| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ilona Klejbor, Saleh Mahmood, Natalia Melka, Adriana Ebertowska, Janusz Morys, Ewa K Stachowiak, Michal K Stachowiak, Mulchand S Pate. Phenylbutyrate administration reduces changes in the cerebellar Purkinje cells population in PDC‑deficient mice. Acta neurobiologiae experimentalis. vol 80. issue 3. 2021-08-04. PMID:32990288. |
in contrast, administration of phenylbutyrate variably lessened the ill effects of pdc deficiency on purkinje cell populations in different areas of the cerebellum. |
2021-08-04 |
2023-08-13 |
mouse |
| Carrie Sheeler, Juao-Guilherme Rosa, Ella Borgenheimer, Aaron Mellesmoen, Orion Rainwater, Marija Cvetanovi. Post-symptomatic Delivery of Brain-Derived Neurotrophic Factor (BDNF) Ameliorates Spinocerebellar Ataxia Type 1 (SCA1) Pathogenesis. Cerebellum (London, England). vol 20. issue 3. 2021-07-31. PMID:33394333. |
expression of brain-derived neurotrophic factor (bdnf), growth factor important for the survival and function of cerebellar neurons, is decreased in atxn1[82q] mice, the purkinje neuron specific transgenic mouse model of sca1. |
2021-07-31 |
2023-08-13 |
mouse |
| Qinji Zhou, Jingwen Qin, Yaying Liang, Wei Zhang, Siyuan He, Fadel Tissir, Yibo Qu, Libing Zho. Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity. iScience. vol 24. issue 7. 2021-07-27. PMID:34308297. |
celsr3 is required for purkinje cell maturation and regulates cerebellar postsynaptic plasticity. |
2021-07-27 |
2023-08-13 |
Not clear |
| Daneck Lang-Ouellette, Kim M Gruver, Amy Smith-Dijak, François G C Blot, Chloe A Stewart, Pauline de Vanssay de Blavous, Connie H Li, Carter Van Eitrem, Charlotte Rosen, Phyllis L Faust, Martijn Schonewille, Alanna J Wat. Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function. Nature communications. vol 12. issue 1. 2021-07-26. PMID:34226561. |
purkinje cell axonal swellings enhance action potential fidelity and cerebellar function. |
2021-07-26 |
2023-08-13 |
mouse |
| Daneck Lang-Ouellette, Kim M Gruver, Amy Smith-Dijak, François G C Blot, Chloe A Stewart, Pauline de Vanssay de Blavous, Connie H Li, Carter Van Eitrem, Charlotte Rosen, Phyllis L Faust, Martijn Schonewille, Alanna J Wat. Purkinje cell axonal swellings enhance action potential fidelity and cerebellar function. Nature communications. vol 12. issue 1. 2021-07-26. PMID:34226561. |
axonal swellings have been found on purkinje cell axons in the cerebellum both in healthy development and in neurodegenerative diseases, and computational models predicts that axonal swellings impair axonal function. |
2021-07-26 |
2023-08-13 |
mouse |
| Min-Min Lou, Xiao-Qiang Tang, Guang-Ming Wang, Jia He, Fang Luo, Ming-Feng Guan, Fei Wang, Huan Zou, Jun-Ying Wang, Qun Zhang, Ming-Jian Xu, Qi-Li Shi, Li-Bing Shen, Guo-Ming Ma, Yi Wu, Yao-Yang Zhang, Ai-Bin Liang, Ting-Hua Wang, Liu-Lin Xiong, Jian Wang, Jun Xu, Wen-Yuan Wan. Long noncoding RNA BS-DRL1 modulates the DNA damage response and genome stability by interacting with HMGB1 in neurons. Nature communications. vol 12. issue 1. 2021-07-22. PMID:34210972. |
bs-drl1 mediated ddr exhibits cell-type specificity in the cortex and cerebellum in gamma-irradiated mice and bs-drl1 knockout mice show impaired motor function and concomitant purkinje cell degeneration. |
2021-07-22 |
2023-08-13 |
mouse |
| Esther Suk King Lai, Hisako Nakayama, Taisuke Miyazaki, Takanobu Nakazawa, Katsuhiko Tabuchi, Kouichi Hashimoto, Masahiko Watanabe, Masanobu Kan. An Autism-Associated Neuroligin-3 Mutation Affects Developmental Synapse Elimination in the Cerebellum. Frontiers in neural circuits. vol 15. 2021-07-16. PMID:34262438. |
functional magnetic resonance imaging and examination of post-mortem brain in asd patients implicate alteration of cerebellar morphology and purkinje cell (pc) loss. |
2021-07-16 |
2023-08-13 |
mouse |
| Sabine C Winkler, Etsuko Shimobayashi, Josef P Kapfhamme. PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32860158. |
in a transgenic mouse model of sca14 expressing the human s361g mutation, purkinje cell dendritic development is impaired in cerebellar slice cultures similar to pharmacological activation of pkc. |
2021-07-01 |
2023-08-13 |
mouse |
| Sabine C Winkler, Etsuko Shimobayashi, Josef P Kapfhamme. PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells. Molecular neurobiology. vol 57. issue 12. 2021-07-01. PMID:32860158. |
mirna-mediated crmp2 knockdown decreased purkinje cell dendritic outgrowth in dissociated cerebellar cultures as did the transfection of crmp2 mutants with a modified thr555 site. |
2021-07-01 |
2023-08-13 |
mouse |
| Khoa Tran-Anh, Jingyun Zhang, Viet Tuan Nguyen-Minh, Hirofumi Fujita, Tatsumi Hirata, Izumi Sugihar. Common Origin of the Cerebellar Dual Somatotopic Areas Revealed by Tracking Embryonic Purkinje Cell Clusters with Birthdate Tagging. eNeuro. vol 7. issue 6. 2021-06-18. PMID:33055198. |
