| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Colleen M Niswender, Kari A Johnson, C David Weaver, Carrie K Jones, Zixiu Xiang, Qingwei Luo, Alice L Rodriguez, Joy E Marlo, Tomas de Paulis, Analisa D Thompson, Emily L Days, Tasha Nalywajko, Cheryl A Austin, Michael Baxter Williams, Jennifer E Ayala, Richard Williams, Craig W Lindsley, P Jeffrey Con. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Molecular pharmacology. vol 74. issue 5. 2008-11-17. PMID:18664603. |
activation of metabotropic glutamate receptor 4 (mglur4) has been shown to modulate neurotransmission in the basal ganglia and results in antiparkinsonian effects in rodent pd models. |
2008-11-17 |
2023-08-12 |
human |
| András Csillag, Eszter Bálint, Agota Adám, Gergely Zacha. The organisation of the basal ganglia in the domestic chick (Gallus domesticus): anatomical localisation of DARPP-32 in relation to glutamate. Brain research bulletin. vol 76. issue 3. 2008-09-04. PMID:18498930. |
the organisation of the basal ganglia in the domestic chick (gallus domesticus): anatomical localisation of darpp-32 in relation to glutamate. |
2008-09-04 |
2023-08-12 |
chicken |
| John G Kerns, Keith H Nuechterlein, Todd S Braver, Deanna M Barc. Executive functioning component mechanisms and schizophrenia. Biological psychiatry. vol 64. issue 1. 2008-08-15. PMID:18549874. |
executive functioning refers to a set of processes involved in complex, goal-directed thought and behavior involving multiple brain regions (e.g., prefrontal cortex, parietal cortex, basal ganglia) and multiple neurotransmitters (e.g., dopamine, glutamate, gamma-aminobutyric acid). |
2008-08-15 |
2023-08-12 |
Not clear |
| Pershia Samadi, Laurent Grégoire, Marc Morissette, Fréderic Calon, Abdallah Hadj Tahar, Nancy Bélanger, Mehdi Dridi, Paul J Bédard, Thérèse Di Paol. Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias. Neuropharmacology. vol 54. issue 2. 2008-05-12. PMID:18001807. |
basal ganglia group ii metabotropic glutamate receptors specific binding in non-human primate model of l-dopa-induced dyskinesias. |
2008-05-12 |
2023-08-12 |
human |
| Pershia Samadi, Laurent Grégoire, Marc Morissette, Fréderic Calon, Abdallah Hadj Tahar, Nancy Bélanger, Mehdi Dridi, Paul J Bédard, Thérèse Di Paol. Basal ganglia group II metabotropic glutamate receptors specific binding in non-human primate model of L-Dopa-induced dyskinesias. Neuropharmacology. vol 54. issue 2. 2008-05-12. PMID:18001807. |
modulation of group ii metabotropic glutamate receptors (mglur2/3) in the basal ganglia, a brain region critically involved in motor control, is considered as an alternative approach in therapy of pd. |
2008-05-12 |
2023-08-12 |
human |
| Nils Kickler, Paul Krack, Valérie Fraix, Jean-François Lebas, Laurent Lamalle, Franck Durif, Alexandre Krainik, Chantal Rémy, Christoph Segebarth, Pierre Polla. Glutamate measurement in Parkinson's disease using MRS at 3 T field strength. NMR in biomedicine. vol 20. issue 8. 2008-02-26. PMID:17334978. |
loss of nigral dopamine neurons in parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. |
2008-02-26 |
2023-08-12 |
Not clear |
| L Chang, C Cloak, R Yakupov, T Erns. Combined and independent effects of chronic marijuana use and HIV on brain metabolites. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 1. issue 1. 2007-12-27. PMID:18040792. |
in contrast, mj (independent of hiv) was associated with decreased basal ganglia na (-5.5%, p = 0.05), cho (-10.6%, p = 0.04), and glutamate (-9.5%, p = 0.05), with increased thalamic creatine (+6.1%, p = 0.05). |
2007-12-27 |
2023-08-12 |
human |
| Adán Hernández, Arturo Sierra, René Valdiosera, Benjamin Florán, David Erlij, Jorge Aceve. Presynaptic D1 dopamine receptors facilitate glutamatergic neurotransmission in the rat globus pallidus. Neuroscience letters. vol 425. issue 3. 2007-12-14. PMID:17845833. |
the results suggest that the dopaminergic control of the glutamate transmission in the globus pallidus may play a role in processing cortical information in the indirect pathway of the basal ganglia. |
2007-12-14 |
2023-08-12 |
rat |
| T Antonelli, K Fuxe, M C Tomasini, E Mazzoni, L F Agnati, S Tanganelli, L Ferrar. Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment. Progress in neurobiology. vol 83. issue 2. 2007-11-21. PMID:17673354. |
the possible increase in nt levels in the basal ganglia under pathological conditions leading to the nts1 enhancement of glutamate signalling may contribute to the neurodegeneration of the nigro-striatal dopaminergic neurons found in parkinson's disease, especially in view of the high density of nts1 receptors in these neurons. |
2007-11-21 |
2023-08-12 |
Not clear |
