Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Yuto Okuno, Kazuto Sakoori, Kyoko Matsuyama, Miwako Yamasaki, Masahiko Watanabe, Kouichi Hashimoto, Takaki Watanabe, Masanobu Kan. PTPδ is a presynaptic organizer for the formation and maintenance of climbing fiber to Purkinje cell synapses in the developing cerebellum. Frontiers in molecular neuroscience. vol 16. 2023-07-10. PMID:37426069. |
in the cerebellum of neonatal rodents, each purkinje cell (pc) receives synaptic inputs from multiple (more than 4) climbing fibers (cfs). |
2023-07-10 |
2023-08-14 |
mouse |
Haoran Huang, Vikram G Shakkotta. Targeting Ion Channels and Purkinje Neuron Intrinsic Membrane Excitability as a Therapeutic Strategy for Cerebellar Ataxia. Life (Basel, Switzerland). vol 13. issue 6. 2023-06-28. PMID:37374132. |
in this review, we propose that perturbations in cerebellar purkinje neuron intrinsic membrane excitability, a result of ion channel dysregulation, is a common pathophysiologic mechanism that drives motor impairment and vulnerability to degeneration in cerebellar ataxias of widely differing genetic etiologies. |
2023-06-28 |
2023-08-14 |
Not clear |
Micaela Lucarelli, Serena Camuso, Chiara Di Pietro, Francesco Bruno, Piergiorgio La Rosa, Daniela Marazziti, Maria Teresa Fiorenza, Sonia Canterin. Reduced Cerebellar BDNF Availability Affects Postnatal Differentiation and Maturation of Granule Cells in a Mouse Model of Cholesterol Dyshomeostasis. Molecular neurobiology. 2023-06-14. PMID:37314654. |
the prominent feature of the disorder is the progressive purkinje cell degeneration leading to ataxia.in a mouse model of npc1 disease, we have previously demonstrated that impaired sonic hedgehog signaling causes defective proliferation of granule cells (gcs) and abnormal cerebellar morphogenesis. |
2023-06-14 |
2023-08-14 |
mouse |
Xin-Tai Wang, Lin Zhou, Bin-Bin Dong, Fang-Xiao Xu, De-Juan Wang, En-Wei Shen, Xin-Yu Cai, Yin Wang, Na Wang, Sheng-Jian Ji, Wei Chen, Martijn Schonewille, J Julius Zhu, Chris I De Zeeuw, Ying She. cAMP-EPAC-PKCε-RIM1α signaling regulates presynaptic long-term potentiation and motor learning. eLife. vol 12. 2023-05-10. PMID:37159499. |
granule cell-specific blocking of epac-pkcε signaling abolishes presynaptic long-term potentiation at the parallel fiber to purkinje cell synapses and impairs basic performance and learning of cerebellar motor behavior. |
2023-05-10 |
2023-08-14 |
mouse |
Yang Liu, Li-Xin Cao, Wei-Yao Wang, Yong-Rui Piao, Jun-Ya Wang, Chun-Ping Chu, Yan-Hua Bing, De-Lai Qi. GLP-1 enhances hyperpolarization-activated currents of mouse cerebellar Purkinje cell Frontiers in molecular neuroscience. vol 16. 2023-04-24. PMID:37089690. |
in the cerebellar cortex, glp-1 receptor is abundantly expressed in the molecular layer, purkinje cell (pc) layer and granular layer, indicating that glp-1 may modulate the cerebellar neuronal activity. |
2023-04-24 |
2023-08-14 |
mouse |
An Cheng, Ichiro Kawahata, Yifei Wang, Wenbin Jia, Wang Haoyang, Tomoki Sekimori, Yi Chen, Hiroyoshi Suzuki, Atsushi Takeda, Nadia Stefanova, David I Finkelstein, Wenbo Ma, Min Chen, Takuya Sasaki, Kohji Fukunag. Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation. Brain : a journal of neurology. 2023-04-21. PMID:37082980. |
lastly, aav5-dependent epsin-2 knock-down mice exhibited decreased levels of αsyn aggregate accumulation in purkinje neurons and oligodendrocytes, as well as improved myelin levels and purkinje neuron function in the cerebellum and motor performance. |
2023-04-21 |