common origin of the cerebellar dual somatotopic areas revealed by tracking embryonic purkinje cell clusters with birthdate tagging. |
2021-06-18 |
2023-08-13 |
Not clear |
| Khoa Tran-Anh, Jingyun Zhang, Viet Tuan Nguyen-Minh, Hirofumi Fujita, Tatsumi Hirata, Izumi Sugihar. Common Origin of the Cerebellar Dual Somatotopic Areas Revealed by Tracking Embryonic Purkinje Cell Clusters with Birthdate Tagging. eNeuro. vol 7. issue 6. 2021-06-18. PMID:33055198. |
as developing pcs guide formation of the module-specific proper neuronal circuits in the cerebellum, we hypothesized that the rearrangement of embryonic purkinje cell (pc) clusters shapes the adult cerebellar compartmentalization. |
2021-06-18 |
2023-08-13 |
Not clear |
| Cristián Gutiérrez-Ibáñez, Max R Dannish, Tobias Kohl, Lutz Kettler, Catherine E Carr, Ryan K Tisdale, Andrew N Iwaniuk, Harald Luksch, Douglas R Wyli. Zebrin Expression in the Cerebellum of Two Crocodilian Species. Brain, behavior and evolution. vol 95. issue 1. 2021-06-15. PMID:32155640. |
orthogonal to the lobules, the cerebellum is comprised of sagittal zones that are revealed in the pattern of afferent inputs, the projection patterns of purkinje cells, and purkinje cell response properties, among other features. |
2021-06-15 |
2023-08-13 |
Not clear |
| D González-Tapia, M M González-Ramírez, N Vázquez-Hernández, I González-Burgo. Motor learning induces plastic changes in Purkinje cell dendritic spines in the rat cerebellum. Neurologia (Barcelona, Spain). vol 35. issue 7. 2021-06-14. PMID:29249302. |
motor learning induces plastic changes in purkinje cell dendritic spines in the rat cerebellum. |
2021-06-14 |
2023-08-13 |
rat |
| Yurie Rai, Takaki Watanabe, Kyoko Matsuyama, Kenji Sakimura, Naofumi Uesaka, Masanobu Kan. Phospholipase C β3 is Required for Climbing Fiber Synapse Elimination in Aldolase C-positive Compartments of the Developing Mouse Cerebellum. Neuroscience. vol 462. 2021-05-14. PMID:32360594. |
in the cerebellum of neonatal mice, multiple climbing fibers (cfs) form excitatory synapses on each purkinje cell (pc). |
2021-05-14 |
2023-08-13 |
mouse |
| Stephen G Lisberge. The Rules of Cerebellar Learning: Around the Ito Hypothesis. Neuroscience. vol 462. 2021-05-14. PMID:32866603. |
(1) climbing fiber inputs to the cerebellum drive early, fast, poorly-retained learning in the parallel fiber to purkinje cell synapse. |
2021-05-14 |
2023-08-13 |
monkey |
| Stephen G Lisberge. The Rules of Cerebellar Learning: Around the Ito Hypothesis. Neuroscience. vol 462. 2021-05-14. PMID:32866603. |
(2) learned purkinje cell outputs drive late, slow, well-retained learning in non-purkinje cell inputs to neurons in the cerebellar nucleus, transferring learning from the cortex to the nucleus. |
2021-05-14 |
2023-08-13 |
monkey |
| Jinya Soga, Masayuki Matsuyama, Hiroaki Miura, Stephen Highstein, Robert Baker, Yutaka Hirat. Cerebellar Roles in Frequency Competitive Motor Learning of the Vestibulo-ocular Reflex. Neuroscience. vol 462. 2021-05-14. PMID:32946949. |
these results demonstrate that the cerebellum is required for all frequency competitive vor motor learning and purkinje cell activity therein is well correlated with all gain-down behaviors independent of frequency. |
2021-05-14 |
2023-08-13 |
Not clear |
| Jinsook Kim, George J Augustin. Molecular Layer Interneurons: Key Elements of Cerebellar Network Computation and Behavior. Neuroscience. vol 462. 2021-05-14. PMID:33075461. |
molecular layer interneurons (mlis) play an important role in cerebellar information processing by controlling purkinje cell (pc) activity via inhibitory synaptic transmission. |
2021-05-14 |
2023-08-13 |
Not clear |
| Adi Lixenberg, Merav Yarkoni, Yehudit Botschko, Mati Joshu. Encoding of eye movements explains reward-related activity in cerebellar simple spikes. Journal of neurophysiology. vol 123. issue 2. 2021-05-12. PMID:31940216. |
to test how reward-related signals interact with sensorimotor processing in the cerebellum, we recorded purkinje cell simple spike activity in the cerebellar floccular complex while monkeys were engaged in smooth pursuit eye movement tasks. |
2021-05-12 |
2023-08-13 |
monkey |
| Chia-Wei Lin, Chia-Hao Fan, Ya-Chin Chang, Hsiu Mei Hsieh-L. ERK activation precedes Purkinje cell loss in mice with Spinocerebellar ataxia type 17. Neuroscience letters. vol 738. 2021-04-30. PMID:32877710. |
the levels of perk, calbindin, and gliosis markers on the mouse cerebellum at 4-8 weeks old were analyzed to elucidate the correlation among behavioral performance, erk activation and purkinje cell degeneration. |
2021-04-30 |
2023-08-13 |
mouse |