| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rodrigo Muñoz-Castañeda, David Díaz, Leticia Peris, Annie Andrieux, Christophe Bosc, José M Muñoz-Castañeda, Carsten Janke, José R Alonso, Marie-Jo Moutin, Eduardo Weruag. Cytoskeleton stability is essential for the integrity of the cerebellum and its motor- and affective-related behaviors. Scientific reports. vol 8. issue 1. 2019-08-12. PMID:29449678. |
such association was here studied using the purkinje cell degeneration mutant mouse, a model of selective and progressive cerebellar degeneration that lacks the cytosolic carboxypeptidase 1 (ccp1). |
2019-08-12 |
2023-08-13 |
mouse |
| Soichi Nagao, Takeru Hond. [Artificial Intelligence and Cerebellar Motor Learning]. Brain and nerve = Shinkei kenkyu no shinpo. vol 71. issue 7. 2019-08-07. PMID:31289241. |
ten years later, ito found the synaptic plasticity of long-term depression at cerebellar purkinje cell synapses, which underlies cerebellar learning. |
2019-08-07 |
2023-08-13 |
Not clear |
| Maria Sundberg, Ivan Tochitsky, David E Buchholz, Kellen Winden, Ville Kujala, Kush Kapur, Deniz Cataltepe, Daria Turner, Min-Joon Han, Clifford J Woolf, Mary E Hatten, Mustafa Sahi. Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin. Molecular psychiatry. vol 23. issue 11. 2019-07-31. PMID:29449635. |
here, we developed a cerebellar purkinje cell (pc) model of tsc with patient-derived human induced pluripotent stem cells (hipscs) to characterize the molecular mechanisms underlying cerebellar abnormalities in asd and tsc. |
2019-07-31 |
2023-08-13 |
human |
| Sung Min Nam, Jin Seok Seo, Sang-Soep Nahm, Byung-Joon Chan. Effects of Ascorbic Acid on Osteopontin Expression and Axonal Myelination in the Developing Cerebellum of Lead-Exposed Rat Pups. International journal of environmental research and public health. vol 16. issue 6. 2019-07-24. PMID:30893812. |
at postnatal day (pnd) 21, results from nissl staining and opn immunohistochemistry demonstrated that opn was detected in the purkinje cell layer in the cerebellum. |
2019-07-24 |
2023-08-13 |
rat |
| Lauren M Watson, Maggie M K Wong, Jane Vowles, Sally A Cowley, Esther B E Becke. A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum (London, England). vol 17. issue 4. 2019-07-23. PMID:29397531. |
by day 35 of differentiation, subpopulations of cells representative of the two cerebellar germinal zones, the rhombic lip (atoh1-positive) and ventricular zone (ptf1a-positive), could be identified, with the latter giving rise to cells positive for purkinje cell progenitor-specific markers, including lhx5, kirrel2, olig2 and skor2. |
2019-07-23 |
2023-08-13 |
mouse |
| Lauren M Watson, Maggie M K Wong, Jane Vowles, Sally A Cowley, Esther B E Becke. A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells. Cerebellum (London, England). vol 17. issue 4. 2019-07-23. PMID:29397531. |
further maturation was observed following dissociation and co-culture of these cerebellar progenitors with mouse cerebellar cells, with 10% of human cells staining positive for the purkinje cell marker calbindin by day 70 of differentiation. |
2019-07-23 |
2023-08-13 |
mouse |
| Rebecca M Long, Janelle M P Pakan, David J Graham, Peter L Hurd, Cristian Gutierrez-Ibañez, Douglas R Wyli. Modulation of complex spike activity differs between zebrin-positive and -negative Purkinje cells in the pigeon cerebellum. Journal of neurophysiology. vol 120. issue 1. 2019-07-16. PMID:29589816. |
the cerebellum is organized into parasagittal zones defined by its climbing and mossy fiber inputs, efferent projections, and purkinje cell (pc) response properties. |
2019-07-16 |
2023-08-13 |
pigeon |
| Maxime W C Rousseaux, Tyler Tschumperlin, Hsiang-Chih Lu, Elizabeth P Lackey, Vitaliy V Bondar, Ying-Wooi Wan, Qiumin Tan, Carolyn J Adamski, Jillian Friedrich, Kirk Twaroski, Weili Chen, Jakub Tolar, Christine Henzler, Ajay Sharma, Aleksandar Bajić, Tao Lin, Lisa Duvick, Zhandong Liu, Roy V Sillitoe, Huda Y Zoghbi, Harry T Or. ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism. Neuron. vol 97. issue 6. 2019-07-15. PMID:29526553. |
importantly, loss of cic in the cerebellum does not cause ataxia or purkinje cell degeneration. |
2019-07-15 |
2023-08-13 |
Not clear |
| Ioannis Mavroudi. Cerebellar pathology in Alzheimer's disease. Hellenic journal of nuclear medicine. vol 22 Suppl. 2019-07-12. PMID:30877735. |
although the cerebellum has not been extensively studied in ad, recent studies have revealed evidence of a unique pathological pattern of the cerebellar cortex, including loss of purkinje cells, synaptic alterations in the mossy fibres, granule cell dendrites, parallel fibres and purkinje cell dendrites with substantial loss of dendritic spines, and considerable alterations in ultrathin sections. |
2019-07-12 |
2023-08-13 |
monkey |
