| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Maria Mancini, Silvia Natoli, Fabrizio Gardoni, Monica Di Luca, Antonio Pisan. Dopamine Transmission Imbalance in Neuroinflammation: Perspectives on Long-Term COVID-19. International journal of molecular sciences. vol 24. issue 6. 2023-03-29. PMID:36982693. |
dopamine (da) is a key neurotransmitter in the basal ganglia, implicated in the control of movement and motivation. |
2023-03-29 |
2023-08-14 |
Not clear |
| Masahiro Naga. [Development of disease-modifying drugs for Parkinson's disease. Is it a tough road?] Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 2023-03-29. PMID:36990797. |
levodopa, a dopamine precursor, is the mainstay of treatment for parkinson's disease to correct the malfunction of basal ganglia circuits caused by dopamine deficiency in the brain. |
2023-03-29 |
2023-08-14 |
Not clear |
| Alana Jaskir, Michael J Fran. On the normative advantages of dopamine and striatal opponency for learning and choice. eLife. vol 12. 2023-03-22. PMID:36946371. |
the basal ganglia (bg) contribute to reinforcement learning (rl) and decision making, but unlike artificial rl agents, it relies on complex circuitry and dynamic dopamine modulaton of opponent striatal pathways to do so. |
2023-03-22 |
2023-08-14 |
Not clear |
| Mojtaba Madadi Asl, Abdol-Hossein Vahabie, Alireza Valizadeh, Peter A Tas. Spike-Timing-Dependent Plasticity Mediated by Dopamine and its Role in Parkinson's Disease Pathophysiology. Frontiers in network physiology. vol 2. 2023-03-17. PMID:36926058. |
motor symptoms of pd are linked to the significant dopamine (da) loss in substantia nigra pars compacta (snc) followed by basal ganglia (bg) circuit dysfunction. |
2023-03-17 |
2023-08-14 |
Not clear |
| Katsunori Kitan. The network configuration in Parkinsonian state compensates network activity change caused by loss of dopamine. Physiological reports. vol 11. issue 4. 2023-02-21. PMID:36802196. |
parkinson's disease is a movement disorder caused by dopamine depletion in the basal ganglia. |
2023-02-21 |
2023-08-14 |
Not clear |
| Finnegan J Calabro, David Montez, Bart Larsen, Charles Laymon, William Foran, Michael Hallquist, Julie Price, Beatriz Lun. Striatal dopamine supports reward expectation and learning: A simultaneous PET/fMRI study. NeuroImage. 2022-12-31. PMID:36586541. |
however, competing evidence supports human dopamine signaling in the basal ganglia as also contributing to the generation of higher order learning heuristics. |
2022-12-31 |
2023-08-14 |
human |
| Maeri Yamamoto, Toshiya Inad. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Japanese journal of radiology. 2022-12-08. PMID:36480104. |
several previous pet studies on the central dopaminergic transmission-related ligands in patients with adhd have shown altered binding of dopamine markers in the basal ganglia. |
2022-12-08 |
2023-08-14 |
Not clear |
| Jun Lu, Siamak K Sorooshyar. Machine Learning Identifies a Rat Model of Parkinson's Disease via Sleep-Wake Electroencephalogram. Neuroscience. 2022-12-05. PMID:36470477. |
we hypothesize that nigrostriatal dopamine acting at the basal ganglia regulates cortical activity in sleep and wake state, and its depletion systemically alters electroencephalogram (eeg) across frequencies during sleep-wake state. |
2022-12-05 |
2023-08-14 |
rat |
| M Amin, R Wu, T T Postolache, C Gragnol. Linkage and association of novel DRD2 variants to the comorbidity of type 2 diabetes and depression. European review for medical and pharmacological sciences. vol 26. issue 22. 2022-12-02. PMID:36459020. |
the dopamine receptor 2 (drd2) binds dopamine in both central tissues (e.g., basal ganglia, pituitary gland) and peripheral tissues (e.g., adrenal gland, kidneys, intestine) and mediates dopamine actions in cognition, emotional processing, and prolactin-secretion inhibition and stimulation, and in drd2-/- knockout mice insulin secretion is impaired. |
2022-12-02 |
2023-08-14 |
mouse |
| Kazuki Nakahara, Hiroaki Okuda, Ayami Isonishi, Yoshie Kawabe, Tatsuhide Tanaka, Kouko Tatsumi, Akio Wanak. Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice. Journal of chemical neuroanatomy. 2022-11-20. PMID:36403747. |
in parkinson's disease (pd), a decrease in dopamine levels in the striatum causes abnormal circuit activity in the basal ganglia, resulting in increased output via the substantia nigra pars reticulata (snr). |
2022-11-20 |
2023-08-14 |
mouse |
| Kazuki Nakahara, Hiroaki Okuda, Ayami Isonishi, Yoshie Kawabe, Tatsuhide Tanaka, Kouko Tatsumi, Akio Wanak. Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice. Journal of chemical neuroanatomy. 2022-11-20. PMID:36403747. |
