| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niceto R Luque, Francisco Naveros, Richard R Carrillo, Eduardo Ros, Angelo Arle. Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. PLoS computational biology. vol 15. issue 3. 2019-04-29. PMID:30860991. |
a detailed purkinje cell model reproduces the three spike-firing patterns that are shown to regulate the cerebellar output. |
2019-04-29 |
2023-08-13 |
Not clear |
| Jakub Trzesniewski, Sandrine Altmann, Levy Jäger, Josef P Kapfhamme. Reduced Purkinje cell size is compatible with near normal morphology and function of the cerebellar cortex in a mouse model of spinocerebellar ataxia. Experimental neurology. vol 311. 2019-04-10. PMID:30312605. |
we have now done a more extensive study of cerebellar morphology in these mice and show by rapid golgi staining that there is a marked reduction of purkinje cell dendritic tree size throughout the cerebellum. |
2019-04-10 |
2023-08-13 |
mouse |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
an expandable embryonic stem cell-derived purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Gustavo A Higuera, Grazia Iaffaldano, Meiwand Bedar, Guy Shpak, Robin Broersen, Shashini T Munshi, Catherine Dupont, Joost Gribnau, Femke M S de Vrij, Steven A Kushner, Chris I De Zeeu. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. Scientific reports. vol 7. issue 1. 2019-03-21. PMID:28821816. |
many forms of ataxia result from degeneration of cerebellar purkinje cells, but thus far it has not been possible to efficiently generate purkinje neuron (pn) progenitors from human or mouse pluripotent stem cells, let alone to develop a methodology for in vivo transplantation in the adult cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Fengjun Ma, Zhiqiang Dong, Michael A Berberogl. Expression of RNA-binding protein Rbfox1l demarcates a restricted population of dorsal telencephalic neurons within the adult zebrafish brain. Gene expression patterns : GEP. vol 31. 2019-03-21. PMID:30634066. |
in the cerebellum, rbfox1l and rbfox2 are expressed in the purkinje cell layer, reminiscent of rbfox1 and rbfox2 expression in the mammalian cerebellum. |
2019-03-21 |
2023-08-13 |
mouse |
| Hirokazu Hirai, Masanobu Kan. Type 1 metabotropic glutamate receptor and its signaling molecules as therapeutic targets for the treatment of cerebellar disorders. Current opinion in pharmacology. vol 38. 2019-03-14. PMID:29525719. |
since the signaling pathway triggered by mglur1 activation in purkinje cell plays a pivotal role in coordinated movements and motor learning, pharmacological repair of aberrant mglur1 signaling in purkinje cell is critical for mitigation of cerebellar symptoms. |
2019-03-14 |
2023-08-13 |
Not clear |
| Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Bae. Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:29341299. |
in order to investigate whether peroxisomal β-oxidation is essential within purkinje cells, the sole output neurons of the cerebellum, we generated and characterized a mouse model with purkinje cell selective deletion of the mfp2 gene. |
2019-03-05 |
2023-08-13 |
mouse |
| Stephanie De Munter, Dorien Bamps, Ana Rita Malheiro, Ritesh Kumar Baboota, Pedro Brites, Myriam Bae. Autonomous Purkinje cell axonal dystrophy causes ataxia in peroxisomal multifunctional protein-2 deficiency. Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:29341299. |
we show that selective loss of mfp2 from mature cerebellar purkinje neurons causes a late-onset motor phenotype and progressive purkinje cell degeneration, thereby mimicking ataxia and cerebellar deterioration in patients with mild hsd17b4 mutations. |
2019-03-05 |
2023-08-13 |
mouse |
| Sébastien Roux, Yannick Bailly, Jean L Boss. Regional and sex-dependent alterations in Purkinje cell density in the valproate mouse model of autism. Neuroreport. vol 30. issue 2. 2019-02-25. PMID:30461560. |
neuropathological and neuroimaging studies indicate a decrease in purkinje cell (pc) density in the cerebellum of autistic patients and rodent models of autism. |
2019-02-25 |
2023-08-13 |
mouse |
| Sara M Schaefer, Ana Vives Rodriguez, Elan D Loui. Brain circuits and neurochemical systems in essential tremor: insights into current and future pharmacotherapeutic approaches. Expert review of neurotherapeutics. vol 18. issue 2. 2019-02-19. PMID:29206482. |