| Vincent Picher-Martel, Nicolas Dupr. Current and Promising Therapies in Autosomal Recessive Ataxias. CNS & neurological disorders drug targets. vol 17. issue 3. 2019-07-11. PMID:29676235. |
the genetic mutations mostly result in the accumulation of toxic metabolites which causes purkinje neuron lost and eventual cerebellar dysfunction. |
2019-07-11 |
2023-08-13 |
Not clear |
| Brittney L Gurda, Jessica H Bagel, Samantha J Fisher, Mark L Schultz, Andrew P Lieberman, Peter Hand, Charles H Vite, Gary P Swai. LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss. Journal of neuropathology and experimental neurology. vol 77. issue 3. 2019-07-01. PMID:29346563. |
high densities of accumulated lc3 were seen in subdivisions of the inferior olive, which project to cerebellar regions that show the most purkinje cell loss, suggesting that autophagic abnormalities in specific climbing fibers may contribute to the spatial pattern of purkinje cell loss seen. |
2019-07-01 |
2023-08-13 |
Not clear |
| Laurentiu S Popa, Martha L Streng, Timothy J Ebne. Purkinje Cell Representations of Behavior: Diary of a Busy Neuron. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 25. issue 3. 2019-06-27. PMID:29985093. |
fundamental for understanding cerebellar function is determining the representations in purkinje cell activity, the sole output of the cerebellar cortex. |
2019-06-27 |
2023-08-13 |
Not clear |
| Vien Nguyen, Khalida Sabeur, Emin Maltepe, Kurosh Ameri, Omer Bayraktar, David H Rowitc. Sonic Hedgehog Agonist Protects Against Complex Neonatal Cerebellar Injury. Cerebellum (London, England). vol 17. issue 2. 2019-06-26. PMID:29134361. |
in the setting of hypoxia and prednisolone, administration of a small molecule smoothened-hedgehog agonist (sag) preserved cerebellar volume and protected against purkinje cell death. |
2019-06-26 |
2023-08-13 |
mouse |
| Richard Hawke. The Ferdinando Rossi Memorial Lecture: Zones and Stripes-Pattern Formation in the Cerebellum. Cerebellum (London, England). vol 17. issue 1. 2019-06-14. PMID:28965328. |
cerebellar architecture is organized around the purkinje cell. |
2019-06-14 |
2023-08-13 |
mouse |
| Ryosuke Tsumagari, Yasuhito Shira. [Importance of diacylglycerol signaling in cerebellar motor coordination]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 152. issue 2. 2019-05-30. PMID:30101866. |
the only output neuron in cerebellum, purkinje cell, regulates long term depression (ltd). |
2019-05-30 |
2023-08-13 |
mouse |
| Maryam Rahimi-Balaei, Xiaodan Jiao, Shahin Shabanipour, Rajiv Dixit, Carol Schuurmans, Hassan Marzba. Zebrin II Is Ectopically Expressed in Microglia in the Cerebellum of Neurogenin 2 Null Mice. Cerebellum (London, England). vol 18. issue 1. 2019-05-20. PMID:29909450. |
zebrin ii/aldolase c expression in the normal cerebellum is restricted to a purkinje cell subset and is the canonical marker for stripes and zones. |
2019-05-20 |
2023-08-13 |
mouse |
| Cullen B Owens, Casper de Boer, Giulia Gennari, Robin Broersen, Johan J Pel, Brian Miller, Wesley Clapp, Ysbrand D van der Werf, Chris I De Zeeu. Early Trajectory Prediction in Elite Athletes. Cerebellum (London, England). vol 17. issue 6. 2019-05-13. PMID:30218394. |
while purkinje cell activity of the oculomotor vermis predicts eye movement speed and direction, more lateral areas of the cerebellum may play a role in more complex tasks, including decision-making. |
2019-05-13 |
2023-08-13 |
Not clear |
| Trace L Stay, Jean Laurens, Roy V Sillitoe, Dora E Angelak. Genetically eliminating Purkinje neuron GABAergic neurotransmission increases their response gain to vestibular motion. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 8. 2019-05-01. PMID:30723151. |
altogether, these data argue that purkinje neuron feedback regulates gain control within the cerebellar circuit. |
2019-05-01 |
2023-08-13 |
mouse |
| Vincenzo Romano, Licia De Propris, Laurens Wj Bosman, Pascal Warnaar, Michiel M Ten Brinke, Sander Lindeman, Chiheng Ju, Arthiha Velauthapillai, Jochen K Spanke, Emily Middendorp Guerra, Tycho M Hoogland, Mario Negrello, Egidio D'Angelo, Chris I De Zeeu. Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity. eLife. vol 7. 2019-04-29. PMID:30561331. |
thus, potentiation at parallel fiber to purkinje cell synapses may contribute to reflex adaptation and enable expression of cerebellar learning through increases in simple spike activity. |
2019-04-29 |
2023-08-13 |
mouse |
| Niceto R Luque, Francisco Naveros, Richard R Carrillo, Eduardo Ros, Angelo Arle. Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS computational biology. vol 15. issue 3. 2019-04-29. PMID:30860991. |
here, a spiking cerebellar model assesses the role of purkinje cell firing patterns in vestibular ocular reflex (vor) adaptation. |
2019-04-29 |
2023-08-13 |
Not clear |