| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niccolò E Mencacci, Marisa M Brockmann, Jinye Dai, Sander Pajusalu, Burcu Atasu, Joaquin Campos, Gabriela Pino, Paulina Gonzalez-Latapi, Christopher Patzke, Michael Schwake, Arianna Tucci, Alan Pittman, Javier Simon-Sanchez, Gemma L Carvill, Bettina Balint, Sarah Wiethoff, Thomas T Warner, Apostolos Papandreou, Audrey Soo, Reet Rein, Liis Kadastik-Eerme, Sanna Puusepp, Karit Reinson, Tiiu Tomberg, Hasmet Hanagasi, Thomas Gasser, Kailash P Bhatia, Manju A Kurian, Ebba Lohmann, Katrin Õunap, Christian Rosenmund, Thomas C Südhof, Nicholas W Wood, Dimitri Krainc, Claudio Acun. Biallelic variants in TSPOAP1, encoding the active-zone protein RIMBP1, cause autosomal recessive dystonia. The Journal of clinical investigation. vol 131. issue 7. 2021-09-28. PMID:33539324. |
in mice, complete loss of rimbp1, known to reduce neurotransmission, led to motor abnormalities reminiscent of dystonia, decreased purkinje cell dendritic arborization, and reduced numbers of cerebellar synapses. |
2021-09-28 |
2023-08-13 |
mouse |
| Aaron Sathyanesan, Panagiotis Kratimenos, Vittorio Gall. Disruption of neonatal Purkinje cell function underlies injury-related learning deficits. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 11. 2021-09-23. PMID:33688045. |
using a novel integration of gcamp6f fiber photometry with automated measurement of cerebellar behavior using the erasmusladder, we causally link cerebellar injury to altered purkinje cell responses during maladaptive behavior. |
2021-09-23 |
2023-08-13 |
Not clear |
| Felipe Cunha, Cristian Gutiérrez-Ibáñez, Kelsey Racicot, Douglas R Wylie, Andrew N Iwaniu. A quantitative analysis of cerebellar anatomy in birds. Brain structure & function. vol 226. issue 8. 2021-09-20. PMID:34357439. |
our estimate of cerebellar folding, the midsagittal foliation index, was a poor predictor of surface area and number of purkinje cells, but surface area was the best predictor of purkinje cell numbers. |
2021-09-20 |
2023-08-13 |
Not clear |
| Foluso A Atiba, Amos A Fatokun, Innocent O Imosemi, Adefolarin O Malom. Kola nut from Cola nitida vent. Schott administered to pregnant rats induces histological alterations in pups' cerebellum. PloS one. vol 16. issue 3. 2021-09-13. PMID:33684143. |
paraffin sections of the cerebellum were stained with haematoxylin and eosin for cerebellar cytoarchitecture, cresyl violet stain for purkinje cell count, glial fibrillary acidic protein (gfap) immunohistochemistry (ihc) for estimation of gliosis, and b-cell lymphoma 2 (bcl-2) ihc for apoptosis induction. |
2021-09-13 |
2023-08-13 |
human |
| Madeline Garza, Amanda L Pique. Update in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia. Frontiers in neurology. vol 12. 2021-09-08. PMID:34489848. |
some of the first autoantibodies identified against antigen targets include anti-neuronal nuclear antibody type 1 (anna-1 or anti-hu) and purkinje cell cytoplasmic antibody (pca-1) also known as anti-yo have been identified in paraneoplastic cerebellar degeneration. |
2021-09-08 |
2023-08-13 |
Not clear |
| Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Ya. Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum. Ecotoxicology and environmental safety. vol 224. 2021-09-07. PMID:34450424. |
the results of hematoxylin and eosin and nissl staining indicated that acr impaired the structures of all three layers of the cerebellum, especially the purkinje cell layer, showing abnormal morphology with nucleus condensation and pyknosis. |
2021-09-07 |
2023-08-13 |
human |
| Ravi Chopra, David D Bushart, John P Cooper, Dhananjay Yellajoshyula, Logan M Morrison, Haoran Huang, Hillary P Handler, Luke J Man, Warunee Dansithong, Daniel R Scoles, Stefan M Pulst, Harry T Orr, Vikram G Shakkotta. Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32964235. |
atxn1[82q] purkinje neurons from the anterior cerebellum were found to degenerate earlier than those from the nodular zone, and this early degeneration was associated with selective dysregulation of ion channel transcripts and altered purkinje neuron spiking. |
2021-08-30 |
2023-08-13 |
Not clear |
| Astrid Buchberger, Lena Schepergerdes, Maren Flaßhoff, Conrad Kunick, Reinhard W Köste. A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression. The Journal of biological chemistry. vol 297. issue 1. 2021-08-26. PMID:34090874. |
this impaired purkinje cell organization was progressive, leading to an age-dependent dispersal of purkinje neurons throughout the cerebellar molecular layer with larval swim deficits resulting in miscoordination of swimming and reduced exploratory behavior in aged adults. |
2021-08-26 |
2023-08-13 |
human |
| Anastasia Rumyantseva, Elisa Motori, Aleksandra Trifunovi. DARS2 is indispensable for Purkinje cell survival and protects against cerebellar ataxia. Human molecular genetics. vol 29. issue 17. 2021-08-24. PMID:32766765. |
we used conditional purkinje cell (pcs)-specific dars2 deletion to elucidate further the cell-type-specific contribution of this class of neurons to the cerebellar impairment observed in lbsl. |