| Xuebing Cao, Li Liang, John R Hadcock, Philip A Iredale, David A Griffith, Frank S Menniti, Stewart Factor, J Timothy Greenamyre, Stella M Pap. Blockade of cannabinoid type 1 receptors augments the antiparkinsonian action of levodopa without affecting dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated rhesus monkeys. The Journal of pharmacology and experimental therapeutics. vol 323. issue 1. 2007-11-05. PMID:17630359. |
drugs acting at cannabinoid type 1 receptors (cb1) have modulatory effects on glutamate and gaba neurotransmission in basal ganglia; thus, they potentially affect motor behavior in the parkinsonian setting. |
2007-11-05 |
2023-08-12 |
monkey |
| Kijiro Hashimoto, Tatsuo Nakahara, Hidetaka Yamada, Makoto Hirano, Toshihide Kuroki, Shigenobu Kanb. A neurotoxic dose of methamphetamine induces gene expression of Homer 1a, but not Homer 1b or 1c, in the striatum and nucleus accumbens. Neurochemistry international. vol 51. issue 2-4. 2007-10-25. PMID:17630046. |
homer proteins, which regulate the signaling pathway of metabotropic glutamate receptors, may contribute to the glutamatergic modulation of dopamine neurons in the basal ganglia. |
2007-10-25 |
2023-08-12 |
rat |
| Allison P Berg, Neil Sen, Douglas A Baylis. TrpC3/C7 and Slo2.1 are molecular targets for metabotropic glutamate receptor signaling in rat striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 33. 2007-09-14. PMID:17699666. |
large aspiny cholinergic interneurons provide the sole source of striatal acetylcholine, a neurotransmitter critical for basal ganglia function; these tonically active interneurons receive excitatory inputs from corticostriatal glutamatergic afferents that act, in part, via metabotropic glutamate receptors (mglurs). |
2007-09-14 |
2023-08-12 |
human |
| Dirk Mayer, Natalie M Zahr, Edith V Sullivan, Adolf Pfefferbau. In vivo metabolite differences between the basal ganglia and cerebellum of the rat brain detected with proton MRS at 3T. Psychiatry research. vol 154. issue 3. 2007-07-03. PMID:17346948. |
we, therefore, implemented constant time press (ct-press) to quantify major metabolite and neurotransmitter biochemical signals, including glutamate, in two brain regions of the rat, basal ganglia and cerebellum. |
2007-07-03 |
2023-08-12 |
rat |
| J Konieczny, J Wardas, K Kuter, A Pilc, K Ossowsk. The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats. Neuroscience. vol 145. issue 2. 2007-06-26. PMID:17224239. |
group iii metabotropic glutamate receptors (mglurs) are widely distributed in the basal ganglia, especially on the terminals of pathways which seem to be overactive in parkinson's disease. |
2007-06-26 |
2023-08-12 |
rat |
| Flora Mela, Matteo Marti, Andrzej Dekundy, Wojciech Danysz, Michele Morari, M Angela Cenc. Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease. Journal of neurochemistry. vol 101. issue 2. 2007-06-01. PMID:17359492. |
in this study, we addressed the role of mglur5 in l-dopa-induced dyskinesia, a movement disorder that is due to abnormal activation of both dopamine and glutamate receptors in the basal ganglia. |
2007-06-01 |
2023-08-12 |
rat |
| Jeannette Henning, Dirk Koczan, Anne Glass, Thomas Karopka, Jens Pahnke, Arndt Rolfs, Reiner Benecke, Ulrike Gims. Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression. The European journal of neuroscience. vol 25. issue 1. 2007-04-05. PMID:17241285. |
this downregulation could result in a reduced sensitivity towards glutamate in basal ganglia downstream of stn. |
2007-04-05 |
2023-08-12 |
rat |
| Roy M Smeal, Renee C Gaspar, Kristen A Keefe, Karen S Wilco. A rat brain slice preparation for characterizing both thalamostriatal and corticostriatal afferents. Journal of neuroscience methods. vol 159. issue 2. 2007-03-27. PMID:16899300. |
the striatum, the primary input nucleus of the basal ganglia, is crucially involved in motor and cognitive function and receives significant glutamate input from the cortex and thalamus. |
2007-03-27 |
2023-08-12 |
rat |
| A Galvan, M Kuwajima, Y Smit. Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function? Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17059868. |
glutamate and gaba receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function? |
2007-01-26 |
2023-08-12 |
rat |
| A Galvan, M Kuwajima, Y Smit. Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function? Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17059868. |
gaba and glutamate, the main transmitters in the basal ganglia, exert their effects through ionotropic and metabotropic receptors. |
2007-01-26 |
2023-08-12 |
rat |
| A Galvan, M Kuwajima, Y Smit. Glutamate and GABA receptors and transporters in the basal ganglia: what does their subsynaptic localization reveal about their function? Neuroscience. vol 143. issue 2. 2007-01-26. PMID:17059868. |
in this article, we review recent findings on the ultrastructural localization of gaba and glutamate receptors and transporters in monkey and rat basal ganglia, at synaptic, extrasynaptic and presynaptic sites. |
2007-01-26 |
2023-08-12 |
rat |