2023-08-14 |
mouse |
Yaroslav Kolinko, Milena Kralickova, Jan Cendeli. Reduction of Microvessel Number and Length in the Cerebellum of Purkinje Cell Degeneration Mice. Cerebellum (London, England). 2023-04-18. PMID:37071329. |
reduction of microvessel number and length in the cerebellum of purkinje cell degeneration mice. |
2023-04-18 |
2023-08-14 |
mouse |
Yaroslav Kolinko, Milena Kralickova, Jan Cendeli. Reduction of Microvessel Number and Length in the Cerebellum of Purkinje Cell Degeneration Mice. Cerebellum (London, England). 2023-04-18. PMID:37071329. |
in this study, we compared the vascularity of the individual cerebellar components of 3-month-old wild-type mice (n = 8) and purkinje cell degeneration (pcd) mutant mice, which represent a model of hereditary cerebellar degeneration (n = 8). |
2023-04-18 |
2023-08-14 |
mouse |
Sol Pose-Méndez, Paul Schramm, Barbara Winter, Jochen C Meier, Konstantinos Ampatzis, Reinhard W Köste. Lifelong regeneration of cerebellar Purkinje cells after induced cell ablation in zebrafish. eLife. vol 12. 2023-04-12. PMID:37042514. |
however, regeneration of the principal neuron of the evolutionary conserved cerebellum, the purkinje cell (pc), is believed to be limited to developmental stages based on invasive lesions. |
2023-04-12 |
2023-08-14 |
zebrafish |
Sarmad Hayder Weli Weli, Ahmad Yahyazade. Neuroprotective potential of Ginkgo biloba on alteration of rat cerebellum following prenatal exposure to cyclophosphamide. Journal of chemical neuroanatomy. vol 130. 2023-03-29. PMID:36989922. |
in the sk + gb group, the total number purkinje cell, and granular cells, as well as the mean volumes of molecular layer, granular layer, white matter, and cerebellum were significantly increased than the sk group (p < 0.05). |
2023-03-29 |
2023-08-14 |
rat |
Hoda Ranjbar, Monavareh Soti, Kristi A Kohlmeier, Mahyar Janahmadi, Mohammad Shaban. Pharmacologic antagonism of CB1 receptors improves electrophysiological alterations in Purkinje cells exposed to 3-AP. BMC neuroscience. vol 24. issue 1. 2023-03-03. PMID:36869289. |
although ataxia is associated with cerebellar dysfunction, little is known about the effects of 3-ap exposure on purkinje cell electrophysiological properties. |
2023-03-03 |
2023-08-14 |
Not clear |
Felicity R Sterling, Jon D'Amico, Alexandria M Brumfield, Kara L Huegel, Patricia S Vaughan, Kathryn Morris, Shelby Schwarz, Michelle V Joyce, Bill Boggess, Matthew M Champion, Kevin Maciuba, Philip Allen, Eric Marasco, Grant Koch, Peter Gonzalez, Shannon Hodges, Shannon Leahy, Erica Gerstbauer, Edward H Hinchcliffe, Kevin T Vaugha. StARD9 is a novel lysosomal kinesin required for membrane tubulation, cholesterol transport and Purkinje cell survival. Journal of cell science. vol 136. issue 5. 2023-03-02. PMID:36861884. |
the pathological accumulation of cholesterol is a signature feature of niemann-pick type c (npc) disease, in which excessive lipid levels induce purkinje cell death in the cerebellum. |
2023-03-02 |
2023-08-14 |
mouse |
David J Herzfeld, Mati Joshua, Stephen G Lisberge. Rate versus synchrony codes for cerebellar control of motor behavior. bioRxiv : the preprint server for biology. 2023-02-24. PMID:36824885. |
simultaneous recordings from purkinje cell pairs in the cerebellar flocculus of rhesus macaques revealed how these cells coordinate their activity to drive smooth pursuit eye movements. |
2023-02-24 |
2023-08-14 |
Not clear |
