| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shijia Ren, Meifang Chen, Lanying Yang, Zaiqun Li. 5-Hydroxytryptamine and Dopamine Neurons in the Cerebellum of the New-Hatching Yangtze Alligator Alligator sinensis. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 6. 2020-07-06. PMID:30315688. |
the results of cerebellar histological structure showed that there was a ventriculus cerebelli in the cerebellum of the new-hatching yangtze alligator, the surface of the cerebellar cortex was not very smooth, the cerebellar cortex could be divided into four layers, which include external granular layer, molecular layer, purkinje cell layer and granular layer, purkinje cell layer could be characterized specially by multilayer, two cerebellar nuclei termed as the nucleus cerebelli lateralis and the nucleus cerebelli medialis were found in the cerebellar medulla. |
2020-07-06 |
2023-08-13 |
Not clear |
| Julia Saifetiarova, Manzoor A Bha. Ablation of cytoskeletal scaffolding proteins, Band 4.1B and Whirlin, leads to cerebellar purkinje axon pathology and motor dysfunction. Journal of neuroscience research. vol 97. issue 3. 2020-07-01. PMID:30447021. |
using 4.1b and whrn single and double mutant animals, we show that both proteins are expressed in common cellular compartments of the cerebellum and play cooperative roles in preservation of the integrity of purkinje neuron myelinated axons. |
2020-07-01 |
2023-08-13 |
Not clear |
| Lidia Yshii, Béatrice Pignolet, Emilie Mauré, Mandy Pierau, Monika Brunner-Weinzierl, Oliver Hartley, Jan Bauer, Roland Libla. IFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration. JCI insight. vol 4. issue 7. 2020-06-29. PMID:30944244. |
in an animal model, in which a neo-self-antigen was expressed in both purkinje neurons and implanted breast tumor cells, immune checkpoint blockade led to complete tumor control at the expense of cerebellum infiltration by t cells and purkinje neuron loss, thereby mimicking pcd. |
2020-06-29 |
2023-08-13 |
mouse |
| Ruth Sheffer, Michal Gur, Rebecca Brooks, Somaya Salah, Muhannad Daana, Nitay Fraenkel, Eli Eisenstein, Malcolm Rabie, Yoram Nevo, Chaim Jalas, Orly Elpeleg, Shimon Edvardson, Tamar Hare. Biallelic variants in AGTPBP1, involved in tubulin deglutamylation, are associated with cerebellar degeneration and motor neuropathy. European journal of human genetics : EJHG. vol 27. issue 9. 2020-06-12. PMID:30976113. |
in the mutant mice, cerebellar atrophy due to purkinje cell degeneration is observed, likely due to increased tubulin polyglutamylation in affected brain areas. |
2020-06-12 |
2023-08-13 |
mouse |
| Weisong Duan, Moran Guo, Le Yi, Jie Zhang, Yue Bi, Yakun Liu, Yuanyuan Li, Zhongyao Li, Yanqin Ma, Guisen Zhang, Yaling Liu, Xueqing Song, Chunyan L. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging. vol 11. issue 8. 2020-05-21. PMID:31039129. |
the purkinje cell layer of the cerebellum presented dendritic swelling, abnormally shaped astrocytes, and p62- and ubiquitin-positive aggregates, suggesting impaired autophagy. |
2020-05-21 |
2023-08-13 |
mouse |
| Tianyu Tang, Timothy A Blenkinsop, Eric J Lan. Complex spike synchrony dependent modulation of rat deep cerebellar nuclear activity. eLife. vol 8. 2020-05-18. PMID:30624204. |
the rules governing cerebellar output are not fully understood, but must involve purkinje cell (pc) activity, as pcs are the major input to deep cerebellar nuclear (dcn) cells (which form the majority of cerebellar output). |
2020-05-18 |
2023-08-13 |
rat |
