| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle Imlau, Mamoun Saeed, Jane Cryan, Seamus Hoey, Myles McKenna, Hanne Jahns, Pamela Kell. Dysplastic gangliocytoma of the cerebellum in a cat. Veterinary pathology. 2022-02-08. PMID:35130805. |
postmortem examination confirmed the mri findings, and histopathology showed numerous large dysplastic neurons populating and displacing the purkinje cell layer and extending into the molecular and granular layers of the cerebellum. |
2022-02-08 |
2023-08-13 |
cat |
| Hanako Aoki, Miwa Higashi, Michi Okita, Noboru Ando, Shigeo Murayama, Kinya Ishikawa, Takanori Yokot. Thymidine Kinase 2 and Mitochondrial Protein COX I in the Cerebellum of Patients with Spinocerebellar Ataxia Type 31 Caused by Penta-nucleotide Repeats (TTCCA) Cerebellum (London, England). 2022-01-27. PMID:35084690. |
thymidine kinase 2 and mitochondrial protein cox i in the cerebellum of patients with spinocerebellar ataxia type 31 caused by penta-nucleotide repeats (ttcca) spinocerebellar ataxia type 31 (sca31), an autosomal-dominant neurodegenerative disorder characterized by progressive cerebellar ataxia with purkinje cell degeneration, is caused by a heterozygous 2.5-3.8 kilobase penta-nucleotide repeat of (ttcca) |
2022-01-27 |
2023-08-13 |
Not clear |
| Carlos Del Pilar, Rafael Lebrón-Galán, Ester Pérez-Martín, Laura Pérez-Revuelta, Carmelo Antonio Ávila-Zarza, José Ramón Alonso, Diego Clemente, Eduardo Weruaga, David Día. The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations. Frontiers in cellular neuroscience. vol 15. 2021-12-17. PMID:34916910. |
consequently, a model of human cerebellar degeneration and ataxia -the purkinje cell degeneration (pcd) mouse- has been employed, as it allows the study of different processes of selective neuronal death in the same animal, i.e., purkinje cells in the cerebellum and mitral cells in the olfactory bulb. |
2021-12-17 |
2023-08-13 |
mouse |
| Shelanah Salih, Zubair Nizamudeen, Nigel De Melo, Lisa Chakrabarti, Virginie Sottil. Sox-positive cell population in the adult cerebellum increases upon tissue degeneration. Experimental neurology. 2021-12-13. PMID:34902356. |
in a mouse model of cerebellar degeneration, progressive purkinje cell loss was linked to cerebellar cortex disorganisation and a significant increase in sox-positive cells compared to matching controls. |
2021-12-13 |
2023-08-13 |
mouse |
| Xu Zhang, Roeland Hancock, Sabato Santaniell. Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses. PLoS computational biology. vol 17. issue 12. 2021-12-09. PMID:34882680. |
we then pair the ef with multicompartment models of the purkinje cell (pc), deep cerebellar neuron (dcn), and granule cell (grc) and quantify the acute response of these neurons under various orientations, physiological conditions, and sequences of presynaptic stimuli. |
2021-12-09 |
2023-08-13 |
Not clear |
| Chunlian Song, Xin Huang, Yunmei Gao, Xue Zhang, Yulei Wang, Yajing Zhang, Tao Lv, Zhihui Zhang, Yalun Zhang, Qiong Pan, Yue Shu, Xianghua Sh. Histopathology of brain functional areas in pigs infected by porcine pseudorabies virus. Research in veterinary science. vol 141. 2021-12-08. PMID:34763257. |
immunohistochemistry showed that the virus was mainly localized in neurons, microglia, nerve fibers, cerebellar granular layer, and purkinje cell layer. |
2021-12-08 |
2023-08-13 |
Not clear |