a characteristic feature of glutamatergic synaptic transmission in the basal ganglia circuitry under conditions of dopamine depletion is enhanced synaptic activity of nmda receptors. |
2022-11-20 |
2023-08-14 |
mouse |
| Md Mominur Rahman, Md Rezaul Islam, Sadia Afsana Mim, Nasrin Sultana, Dinesh Kumar Chellappan, Kamal Dua, Mohammad Amjad Kamal, Rohit Sharma, Talha Bin Emra. Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation. Oxidative medicine and cellular longevity. vol 2022. 2022-10-03. PMID:36187336. |
gpr6, gpr52, and gpr8 are termed orphan gpcrs because they colocalize with dopamine d1 and d2 receptors in neurons of the basal ganglia, either alone or with both receptors. |
2022-10-03 |
2023-08-14 |
Not clear |
| Alexander N Rodichkin, Melissa K Edler, Jennifer L McGlothan, Tomás R Guilart. Pathophysiological studies of aging Slc39a14 knockout mice to assess the progression of Manganese-Induced Dystonia-Parkinsonism. Neurotoxicology. 2022-09-24. PMID:36152728. |
neurochemical, neuropathological, and functional assessment of the dopaminergic system of the basal ganglia revealed absence of neurodegenerative changes of dopamine (da) neurons in the substantia nigra pars compacta (snc), with no changes in da or metabolite concentrations in the striatum of slc39a14-ko mice relative to wildtype (wt). |
2022-09-24 |
2023-08-14 |
mouse |
| Montserrat Padilla-Orozco, Mariana Duhne, Alejandra Fuentes-Serrano, Aidán Ortega, Elvira Galarraga, José Bargas, Esther Lara-Gonzále. Synaptic determinants of cholinergic interneurons hyperactivity during parkinsonism. Frontiers in synaptic neuroscience. vol 14. 2022-09-23. PMID:36147730. |
parkinson's disease is a neurodegenerative ailment generated by the loss of dopamine in the basal ganglia, mainly in the striatum. |
2022-09-23 |
2023-08-14 |
Not clear |
| Jacob D Jones, Holly Timblin, Fawn Baxte. Cumulative Effect of Head Injuries on Nonmotor Outcomes in Parkinson's Disease. The Journal of neuropsychiatry and clinical neurosciences. 2022-09-21. PMID:36128680. |
parkinson's disease (pd) is a neurodegenerative movement disorder that is a result of dopamine depletion in the basal ganglia. |
2022-09-21 |
2023-08-14 |
Not clear |
| Jonah Gordon, Gavin Lockard, Molly Monsour, Adam Alayli, Hassan Choudhary, Cesario V Borlonga. Sequestration of Inflammation in Parkinson's Disease via Stem Cell Therapy. International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077534. |
gold standard treatment includes exogenous dopamine therapy in the form of levodopa-carbidopa, or surgical intervention with a deep brain stimulator to the subcortical basal ganglia. |
2022-09-09 |
2023-08-14 |
Not clear |
| Balachandar Vellingiri, Mamatha Chandrasekhar, S Sri Sabari, Abilash Valsala Gopalakrishnan, Arul Narayanasamy, Dhivya Venkatesan, Mahalaxmi Iyer, Kavindra Kesari, Abhijit De. Neurotoxicity of pesticides - A link to neurodegeneration. Ecotoxicology and environmental safety. vol 243. 2022-08-27. PMID:36029574. |
the physiological changes occur due to dopamine depletion in basal ganglia region of the brain. |
2022-08-27 |
2023-08-14 |
Not clear |
| M Grall-Bronnec, C Victorri-Vigneau, T Rouaud, A Verholleman, B Schreck, J Leboucher, E Thiabaud, F Feuillet, M Roy, J B Hardouin, M Guillou-Landreat, P Derkinderen, G Challet-Bouj. Parkinson's disease and iatrogenic impulsive-compulsive behaviors: A case/non-case study to build a complete model of individual vulnerability. Journal of behavioral addictions. 2022-08-12. PMID:35960604. |
first-line medications consist of drugs that act by counteracting dopamine deficiency in the basal ganglia. |
2022-08-12 |
2023-08-14 |
Not clear |
| Florence Véronneau-Veilleux, Philippe Robaey, Mauro Ursino, Fahima Nekk. A mechanistic model of ADHD as resulting from dopamine phasic/tonic imbalance during reinforcement learning. Frontiers in computational neuroscience. vol 16. 2022-08-04. PMID:35923915. |
to this end, we combined a dynamic model of dopamine with a neurocomputational model of the basal ganglia with multiple action channels. |
2022-08-04 |
2023-08-14 |
human |
| Elissavet Akrioti, Timokratis Karamitros, Panagiotis Gkaravelas, Georgia Kouroupi, Rebecca Matsas, Era Taoufi. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease. Biomolecules. vol 12. issue 7. 2022-07-27. PMID:35883433. |
neurodegeneration of dopamine neurons leads to a prominent dopaminergic deficiency in the basal ganglia, responsible for motor disturbances. |
2022-07-27 |
2023-08-14 |
Not clear |