| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Glenda M Hallida. Thalamic changes in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082979. |
because dopamine replacement therapies largely alleviate these motor circuit abnormalities, it has been assumed that pathology in the basal ganglia is entirely responsible for the aberrant thalamic activity which then permeates the motor circuits. |
2010-03-31 |
2023-08-12 |
Not clear |
| Lydia Kerkerian-Le Goff, Loreline Jouve, Christophe Melon, Pascal Sali. Rationale for targeting the thalamic centre-median parafascicular complex in the surgical treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20082982. |
finally, the benefits provided by cm/pf-hfs were associated with widespread impact on the changes in neuronal metabolic activity induced by the dopamine depletion in the basal ganglia. |
2010-03-31 |
2023-08-12 |
rat |
| Erik Ch Wolter. Non-motor extranigral signs and symptoms in Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083010. |
in this disease, synucleinopathic-induced, nigral dopamine deficiency-related dysfunction of the basal ganglia is held responsible for the characteristic levodopa-responsive motor signs and symptoms (bradykinesia, hypokinesia, rigidity), known as parkinsonism and essential for clinical diagnosis in pd, as well as subtle motivational and cognitive dysfunctions. |
2010-03-31 |
2023-08-12 |
Not clear |
| Fabrizio Stocch. The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083012. |
this hypothesis has arisen from studies of the normal basal ganglia demonstrating that nigral dopaminergic neurons normally fire continuously and striatal dopamine levels are relatively constant. |
2010-03-31 |
2023-08-12 |
monkey |
| Fabrizio Stocch. The therapeutic concept of continuous dopaminergic stimulation (CDS) in the treatment of Parkinson's disease. Parkinsonism & related disorders. vol 15 Suppl 3. 2010-03-31. PMID:20083012. |
in mptp monkeys, pulsatile stimulation of striatal dopamine receptors with short-acting agents is associated with the induction of molecular and physiologic changes in basal ganglia neurons and the development of motor complications. |
2010-03-31 |
2023-08-12 |
monkey |
| Jon-Eric VanLeeuwen, Giselle M Petzinger, John P Walsh, Garnik K Akopian, Marta Vuckovic, Michael W Jakowe. Altered AMPA receptor expression with treadmill exercise in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Journal of neuroscience research. vol 88. issue 3. 2010-03-30. PMID:19746427. |
dopamine depletion leads to impaired motor performance and increased glutamatergic-mediated hyperexcitability of medium spiny neurons in the basal ganglia. |
2010-03-30 |
2023-08-12 |
mouse |
| Daniel G Dillon, Ryan Bogdan, Jesen Fagerness, Avram J Holmes, Roy H Perlis, Diego A Pizzagall. Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Human brain mapping. vol 31. issue 2. 2010-03-22. PMID:19621370. |
in control analyses, associations between basal ganglia responses to gains and functional polymorphisms in the dopamine transporter (dat1) and catechol-o-methyltransferase (comt) genes were also explored. |
2010-03-22 |
2023-08-12 |
Not clear |
| Naoya Hamaue, Akihiko Ogata, Mutsuko Terado, Shirou Tsuchida, Ichiro Yabe, Hidenao Sasaki, Masahiko Hirafuji, Hiroko Togashi, Takashi Aok. Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus. Brain research. vol 1309. 2010-02-26. PMID:19879254. |
entacapone, a catechol-o-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of parkinson's disease induced by japanese encephalitis virus. |
2010-02-26 |
2023-08-12 |
rat |
| Mohamed Khalil Tamim, Pershia Samadi, Marc Morissette, Laurent Grégoire, Bazoumana Ouattara, Daniel Lévesque, Claude Rouillard, Thérèse Di Paol. Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides. Neuropharmacology. vol 58. issue 1. 2010-02-25. PMID:19576910. |
dopamine denervation in parkinson's disease and repeated levodopa (l-dopa) administration that induces dyskinesias are associated with an enhancement of basal ganglia neuropeptide transmission. |
2010-02-25 |
2023-08-12 |
monkey |
| Irene Avila, Louise C Parr-Brownlie, Elena Brazhnik, Edward Castañeda, Debra A Bergstrom, Judith R Walter. Beta frequency synchronization in basal ganglia output during rest and walk in a hemiparkinsonian rat. Experimental neurology. vol 221. issue 2. 2010-02-16. PMID:19948166. |
the unilaterally lesioned rat model of parkinson's disease allows examination of this hypothesis by direct comparison of beta activity in basal ganglia output in non-lesioned and dopamine cell lesioned hemispheres during motor activity. |
2010-02-16 |
2023-08-12 |
rat |
