| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iulia Craciun, Cristián Gutiérrez-Ibáñez, Jeremy R Corfield, Peter L Hurd, Douglas R Wyli. Topographic Organization of Inferior Olive Projections to the Zebrin II Stripes in the Pigeon Cerebellar Uvula. Frontiers in neuroanatomy. vol 12. 2020-09-30. PMID:29599710. |
as in other areas of the cerebellum, the uvula is organized into sagittal zones, which is apparent with respect to afferent inputs, the projection patterns of purkinje cell (pc) efferents, the response properties of pcs and the expression of molecular markers such as zebrin ii (zii). |
2020-09-30 |
2023-08-13 |
pigeon |
| Zhenfei Ning, John M Williams, Romika Kumari, Pavel V Baranov, Tom Moor. Opposite Expression Patterns of Frontiers in psychiatry. vol 10. 2020-09-30. PMID:31275178. |
cerebellar abnormalities, including purkinje cell deficits in the vermis, are consistently reported, and rodent models of cerebellar dysfunction exhibit features analogous to human autism. |
2020-09-30 |
2023-08-13 |
human |
| Xinyu Hao, Shuangming Yang, Jiang Wang, Bin Deng, Xile Wei, Guosheng Y. Efficient Implementation of Cerebellar Purkinje Cell With the CORDIC Algorithm on LaCSNN. Frontiers in neuroscience. vol 13. 2020-09-30. PMID:31680818. |
purkinje cell is an important neuron for the cerebellar information processing. |
2020-09-30 |
2023-08-13 |
Not clear |
| Chuck T Chen, Joseph A Schultz, Sophie E Haven, Breanne Wilhite, Chi-Hsiu Liu, Jing Chen, Joseph R Hibbel. Loss of RAR-related orphan receptor alpha (RORα) selectively lowers docosahexaenoic acid in developing cerebellum. Prostaglandins, leukotrienes, and essential fatty acids. vol 152. 2020-09-30. PMID:31835092. |
deficiency in retinoid acid receptor-related orphan receptor alpha (rorα) of staggerer mice results in extensive granule and purkinje cell loss in the cerebellum as well as in learned motor deficits, cognition impairments and perseverative tendencies that are commonly observed in autistic spectrum disorder (asd). |
2020-09-30 |
2023-08-13 |
mouse |
| David E Buchholz, Thomas S Carroll, Arif Kocabas, Xiaodong Zhu, Hourinaz Behesti, Phyllis L Faust, Lauren Stalbow, Yin Fang, Mary E Hatte. Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 26. 2020-09-30. PMID:32546527. |
to analyze human purkinje cell (pc) differentiation, we optimized a protocol to generate human pluripotent stem cell-derived purkinje cells (hpsc-pcs) that formed synapses when cultured with mouse cerebellar glia and granule cells and fired large calcium currents, measured with the genetically encoded calcium indicator jrgeco1a. |
2020-09-30 |
2023-08-13 |
mouse |
| Ludovic Galas, Magalie Bénard, Alexis Lebon, Yutaro Komuro, Damien Schapman, Hubert Vaudry, David Vaudry, Hitoshi Komur. Postnatal Migration of Cerebellar Interneurons. Brain sciences. vol 7. issue 6. 2020-09-29. PMID:28587295. |
the combination of fluorescent labeling and ex/in vivo imaging revealed a cellular highway network within cerebellar cortical layers (the external granular layer, the molecular layer, the purkinje cell layer, and the internal granular layer). |
2020-09-29 |
2023-08-13 |
Not clear |
| Romain Helleringer, Oana Chever, Hervé Daniel, Micaela Galant. Oxygen and Glucose Deprivation Induces Bergmann Glia Membrane Depolarization and Ca Frontiers in cellular neuroscience. vol 11. 2020-09-29. PMID:29163059. |
in the cerebellum, glutamate is the principal mediator of purkinje neuron anoxic depolarization during episodes of oxygen and glucose deprivation (ogd). |
2020-09-29 |
2023-08-13 |
Not clear |
| Jaime Moreira Pires, Maira Licia Foresti, Clivandir Severino Silva, Débora Bandeira Rêgo, Michele Longoni Calió, Amanda Cristina Mosini, Thabatta Karollynne Estevam Nakamura, Ana Teresa F Leslie, Luiz Eugênio Mell. Lipopolysaccharide-Induced Systemic Inflammation in the Neonatal Period Increases Microglial Density and Oxidative Stress in the Cerebellum of Adult Rats. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32581717. |
the cerebellum was evaluated for different parameters: microglial and purkinje cell densities, oxidative stress levels, and tumor necrosis factor alpha (tnf-α) mrna expression. |
2020-09-28 |
2023-08-13 |
human |
| Jaime Moreira Pires, Maira Licia Foresti, Clivandir Severino Silva, Débora Bandeira Rêgo, Michele Longoni Calió, Amanda Cristina Mosini, Thabatta Karollynne Estevam Nakamura, Ana Teresa F Leslie, Luiz Eugênio Mell. Lipopolysaccharide-Induced Systemic Inflammation in the Neonatal Period Increases Microglial Density and Oxidative Stress in the Cerebellum of Adult Rats. Frontiers in cellular neuroscience. vol 14. 2020-09-28. PMID:32581717. |
stereological analyses indicated increased microglial density in the cerebellum that was not accompanied by purkinje cell loss or altered tnf-α expression in adult animals. |
2020-09-28 |
2023-08-13 |
human |
| Lauren N Miterko, Joshua J White, Tao Lin, Amanda M Brown, Kevin J O'Donovan, Roy V Sillito. Persistent motor dysfunction despite homeostatic rescue of cerebellar morphogenesis in the Car8 waddles mutant mouse. Neural development. vol 14. issue 1. 2020-09-18. PMID:30867000. |
accordingly, disrupting purkinje cell development impairs cerebellar morphogenesis and motor function. |
