| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teresa Morera-Herreras, Cristina Miguelez, Asier Aristieta, José Ángel Ruiz-Ortega, Luisa Uged. Endocannabinoid modulation of dopaminergic motor circuits. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22701427. |
on the other hand, there are profound changes in cb(1) receptor cannabinoid signaling in the basal ganglia circuits after dopamine depletion (as happens in parkinson's disease) and following l-dopa replacement therapy. |
2012-10-02 |
2023-08-12 |
Not clear |
| Kelly A Meulendyke, Mikhail V Pletnikov, Elizabeth L Engle, Patrick M Tarwater, David R Graham, M Christine Zin. Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 2. 2012-09-24. PMID:22198699. |
da decline was not due to direct loss of dopaminergic projections to the basal ganglia as there was no difference in tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter 2 or synaptophysin between minocycline-treated and untreated macaques. |
2012-09-24 |
2023-08-12 |
Not clear |
| A Mohajjel Nayebi A, H Sheidae. Buspirone improves haloperidol-induced Parkinson disease in mice through 5-HT(1A) recaptors. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 18. issue 1. 2012-08-23. PMID:22615592. |
the available literatures show that 5-ht(1a) receptors are widely distributed throughout the basal ganglia, and their activation facilitate dopamine release. |
2012-08-23 |
2023-08-12 |
mouse |
| Micaela Morelli, Fabio Blandini, Nicola Simola, Robert A Hause. A(2A) Receptor Antagonism and Dyskinesia in Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22754707. |
the unique cellular and regional distribution of adenosine a(2a) receptors in basal ganglia areas that are richly innervated by dopamine, and their antagonistic role towards dopamine receptor stimulation, have positioned a(2a) receptor antagonists as an attractive nondopaminergic target to improve the motor deficits that characterize pd. |
2012-08-23 |
2023-08-12 |
Not clear |
| Melissa L Perreault, Theresa Fan, Mohammed Alijaniaram, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. PloS one. vol 7. issue 3. 2012-08-20. PMID:22428025. |
this could have broad implications in understanding how dysregulation of neurotransmission within basal ganglia contributes to dopamine neuronal dysfunction. |
2012-08-20 |
2023-08-12 |
Not clear |
| Masato Kinboshi, Manabu Inoue, Yasuhiro Kojima, Tomokazu Nakagawa, Masutaro Kanda, Hiroshi Shibasak. [Elderly case of moyamoya disease presenting with hemichorea]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 1. 2012-08-17. PMID:22260975. |
in the present case, increased rcbf in the basal ganglia and remarkable effect of a dopamine d2 blocker suggest functional abnormality of the corresponding striatum as an underlying cause of hemichorea. |
2012-08-17 |
2023-08-12 |
Not clear |
| Elena Brazhnik, Ana V Cruz, Irene Avila, Marian I Wahba, Nikolay Novikov, Neda M Ilieva, Alex J McCoy, Colin Gerber, Judith R Walter. State-dependent spike and local field synchronization between motor cortex and substantia nigra in hemiparkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674263. |
to gain insight into processes underlying this activity, this study explores relationships between oscillatory activity in motor cortex and basal ganglia output in behaving rats after dopamine cell lesion. |
2012-08-09 |
2023-08-12 |
rat |
| Elena Brazhnik, Ana V Cruz, Irene Avila, Marian I Wahba, Nikolay Novikov, Neda M Ilieva, Alex J McCoy, Colin Gerber, Judith R Walter. State-dependent spike and local field synchronization between motor cortex and substantia nigra in hemiparkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674263. |
high coherence between lfp oscillations in cortex and snpr supports the view that cortical activity facilitates entrainment and synchronization of activity in basal ganglia after loss of dopamine. |
2012-08-09 |
2023-08-12 |
rat |
| C A Brown, M C Campbell, M Karimi, S D Tabbal, S K Loftin, L L Tian, S M Moerlein, J S Perlmutte. Dopamine pathway loss in nucleus accumbens and ventral tegmental area predicts apathetic behavior in MPTP-lesioned monkeys. Experimental neurology. vol 236. issue 1. 2012-08-07. PMID:22579525. |
although dysfunction of basal ganglia pathways may contribute to apathy, the role of dopamine remains largely unknown. |
2012-08-07 |
2023-08-12 |
monkey |
| Andrew M Clark, Sebastien Bouret, Adrienne M Young, Barry J Richmon. Intersection of reward and memory in monkey rhinal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593056. |
signals related to reward prediction and valuation are believed to be encoded in a circuit centered around midbrain dopamine neurons and their targets in the prefrontal cortex and basal ganglia. |