2021-08-24 |
2023-08-13 |
Not clear |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
utilizing the non-human primate baboon cerebellum, we investigated purkinje cell development during the last trimester of pregnancy and the effect of nicu experience following premature birth on developmental features of purkinje cells. |
2021-08-21 |
2023-08-13 |
human |
| Tara Barron, Jun Hee Ki. Preterm Birth Impedes Structural and Functional Development of Cerebellar Purkinje Cells in the Developing Baboon Cerebellum. Brain sciences. vol 10. issue 12. 2021-08-21. PMID:33255158. |
in addition, these alterations impact purkinje cell output, reducing the spontaneous firing frequency in deep cerebellar nucleus (dcn) neurons. |
2021-08-21 |
2023-08-13 |
human |
| Marco Canepar. Is Purkinje Neuron Hyperpolarisation Important for Cerebellar Synaptic Plasticity? A Retrospective and Prospective Analysis. Cerebellum (London, England). vol 19. issue 6. 2021-08-19. PMID:32654026. |
is purkinje neuron hyperpolarisation important for cerebellar synaptic plasticity? |
2021-08-19 |
2023-08-13 |
Not clear |
| Margherita De Silva, Javad Sadeghinezhad, Jens R Nyengaard, Mahdi Aghabalazadeh Asl, Ava Saeidi, Nadia De Sordi, Roberto Chiocchetti, Annamaria Grandi. Design-based stereological study of the guinea-pig (Cavia porcellus) cerebellum. Journal of anatomy. vol 239. issue 2. 2021-08-18. PMID:33763861. |
cerebellar total volume, gray and white matter volume fractions, molecular and granular layers volume fractions, cerebellar surface area, purkinje cellular and nuclear volumes, and the purkinje cell total count were stereologically estimated. |
2021-08-18 |
2023-08-13 |
human |
| Margherita De Silva, Javad Sadeghinezhad, Jens R Nyengaard, Mahdi Aghabalazadeh Asl, Ava Saeidi, Nadia De Sordi, Roberto Chiocchetti, Annamaria Grandi. Design-based stereological study of the guinea-pig (Cavia porcellus) cerebellum. Journal of anatomy. vol 239. issue 2. 2021-08-18. PMID:33763861. |
the cerebellar surface area was estimated through the use of test lines; purkinje cellular and nuclear volumes were analysed using the nucleator technique, whereas the purkinje cell total count was obtained by means of the optical disector technique. |
2021-08-18 |
2023-08-13 |
human |
| Anton N Shuvaev, Olga S Belozor, Oleg I Mozhei, Elena D Khilazheva, Andrey N Shuvaev, Yana V Fritsler, S Kasparo. Protective Effect of Memantine on Bergmann Glia and Purkinje Cells Morphology in Optogenetic Model of Neurodegeneration in Mice. International journal of molecular sciences. vol 22. issue 15. 2021-08-16. PMID:34360588. |
here we induced reactive transformation of cerebellar bergmann glia (bg) using this novel optogenetic approach and tested whether memantine could counteract changes in bg and purkinje cell (pc) morphology and expression of the main glial glutamate transporter-excitatory amino acid transporter 1 (eaat1). |
2021-08-16 |
2023-08-13 |
mouse |
| Jan Voog. The Theories of Gerbrandus Jelgersma (1859-1942) on the Function of the Cerebellum. Cerebellum (London, England). 2021-08-12. PMID:34383219. |
both afferent systems of the cerebellum, the mossy fiber-parallel fiber system and the climbing fibers terminate on the purkinje cell dendrites. |
2021-08-12 |
2023-08-13 |
Not clear |
| Jan Voog. The Theories of Gerbrandus Jelgersma (1859-1942) on the Function of the Cerebellum. Cerebellum (London, England). 2021-08-12. PMID:34383219. |
when the purkinje cell compares these inputs and notices a difference between instruction and execution, it sends a correction through the descending limb of the superior cerebellar peduncle to the anterior horn cells. |
2021-08-12 |
2023-08-13 |
Not clear |
| Ryaan El-Andari, Felipe Cunha, Barbara Tschirren, Andrew N Iwaniu. Selection for Divergent Reproductive Investment Affects Neuron Size and Foliation in the Cerebellum. Brain, behavior and evolution. vol 95. issue 2. 2021-08-10. PMID:32784306. |
purkinje cell size and cerebellar foliation did not significantly covary with any cerebellar measures, but differed significantly between the selection lines. |
2021-08-10 |
2023-08-13 |
Not clear |
| Ryaan El-Andari, Felipe Cunha, Barbara Tschirren, Andrew N Iwaniu. Selection for Divergent Reproductive Investment Affects Neuron Size and Foliation in the Cerebellum. Brain, behavior and evolution. vol 95. issue 2. 2021-08-10. PMID:32784306. |
these results suggest that within species, the layers of the cerebellum increase in a coordinated fashion, but purkinje cell size and cerebellar foliation do not increase proportionally with overall cerebellum size. |
2021-08-10 |
2023-08-13 |
Not clear |
| Ryaan El-Andari, Felipe Cunha, Barbara Tschirren, Andrew N Iwaniu. Selection for Divergent Reproductive Investment Affects Neuron Size and Foliation in the Cerebellum. Brain, behavior and evolution. vol 95. issue 2. 2021-08-10. PMID:32784306. |
in contrast, selection for differential reproductive investment affects purkinje cell size and cerebellar foliation, but not other quantitative measures of cerebellar anatomy. |
2021-08-10 |
2023-08-13 |
Not clear |