |
| K Jensen, J D Lambert, M S Jense. Tetanus-induced asynchronous GABA release in cultured hippocampal neurons. Brain research. vol 880. issue 1-2. 2000-12-21. PMID:11033007. |
tetanus-induced asynchronous gaba release in cultured hippocampal neurons. |
2000-12-21 |
2023-08-12 |
Not clear |
| K Jensen, J D Lambert, M S Jense. Tetanus-induced asynchronous GABA release in cultured hippocampal neurons. Brain research. vol 880. issue 1-2. 2000-12-21. PMID:11033007. |
asynchronous gaba release was studied in cultured hippocampal neurons using paired whole-cell recordings. |
2000-12-21 |
2023-08-12 |
Not clear |
| M Matsubara, S Suzuki, K Miura, M Terashima, S Sugita, H Kimura, S Hatsuda, T Mori, H Murakami, T Hayashi, T Ohta, M Ohar. Electrophysiologic analysis of antidepressant drug effects on the GABA(A) receptor complex based upon antagonist-induced encephalographic power spectrum changes. Neuropsychobiology. vol 42. issue 3. 2000-12-05. PMID:11015033. |
to better understand antidepressant drug effects on the gaba(a) receptor complex (the gaba(a) receptor, chloride ionophore and benzodiazepine receptor), we investigated how antidepressants influenced power spectrum changes induced by pentylenetetrazol (ptz), a chloride ionophore antagonist, in the rat hippocampal electroencephalogram (eeg). |
2000-12-05 |
2023-08-12 |
rat |
| B Birnir, M Eghbali, A B Everitt, P W Gag. Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons. British journal of pharmacology. vol 131. issue 4. 2000-12-05. PMID:11030718. |
bicuculline, pentobarbital and diazepam modulate spontaneous gaba(a) channels in rat hippocampal neurons. |
2000-12-05 |
2023-08-12 |
rat |