2020-09-18 |
2023-08-13 |
mouse |
| Clévio Nóbrega, Liliana Mendonça, Adriana Marcelo, Antonin Lamazière, Sandra Tomé, Gaetan Despres, Carlos A Matos, Fatich Mechmet, Dominique Langui, Wilfred den Dunnen, Luis Pereira de Almeida, Nathalie Cartier, Sandro Alve. Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia. Acta neuropathologica. vol 138. issue 5. 2020-09-15. PMID:31197505. |
in particular, improvement in purkinje cell number and reduction of cerebellar atrophy are observed in aavrh10-cyp46a1-treated mice. |
2020-09-15 |
2023-08-13 |
mouse |
| Weipang Chang, Andrea Pedroni, Victoria Hohendorf, Stefania Giacomello, Masahiko Hibi, Reinhard W Köster, Konstantinos Ampatzi. Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 29. 2020-09-14. PMID:32632015. |
dual patch-clamp recordings showed that the cerebellar circuit contains all purkinje cell types that cross-communicate extensively using chemical and electrical synapses. |
2020-09-14 |
2023-08-13 |
zebrafish |
| Weipang Chang, Andrea Pedroni, Victoria Hohendorf, Stefania Giacomello, Masahiko Hibi, Reinhard W Köster, Konstantinos Ampatzi. Functionally distinct Purkinje cell types show temporal precision in encoding locomotion. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 29. 2020-09-14. PMID:32632015. |
thus, we show intricately organized purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions. |
2020-09-14 |
2023-08-13 |
zebrafish |
| Wolfgang Wagner, Kristina Lippmann, Frank F Heisler, Kira V Gromova, Franco L Lombino, Mona K Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R Schwarz, Jens Eilers, Matthias Kneusse. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell reports. vol 28. issue 1. 2020-08-27. PMID:31269433. |
we find that myosin vi localizes at cerebellar parallel fiber to purkinje cell synapses and that the myosin is indispensable for long-term depression of ampa-receptor-mediated synaptic signal transmission at this synapse. |
2020-08-27 |
2023-08-13 |
Not clear |
| Vanessa Hull, Yan Wang, Travis Burns, Sheng Zhang, Sarah Sternbach, Jennifer McDonough, Fuzheng Guo, David Pleasur. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Annals of neurology. vol 87. issue 3. 2020-08-03. PMID:31925837. |
we now demonstrate that inhibiting naa synthesis by intracisternal administration of a locked nucleic acid antisense oligonucleotide to young-adult aspartoacylase-deficient mice reverses their pre-existing ataxia and diminishes cerebellar and thalamic vacuolation and purkinje cell dendritic atrophy. |
2020-08-03 |
2023-08-13 |
mouse |
| Zhi Zhang, Shilpa Narayan, Lilly Su, Hanaa Al-Alawyat, Jinhuan Liu, Sujatha Kanna. Cerebellar injury and impaired function in a rabbit model of maternal inflammation induced neonatal brain injury. Neurobiology of learning and memory. vol 165. 2020-07-30. PMID:30016703. |
the findings of altered purkinje cell morphology were consistent with impaired cerebellar function as tested by eye-blink conditioning at 1 month of age. |
2020-07-30 |
2023-08-13 |
rabbit |
| Andrea Cabrera-Pastor, Marta Llansola, Carmina Montoliu, Michele Malaguarnera, Tiziano Balzano, Lucas Taoro-Gonzalez, Raquel García-García, Alba Mangas-Losada, Paula Izquierdo-Altarejos, Yaiza M Arenas, Paola Leone, Vicente Felip. Peripheral inflammation induces neuroinflammation that alters neurotransmission and cognitive and motor function in hepatic encephalopathy: Underlying mechanisms and therapeutic implications. Acta physiologica (Oxford, England). vol 226. issue 2. 2020-07-21. PMID:30830722. |
we summarize studies showing that mhe in cirrhotic patients is associated with alterations in the immune system and that patients died with he show neuroinflammation in cerebellum, with microglial and astrocytic activation and purkinje cell loss. |
2020-07-21 |
2023-08-13 |
rat |
| Samuel S McAfee, Yu Liu, Roy V Sillitoe, Detlef H Hec. Cerebellar Lobulus Simplex and Crus I Differentially Represent Phase and Phase Difference of Prefrontal Cortical and Hippocampal Oscillations. Cell reports. vol 27. issue 8. 2020-07-16. PMID:31116979. |
we simultaneously recorded purkinje cell (pc) single-unit spike activity in cerebellar lobulus simplex (ls) and crus i and local field potential (lfp) activity in the medial prefrontal cortex (mpfc) and dorsal hippocampus ca1 region (dca1). |
2020-07-16 |
2023-08-13 |
Not clear |
| David Díaz, Carlos Del Pilar, José Carretero, José Ramón Alonso, Eduardo Weruag. Daily bone marrow cell transplantations for the management of fast neurodegenerative processes. Journal of tissue engineering and regenerative medicine. vol 13. issue 9. 2020-07-08. PMID:31272136. |
here we have employed a model of aggressive cerebellar neurodegeneration, the purkinje cell degeneration mouse, to optimize a cell therapy based on bone marrow-derived cell and cell fusion. |
2020-07-08 |
2023-08-13 |
mouse |
| Jennifer Rakotomamonjy, Alicia Guemez-Gambo. Purkinje Cell Survival in Organotypic Cerebellar Slice Cultures. Journal of visualized experiments : JoVE. issue 154. 2020-07-08. PMID:31904025. |
purkinje cell survival in organotypic cerebellar slice cultures. |
2020-07-08 |
2023-08-13 |
mouse |