| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bazoumana Ouattara, Fabrizio Gasparini, Marc Morissette, Laurent Grégoire, Pershia Samadi, Baltazar Gomez-Mancilla, Thérèse Di Paol. Effect of L-Dopa on metabotropic glutamate receptor 5 in the brain of parkinsonian monkeys. Journal of neurochemistry. vol 113. issue 3. 2010-05-04. PMID:20132464. |
behavioral investigations of selective and potent metabotropic glutamate receptor type 5 (mglur5) antagonists in animal models suggest involvement of mglur5 in compensatory mechanisms of the basal ganglia circuitry in parkinson's disease and levodopa (l-dopa) induced motor complications. |
2010-05-04 |
2023-08-12 |
monkey |
| K Buck, P Voehringer, B Ferge. Site-specific action of L-3,4-dihydroxyphenylalanine in the striatum but not globus pallidus and substantia nigra pars reticulata evokes dyskinetic movements in chronic L-3,4-dihydroxyphenylalanine-treated 6-hydroxydopamine-lesioned rats. Neuroscience. vol 166. issue 2. 2010-05-03. PMID:20026252. |
we have investigated the effect of an acute and local administration of l-dopa, gaba and glutamate to provoke dyskinetic movements in three basal ganglia structures (striatum, globus pallidus (gp) and substantia nigra pars reticulata (snr)) of chronically l-dopa-treated, unilaterally 6-hydroxydopamine-lesioned rats. |
2010-05-03 |
2023-08-12 |
rat |
| Craig W Lindsley, Colleen M Niswender, Darren W Engers, Corey R Hopkin. Recent progress in the development of mGluR4 positive allosteric modulators for the treatment of Parkinson's disease. Current topics in medicinal chemistry. vol 9. issue 10. 2010-03-04. PMID:19754407. |
due to its expression in the basal ganglia, the family 3 gpcr metabotropic glutamate receptor subtype 4 (mglur4) has recently garnered a great deal of attention as a putative target for the treatment of parkinson's disease and a variety of other cns disorders. |
2010-03-04 |
2023-08-12 |
Not clear |
| Kari A Johnson, P Jeffrey Conn, Colleen M Niswende. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS & neurological disorders drug targets. vol 8. issue 6. 2010-02-12. PMID:19702565. |
the ability of ionotropic and metabotropic glutamate receptors to modulate neurotransmission throughout the basal ganglia suggests that these receptors may be targets for reversing the effects of altered neurotransmission in pd. |
2010-02-12 |
2023-08-12 |
Not clear |
| Corinne Beurrier, Sebastien Lopez, Delphine Révy, Chelliah Selvam, Cyril Goudet, Morgane Lhérondel, Paolo Gubellini, Lydia Kerkerian-LeGoff, Francine Acher, Jean-Philippe Pin, Marianne Amalri. Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 23. issue 10. 2009-11-05. PMID:19525404. |
increasing interest is addressed to the selective targeting of group iii metabotropic glutamate (mglu) receptors that inhibit transmitter release at presumably overactive synapses in the basal ganglia. |
2009-11-05 |
2023-08-12 |
mouse |
| Micaela Morelli, Anna R Carta, Peter Jenne. Adenosine A2A receptors and Parkinson's disease. Handbook of experimental pharmacology. issue 193. 2009-09-24. PMID:19639294. |
a(2a)ar antagonists can modulate gamma-aminobutyric acid (gaba) and glutamate release in basal ganglia and other key neurotransmitters that modulate motor activity. |
2009-09-24 |
2023-08-12 |
Not clear |
| Osnat Ben-Shahar, Ilona Obara, Alexis W Ary, Natalie Ma, Mario A Mangiardi, Robert L Medina, Karen K Szumlinsk. Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. Synapse (New York, N.Y.). vol 63. issue 7. 2009-08-13. PMID:19306440. |
human cocaine addicts show altered function within the basal ganglia and the medial prefrontal cortex (mpfc) and altered glutamate function within these areas is postulated to be critical for cocaine addiction. |
2009-08-13 |
2023-08-12 |
human |
| Daniella Rylander, Alessandra Recchia, Flora Mela, Andrzej Dekundy, Wojciech Danysz, M Angela Cenc. Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling. The Journal of pharmacology and experimental therapeutics. vol 330. issue 1. 2009-07-27. PMID:19357321. |
l-dopa-induced dyskinesia (lid) in parkinson's disease has been linked to altered dopamine and glutamate transmission within the basal ganglia. |
2009-07-27 |
2023-08-12 |
rat |
| Dario Cuomo, Giuseppina Martella, Emanuela Barabino, Paola Platania, Daniela Vita, Graziella Madeo, Chelliah Selvam, Cyril Goudet, Nadia Oueslati, Jean-Philippe Pin, Francine Acher, Antonio Pisani, Corinne Beurrier, Christophe Melon, Lydia Kerkerian-Le Goff, Paolo Gubellin. Metabotropic glutamate receptor subtype 4 selectively modulates both glutamate and GABA transmission in the striatum: implications for Parkinson's disease treatment. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19519781. |
these results demonstrate that mglu4 receptor selectively modulates striatal glutamate and gaba synaptic transmission, suggesting that it could represent an interesting target for selective pharmacological intervention in movement disorders involving basal ganglia circuitry. |
2009-07-16 |
2023-08-12 |
mouse |
| Shin'Ya Tayoshi, Satsuki Sumitani, Kyoko Taniguchi, Sumiko Shibuya-Tayoshi, Shusuke Numata, Jun-ichi Iga, Masahito Nakataki, Shu-ichi Ueno, Masafumi Harada, Tetsuro Ohmor. Metabolite changes and gender differences in schizophrenia using 3-Tesla proton magnetic resonance spectroscopy (1H-MRS). Schizophrenia research. vol 108. issue 1-3. 2009-06-16. PMID:19097753. |