| Qiong Liu, Shanshan Huang, Peng Yin, Su Yang, Jennifer Zhang, Liang Jing, Siying Cheng, Beisha Tang, Xiao-Jiang Li, Yongcheng Pan, Shihua L. Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17. Nature communications. vol 11. issue 1. 2020-05-05. PMID:32107387. |
crispr/cas9-mediated deletion of inpp5a in the cerebellum of wild-type mice leads to purkinje cell degeneration, and inpp5a overexpression decreases inositol 1,4,5-trisphosphate (ip |
2020-05-05 |
2023-08-13 |
mouse |
| Aurora Badaloni, Filippo Casoni, Laura Croci, Francesca Chiara, Antonella Bizzoca, Gianfranco Gennarini, Ottavio Cremona, Richard Hawkes, G Giacomo Consale. Dynamic Expression and New Functions of Early B Cell Factor 2 in Cerebellar Development. Cerebellum (London, England). vol 18. issue 6. 2020-04-10. PMID:31273610. |
the early b cell factor 2 (ebf2) gene plays an important role in the establishment of cerebellar cortical topography and in purkinje cell (pc) subtype specification. |
2020-04-10 |
2023-08-13 |
Not clear |
| Kazuyoshi Tsutsu. Kobayashi award: Discovery of cerebellar and pineal neurosteroids and their biological actions on the growth and survival of Purkinje cells during development (review). General and comparative endocrinology. vol 284. 2020-02-25. PMID:30339808. |
in the mid 1990s, the purkinje cell, an important cerebellar neuron, was discovered as a major cell producing neurosteroids in the brain of vertebrates. |
2020-02-25 |
2023-08-13 |
Not clear |
| Kazuyoshi Tsutsu. Kobayashi award: Discovery of cerebellar and pineal neurosteroids and their biological actions on the growth and survival of Purkinje cells during development (review). General and comparative endocrinology. vol 284. 2020-02-25. PMID:30339808. |
progesterone and estradiol, which are known as sex steroid hormones, are actively synthesized de novo from cholesterol in the purkinje cell during development, when cerebellar neuronal circuit formation occurs. |
2020-02-25 |
2023-08-13 |
Not clear |
| Hassan Marzban, Maryam Rahimi-Balaei, Richard Hawke. Early trigeminal ganglion afferents enter the cerebellum before the Purkinje cells are born and target the nuclear transitory zone. Brain structure & function. vol 224. issue 7. 2020-02-18. PMID:31256239. |
in the standard model for the development of climbing and mossy fiber afferent pathways to the cerebellum, the ingrowing axons target the embryonic purkinje cell somata (around embryonic ages (e13-e16 in mice). |
2020-02-18 |
2023-08-13 |
mouse |
| Hassan Marzban, Maryam Rahimi-Balaei, Richard Hawke. Early trigeminal ganglion afferents enter the cerebellum before the Purkinje cells are born and target the nuclear transitory zone. Brain structure & function. vol 224. issue 7. 2020-02-18. PMID:31256239. |
double immunostaining for naa and markers of the different domains in the cerebellar primordium reveal that afferents first target the nuclear transitory zone (e9-e10), and only later (e10-e11) are the axons, either collaterals from the trigeminal ganglion or a new afferent source (e.g., vestibular ganglia), seen in the purkinje cell plate. |
2020-02-18 |
2023-08-13 |
mouse |
| Shintaro Saegusa, Masahiro Fukaya, Wataru Kakegawa, Manabu Tanaka, Osamu Katsumata, Takeyuki Sugawara, Yoshinobu Hara, Makoto Itakura, Tadashi Okubo, Toshiya Sato, Michisuke Yuzaki, Hiroyuki Sakagam. Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions. PloS one. vol 14. issue 5. 2020-02-11. PMID:31095630. |
mice lacking efa6c/psd2, a guanine nucleotide exchange factor for arf6, exhibit lower purkinje cell synaptic density but normal cerebellar motor functions. |
2020-02-11 |
2023-08-13 |
mouse |