2012-07-27 |
2023-08-12 |
monkey |
| Karin Foerde, Daphna Shoham. The role of the basal ganglia in learning and memory: insight from Parkinson's disease. Neurobiology of learning and memory. vol 96. issue 4. 2012-07-19. PMID:21945835. |
these findings have led to new discoveries about the role of the basal ganglia in learning and highlighted the essential role of dopamine in specific forms of learning. |
2012-07-19 |
2023-08-12 |
Not clear |
| Miguel Schwartz, Sergiu Sabeta. An approach to the continuous dopaminergic stimulation in Parkinson's disease. The Israel Medical Association journal : IMAJ. vol 14. issue 3. 2012-07-10. PMID:22675859. |
dopaminergic neurons in the basal ganglia normally fire in a continuous manner, maintaining the striatal dopamine concentration at a relatively constant level. |
2012-07-10 |
2023-08-12 |
Not clear |
| B A Morrow, R H Roth, D E Redmond, S Diano, J D Elswort. Susceptibility to a parkinsonian toxin varies during primate development. Experimental neurology. vol 235. issue 1. 2012-06-29. PMID:22366325. |
symptoms of parkinson's disease typically emerge later in life when loss of nigrostriatal dopamine neuron function exceeds the threshold of compensatory mechanisms in the basal ganglia. |
2012-06-29 |
2023-08-12 |
Not clear |
| Peter B Schwarz, John H Peeve. Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons. Journal of neurophysiology. vol 106. issue 3. 2012-06-26. PMID:21653722. |
dopamine controls movement by modulation of higher-order motor centers (e.g., basal ganglia) but may also regulate movement by directly controlling motoneuron function. |
2012-06-26 |
2023-08-12 |
rat |
| N R Ferreira, M Mitkovski, W Stühmer, L A Pardo, E A Del Be. Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion. Neurotoxicity research. vol 21. issue 3. 2012-06-26. PMID:22048886. |
as dopamine may directly affect k(+) channels, we evaluated whether a nigrostriatal dopaminergic lesion induced by the neurotoxin 6-hydroxydopamine (6-ohda) would alter eag1-k(+) channel expression in the rat basal ganglia and related brain regions. |
2012-06-26 |
2023-08-12 |
rat |
| Iain S McGregor, Michael T Bowe. Breaking the loop: oxytocin as a potential treatment for drug addiction. Hormones and behavior. vol 61. issue 3. 2012-06-25. PMID:22198308. |
very recent preclinical studies have illustrated a remarkable ability of exogenously delivered oxytocin to inhibit stimulant and alcohol self-administration, to alter associated drug-induced changes in dopamine, glutamate and fos expression in cortical and basal ganglia sites, and to prevent stress and priming-induced relapse to drug seeking. |
2012-06-25 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
this study demonstrates that (1) dopamine d1 and d2 receptors in striatum, like nigral d1 receptors, are needed for mamph-induced striatal dat reductions, (2) these same receptors are needed for mamph-induced sert loss, and (3) these widespread influences of striatal dopamine receptor antagonists are likely attributable to circuits connecting basal ganglia to thalamus and cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| E Loyens, A Schallier, S Y Chai, D De Bundel, P Vanderheyden, Y Michotte, I Smolder. Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures. Seizure. vol 20. issue 8. 2012-06-18. PMID:21612947. |
it has been hypothesized that the latter effects on seizures could be established via a modulatory effect on dopamine receptors in the basal ganglia or via an indirect interaction between ang iv and adenosine a1 receptors. |
2012-06-18 |
2023-08-12 |
mouse |
| Catherine Bédard, Marie-Josée Wallman, Emmanuelle Pourcher, Peter V Gould, André Parent, Martin Paren. Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea. Parkinsonism & related disorders. vol 17. issue 8. 2012-06-18. PMID:21664855. |
in contrast to our vast knowledge of the dopamine (da) system, much less is known about the involvement of serotonin (5-ht) in neurodegenerative diseases affecting the basal ganglia. |
2012-06-18 |
2023-08-12 |
Not clear |
| Silke Anders, Benjamin Sack, Anna Pohl, Thomas Münte, Peter Pramstaller, Christine Klein, Ferdinand Binkofsk. Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. Brain : a journal of neurology. vol 135. issue Pt 4. 2012-06-08. PMID:22434215. |
neuroimaging studies provide evidence that increased motor-related cortical activity can compensate for progressive dopaminergic nerve degeneration in carriers of a single mutant parkin or pink1 gene, who show a mild but significant reduction of dopamine metabolism in the basal ganglia in the complete absence of clinical motor signs. |
2012-06-08 |
2023-08-12 |
human |