| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
methamphetamine-induced partial dopamine depletions are associated with impaired basal ganglia function, including decreased preprotachykinin mrna expression and impaired transcriptional activation of activity-regulated, cytoskeleton-associated (arc) gene in striatum. |
2013-07-01 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
recent work implicates deficits in phasic dopamine signaling as a potential mechanism linking methamphetamine-induced dopamine loss to impaired basal ganglia function. |
2013-07-01 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
this study thus sought to establish a causal link between phasic dopamine transmission and altered basal ganglia function by determining whether the deficits in striatal neuron gene expression could be restored by increasing phasic dopamine release. |
2013-07-01 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
these results suggest that disruption of phasic dopamine signaling likely underlies methamphetamine-induced impairments in basal ganglia function, and that restoring phasic dopamine signaling may be a viable approach to manage long-term consequences of methamphetamine-induced dopamine loss on basal ganglia functions. |
2013-07-01 |
2023-08-12 |
rat |
| Jesper Ericsson, Marcus Stephenson-Jones, Juan Pérez-Fernández, Brita Robertson, Gilad Silberberg, Sten Grillne. Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637194. |
the functions of the basal ganglia are critically dependent on dopamine. |
2013-07-01 |
2023-08-12 |
Not clear |
| Jesper Ericsson, Marcus Stephenson-Jones, Juan Pérez-Fernández, Brita Robertson, Gilad Silberberg, Sten Grillne. Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637194. |
although the detailed organization of the basal ganglia is conserved throughout the vertebrate phylum, it was unknown whether the differential dopamine modulation of the direct and indirect pathways is present in non-mammalian species. |
2013-07-01 |
2023-08-12 |
Not clear |
| Richard Lévy, Bernard Pillo. [Cognitive disorders in Parkinson's disease without dementia]. Psychologie & neuropsychiatrie du vieillissement. vol 4 Spec No 1. 2013-06-26. PMID:23631045. |
in particular, the caudate dopamine depletion induces a cascade of dysfunction within the basal ganglia, downstream of the striatum, which ultimately affects the prefrontal functions. |
2013-06-26 |
2023-08-12 |
Not clear |
| Shoichi A Shimamoto, Elena S Ryapolova-Webb, Jill L Ostrem, Nicholas B Galifianakis, Kai J Miller, Philip A Star. Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616531. |
in parkinson's disease (pd), striatal dopamine denervation results in a cascade of abnormalities in the single-unit activity of downstream basal ganglia nuclei that include increased firing rate, altered firing patterns, and increased oscillatory activity. |
2013-06-25 |
2023-08-12 |
Not clear |
| Hiromi Sano, Satomi Chiken, Takatoshi Hikida, Kazuto Kobayashi, Atsushi Namb. Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616563. |
the basal ganglia control voluntary movements through three parallel pathways mediated by the input stations: the hyperdirect pathway, which conveys direct cortical inputs to the substantia nigra pars reticulata (snr), the output nucleus, through the stn; the direct pathway, which arises from striatal neurons expressing dopamine d1 receptors and projects to the snr; and the indirect pathway, which arises from striatal neurons expressing dopamine d2 receptors (d2rs) and projects indirectly to the snr by way of the globus pallidus (gp) and stn. |
2013-06-25 |
2023-08-12 |
mouse |
| Claudio Da Cunha, Alexander Gomez-A, Charles D Blah. The role of the basal ganglia in motivated behavior. Reviews in the neurosciences. vol 23. issue 5-6. 2013-06-18. PMID:23079510. |
the strength of these synapses is altered when the levels of extracellular dopamine in the basal ganglia undergo phasic increases or decreases, which signal outcomes that are, respectively, better or worse than expected. |
2013-06-18 |
2023-08-12 |
Not clear |
| Choongseok Park, Leonid L Rubchinsk. Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia. PloS one. vol 7. issue 12. 2013-06-17. PMID:23284707. |