| Sung Min Nam, Jin Seok Seo, Tae-Hun Go, Sang-Soep Nahm, Byung-Joon Chan. Ascorbic Acid Supplementation Prevents the Detrimental Effects of Prenatal and Postnatal Lead Exposure on the Purkinje Cell and Related Proteins in the Cerebellum of Developing Rats. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30488169. |
ascorbic acid supplementation prevents the detrimental effects of prenatal and postnatal lead exposure on the purkinje cell and related proteins in the cerebellum of developing rats. |
2020-02-04 |
2023-08-13 |
rat |
| Regina T Martuscello, Elan D Louis, Phyllis L Faus. A Stainless Protocol for High Quality RNA Isolation from Laser Capture Microdissected Purkinje Cells in the Human Post-Mortem Cerebellum. Journal of visualized experiments : JoVE. issue 143. 2020-01-24. PMID:30735198. |
the purkinje cell of the cerebellum is a good candidate for stainless visualization, due to its size and characteristic location. |
2020-01-24 |
2023-08-13 |
human |
| Katarzyna O Rojek, Joanna Krzemień, Hubert Doleżyczek, Paweł M Boguszewski, Leszek Kaczmarek, Witold Konopka, Marcin Rylski, Jacek Jaworski, Lars Holmgren, Tomasz J Prószyńsk. Amot and Yap1 regulate neuronal dendritic tree complexity and locomotor coordination in mice. PLoS biology. vol 17. issue 5. 2019-12-16. PMID:31042703. |
the conditional deletion of amot and yap1 in neurons led to a decrease in the complexity of purkinje cell dendritic trees, abnormal cerebellar morphology, and impairments in motor coordination. |
2019-12-16 |
2023-08-13 |
mouse |
| Visou Ady, Brenda Toscano-Márquez, Moushumi Nath, Philip K Chang, Jeanette Hui, Anna Cook, François Charron, Roxanne Larivière, Bernard Brais, R Anne McKinney, Alanna J Wat. Altered synaptic and firing properties of cerebellar Purkinje cells in a mouse model of ARSACS. The Journal of physiology. vol 596. issue 17. 2019-12-11. PMID:29928778. |
autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs) is an early-onset neurodegenerative human disease characterized in part by ataxia and purkinje cell loss in anterior cerebellar lobules. |
2019-12-11 |
2023-08-13 |
mouse |
| Kohki Konishi, Masafumi Mimura, Takao Nonaka, Ichiro Sase, Hideo Nishioka, Mitsuo Sug. Practical method of cell segmentation in electron microscope image stack using deep convolutional neural network☆. Microscopy (Oxford, England). vol 68. issue 4. 2019-12-06. PMID:31220299. |
we segmented a cerebellar purkinje cell from an image stack of a mouse cerebellum cortex in less than two working days, which is much shorter than that of the conventional method. |
2019-12-06 |
2023-08-13 |
mouse |
| Alicia K Au, Yaming Chen, Lina Du, Craig M Smith, Mioara D Manole, Sirine A Baltagi, Charleen T Chu, Rajesh K Aneja, Hülya Bayır, Patrick M Kochanek, Robert S B Clar. Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro. Biochimica et biophysica acta. vol 1852. issue 9. 2019-11-20. PMID:26071643. |
increased autophagy/mitophagy is thought to contribute to cerebellar dysfunction in purkinje cell degeneration mice. |
2019-11-20 |
2023-08-13 |
mouse |
| Alicia K Au, Yaming Chen, Lina Du, Craig M Smith, Mioara D Manole, Sirine A Baltagi, Charleen T Chu, Rajesh K Aneja, Hülya Bayır, Patrick M Kochanek, Robert S B Clar. Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro. Biochimica et biophysica acta. vol 1852. issue 9. 2019-11-20. PMID:26071643. |
treatment with atg7 sirna: 1) reduced atg7 protein expression in the cerebellum by 56%; 2) prevented the typical ischemia-induced formation of lc3-ii in the cerebellum 24h after asphyxial cardiac arrest; 3) improved performance on the beam-balance apparatus on days 1-5; and 4) increased calbindin-labeled purkinje cell survival assessed on day 14. |
2019-11-20 |
2023-08-13 |
mouse |