the aim of this study was to investigate the changes in metabolites, including glutamate (glu), in the anterior cingulate cortex (acc) and the left basal ganglia (ltbg) of patients with chronic schizophrenia using proton magnetic resonance spectroscopy ((1)h-mrs). |
2009-06-16 |
2023-08-12 |
human |
| Pershia Samadi, Alex Rajput, Frédéric Calon, Laurent Grégoire, Oleh Hornykiewicz, Ali H Rajput, Thèrèse Di Paol. Metabotropic glutamate receptor II in the brains of Parkinsonian patients. Journal of neuropathology and experimental neurology. vol 68. issue 4. 2009-04-28. PMID:19287314. |
modulation of basal ganglia group ii metabotropic glutamate receptors (mglur2/3) is a potential therapeutic alternative to levodopa in parkinson disease (pd). |
2009-04-28 |
2023-08-12 |
Not clear |
| M G Morgese, T Cassano, S Gaetani, T Macheda, L Laconca, P Dipasquale, L Ferraro, T Antonelli, V Cuomo, A Giuffrid. Neurochemical changes in the striatum of dyskinetic rats after administration of the cannabinoid agonist WIN55,212-2. Neurochemistry international. vol 54. issue 1. 2009-04-24. PMID:19010365. |
chronic use of levodopa, the most effective treatment for parkinson's disease, causes abnormal involuntary movements named dyskinesias, which are linked to maladaptive changes in plasticity and disturbances of dopamine and glutamate neurotransmission in the basal ganglia. |
2009-04-24 |
2023-08-12 |
rat |
| Linda Chang, Caroline S Jiang, Thomas Erns. Effects of age and sex on brain glutamate and other metabolites. Magnetic resonance imaging. vol 27. issue 1. 2009-04-16. PMID:18687554. |
our reanalyzed data no longer show sex differences in brain glutamate levels in four brain regions measured, but we continue to observe significant age-related declines in glutamate, especially in the parietal gray matter and basal ganglia, and to a lesser degree in the frontal white matter. |
2009-04-16 |
2023-08-12 |
human |
| Linda Chang, Caroline S Jiang, Thomas Erns. Effects of age and sex on brain glutamate and other metabolites. Magnetic resonance imaging. vol 27. issue 1. 2009-04-16. PMID:18687554. |
further analyses confirm that the basal ganglia and frontal white matter glutamate declines were predominantly due to a decline in men, but not women. |
2009-04-16 |
2023-08-12 |
human |
| Norman C Reynolds, Robert W Prost, Leighton P Mark, Suja A Josep. MR-spectroscopic findings in juvenile-onset Huntington's disease. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 13. 2009-04-08. PMID:18759332. |
despite clinical variability, the predominate (1)h-mrs abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine. |
2009-04-08 |
2023-08-12 |
Not clear |
| Sebastien Lopez, Nathalie Turle-Lorenzo, Tom H Johnston, Jonathan M Brotchie, Stephan Schann, Pascal Neuville, Marianne Amalri. Functional interaction between adenosine A2A and group III metabotropic glutamate receptors to reduce parkinsonian symptoms in rats. Neuropharmacology. vol 55. issue 4. 2009-02-06. PMID:18625257. |
non-dopaminergic drugs acting either on adenosine a2a or metabotropic glutamate (mglu) receptors reduce motor impairment in animal models of parkinson's disease (pd), suggesting a possible functional interaction between these receptors to regulate basal ganglia function. |
2009-02-06 |
2023-08-12 |
rat |
| Susan H Fox, Rosalind Chuang, Jonathan M Brotchi. Parkinson's disease--opportunities for novel therapeutics to reduce the problems of levodopa therapy. Progress in brain research. vol 172. 2009-01-15. PMID:18772047. |
alternatively, postsynaptic 5-ht(1a), presynaptic 5-ht(1b/1d) receptors and 5-ht(2c) receptors may modulate gaba and glutamate release within other basal ganglia nuclei to reduce lid. |
2009-01-15 |
2023-08-12 |
Not clear |
| Francisco Mora, Gregorio Segovia, Alberto Del Arc. Glutamate-dopamine-GABA interactions in the aging basal ganglia. Brain research reviews. vol 58. issue 2. 2008-12-18. PMID:18036669. |
in this review we focus mostly on our own results on the interaction of the neurotransmitters glutamate, dopamine and gaba in the basal ganglia during the normal process of aging. |
2008-12-18 |
2023-08-12 |
rat |
| Luca Ferraro, Maria Cristina Tomasini, Roberta Mazza, Kjell Fuxe, Jacqueline Fournier, Sergio Tanganelli, Tiziana Antonell. Neurotensin receptors as modulators of glutamatergic transmission. Brain research reviews. vol 58. issue 2. 2008-12-18. PMID:18096238. |
in addition, in different rat brain regions, including the basal ganglia, the contribution of nt receptors in modulating and reinforcing glutamate signalling will be shown including the involvement of interactions between nt and nmda receptors. |
2008-12-18 |
2023-08-12 |
rat |
| R Sanchez-Pernaute, J-Q Wang, D Kuruppu, L Cao, W Tueckmantel, A Kozikowski, O Isacson, A-L Brownel. Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. NeuroImage. vol 42. issue 1. 2008-12-08. PMID:18501638. |
the interplay between dopamine and glutamate in the basal ganglia regulates critical aspects of motor learning and behavior. |
2008-12-08 |
2023-08-12 |
Not clear |