two disease models for et have been proposed: 1) the olivary model, which attributes et to a pathological pacemaker in the inferior olivary nucleus, and 2) the cerebellar degeneration model, which postulates that et originates in the cerebellum and could be related to deficient or abnormal purkinje cell (pc) output. |
2019-02-19 |
2023-08-13 |
human |
| Miaozhen Huang, Dineke S Verbee. Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia? Neuroscience letters. vol 688. 2019-02-18. PMID:29421540. |
the genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive purkinje cell degeneration. |
2019-02-18 |
2023-08-13 |
Not clear |
| M M Ten Brinke, H J Boele, C I De Zeeu. Conditioned climbing fiber responses in cerebellar cortex and nuclei. Neuroscience letters. vol 688. 2019-02-18. PMID:29689340. |
cerebellar cortical purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (crs), leading to disinhibition of neurons in the cerebellar nuclei that innervate eyelid muscles downstream. |
2019-02-18 |
2023-08-13 |
Not clear |
| N Sumru Bayin, Alexandre Wojcinski, Aurelien Mourton, Hiromitsu Saito, Noboru Suzuki, Alexandra L Joyne. Age-dependent dormant resident progenitors are stimulated by injury to regenerate Purkinje neurons. eLife. vol 7. 2019-02-05. PMID:30091706. |
new pcs are produced from immature foxp2+ purkinje cell precursors (ipcs) that are able to enter the cell cycle and support normal cerebellum development. |
2019-02-05 |
2023-08-13 |
mouse |
| Aaron Sathyanesan, Srikanya Kundu, Joseph Abbah, Vittorio Gall. Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction. Nature communications. vol 9. issue 1. 2018-12-17. PMID:30104642. |
neonatal brain injury causes cerebellar learning deficits and purkinje cell dysfunction. |
2018-12-17 |
2023-08-13 |
mouse |
| Waqas Tahir, Saima Zafar, Franc Llorens, Amandeep Singh Arora, Katrin Thüne, Matthias Schmitz, Nadine Gotzmann, Niels Kruse, Brit Mollenhauer, Juan Maria Torres, Olivier Andréoletti, Isidre Ferrer, Inga Zer. Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt-Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress. Molecular neurobiology. vol 55. issue 1. 2018-12-11. PMID:27975168. |
cerebellar damage and granular and purkinje cell loss in sporadic creutzfeldt-jakob disease (scjd) highlight a critical involvement of the cerebellum during symptomatic progression of the disease. |
2018-12-11 |
2023-08-13 |
mouse |
| Joshua J White, Roy V Sillito. Genetic silencing of olivocerebellar synapses causes dystonia-like behaviour in mice. Nature communications. vol 8. 2018-12-11. PMID:28374839. |
by blocking olivocerebellar excitatory neurotransmission, we eliminated purkinje cell complex spikes and induced aberrant cerebellar nuclear activity. |
2018-12-11 |
2023-08-13 |
mouse |
| Ruslan L Nuryyev, Toni L Uhlendorf, Wesley Tierney, Suren Zatikyan, Oleg Kopyov, Alex Kopyov, Jessica Ochoa, William Van Trigt, Cindy S Malone, Randy W Cohe. Transplantation of Human Neural Progenitor Cells Reveals Structural and Functional Improvements in the Spastic Han-Wistar Rat Model of Ataxia. Cell transplantation. vol 26. issue 11. 2018-12-11. PMID:29338380. |
in addition, cerebellar histology revealed that the transplanted hnpcs displayed signs of migration and signs of neuronal development in the degenerated purkinje cell layer. |
2018-12-11 |
2023-08-13 |
human |
| Tomoo Hiran. Purkinje Neurons: Development, Morphology, and Function. Cerebellum (London, England). vol 17. issue 6. 2018-12-11. PMID:30284678. |
in other words, all computational results within the cortex are transmitted by purkinje cell axons, which inhibit neurons in the cerebellar or vestibular nucleus. |
2018-12-11 |
2023-08-13 |
Not clear |
| Daniel R Scoles, Stefan M Puls. Oligonucleotide therapeutics in neurodegenerative diseases. RNA biology. vol 15. issue 6. 2018-11-14. PMID:29560813. |
we demonstrated that reduction of atxn2 expression in sca2 mice treated by intracerebroventicular injection (icv) of atxn2 aso delayed motor phenotype onset, improved the expression of several genes demonstrated abnormally reduced by transcriptomic profiling of sca2 mice, and restored abnormal purkinje cell firing frequency in acute cerebellar sections. |
2018-11-14 |
2023-08-13 |
mouse |
| Christina Valkova, Lutz Liebmann, Andreas Krämer, Christian A Hübner, Christoph Kaethe. The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels. Scientific reports. vol 7. 2018-10-29. PMID:28117367. |
mice with a purkinje cell (pc) specific deletion of rer1 showed normal polarization and differentiation of pcs and normal development of the cerebellum. |
2018-10-29 |
2023-08-13 |
mouse |