| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Ghosh, B J Liddl. Emergency presentations of Parkinson's disease: early recognition and treatment are crucial for optimum outcome. Postgraduate medical journal. vol 87. issue 1024. 2011-12-01. PMID:21106801. |
pathophysiologically the illness is due to a disruption of dopamine production in the basal ganglia and leads to a wide array of symptoms. |
2011-12-01 |
2023-08-12 |
Not clear |
| Léon Trembla. [Pathophysiology of Parkinson's disease: an update]. Bulletin de l'Academie nationale de medecine. vol 194. issue 7. 2011-11-29. PMID:22043627. |
to better understand the nature and diversity of the symptoms of parkinson's disease it is necessary to integrate clinical knowledge on 1) the role of dopamine, 2) the anatomical and functional organization of the basal ganglia, and 3) the dysfunctions observed in mptp-treated monkeys. |
2011-11-29 |
2023-08-12 |
monkey |
| Ewa Taracha, Wanda Dyr, Marta Ćwiek, Danuta Turzyńska, Jerzy Walkowiak, Edyta Wyszogrodzka, Wojciech Kostowski, Adam Płaźnik, Stanisław J Chrapust. Diverse behavioral, monoaminergic and Fos protein responses to opioids in Warsaw high-alcohol preferring and Warsaw low-alcohol preferring rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 2. 2011-11-22. PMID:21216264. |
these differences were associated with differences in monoamine metabolite levels that were suggestive of elevated basal ganglia and lowered frontal cortical dopamine function, and of lowered somatosensory cortex serotonin function, in the morphine-challenged whp rats (irrespective of the pretreatment type). |
2011-11-22 |
2023-08-12 |
rat |
| Alessandra Bonito-Oliva, Michael Feyder, Gilberto Fison. Deciphering the Actions of Antiparkinsonian and Antipsychotic Drugs on cAMP/DARPP-32 Signaling. Frontiers in neuroanatomy. vol 5. 2011-11-10. PMID:21808606. |
there are two large populations of striatal msns, which differ based on their connectivity to the output nuclei of the basal ganglia and on their ability to express dopamine d1 receptors (d1rs) or d2rs. |
2011-11-10 |
2023-08-12 |
Not clear |
| Lea Tenenholz Grinberg, Udo Rueb, Helmut Heinse. Brainstem: neglected locus in neurodegenerative diseases. Frontiers in neurology. vol 2. 2011-11-10. PMID:21808630. |
however, pd pathophysiology was explained by dopamine depletion in the telencephalic basal ganglia due to insufficiency and degeneration of the projection neurons located in sn. |
2011-11-10 |
2023-08-12 |
Not clear |
| Thomas Del'guidice, Morgane Lemasson, Jean-Martin Beaulie. Role of Beta-arrestin 2 downstream of dopamine receptors in the Basal Ganglia. Frontiers in neuroanatomy. vol 5. 2011-11-10. PMID:21922001. |
role of beta-arrestin 2 downstream of dopamine receptors in the basal ganglia. |
2011-11-10 |
2023-08-12 |
Not clear |
| Thomas Del'guidice, Morgane Lemasson, Jean-Martin Beaulie. Role of Beta-arrestin 2 downstream of dopamine receptors in the Basal Ganglia. Frontiers in neuroanatomy. vol 5. 2011-11-10. PMID:21922001. |
overall, the identification of a cell signaling function for βarr downstream of dopamine receptors underscores the intricate complexity of the intertwined mechanisms regulating and mediating cell signaling in the basal ganglia. |
2011-11-10 |
2023-08-12 |
Not clear |
| Aryn H Gittis, Giao B Hang, Eva S LaDow, Liza R Shoenfeld, Bassam V Atallah, Steven Finkbeiner, Anatol C Kreitze. Rapid target-specific remodeling of fast-spiking inhibitory circuits after loss of dopamine. Neuron. vol 71. issue 5. 2011-10-28. PMID:21903079. |
in parkinson's disease (pd), dopamine depletion alters neuronal activity in the direct and indirect pathways and leads to increased synchrony in the basal ganglia network. |
2011-10-28 |
2023-08-12 |
Not clear |
| Shesharao M Wanjerkhede, Raju S Bap. Role of CAMKII in reinforcement learning: a computational model of glutamate and dopamine signaling pathways. Biological cybernetics. vol 104. issue 6. 2011-10-24. PMID:21701878. |
timely release of dopamine (da) at the striatum seems to be important for reinforcement learning (rl) mediated by the basal ganglia. |
2011-10-24 |
2023-08-12 |
Not clear |
| Ahmed A Moustafa, Mark A Gluc. Computational cognitive models of prefrontal-striatal-hippocampal interactions in Parkinson's disease and schizophrenia. Neural networks : the official journal of the International Neural Network Society. vol 24. issue 6. 2011-09-30. PMID:21411277. |
in our models, pd is associated with reduced dopamine levels in the basal ganglia and prefrontal cortex. |
2011-09-30 |
2023-08-12 |
Not clear |
| Ahmed A Moustafa, Mark A Gluc. Computational cognitive models of prefrontal-striatal-hippocampal interactions in Parkinson's disease and schizophrenia. Neural networks : the official journal of the International Neural Network Society. vol 24. issue 6. 2011-09-30. PMID:21411277. |
