| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David D Bushart, Vikram G Shakkotta. Vulnerability of Human Cerebellar Neurons to Degeneration in Ataxia-Causing Channelopathies. Frontiers in systems neuroscience. vol 16. 2022-06-27. PMID:35757096. |
human ataxia-causing channelopathies that result in even haploinsufficiency can result in cerebellar atrophy and cerebellar purkinje neuron loss. |
2022-06-27 |
2023-08-14 |
mouse |
| Eric J Lang, Adrian Handfort. Is the inferior olive central to essential tremor? Yes. International review of neurobiology. vol 163. 2022-06-24. PMID:35750361. |
much evidence shows that the olivocerebellar system is the main system capable of generating the widespread synchronous oscillatory purkinje cell (pc) complex spike (cs) activity across the cerebellar cortex that would be capable of generating the type of bursting cerebellar output from the deep cerebellar nuclei (dcn) that could underlie tremor. |
2022-06-24 |
2023-08-14 |
mouse |
| Steven Bellows, Joohi Jimenez-Shahe. Is essential tremor a disorder of GABA dysfunction? No. International review of neurobiology. vol 163. 2022-06-24. PMID:35750366. |
hypersynchrony of purkinje cell activity may account for excessive oscillatory cerebellar output, with potential contributions along multiple sites of the olivocerebellar loop. |
2022-06-24 |
2023-08-14 |
mouse |
| Phyllis L Faus. Is essential tremor a degenerative disorder or an electric disorder? Degenerative disorder. International review of neurobiology. vol 163. 2022-06-24. PMID:35750370. |
most of these pathological changes are centered on the purkinje cell and connected neuronal populations, which can result in partial loss of purkinje cells and circuitry reorganizations that would disturb cerebellar function. |
2022-06-24 |
2023-08-14 |
Not clear |
| Kazuyuki Miyamoto, Motoyasu Nakamura, Hirokazu Ohtaki, Keisuke Suzuki, Hiroki Yamaga, Kaoru Yanagisawa, Atsuo Maeda, Masaharu Yagi, Munetaka Hayashi, Kazuho Honda, Kenji Doh. Heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, Purkinje cell degeneration, and synaptic impairment in the cerebellum. Scientific reports. vol 12. issue 1. 2022-06-22. PMID:35732789. |
heatstroke-induced late-onset neurological deficits in mice caused by white matter demyelination, purkinje cell degeneration, and synaptic impairment in the cerebellum. |
2022-06-22 |
2023-08-14 |
mouse |
| Harry T Or. Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway. Cerebellum (London, England). 2022-06-22. PMID:35733029. |
this is a summary of the virtual presentation given at the 2021 meeting of the society for research on the cerebellum and ataxias, https://www.meetings.be/srca2021/ , where the therapeutic potential of the cck-cck1r pathway for treating diseases involving purkinje cell degeneration was presented. |
2022-06-22 |
2023-08-14 |
mouse |
| Andrea Pirone, Chiara Magliaro, Carlo Cantile, Carla Lenzi, Alessandra Coli, Vincenzo Miragliott. Comparative and quantitative morphology of the pig and wild boar cerebellum for identifying possible effects of domestication. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2022-06-01. PMID:35644466. |
our results showed that: (i) the foliation index, expressing the rate of cerebellar cortical folding, and the number of granular cells were not significantly different between pigs and wild boars; (ii) area of the granular layer and the molecular layer, and area of white matter were lower in pigs; (iii) the fraction area, grey matter/white matter, was higher in pigs; (iv) the purkinje cell linear density and their soma area were higher in wild boars. |
2022-06-01 |
2023-08-13 |
human |
| Xiu-Xiu Liu, Xing-Hui Chen, Zhi-Wei Zheng, Qin Jiang, Chen Li, Lin Yang, Xiang Chen, Xing-Feng Mao, Hao-Yang Yuan, Li-Li Feng, Quan Jiang, Wei-Xing Shi, Takuya Sasaki, Kohji Fukunaga, Zhong Chen, Feng Han, Ying-Mei L. BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination. Signal transduction and targeted therapy. vol 7. issue 1. 2022-05-31. PMID:35641478. |
through cell-type-specific manipulations, we discovered a novel gabaergic purkinje cell (pc) circuit in the cerebellar iv/v lobe that projected to camkiiα |
2022-05-31 |
2023-08-13 |
Not clear |
| Eric Avila, Nico A Flierman, Peter J Holland, Pieter R Roelfsema, Maarten A Frens, Aleksandra Badura, Chris I De Zeeu. Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques. Frontiers in cellular neuroscience. vol 16. 2022-05-16. PMID:35573834. |
purkinje cell activity in the medial and lateral cerebellum during suppression of voluntary eye movements in rhesus macaques. |
2022-05-16 |
2023-08-13 |
Not clear |
| Eric Avila, Nico A Flierman, Peter J Holland, Pieter R Roelfsema, Maarten A Frens, Aleksandra Badura, Chris I De Zeeu. Purkinje Cell Activity in the Medial and Lateral Cerebellum During Suppression of Voluntary Eye Movements in Rhesus Macaques. Frontiers in cellular neuroscience. vol 16. 2022-05-16. PMID:35573834. |
here, we measured purkinje cell (pc) responses in the medial and lateral cerebellum in two rhesus macaques during pro- and anti-saccade tasks. |
2022-05-16 |
2023-08-13 |
Not clear |