Fabrice Faure, Lidia Yshii, Toufic Renno, Isabelle Coste, Bastien Joubert, Virginie Desestret, Roland Liblau, Jérôme Honnora. A Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model. Cerebellum (London, England). 2023-02-02. PMID:36729270. |
ataxia and gait instability were assessed in treated mice as well as autoantibody levels, purkinje cell density, and immune infiltration in the cerebellum. |
2023-02-02 |
2023-08-14 |
mouse |
Audrey Bonnan, Ke Zhang, Michael A Gaffield, Jason M Christi. Expression of a form of cerebellar motor memory requires learned alterations to the activity of inhibitory molecular layer interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2023-01-14. PMID:36639897. |
procedural memories formed in the cerebellum in response to motor errors depend on changes to purkinje cell (pc) spiking patterns that correct movement when the erroneous context is repeated. |
2023-01-14 |
2023-08-14 |
mouse |
Ling-Ge Cui, Lin Liu, Mu-Zi Li, Yu Zhu, Xiang-Yu Ma, Xue-Nan Li, Jin-Long L. Phthalate induces mitochondrial injury in cerebellum through Sirt1-PGC-1α and PINK1/Parkin-mediated signal pathways. Life sciences. 2023-01-09. PMID:36623767. |
in present study, we set dehp-caused cerebellar injury models of quail and implied that dehp induced cerebellar dysplasia by abnormity of purkinje cell and reduction of cerebellar granule cell. |
2023-01-09 |
2023-08-14 |
Not clear |
Mireia Ortega, Ilario De Toma, Álvaro Fernández-Blanco, Anna Calderón, Lucía Barahona, Ramón Trullàs, Eduard Sabidó, Mara Diersse. Proteomic profiling reveals mitochondrial dysfunction in the cerebellum of transgenic mice overexpressing DYRK1A, a Down syndrome candidate gene. Frontiers in molecular neuroscience. vol 15. 2023-01-02. PMID:36590914. |
dyrk1a has also been implicated in cerebellar abnormalities observed in association with ds, and normalization of dyrk1a dosage rescues granular and purkinje cell densities in a trisomic ds mouse model. |
2023-01-02 |
2023-08-14 |
mouse |
Jonathan Mapelli, Giulia Maria Boiani, Egidio D'Angelo, Albertino Bigiani, Daniela Gandolf. Long-Term Synaptic Plasticity Tunes the Gain of Information Channels through the Cerebellum Granular Layer. Biomedicines. vol 10. issue 12. 2022-12-23. PMID:36551941. |
thus, akin with the expansion recoding process theoretically attributed to the cerebellum granular layer, ltp and ltd could implement selective filtering lines channeling information toward the molecular and purkinje cell layers for further processing. |
2022-12-23 |
2023-08-14 |
Not clear |
A Barri, M T Wiechert, M Jazayeri, D A DiGregori. Synaptic basis of a sub-second representation of time in a neural circuit model. Nature communications. vol 13. issue 1. 2022-12-22. PMID:36550115. |
a cerebellar circuit model equipped with dynamic synapses produced a diverse set of transient granule cell firing patterns that provided a temporal basis set for learning precisely timed pauses in purkinje cell activity during simulated delay eyelid conditioning and bayesian interval estimation. |
2022-12-22 |
2023-08-14 |
Not clear |
Asha Vijayan, Shyam Diwaka. A cerebellum inspired spiking neural network as a multi-model for pattern classification and robotic trajectory prediction. Frontiers in neuroscience. vol 16. 2022-12-15. PMID:36518530. |
in the current work, a cerebellum-inspired spiking neural network with dynamics of cerebellar neurons and learning mechanisms attributed to the granular layer, purkinje cell (pc) layer, and cerebellar nuclei interconnected by excitatory and inhibitory synapses was implemented. |
2022-12-15 |
2023-08-14 |
Not clear |