| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Ochi, S Shiozaki, H Kas. Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease. Neuroscience. vol 127. issue 1. 2004-10-14. PMID:15219684. |
adenosine a(2a) receptor-mediated modulation of gaba and glutamate release in the output regions of the basal ganglia in a rodent model of parkinson's disease. |
2004-10-14 |
2023-08-12 |
rat |
| M Ochi, S Shiozaki, H Kas. Adenosine A(2A) receptor-mediated modulation of GABA and glutamate release in the output regions of the basal ganglia in a rodent model of Parkinson's disease. Neuroscience. vol 127. issue 1. 2004-10-14. PMID:15219684. |
in the present study, we determine whether a(2a) receptor-mediated modulation is associated with changes in the release of gaba and glutamate in the substantia nigra pars reticulata (snr), an output structure of the whole basal ganglia network, using in vivo microdialysis in a rat parkinson's disease (pd) model. |
2004-10-14 |
2023-08-12 |
rat |
| Beth E Fisher, Giselle M Petzinger, Kerry Nixon, Elizabeth Hogg, Samuel Bremmer, Charles K Meshul, Michael W Jakowe. Exercise-induced behavioral recovery and neuroplasticity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse basal ganglia. Journal of neuroscience research. vol 77. issue 3. 2004-09-09. PMID:15248294. |
the expression of proteins and genes involved in basal ganglia function including the dopamine transporter (dat), tyrosine hydroxylase (th), and the dopamine d1 and d2 receptors, as well as alterations on glutamate immunolabeling were determined. |
2004-09-09 |
2023-08-12 |
mouse |
| H-J Hu, L-W Chen, K K L Yung, Y S Cha. Differential expression of AMPA receptor subunits in substance P receptor-containing neurons of the caudate-putamen of rats. Neuroscience research. vol 49. issue 3. 2004-09-07. PMID:15196776. |
previous evidence has suggested that glutamate-driving neurotransmission and glutamate-excitotoxicity are modulated by substance p in the basal ganglia, but the assembly of glutamate receptors mediating this process remains to be delineated. |
2004-09-07 |
2023-08-12 |
rat |
| Mario van der Stelt, Vincenzo Di Marz. The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders. European journal of pharmacology. vol 480. issue 1-3. 2004-07-22. PMID:14623357. |
by activating presynaptic cannabinoid cb1 receptors, they can reduce glutamate release in dorsal and ventral striatum (nucleus accumbens) and alter synaptic plasticity, thereby modulating neurotransmission in the basal ganglia and in the mesolimbic reward system. |
2004-07-22 |
2023-08-12 |
Not clear |
| W S Chan, C W Yeung, E K Y Chung, W K Lau, Y S Chan, K K L Yun. Differential expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate glutamate receptors in the rat striatum during postnatal development. Neuro-Signals. vol 12. issue 6. 2004-03-29. PMID:14739560. |
alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (ampa)-type glutamate receptors (glur1-4) are one of the most important ionotropic glutamate receptors in the striatum, a key region of the basal ganglia. |
2004-03-29 |
2023-08-12 |
rat |
| Jean-Jacques Bacci, Philippe Kachidian, Lydia Kerkerian-Le Goff, Pascal Sali. Intralaminar thalamic nuclei lesions: widespread impact on dopamine denervation-mediated cellular defects in the rat basal ganglia. Journal of neuropathology and experimental neurology. vol 63. issue 1. 2004-03-10. PMID:14748558. |
we also provide immunohistochemical evidence that thalamic lesions markedly decreased striatal expression of the vesicular glutamate transporter vglut2, confirming the association of this transporter with the thalamic projections to the basal ganglia. |
2004-03-10 |
2023-08-12 |
rat |
| M J Marino, H Awad, O Poisik, M Wittmann, P J Con. Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia. Amino acids. vol 23. issue 1-3. 2004-02-26. PMID:12373536. |
localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia. |
2004-02-26 |
2023-08-12 |
Not clear |
| M J Marino, H Awad, O Poisik, M Wittmann, P J Con. Localization and physiological roles of metabotropic glutamate receptors in the direct and indirect pathways of the basal ganglia. Amino acids. vol 23. issue 1-3. 2004-02-26. PMID:12373536. |
in this review we summarize anatomical and physiological data from our work and the work of other laboratories describing the distribution and physiological roles of metabotropic glutamate receptors in the basal ganglia with emphasis on possible therapeutic targets. |
2004-02-26 |
2023-08-12 |
Not clear |
| Michael J Marino, Ornella Valenti, P Jeffrey Con. Glutamate receptors and Parkinson's disease: opportunities for intervention. Drugs & aging. vol 20. issue 5. 2004-02-19. PMID:12696997. |