| Shu Ho, Rebecca Lajaunie, Marion Lerat, Mickaël Le, Valérie Crépel, Karine Loulier, Jean Livet, Jean-Pierre Kessler, Païkan Marcagg. A stable proportion of Purkinje cell inputs from parallel fibers are silent during cerebellar maturation. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 45. 2021-12-07. PMID:34740966. |
a stable proportion of purkinje cell inputs from parallel fibers are silent during cerebellar maturation. |
2021-12-07 |
2023-08-13 |
mouse |
| Ester Pérez-Martín, Rodrigo Muñoz-Castañeda, Marie-Jo Moutin, Carmelo A Ávila-Zarza, José M Muñoz-Castañeda, Carlos Del Pilar, José R Alonso, Annie Andrieux, David Díaz, Eduardo Weruag. Oleoylethanolamide Delays the Dysfunction and Death of Purkinje Cells and Ameliorates Behavioral Defects in a Mouse Model of Cerebellar Neurodegeneration. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 18. issue 3. 2021-12-04. PMID:33829414. |
in this study, we evaluated the effects of oea on the disruption of both cerebellar structure and physiology and on the behavior of purkinje cell degeneration (pcd) mutant mice. |
2021-12-04 |
2023-08-13 |
mouse |
| François G C Blot, Wilhelmina H J J Krijnen, Sandra Den Hoedt, Catarina Osório, Joshua J White, Monique T Mulder, Martijn Schonewill. Sphingolipid metabolism governs Purkinje cell patterned degeneration in Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 36. 2021-12-02. PMID:34479994. |
sphingolipid metabolism governs purkinje cell patterned degeneration in patterned degeneration of purkinje cells (pcs) can be observed in a wide range of neuropathologies, but mechanisms behind nonrandom cerebellar neurodegeneration remain unclear. |
2021-12-02 |
2023-08-13 |
Not clear |
| Sinem Balta Beylergil, Palak Gupta, Aasef G Shaik. Does Inferior-Olive Hypersynchrony Affect Vestibular Heading Perception? Cerebellum (London, England). vol 20. issue 5. 2021-11-30. PMID:31939030. |
deficiency in cerebellar function due to purkinje cell loss results in inaccurate multisensory integration and impaired heading perception. |
2021-11-30 |
2023-08-13 |
Not clear |
| Rin Khang, Areum Jo, Hojin Kang, Hanna Kim, Eunsang Kwag, Ji-Yeong Lee, Okjae Koo, Jinsu Park, Hark Kyun Kim, Dong-Gyu Jo, Inwoo Hwang, Jee-Yin Ahn, Yunjong Lee, Jeong-Yun Choi, Yun-Song Lee, Joo-Ho Shi. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Scientific reports. vol 11. issue 1. 2021-11-27. PMID:34815492. |
we confirmed the reduction of zfp212 and pld3 in the cb of an alcohol-induced cerebellar degeneration mouse model, suggesting that the znf212-pld3 relationship is important for purkinje cell survival. |
2021-11-27 |
2023-08-13 |
mouse |
| Jae-Min Lee, Jongmin Park, Joo-Hee Lee, Hyo-Bum Kwak, Mi-Hyun No, Jun-Won Heo, Youn-Jung Ki. Low-intensity treadmill exercise protects cognitive impairment by enhancing cerebellar mitochondrial calcium retention capacity in a rat model of chronic cerebral hypoperfusion. Journal of exercise rehabilitation. vol 17. issue 5. 2021-11-23. PMID:34805021. |
the present study showed that lite hindered the deficit of spatial working memory and loss of purkinje cell in the cerebellum induced by cch. |
2021-11-23 |
2023-08-13 |
rat |
| Pamela McMillan, Jeanna Wheeler, Rachel E Gatlin, Laura Taylor, Tim Strovas, Misa Baum, Thomas D Bird, Caitlin Latimer, C Dirk Keene, Brian C Kraemer, Nicole F Liachk. Adult onset pan-neuronal human tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. Acta neuropathologica communications. vol 8. issue 1. 2021-11-09. PMID:33228809. |