we also describe an extended model that includes simulation of the different functional role of d1 and d2 dopamine receptors in the basal ganglia and prefrontal cortex, a dissociation we argue is essential for understanding the non-uniform effects of levodopa, dopamine agonists, and antipsychotics on cognition. |
2011-09-30 |
2023-08-12 |
Not clear |
| Choongseok Park, Robert M Worth, Leonid L Rubchinsk. Neural dynamics in parkinsonian brain: the boundary between synchronized and nonsynchronized dynamics. Physical review. E, Statistical, nonlinear, and soft matter physics. vol 83. issue 4 Pt 1. 2011-09-30. PMID:21599224. |
we show that the experimentally observed intermittent synchrony can be generated just by moderately increased coupling strength in the basal ganglia circuits due to the lack of dopamine. |
2011-09-30 |
2023-08-12 |
human |
| A Jon Stoessl, David J Brooks, David Eidelber. Milestones in neuroimaging. Movement disorders : official journal of the Movement Disorder Society. vol 26. issue 6. 2011-09-30. PMID:21626537. |
in addition to utility in diagnosis, these have led to novel insights into the pathogenesis of basal ganglia disease and the role of dopamine and the basal ganglia in normal health. |
2011-09-30 |
2023-08-12 |
Not clear |
| Jan Kehler, Jacob Nielse. PDE10A inhibitors: novel therapeutic drugs for schizophrenia. Current pharmaceutical design. vol 17. issue 2. 2011-09-29. PMID:21355834. |
biochemical and behavioral data indicate that pde10a inhibition activates camp/pka signalling in the basal ganglia, leading to the potentiation of dopamine d₁ receptor signalling, and concomitant inhibition of dopamine d₂ receptor signalling. |
2011-09-29 |
2023-08-12 |
Not clear |
| I G Sil'ki. [A possible mechanism of participation of neuronal loops cortex - basal ganglia - thalamus - cortex in time perception]. Uspekhi fiziologicheskikh nauk. vol 42. issue 2. 2011-09-28. PMID:21735704. |
the time of repeated excitation which determines clock rate of "intrinsic clock", depends on dopamine influence at functioning of the cortico - basal ganglia - thalamocortical loop that promotes contrasted amplification of activity of cortical neurones, firstly activated by stimulus. |
2011-09-28 |
2023-08-12 |
Not clear |
| I G Sil'ki. [A possible mechanism of participation of neuronal loops cortex - basal ganglia - thalamus - cortex in time perception]. Uspekhi fiziologicheskikh nauk. vol 42. issue 2. 2011-09-28. PMID:21735704. |
the mechanism of time perception is similar for stimuli of different modalities owing to resemblance of functioning of topically organised cortico - basal ganglia - thalamocortical loops, it follows from our model that the more (less) concentration of dopamine in the striatumm the higher (low) clock rate, so the real interval will be estimated more (less) precisely and perceived as longer (short). |
2011-09-28 |
2023-08-12 |
Not clear |
| Marie-Josée Wallman, Dave Gagnon, Martin Paren. Serotonin innervation of human basal ganglia. The European journal of neuroscience. vol 33. issue 8. 2011-09-16. PMID:21375599. |
the fact that all components of human basal ganglia receive a dense 5-ht input indicates that, in concert with dopamine, 5-ht plays a crucial role in the functional organization of these motor-related structures, which are often targeted in neurodegenerative diseases. |
2011-09-16 |
2023-08-12 |
human |
| Hitoshi Kita, Takako Kit. Cortical stimulation evokes abnormal responses in the dopamine-depleted rat basal ganglia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 28. 2011-09-12. PMID:21753008. |
motor disabilities in patients and animal models of parkinson's disease (pd) may be caused by dopamine (da)-depleted basal ganglia that abnormally process the information originating from mc. |
2011-09-12 |
2023-08-12 |
human |
| Lazlo Horvath, Ingrid van Marion, Khalid Taï, Troels Tolstrup Nielsen, Cecilia Lundber. Knockdown of GAD67 protein levels normalizes neuronal activity in a rat model of Parkinson's disease. The journal of gene medicine. vol 13. issue 3. 2011-08-23. PMID:21449035. |
the loss of dopamine upregulates gad67 expression in the striatal projection neurons and causes other changes in the activity of the basal ganglia circuit. |
2011-08-23 |
2023-08-12 |
rat |
| Robert H Howlan. Drug therapies for tardive dyskinesia: Part 1. Journal of psychosocial nursing and mental health services. vol 49. issue 6. 2011-08-05. PMID:21598866. |
blocking dopamine (da) receptors in the basal ganglia can cause parkinsonian symptoms, acute dystonia, akathisia, tardive dyskinesia (td), and neuroleptic malignant syndrome. |
2011-08-05 |
2023-08-12 |
Not clear |