| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Brazhnik, Ana V Cruz, Irene Avila, Marian I Wahba, Nikolay Novikov, Neda M Ilieva, Alex J McCoy, Colin Gerber, Judith R Walter. State-dependent spike and local field synchronization between motor cortex and substantia nigra in hemiparkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674263. |
to gain insight into processes underlying this activity, this study explores relationships between oscillatory activity in motor cortex and basal ganglia output in behaving rats after dopamine cell lesion. |
2012-08-09 |
2023-08-12 |
rat |
| Elena Brazhnik, Ana V Cruz, Irene Avila, Marian I Wahba, Nikolay Novikov, Neda M Ilieva, Alex J McCoy, Colin Gerber, Judith R Walter. State-dependent spike and local field synchronization between motor cortex and substantia nigra in hemiparkinsonian rats. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674263. |
high coherence between lfp oscillations in cortex and snpr supports the view that cortical activity facilitates entrainment and synchronization of activity in basal ganglia after loss of dopamine. |
2012-08-09 |
2023-08-12 |
rat |
| C A Brown, M C Campbell, M Karimi, S D Tabbal, S K Loftin, L L Tian, S M Moerlein, J S Perlmutte. Dopamine pathway loss in nucleus accumbens and ventral tegmental area predicts apathetic behavior in MPTP-lesioned monkeys. Experimental neurology. vol 236. issue 1. 2012-08-07. PMID:22579525. |
although dysfunction of basal ganglia pathways may contribute to apathy, the role of dopamine remains largely unknown. |
2012-08-07 |
2023-08-12 |
monkey |
| Andrew M Clark, Sebastien Bouret, Adrienne M Young, Barry J Richmon. Intersection of reward and memory in monkey rhinal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 20. 2012-07-27. PMID:22593056. |
signals related to reward prediction and valuation are believed to be encoded in a circuit centered around midbrain dopamine neurons and their targets in the prefrontal cortex and basal ganglia. |
2012-07-27 |
2023-08-12 |
monkey |
| Karin Foerde, Daphna Shoham. The role of the basal ganglia in learning and memory: insight from Parkinson's disease. Neurobiology of learning and memory. vol 96. issue 4. 2012-07-19. PMID:21945835. |
these findings have led to new discoveries about the role of the basal ganglia in learning and highlighted the essential role of dopamine in specific forms of learning. |
2012-07-19 |
2023-08-12 |
Not clear |
| Miguel Schwartz, Sergiu Sabeta. An approach to the continuous dopaminergic stimulation in Parkinson's disease. The Israel Medical Association journal : IMAJ. vol 14. issue 3. 2012-07-10. PMID:22675859. |
dopaminergic neurons in the basal ganglia normally fire in a continuous manner, maintaining the striatal dopamine concentration at a relatively constant level. |
2012-07-10 |
2023-08-12 |
Not clear |
| B A Morrow, R H Roth, D E Redmond, S Diano, J D Elswort. Susceptibility to a parkinsonian toxin varies during primate development. Experimental neurology. vol 235. issue 1. 2012-06-29. PMID:22366325. |
symptoms of parkinson's disease typically emerge later in life when loss of nigrostriatal dopamine neuron function exceeds the threshold of compensatory mechanisms in the basal ganglia. |
2012-06-29 |
2023-08-12 |
Not clear |
| Peter B Schwarz, John H Peeve. Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons. Journal of neurophysiology. vol 106. issue 3. 2012-06-26. PMID:21653722. |
dopamine controls movement by modulation of higher-order motor centers (e.g., basal ganglia) but may also regulate movement by directly controlling motoneuron function. |
2012-06-26 |
2023-08-12 |
rat |
| N R Ferreira, M Mitkovski, W Stühmer, L A Pardo, E A Del Be. Ether-à-go-go 1 (Eag1) potassium channel expression in dopaminergic neurons of basal ganglia is modulated by 6-hydroxydopamine lesion. Neurotoxicity research. vol 21. issue 3. 2012-06-26. PMID:22048886. |
as dopamine may directly affect k(+) channels, we evaluated whether a nigrostriatal dopaminergic lesion induced by the neurotoxin 6-hydroxydopamine (6-ohda) would alter eag1-k(+) channel expression in the rat basal ganglia and related brain regions. |
2012-06-26 |
2023-08-12 |
rat |
| Iain S McGregor, Michael T Bowe. Breaking the loop: oxytocin as a potential treatment for drug addiction. Hormones and behavior. vol 61. issue 3. 2012-06-25. PMID:22198308. |
very recent preclinical studies have illustrated a remarkable ability of exogenously delivered oxytocin to inhibit stimulant and alcohol self-administration, to alter associated drug-induced changes in dopamine, glutamate and fos expression in cortical and basal ganglia sites, and to prevent stress and priming-induced relapse to drug seeking. |
2012-06-25 |
2023-08-12 |
Not clear |