these behavioral phenotypes occur in conjunction with progressive weight loss, neuroinflammation, and severe cerebellar degeneration with purkinje neuron loss. |
2021-11-09 |
2023-08-13 |
mouse |
| Adrian Handforth, Eric J Lan. Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature. Cerebellum (London, England). vol 20. issue 2. 2021-11-05. PMID:33048308. |
increased purkinje cell complex spike and deep cerebellar nucleus synchrony as a potential basis for syndromic essential tremor. |
2021-11-05 |
2023-08-13 |
rat |
| Melanie P Jensen, James B Rowe, Kieren S J Allinso. A case report of metastatic renal cell carcinoma causing corticobasal syndrome. Clinical neuropathology. vol 40. issue 3. 2021-11-02. PMID:33433315. |
there was also purkinje cell loss and mild lymphocytic inflammation in the cerebellum, but the significance of this was unclear. |
2021-11-02 |
2023-08-13 |
Not clear |
| Yuning Liu, Hong Xing, Bradley J Wilkes, Fumiaki Yokoi, Huanxin Chen, David E Vaillancourt, Yuqing L. The abnormal firing of Purkinje cells in the knockin mouse model of DYT1 dystonia. Brain research bulletin. vol 165. 2021-10-26. PMID:32976982. |
manipulating the purkinje cell firing and cerebellar output may show great promise for treating dyt1 dystonia. |
2021-10-26 |
2023-08-13 |
mouse |
| David D Bushart, Annie J Zalon, Hongjiu Zhang, Logan M Morrison, Yuanfang Guan, Henry L Paulson, Vikram G Shakkottai, Hayley S McLoughli. Antisense Oligonucleotide Therapy Targeted Against ATXN3 Improves Potassium Channel-Mediated Purkinje Neuron Dysfunction in Spinocerebellar Ataxia Type 3. Cerebellum (London, England). vol 20. issue 1. 2021-10-25. PMID:32789747. |
previous studies suggest that potassium channel dysfunction underlies early abnormalities in cerebellar cortical purkinje neuron firing in sca3. |
2021-10-25 |
2023-08-13 |
mouse |
| Meike E van der Heijden, Elizabeth P Lackey, Ross Perez, Fatma S Ișleyen, Amanda M Brown, Sarah G Donofrio, Tao Lin, Huda Y Zoghbi, Roy V Sillito. Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons. eLife. vol 10. 2021-10-19. PMID:34542409. |
these data argue that excitatory cerebellar neurons define the maturation time-window for postnatal purkinje cell functions and refine cerebellar-dependent behaviors. |
2021-10-19 |
2023-08-13 |
mouse |
| Thien Timothy Hua, Julie Bejoy, Liqing Song, Zhe Wang, Ziwei Zeng, Yi Zhou, Yan Li, Qing-Xiang Amy San. Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways. Tissue engineering. Part A. vol 27. issue 13-14. 2021-10-15. PMID:32873223. |
different combinations of the morphogens (ra/chir, ra/pmr, chir/pmr, and ra/chir/pmr) were utilized, and the spheroids (day 35) were characterized for the markers of three cerebellum layers (the molecular layer, the purkinje cell layer, and the granule cell layer). |
2021-10-15 |
2023-08-13 |
human |
| Joshua J White, Laurens W J Bosman, Francois G C Blot, Catarina Osório, Bram W Kuppens, Wilhelmina H J J Krijnen, Charlotte Andriessen, Chris I De Zeeuw, Dick Jaarsma, Martijn Schonewill. Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1. Brain pathology (Zurich, Switzerland). vol 31. issue 5. 2021-10-13. PMID:33724582. |
our results show that, in a mouse model otherwise characterized by widespread purkinje cell degeneration, sparing of specific subpopulations is sufficient to maintain normal performance of specific behaviors within the context of the functional, modular map of the cerebellum. |
2021-10-13 |
2023-08-13 |
mouse |