| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Xu, R Cormier, T Fu, D F Covey, K E Isenberg, C F Zorumski, S Menneric. Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 9. 2000-06-02. PMID:10777778. |
surprisingly, chronic blockade of gaba(a) receptor activity for 5-8 d in vitro enhanced survival of hippocampal neurons, suggesting that gaba(a) receptor overactivation may be neurotoxic. |
2000-06-02 |
2023-08-12 |
Not clear |
| K Lukasiuk, A Pitkäne. GABA(A)-mediated toxicity of hippocampal neurons in vitro. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820205. |
gaba(a)-mediated toxicity of hippocampal neurons in vitro. |
2000-06-02 |
2023-08-12 |
rat |
| K Lukasiuk, A Pitkäne. GABA(A)-mediated toxicity of hippocampal neurons in vitro. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820205. |
in the present study, we examined whether the elevation of gaba by gamma-vinyl-gaba protects cultured rat fetal hippocampal neurons against toxicity induced by a 20-min incubation with 100 microm l-glutamate. |
2000-06-02 |
2023-08-12 |
rat |
| K Lukasiuk, A Pitkäne. GABA(A)-mediated toxicity of hippocampal neurons in vitro. Journal of neurochemistry. vol 74. issue 6. 2000-06-02. PMID:10820205. |
these data indicate that, under depolarizing conditions, an increased gaba level is toxic for a subpopulation of developing hippocampal neurons in vitro. |
2000-06-02 |
2023-08-12 |
rat |
| J E Madl, S M Roye. Glutamate dependence of GABA levels in neurons of hypoxic and hypoglycemic rat hippocampal slices. Neuroscience. vol 96. issue 4. 2000-05-31. PMID:10727784. |
glutamate dependence of gaba levels in neurons of hypoxic and hypoglycemic rat hippocampal slices. |
2000-05-31 |
2023-08-12 |
rat |
| J E Madl, S M Roye. Glutamate dependence of GABA levels in neurons of hypoxic and hypoglycemic rat hippocampal slices. Neuroscience. vol 96. issue 4. 2000-05-31. PMID:10727784. |
we examined whether differences in glutamate levels may contribute to these altered gaba levels in hippocampal slices. |
2000-05-31 |
2023-08-12 |
rat |
| M Sassoè-Pognetto, P Panzanelli, W Sieghart, J M Fritsch. Colocalization of multiple GABA(A) receptor subtypes with gephyrin at postsynaptic sites. The Journal of comparative neurology. vol 420. issue 4. 2000-05-31. PMID:10805922. |
by using confocal laser scanning microscopy, gaba(a)-receptor subunit staining revealed brightly stained clusters that were colocalized with gephyrin-positive clusters of similar size and distribution in several brain regions, including cerebellum, hippocampus, thalamus, and olfactory bulb. |
2000-05-31 |
2023-08-12 |
rat |
| C Heim, J Zhang, J Lan, M Sieklucka, T Kurz, P Riederer, M Gerlach, K H Sonta. Cerebral oligaemia episode triggers free radical formation and late cognitive deficiencies. The European journal of neuroscience. vol 12. issue 2. 2000-05-25. PMID:10712651. |
analysis at bcca of hippocampal metabolism using microdialysis showed increased release of glutamate, aspartate and gamma-aminobutyric acid, followed by a progressive rise in the formation of hydroxyl free radicals measured as 2,3-dihydroxybenzoic acid (2,3-dhba), their reaction product with salicylate, though only in the re-perfusion phase. |
2000-05-25 |
2023-08-12 |
rat |
| W Shen, S Mennerick, D F Covey, C F Zorumsk. Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 10. 2000-05-25. PMID:10804198. |
we examined the effects of the neurosteroid pregnenolone sulfate (ps) on gaba(a) receptor-mediated synaptic currents and currents elicited by rapid applications of gaba onto nucleated outside-out patches in cultured postnatal rat hippocampal neurons. |
2000-05-25 |
2023-08-12 |
rat |
| C Chen, N G Baza. Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. Neuroreport. vol 10. issue 18. 2000-05-23. PMID:10716218. |
platelet-activating factor inhibits ionotropic gaba receptor activity in cultured hippocampal neurons. |
2000-05-23 |
2023-08-12 |
Not clear |
| C Chen, N G Baza. Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. Neuroreport. vol 10. issue 18. 2000-05-23. PMID:10716218. |
the purpose of the present study was to investigate the possible actions of paf on ionotropic gaba receptor responses in primary cultured hippocampal neurons using the whole-cell and single channel patch clamp techniques. |