| Noah B Gross, Patrick C Duncker, John F Marshal. Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse (New York, N.Y.). vol 65. issue 11. 2012-06-18. PMID:21584865. |
this study demonstrates that (1) dopamine d1 and d2 receptors in striatum, like nigral d1 receptors, are needed for mamph-induced striatal dat reductions, (2) these same receptors are needed for mamph-induced sert loss, and (3) these widespread influences of striatal dopamine receptor antagonists are likely attributable to circuits connecting basal ganglia to thalamus and cortex. |
2012-06-18 |
2023-08-12 |
Not clear |
| E Loyens, A Schallier, S Y Chai, D De Bundel, P Vanderheyden, Y Michotte, I Smolder. Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures. Seizure. vol 20. issue 8. 2012-06-18. PMID:21612947. |
it has been hypothesized that the latter effects on seizures could be established via a modulatory effect on dopamine receptors in the basal ganglia or via an indirect interaction between ang iv and adenosine a1 receptors. |
2012-06-18 |
2023-08-12 |
mouse |
| Catherine Bédard, Marie-Josée Wallman, Emmanuelle Pourcher, Peter V Gould, André Parent, Martin Paren. Serotonin and dopamine striatal innervation in Parkinson's disease and Huntington's chorea. Parkinsonism & related disorders. vol 17. issue 8. 2012-06-18. PMID:21664855. |
in contrast to our vast knowledge of the dopamine (da) system, much less is known about the involvement of serotonin (5-ht) in neurodegenerative diseases affecting the basal ganglia. |
2012-06-18 |
2023-08-12 |
Not clear |
| Silke Anders, Benjamin Sack, Anna Pohl, Thomas Münte, Peter Pramstaller, Christine Klein, Ferdinand Binkofsk. Compensatory premotor activity during affective face processing in subclinical carriers of a single mutant Parkin allele. Brain : a journal of neurology. vol 135. issue Pt 4. 2012-06-08. PMID:22434215. |
neuroimaging studies provide evidence that increased motor-related cortical activity can compensate for progressive dopaminergic nerve degeneration in carriers of a single mutant parkin or pink1 gene, who show a mild but significant reduction of dopamine metabolism in the basal ganglia in the complete absence of clinical motor signs. |
2012-06-08 |
2023-08-12 |
human |
| Ignacio Obeso, Leonora Wilkinson, Marjan Jahanshah. Levodopa medication does not influence motor inhibition or conflict resolution in a conditional stop-signal task in Parkinson's disease. Experimental brain research. vol 213. issue 4. 2012-06-01. PMID:21796541. |
evidence from animal, clinical, and imaging studies suggests that the basal ganglia and their frontal connections mediate motor inhibition, but the role of dopamine remains unclear. |
2012-06-01 |
2023-08-12 |
human |
| Y Iris Chen, Jia-Qian Ren, Ted J Kaptchuk, Kenneth K Kwon. Restoring cerebral dopamine homeostasis by electrical forepaw stimulation: an FMRI study. Synapse (New York, N.Y.). vol 66. issue 4. 2012-05-21. PMID:22170513. |
as dopamine function is tightly regulated within the basal ganglia circuitry, cortical perturbation would lead to modulation of dopaminergic activity in the striatum. |
2012-05-21 |
2023-08-12 |
rat |
| Margaret E Ric. H2O2: a dynamic neuromodulator. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 17. issue 4. 2012-05-17. PMID:21666063. |
this rapid signaling has been examined most thoroughly in the nigrostriatal dopamine (da) pathway, which plays a key role in facilitating movement mediated by the basal ganglia. |
2012-05-17 |
2023-08-12 |
Not clear |
| Ana C Barceló, Bárbara Filippini, Jorge H Paz. The striatum and pain modulation. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21789630. |
this analgesic action of the striatum was mediated by activation of its dopamine d(2) receptors and transmitted through the indirect pathways of the basal ganglia and the medullary dorsal reticular nucleus (rvm) to the sensorial nuclei of the trigeminal nerve. |
2012-05-17 |
2023-08-12 |
Not clear |
| Lina Mastrangelo, Ji-Eun Kim, Atsushi Miyanohara, Tae Hyuk Kang, Theodore Friedman. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 9. 2012-05-08. PMID:22331909. |
lesch-nyhan disease (lnd) is an x-linked genetic disorder caused by mutations of the hypoxanthine guanine phosphoribosyltransferase (hprt) purine biosynthesis gene and characterized by aberrant purine metabolism, deficient basal ganglia dopamine levels, dystonia, and severe neurobehavioral manifestations, including compulsive self-injurious behavior. |
2012-05-08 |
2023-08-12 |
human |
| Véronique Sgambato-Faure, Maria Angela Cenc. Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease. Progress in neurobiology. vol 96. issue 1. 2012-05-07. PMID:22075179. |
accumulating evidence indicates that dyskinesias induced by stn-hfs and dopamine replacement therapy are linked to dysregulation of glutamate transmission in the basal ganglia. |
2012-05-07 |
2023-08-12 |
rat |