glutamate plays a central role in the disruption of normal basal ganglia function, and it has been hypothesised that agents acting to restore normal glutamatergic function may provide therapeutic interventions that bypass the severe motor side effects associated with current dopamine replacement strategies. |
2004-02-19 |
2023-08-12 |
Not clear |
| Michael J Marino, Ornella Valenti, P Jeffrey Con. Glutamate receptors and Parkinson's disease: opportunities for intervention. Drugs & aging. vol 20. issue 5. 2004-02-19. PMID:12696997. |
analysis of the effects of glutamate receptor ligands in the basal ganglia circuit suggests that both ionotropic and metabotropic glutamate receptors could have antiparkinsonian actions. |
2004-02-19 |
2023-08-12 |
Not clear |
| O A Andreassen, R J Ferrante, T O Aamo, M F Beal, H A Jørgense. Oral dyskinesias and histopathological alterations in substantia nigra after long-term haloperidol treatment of old rats. Neuroscience. vol 122. issue 3. 2004-02-17. PMID:14622915. |
the pathophysiologic basis of tardive dyskinesia remains unclear, but several lines of evidence suggest that persistent neuronal changes in the basal ganglia produced by oxidative stress or glutamate toxicity may play a role, especially in the elderly. |
2004-02-17 |
2023-08-12 |
rat |
| Jennifer A Feeley Kearney, Roger L Albi. mGluRs: a target for pharmacotherapy in Parkinson disease. Experimental neurology. vol 184 Suppl 1. 2004-01-08. PMID:14597323. |
metabotropic glutamate receptors (mglurs) are g-protein-coupled excitatory amino acid (glutamate) receptors and are abundantly expressed in basal ganglia nuclei. |
2004-01-08 |
2023-08-12 |
rat |
| F Blandini, J T Greenamyr. Protective and symptomatic strategies for therapy of Parkinson's disease. Drugs of today (Barcelona, Spain : 1998). vol 35. issue 6. 2003-10-24. PMID:12973393. |
the excitatory amino acid glutamate plays a central role in the functional modifications that affect the basal ganglia in pd. |
2003-10-24 |
2023-08-12 |
Not clear |
| Kazuya Saitoh, Satoko Hattori, Wen-Jie Song, Tadashi Isa, Kaoru Takakusak. Nigral GABAergic inhibition upon cholinergic neurons in the rat pedunculopontine tegmental nucleus. The European journal of neuroscience. vol 18. issue 4. 2003-10-14. PMID:12925013. |
in the presence of the ionotropic glutamate receptor antagonists, 6-cyano-2, 3-dihydroxy-7-nitro-quinoxaline-2, 3, dione, and dl-2-amino-5-phosphonovaleric acid, single electrical stimuli were applied to the substantia nigra pars reticulata (snr), one of the basal ganglia output nuclei. |
2003-10-14 |
2023-08-12 |
rat |
| Nathalie Breysse, Marianne Amalric, Pascal Sali. Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 23. issue 23. 2003-10-08. PMID:12967992. |
glutamate overactivity within the basal ganglia has been shown to be central to the expression of motor symptoms in advanced stages of parkinson's disease, and metabotropic glutamate receptors (mglurs) represent promising targets for new therapeutic strategies in this pathology. |
2003-10-08 |
2023-08-12 |
rat |
| Michael J Marino, P Jeffrey Conn, Jeffrey P Con. Modulation of the basal ganglia by metabotropic glutamate receptors: potential for novel therapeutics. Current drug targets. CNS and neurological disorders. vol 1. issue 3. 2003-06-17. PMID:12769617. |
modulation of the basal ganglia by metabotropic glutamate receptors: potential for novel therapeutics. |
2003-06-17 |
2023-08-12 |
Not clear |
| Michael J Marino, P Jeffrey Conn, Jeffrey P Con. Modulation of the basal ganglia by metabotropic glutamate receptors: potential for novel therapeutics. Current drug targets. CNS and neurological disorders. vol 1. issue 3. 2003-06-17. PMID:12769617. |
one group of receptors that holds much promise for several basal ganglia disorders is the metabotropic glutamate receptors. |
2003-06-17 |
2023-08-12 |
Not clear |
| Michael J Marino, P Jeffrey Conn, Jeffrey P Con. Modulation of the basal ganglia by metabotropic glutamate receptors: potential for novel therapeutics. Current drug targets. CNS and neurological disorders. vol 1. issue 3. 2003-06-17. PMID:12769617. |
data from behavioral, neurochemical, neuroanatomical and electrophysiological studies has begun to reveal the functional roles that the metabotropic glutamate receptors play in modulating the basal ganglia circuit, and suggests that compounds selectively targeting these receptors may provide novel therapies for a variety of disorders including parkinson's disease, addiction, and epilepsy. |
2003-06-17 |
2023-08-12 |
Not clear |
| Amanpreet Singh, S K Kulkarn. Role of adenosine in drug-induced catatonia in mice. Indian journal of experimental biology. vol 40. issue 8. 2003-04-10. PMID:12597016. |
apart from dopamine, acetylcholine and glutamate, adenosinc has also been identified in the basal ganglia. |
2003-04-10 |
2023-08-12 |
mouse |