| Rubing Zhao-Shea, Bruce N Cohen, Herwig Just, Tristan McClure-Begley, Paul Whiteaker, Sharon R Grady, Outi Salminen, Paul D Gardner, Henry A Lester, Andrew R Tappe. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive {alpha}4 nicotinic receptors via a cholinergic-dependent mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 24. issue 1. 2010-02-02. PMID:19720621. |
recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nachrs) containing alpha4 and beta2 subunits (alpha4beta2*) functionally interact with g-protein-coupled dopamine (da) d(2) receptors in basal ganglia. |
2010-02-02 |
2023-08-12 |
mouse |
| Yun-Hai Qiu, Xin-Yin Wu, Hao Xu, David Sacket. Neuroimaging study of placebo analgesia in humans. Neuroscience bulletin. vol 25. issue 5. 2010-01-25. PMID:19784082. |
further pet studies with dopamine d2/d3 receptor-labeling radiotracer demonstrate that basal ganglia including nac are related to placebo analgesic responses. |
2010-01-25 |
2023-08-12 |
human |
| b' C\\xc3\\xa9sar Quiroz, Rafael Luj\\xc3\\xa1n, Motokazu Uchigashima, Ana Patr\\xc3\\xadcia Simoes, Talia N Lerner, Janusz Borycz, Anil Kachroo, Paula M Canas, Marco Orru, Michael A Schwarzschild, Diane L Rosin, Anatol C Kreitzer, Rodrigo A Cunha, Masahiko Watanabe, Sergi Ferr\\xc3\\xa. Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. TheScientificWorldJournal. vol 9. 2010-01-07. PMID:19936569.' |
basal ganglia processing results from a balanced activation of direct and indirect striatal efferent pathways, which are controlled by dopamine d1 and d2 receptors, respectively. |
2010-01-07 |
2023-08-12 |
Not clear |
| S Arpin, E Lagrue, S Bodard, S Chalon, P Castelna. Basal ganglia neuroprotection with anticonvulsants after energy stress: a comparative study. Metabolic brain disease. vol 24. issue 3. 2009-12-30. PMID:19789969. |
the membrane dopamine transporter (dat) density, which provides a reliable index of dopaminergic neurons survival in the basal ganglia, was assessed by semi-quantitative autoradiography of the striatum. |
2009-12-30 |
2023-08-12 |
mouse |
| Ju Mizuno, Shinya Kato, Minako Watada, Shigeho Morit. [Perioperative management of a patient with Parkinson's disease with intravenous infusion of levodopa]. Masui. The Japanese journal of anesthesiology. vol 58. issue 10. 2009-12-29. PMID:19860235. |
parkinson's disease is a disorder of the extrapyramidal system resulting from the deficiency of dopamine in the basal ganglia. |
2009-12-29 |
2023-08-12 |
Not clear |
| A J Betz, R Vontell, J Valenta, L Worden, K S Sink, L Font, M Correa, T N Sager, J D Salamon. Effects of the adenosine A 2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide. Neuroscience. vol 163. issue 1. 2009-12-15. PMID:19467297. |
furthermore, there is an antagonistic interaction between adenosine a(2a) and dopamine d(2) receptors in the basal ganglia, which is important for motor functions related to the production of parkinsonian symptoms. |
2009-12-15 |
2023-08-12 |
rat |
| M J Dowie, H B Bradshaw, M L Howard, L F B Nicholson, R L M Faull, A J Hannan, M Glas. Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. Neuroscience. vol 163. issue 1. 2009-12-15. PMID:19524019. |
loss of cannabinoid cb1 receptor ligand binding in key brain regions is detected early in hd in human postmortem tissue [glass m, dragunow m, faull rl (2000) the pattern of neurodegeneration in huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and gaba(a) receptor alterations in the human basal ganglia in huntington's disease. |
2009-12-15 |
2023-08-12 |
mouse |
| Andrew R Brown, Bin Hu, Michael C Antle, G Campbell Teske. Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism. Experimental neurology. vol 220. issue 1. 2009-11-13. PMID:19703443. |
the neurophysiologic model of parkinson's disease predicts nigrostriatal dopamine depletion leads to increased inhibitory basal ganglia output resulting in frontal neocortical hypoactivity. |
2009-11-13 |
2023-08-12 |
rat |
| Andrew R Brown, Bin Hu, Michael C Antle, G Campbell Teske. Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism. Experimental neurology. vol 220. issue 1. 2009-11-13. PMID:19703443. |
results suggest basal ganglia dopamine deficiency can affect the topographic organization of sensorimotor neocortex and lead to significant reduction in the size of motor representations. |
2009-11-13 |
2023-08-12 |
rat |
| Monika Meyer-Baron, Guido Knapp, Michael Schäper, Christoph van Thrie. Performance alterations associated with occupational exposure to manganese--a meta-analysis. Neurotoxicology. vol 30. issue 4. 2009-10-27. PMID:19465050. |
the evidence of cognitive and motor performance effects is in accordance with the knowledge about accumulation of manganese in the basal ganglia and the effect of manganese on the neurotransmitter dopamine. |
2009-10-27 |
2023-08-12 |
Not clear |