2000-05-23 |
2023-08-12 |
Not clear |
| M L Beckman, E M Bernstein, M W Quic. Multiple G protein-coupled receptors initiate protein kinase C redistribution of GABA transporters in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 11. 2000-05-22. PMID:10341270. |
multiple g protein-coupled receptors initiate protein kinase c redistribution of gaba transporters in hippocampal neurons. |
2000-05-22 |
2023-08-12 |
rat |
| M L Beckman, E M Bernstein, M W Quic. Multiple G protein-coupled receptors initiate protein kinase C redistribution of GABA transporters in hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 11. 2000-05-22. PMID:10341270. |
we tested this hypothesis by examining the rat brain gaba transporter gat1 endogenously expressed in hippocampal neurons. |
2000-05-22 |
2023-08-12 |
rat |
| K Heese, U Otten, P Mathivet, M Raiteri, C Marescaux, R Bernascon. GABA(B) receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698011. |
in this study we show that single, physiologically-active and non-convulsive doses of the three gaba(b) receptor antagonists cgp 36742, cgp 56433a and cgp 56999a increase ngf and bdnf mrna levels by 200-400% and protein levels by 200-250% in rat neocortex, hippocampus as well as spinal cord. |
2000-05-16 |
2023-08-12 |
rat |
| A F Hoffman, C R Lupic. Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 7. 2000-05-16. PMID:10729327. |
mechanisms of cannabinoid inhibition of gaba(a) synaptic transmission in the hippocampus. |
2000-05-16 |
2023-08-12 |
rat |
| K Mizukami, M Sasaki, M Ishikawa, M Iwakiri, S Hidaka, H Shiraishi, S Iritan. Immunohistochemical localization of gamma-aminobutyric acid(B) receptor in the hippocampus of subjects with schizophrenia. Neuroscience letters. vol 283. issue 2. 2000-05-12. PMID:10739885. |
immunohistochemical localization of gamma-aminobutyric acid(b) receptor in the hippocampus of subjects with schizophrenia. |
2000-05-12 |
2023-08-12 |
human |
| K Mizukami, M Sasaki, M Ishikawa, M Iwakiri, S Hidaka, H Shiraishi, S Iritan. Immunohistochemical localization of gamma-aminobutyric acid(B) receptor in the hippocampus of subjects with schizophrenia. Neuroscience letters. vol 283. issue 2. 2000-05-12. PMID:10739885. |
in order to further elucidate the alterations of this system in schizophrenia, we employed immunohistochemical techniques and examined the expression and anatomical distribution of the gaba(b) receptor in the hippocampus of five subjects with schizophrenia and three age-matched controls. |
2000-05-12 |
2023-08-12 |
human |
| K Mizukami, M Sasaki, M Ishikawa, M Iwakiri, S Hidaka, H Shiraishi, S Iritan. Immunohistochemical localization of gamma-aminobutyric acid(B) receptor in the hippocampus of subjects with schizophrenia. Neuroscience letters. vol 283. issue 2. 2000-05-12. PMID:10739885. |
our findings suggest that in the hippocampus of schizophrenic patients the expression of the gaba(b) receptor is reduced, and raise the possibility that this reduction contributes to the pathophysiological process in the schizophrenic brain. |
2000-05-12 |
2023-08-12 |
human |
| J R Atack, S M Cook, P H Hutson, S E Fil. Kindling induced by pentylenetetrazole in rats is not directly associated with changes in the expression of NMDA or benzodiazepine receptors. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764932. |
specific analysis of gaba(a) receptors containing the alpha5 subunit, which are preferentially localized in the hippocampus, was assessed with [3h]l-655,708. |
2000-05-10 |
2023-08-12 |
rat |
| J R Atack, S M Cook, P H Hutson, S E Fil. Kindling induced by pentylenetetrazole in rats is not directly associated with changes in the expression of NMDA or benzodiazepine receptors. Pharmacology, biochemistry, and behavior. vol 65. issue 4. 2000-05-10. PMID:10764932. |
however, in the hippocampus there was a significant, albeit modest, effect of treatment on the b(max) of [3h]mk-801 binding and the b(max) and k(d) of [3h]l-655,708 binding, i.e., ptz-treated rats had fewer [3h]mk-801 and [3h]l-655,708 binding sites (nmda and alpha5-containing gaba(a) receptors, respectively), but, these reductions were significant only in the relatively seizure-insensitive hooded lister strain. |
2000-05-10 |
2023-08-12 |
rat |