we show how the changes in firing patterns of stn neuron due to the lack of dopamine may lead to transition from a lower to a higher coherent state, roughly matching the synchrony levels observed in basal ganglia in normal and parkinsonian states. |
2013-06-17 |
2023-08-12 |
Not clear |
| Wengang Wang, Ioana Nitulescu, Justin S Lewis, Julia C Lemos, Ian J Bamford, Natasza M Posielski, Granville P Storey, Paul E M Phillips, Nigel S Bamfor. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals of neurology. vol 73. issue 3. 2013-06-14. PMID:23225132. |
however, existing observations suggest that cocaine exposure in utero, as in adults, increases synaptic dopamine and promotes enduring dopamine-dependent plasticity at striatal synapses, altering behaviors and basal ganglia function. |
2013-06-14 |
2023-08-12 |
Not clear |
| Hidetaka Koizumi, Ryoma Morigaki, Shinya Okita, Shinji Nagahiro, Ryuji Kaji, Masanori Nakagawa, Satoshi Got. Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role. Frontiers in cellular neuroscience. vol 7. 2013-06-05. PMID:23730270. |
they are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in parkinson's disease (pd). |
2013-06-05 |
2023-08-12 |
rat |
| Anson J Whitmer, Ian H Gotli. Depressive rumination and the C957T polymorphism of the DRD2 gene. Cognitive, affective & behavioral neuroscience. vol 12. issue 4. 2013-05-03. PMID:22864973. |
the c957t polymorphism of the drd2 gene, which affects functioning of d2 dopamine receptors (drd2) that are expressed predominantly in the indirect pathway of the basal ganglia, has been found to influence suppression and punishment learning. |
2013-05-03 |
2023-08-12 |
Not clear |
| Verena Aliane, Sylvie Pérez, Jean-Michel Deniau, Marie-Louise Keme. Raclopride or high-frequency stimulation of the subthalamic nucleus stops cocaine-induced motor stereotypy and restores related alterations in prefrontal basal ganglia circuits. The European journal of neuroscience. vol 36. issue 9. 2013-04-11. PMID:22845853. |
indeed, cortico-nigral transmission was reduced in the prefrontal but not sensorimotor basal ganglia circuits and dopamine and acetylcholine release was altered in the prefrontal but not sensorimotor territory of the dorsal striatum. |
2013-04-11 |
2023-08-12 |
rat |
| Marta G García, Juan G Puig, Rosa J Torre. Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients. Journal of inherited metabolic disease. vol 35. issue 6. 2013-04-05. PMID:22403020. |
these neurological manifestations suggest a dysfunction in the basal ganglia, and three neurotransmitters have been implicated in the pathogenesis of the disease: dopamine, adenosine and serotonin. |
2013-04-05 |
2023-08-12 |
Not clear |
| Jennifer C Felger, Andrew H Mille. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Frontiers in neuroendocrinology. vol 33. issue 3. 2013-04-05. PMID:23000204. |
cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. |
2013-04-05 |
2023-08-12 |
Not clear |
| Jennifer C Felger, Andrew H Mille. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Frontiers in neuroendocrinology. vol 33. issue 3. 2013-04-05. PMID:23000204. |
data suggest that cytokines released during the inflammatory response target subcortical structures including the basal ganglia as well as dopamine function to acutely induce behavioral changes that support fighting infection and wound healing. |
2013-04-05 |
2023-08-12 |
Not clear |
| Jennifer C Felger, Andrew H Mille. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Frontiers in neuroendocrinology. vol 33. issue 3. 2013-04-05. PMID:23000204. |
however, chronic inflammation and exposure to inflammatory cytokines appears to lead to persisting alterations in the basal ganglia and dopamine function reflected by anhedonia, fatigue, and psychomotor slowing. |
2013-04-05 |
2023-08-12 |
Not clear |
| Jennifer C Felger, Andrew H Mille. Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise. Frontiers in neuroendocrinology. vol 33. issue 3. 2013-04-05. PMID:23000204. |
this multiplicity of changes in the basal ganglia and dopamine function suggest fundamental effects of inflammatory cytokines on dopamine synthesis, packaging, release and/or reuptake, which may sabotage and circumvent the efficacy of current treatment approaches. |
2013-04-05 |
2023-08-12 |
Not clear |