| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| In-Uk Song, Young-Do Kim, Hyun-Ji Cho, Sung-Woo Chung, Yong-An Chun. An FP-CIT PET comparison of the differences in dopaminergic neuronal loss between idiopathic Parkinson disease with dementia and without dementia. Alzheimer disease and associated disorders. vol 27. issue 1. 2013-08-12. PMID:22354157. |
previous studies have demonstrated a decreased density of dopamine transporters (dat) in basal ganglia in patients with idiopathic parkinson disease (ipd) using i-n-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (fp-cit), and the reductions in striatal dat levels were inversely correlated with the severity of motor dysfunction in ipd. |
2013-08-12 |
2023-08-12 |
Not clear |
| Foteini Delis, Ada Mitsacos, Panagiotis Giompre. Lesion of the cerebellar paravermis increases dopamine D1 receptor levels in the contralateral striatum. Journal of chemical neuroanatomy. vol 47. 2013-08-09. PMID:23116569. |
we have previously shown that a complete, genetic, lack of purkinje cells induces an upregulation of dopamine d1 receptors (drd1) in the output of the basal ganglia, the substantia nigra pars reticulata. |
2013-08-09 |
2023-08-12 |
Not clear |
| Masaharu Hayash. [Anti-basal ganglia antibody]. Brain and nerve = Shinkei kenkyu no shinpo. vol 65. issue 4. 2013-08-07. PMID:23568985. |
recently, the relationship between abga and dopamine neurons in the basal ganglia has been examined, and autoantibodies against dopamine receptors were detected in the sera from patients with basal ganglia encephalitis. |
2013-08-07 |
2023-08-12 |
Not clear |
| Lorraine V Kalia, Jonathan M Brotchie, Susan H Fo. Novel nondopaminergic targets for motor features of Parkinson's disease: review of recent trials. Movement disorders : official journal of the Movement Disorder Society. vol 28. issue 2. 2013-08-06. PMID:23225267. |
neurotransmitters other than dopamine are recognized as having modulatory roles within the basal ganglia and can influence the basal ganglia dopaminergic system to alter activity of the direct and indirect pathways. |
2013-08-06 |
2023-08-12 |
Not clear |
| Kenji Morita, Mieko Morishima, Katsuyuki Sakai, Yasuo Kawaguch. Dopaminergic control of motivation and reinforcement learning: a closed-circuit account for reward-oriented behavior. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 20. 2013-08-02. PMID:23678129. |
these results indicate that the suggested roles of dopamine in motivational control and reinforcement learning can be understood in a unified manner through a notion that the indirect pathway of the basal ganglia represents the value of states/actions at a previous time point, an empirically driven key assumption of our model. |
2013-08-02 |
2023-08-12 |
Not clear |
| Khaled-Ezaheir Bennouar, Michelle A Uberti, Christophe Melon, Maria D Bacolod, Hermogenes N Jimenez, Manuel Cajina, Lydia Kerkerian-Le Goff, Darío Doller, Paolo Gubellin. Synergy between L-DOPA and a novel positive allosteric modulator of metabotropic glutamate receptor 4: implications for Parkinson's disease treatment and dyskinesia. Neuropharmacology. vol 66. 2013-07-02. PMID:22491024. |
group iii metabotropic glutamate (mglu) receptors are localized in presynaptic terminals within basal ganglia (bg) circuitry that become hyperactive due to dopamine depletion in parkinson's disease (pd). |
2013-07-02 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
methamphetamine-induced partial dopamine depletions are associated with impaired basal ganglia function, including decreased preprotachykinin mrna expression and impaired transcriptional activation of activity-regulated, cytoskeleton-associated (arc) gene in striatum. |
2013-07-01 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
recent work implicates deficits in phasic dopamine signaling as a potential mechanism linking methamphetamine-induced dopamine loss to impaired basal ganglia function. |
2013-07-01 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
this study thus sought to establish a causal link between phasic dopamine transmission and altered basal ganglia function by determining whether the deficits in striatal neuron gene expression could be restored by increasing phasic dopamine release. |
2013-07-01 |
2023-08-12 |
rat |
| Christopher D Howard, Elissa D Pastuzyn, Melissa L Barker-Haliski, Paul A Garris, Kristen A Keef. Phasic-like stimulation of the medial forebrain bundle augments striatal gene expression despite methamphetamine-induced partial dopamine denervation. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23480199. |
these results suggest that disruption of phasic dopamine signaling likely underlies methamphetamine-induced impairments in basal ganglia function, and that restoring phasic dopamine signaling may be a viable approach to manage long-term consequences of methamphetamine-induced dopamine loss on basal ganglia functions. |
2013-07-01 |