| Xiaofan Yang, Hongqiang Yin, Xiaojing Wang, Yueqing Sun, Xianli Bian, Gaorui Zhang, Anning Li, Aihua Cao, Baomin Li, Darius Ebrahimi-Fakhari, Zhuo Yang, Miriam H Meisler, Qiji Li. Social Deficits and Cerebellar Degeneration in Purkinje Cell Frontiers in molecular neuroscience. vol 15. 2022-05-13. PMID:35557557. |
social deficits and cerebellar degeneration in purkinje cell mutations in the |
2022-05-13 |
2023-08-13 |
Not clear |
| Omid A Zobeiri, Kathleen E Culle. Distinct representations of body and head motion are dynamically encoded by Purkinje cell populations in the macaque cerebellum. eLife. vol 11. 2022-04-25. PMID:35467528. |
distinct representations of body and head motion are dynamically encoded by purkinje cell populations in the macaque cerebellum. |
2022-04-25 |
2023-08-13 |
monkey |
| Michael A Gaffield, Britton A Sauerbrei, Jason M Christi. Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice. eLife. vol 11. 2022-04-22. PMID:35451957. |
to provide functional evidence validating this idea, we measured and manipulated purkinje cell (pc) activity in the lateral cerebellum of mice trained to volitionally perform periodic bouts of licking for regularly allocated water rewards. |
2022-04-22 |
2023-08-13 |
mouse |
| Marion Coolen, Nami Altin, Karthyayani Rajamani, Eva Pereira, Karine Siquier-Pernet, Emilia Puig Lombardi, Nadjeda Moreno, Giulia Barcia, Marianne Yvert, Annie Laquerrière, Aurore Pouliet, Patrick Nitschké, Nathalie Boddaert, Antonio Rausell, Féréchté Razavi, Alexandra Afenjar, Thierry Billette de Villemeur, Almundher Al-Maawali, Khalid Al-Thihli, Julia Baptista, Ana Beleza-Meireles, Catherine Garel, Marine Legendre, Antoinette Gelot, Lydie Burglen, Sébastien Moutton, Vincent Cantagre. Recessive PRDM13 mutations cause fatal perinatal brainstem dysfunction with cerebellar hypoplasia and disrupt Purkinje cells differentiation. American journal of human genetics. 2022-04-07. PMID:35390279. |
notably, histopathological examinations highlighted a sparse and disorganized purkinje cell layer in the cerebellum. |
2022-04-07 |
2023-08-13 |
mouse |
| Ehsan Sedaghat-Nejad, Jay S Pi, Paul Hage, Mohammad Amin Fakharian, Reza Shadmeh. Synchronous spiking of cerebellar Purkinje cells during control of movements. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 14. 2022-03-29. PMID:35349338. |
here we report that, in the cerebellum, purkinje cell populations that share a preference for error convey, to the nucleus, when to decelerate the movement, by reducing their firing rates and temporally synchronizing the remaining spikes. |
2022-03-29 |
2023-08-13 |
Not clear |
| Tuancheng Feng, Lin Luan, Isabel Iscol Katz, Mohammed Ullah, Vivianna M Van Deerlin, John Q Trojanowski, Edward B Lee, Fenghua H. TMEM106B deficiency impairs cerebellar myelination and synaptic integrity with Purkinje cell loss. Acta neuropathologica communications. vol 10. issue 1. 2022-03-15. PMID:35287730. |
tmem106b deficiency impairs cerebellar myelination and synaptic integrity with purkinje cell loss. |
2022-03-15 |
2023-08-13 |
mouse |
| Yasmin Fidler, Jose Rosa Gome. Effects of a Single Dose of X-Ray Irradiation on MMP-9 Expression and Morphology of the Cerebellum Cortex of Adult Rats. Cerebellum (London, England). 2022-03-09. PMID:35262839. |
we conclude that the effects of a single dose of 15-gy x-ray irradiation in the cerebellum were an increase in mmp-9 expression in the first 2 weeks after irradiation, especially surrounding the purkinje cells and in the molecular layers, with morphological changes in the purkinje cell and granular cell layers, suggesting a continuous cell loss throughout the days evaluated after irradiation. |
2022-03-09 |
2023-08-13 |
rat |
| Xiang Chen, Tong Chen, Chen Dong, Huiyao Chen, Xinran Dong, Lin Yang, Liyuan Hu, Huijun Wang, Bingbing Wu, Ye Yao, Yu Xiong, Man Xiong, Yifeng Lin, Wenhao Zho. Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia, ataxia and psychiatric behavior in mice. Journal of genetics and genomics = Yi chuan xue bao. 2022-03-01. PMID:35231638. |
genetic deletion of chd8 in cerebellar granule neuron progenitors (gnps) lead to cerebellar hypoplasia, absent of proliferation layer and ectopic of purkinje neuron. |
2022-03-01 |
2023-08-13 |
mouse |
| Inwoo Hwang, Byeong-Seong Kim, Hyo Rim Ko, Seongbong Cho, Ho Yun Lee, Sung-Woo Cho, Dongryeol Ryu, Sungbo Shim, Jee-Yin Ah. Cerebellar dysfunction and schizophrenia-like behavior in Ebp1-deficient mice. Molecular psychiatry. 2022-02-15. PMID:35165395. |
cerebellar deficits with purkinje cell (pcs) loss are observed in several neurologic disorders. |
2022-02-15 |
2023-08-13 |
mouse |
| G Cheron, D Ristori, J Marquez-Ruiz, A M Cebolla, L Ri. Electrophysiological alterations of the Purkinje cells and deep cerebellar neurons in a mouse model of Alzheimer disease (Electrophysiology on cerebellum of AD mice). The European journal of neuroscience. 2022-02-10. PMID:35141975. |
despite the central position of the purkinje cell in the cerebellum, its electrophysiological behavior in mouse models of alzheimer's disease is scarce in the literature. |
2022-02-10 |
2023-08-13 |
mouse |