2023-08-12 |
rat |
| Jesper Ericsson, Marcus Stephenson-Jones, Juan Pérez-Fernández, Brita Robertson, Gilad Silberberg, Sten Grillne. Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637194. |
the functions of the basal ganglia are critically dependent on dopamine. |
2013-07-01 |
2023-08-12 |
Not clear |
| Jesper Ericsson, Marcus Stephenson-Jones, Juan Pérez-Fernández, Brita Robertson, Gilad Silberberg, Sten Grillne. Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 18. 2013-07-01. PMID:23637194. |
although the detailed organization of the basal ganglia is conserved throughout the vertebrate phylum, it was unknown whether the differential dopamine modulation of the direct and indirect pathways is present in non-mammalian species. |
2013-07-01 |
2023-08-12 |
Not clear |
| Richard Lévy, Bernard Pillo. [Cognitive disorders in Parkinson's disease without dementia]. Psychologie & neuropsychiatrie du vieillissement. vol 4 Spec No 1. 2013-06-26. PMID:23631045. |
in particular, the caudate dopamine depletion induces a cascade of dysfunction within the basal ganglia, downstream of the striatum, which ultimately affects the prefrontal functions. |
2013-06-26 |
2023-08-12 |
Not clear |
| Shoichi A Shimamoto, Elena S Ryapolova-Webb, Jill L Ostrem, Nicholas B Galifianakis, Kai J Miller, Philip A Star. Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616531. |
in parkinson's disease (pd), striatal dopamine denervation results in a cascade of abnormalities in the single-unit activity of downstream basal ganglia nuclei that include increased firing rate, altered firing patterns, and increased oscillatory activity. |
2013-06-25 |
2023-08-12 |
Not clear |
| Hiromi Sano, Satomi Chiken, Takatoshi Hikida, Kazuto Kobayashi, Atsushi Namb. Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 17. 2013-06-25. PMID:23616563. |
the basal ganglia control voluntary movements through three parallel pathways mediated by the input stations: the hyperdirect pathway, which conveys direct cortical inputs to the substantia nigra pars reticulata (snr), the output nucleus, through the stn; the direct pathway, which arises from striatal neurons expressing dopamine d1 receptors and projects to the snr; and the indirect pathway, which arises from striatal neurons expressing dopamine d2 receptors (d2rs) and projects indirectly to the snr by way of the globus pallidus (gp) and stn. |
2013-06-25 |
2023-08-12 |
mouse |
| Claudio Da Cunha, Alexander Gomez-A, Charles D Blah. The role of the basal ganglia in motivated behavior. Reviews in the neurosciences. vol 23. issue 5-6. 2013-06-18. PMID:23079510. |
the strength of these synapses is altered when the levels of extracellular dopamine in the basal ganglia undergo phasic increases or decreases, which signal outcomes that are, respectively, better or worse than expected. |
2013-06-18 |
2023-08-12 |
Not clear |
| Choongseok Park, Leonid L Rubchinsk. Potential mechanisms for imperfect synchronization in parkinsonian basal ganglia. PloS one. vol 7. issue 12. 2013-06-17. PMID:23284707. |
we show how the changes in firing patterns of stn neuron due to the lack of dopamine may lead to transition from a lower to a higher coherent state, roughly matching the synchrony levels observed in basal ganglia in normal and parkinsonian states. |
2013-06-17 |
2023-08-12 |
Not clear |
| Wengang Wang, Ioana Nitulescu, Justin S Lewis, Julia C Lemos, Ian J Bamford, Natasza M Posielski, Granville P Storey, Paul E M Phillips, Nigel S Bamfor. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals of neurology. vol 73. issue 3. 2013-06-14. PMID:23225132. |
however, existing observations suggest that cocaine exposure in utero, as in adults, increases synaptic dopamine and promotes enduring dopamine-dependent plasticity at striatal synapses, altering behaviors and basal ganglia function. |
2013-06-14 |
2023-08-12 |
Not clear |
| Hidetaka Koizumi, Ryoma Morigaki, Shinya Okita, Shinji Nagahiro, Ryuji Kaji, Masanori Nakagawa, Satoshi Got. Response of striosomal opioid signaling to dopamine depletion in 6-hydroxydopamine-lesioned rat model of Parkinson's disease: a potential compensatory role. Frontiers in cellular neuroscience. vol 7. 2013-06-05. PMID:23730270. |
they are involved in the regulation of striatal dopamine functions, and increased opioid transmissions are thought to play a compensatory role in altered functions of the basal ganglia in parkinson's disease (pd). |
2013-06-05 |
2023-08-12 |
rat |
| Anson J Whitmer, Ian H Gotli. Depressive rumination and the C957T polymorphism of the DRD2 gene. Cognitive, affective & behavioral neuroscience. vol 12. issue 4. 2013-05-03. PMID:22864973. |
the c957t polymorphism of the drd2 gene, which affects functioning of d2 dopamine receptors (drd2) that are expressed predominantly in the indirect pathway of the basal ganglia, has been found to influence suppression and punishment learning. |
2013-05-03 |
2023-08-12 |
Not clear |