| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lusha Zhu, Daniel Walsh, Ming Hs. Neuroeconomic measures of social decision-making across the lifespan. Frontiers in neuroscience. vol 6. 2012-10-11. PMID:23049494. |
these includes not only disorders that directly impact dopamine and basal ganglia, such as parkinson's disorder, but also degeneration in which multiple neural pathways are affected over the course of normal aging. |
2012-10-11 |
2023-08-12 |
human |
| R L Albi. The pathophysiology of chorea/ballism and Parkinsonism. Parkinsonism & related disorders. vol 1. issue 1. 2012-10-02. PMID:18590996. |
recent neurobiological investigations indicate the presence of three principles of basal ganglia organization-the existence of segregated striatal output pathways, the differential regulation of these segregated outputs by dopamine, and the importance of the subthalamic nucleus-that provide insight into the pathophysiology of parkinsonism and chorea/ ballism. |
2012-10-02 |
2023-08-12 |
human |
| S L Drinnan, B T Hope, T P Snutch, S R Vincen. G(olf) in the basal ganglia. Molecular and cellular neurosciences. vol 2. issue 1. 2012-10-02. PMID:19912784. |
the basal ganglia contain a well-characterized dopamine-stimulated adenylyl cyclase and d1 dopamine receptors coupled to g(s) are thought to mediate this activity. |
2012-10-02 |
2023-08-12 |
rat |
| S L Drinnan, B T Hope, T P Snutch, S R Vincen. G(olf) in the basal ganglia. Molecular and cellular neurosciences. vol 2. issue 1. 2012-10-02. PMID:19912784. |
it is also the major stimulatory g protein in the basal ganglia, where it may couple d 1 dopamine receptors to adenylyl cyclase. |
2012-10-02 |
2023-08-12 |
rat |
| R A Vaughan, G Uhl, M J Kuha. Recognition of dopamine transporters by antipeptide antibodies. Molecular and cellular neurosciences. vol 4. issue 2. 2012-10-02. PMID:19912924. |
antisera directed against a peptide sequence at the c-terminal region of the transporter's putative second extracellular loop, "peptide 5," recognized photolabeled dopamine transporter protein from rat, dog, and human basal ganglia. |
2012-10-02 |
2023-08-12 |
human |
| Roy A Wis. Rewards wanted: Molecular mechanisms of motivation. Discovery medicine. vol 4. issue 22. 2012-10-02. PMID:20704982. |
since parkinson's disease results in tremor, rigidity, and an inability to initiate voluntary movement, and since the cells are localized in the basal ganglia, a region with the primary motor mechanism of the sub-mammalian brain, dopamine was initially identified with motor function. |
2012-10-02 |
2023-08-12 |
Not clear |
| Gwendolyn G Calhoon, Patricio O'Donnel. Many Roads to Motor Deficits: Loss of Dopamine Signaling in Direct or Indirect Basal Ganglia Pathway Leads to Akinesia through Distinct Physiological Mechanisms. Frontiers in neuroscience. vol 4. 2012-10-02. PMID:21151744. |
many roads to motor deficits: loss of dopamine signaling in direct or indirect basal ganglia pathway leads to akinesia through distinct physiological mechanisms. |
2012-10-02 |
2023-08-12 |
Not clear |
| Free communications 1 pharmacology of dopamine, the Basal Ganglia and schizophrenia. Journal of psychopharmacology (Oxford, England). vol 3. issue 4. 2012-10-02. PMID:22282912. |
free communications 1 pharmacology of dopamine, the basal ganglia and schizophrenia. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mark D Humphries, Mehdi Khamassi, Kevin Gurne. Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22347155. |
here we set out to reconcile recent evidence for dopamine's involvement in the exploration-exploitation trade-off with the existing evidence for basal ganglia control of action selection, by testing the hypothesis that tonic dopamine in the striatum, the basal ganglia's input nucleus, sets the current exploration-exploitation trade-off. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mark D Humphries, Mehdi Khamassi, Kevin Gurne. Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22347155. |
using computational models of the full basal ganglia circuit, we showed that, under this interpretation, the actions of dopamine within the striatum change the basal ganglia's output to favor the level of exploration or exploitation encoded in the probability distribution. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mark D Humphries, Mehdi Khamassi, Kevin Gurne. Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22347155. |
we also found that our models predict striatal dopamine controls the exploration-exploitation trade-off if we instead read-out the probability distribution from the target nuclei of the basal ganglia, where their inhibitory input shapes the cortical input to these nuclei. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mark D Humphries, Mehdi Khamassi, Kevin Gurne. Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22347155. |
finally, by integrating the basal ganglia within a reinforcement learning model, we showed how dopamine's effect on the exploration-exploitation trade-off could be measurable in a forced two-choice task. |
2012-10-02 |
2023-08-12 |
Not clear |
| Mark D Humphries, Mehdi Khamassi, Kevin Gurne. Dopaminergic Control of the Exploration-Exploitation Trade-Off via the Basal Ganglia. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22347155. |
thus, our models support the hypothesis that changes in tonic dopamine within the striatum can alter the exploration-exploitation trade-off by modulating the output of the basal ganglia. |
2012-10-02 |
2023-08-12 |
Not clear |
| Andrea Stocc. Acetylcholine-based entropy in response selection: a model of how striatal interneurons modulate exploration, exploitation, and response variability in decision-making. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22347164. |
their contribution is typically modeled within a reinforcement learning framework, with the basal ganglia learning to select the options associated with highest value and their dopamine inputs conveying performance feedback. |
2012-10-02 |
2023-08-12 |
Not clear |
| Teresa Morera-Herreras, Cristina Miguelez, Asier Aristieta, José Ángel Ruiz-Ortega, Luisa Uged. Endocannabinoid modulation of dopaminergic motor circuits. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22701427. |
on the other hand, there are profound changes in cb(1) receptor cannabinoid signaling in the basal ganglia circuits after dopamine depletion (as happens in parkinson's disease) and following l-dopa replacement therapy. |
2012-10-02 |
2023-08-12 |
Not clear |
| Kelly A Meulendyke, Mikhail V Pletnikov, Elizabeth L Engle, Patrick M Tarwater, David R Graham, M Christine Zin. Early minocycline treatment prevents a decrease in striatal dopamine in an SIV model of HIV-associated neurological disease. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 7. issue 2. 2012-09-24. PMID:22198699. |
da decline was not due to direct loss of dopaminergic projections to the basal ganglia as there was no difference in tyrosine hydroxylase, dopamine transporter, vesicular monoamine transporter 2 or synaptophysin between minocycline-treated and untreated macaques. |
2012-09-24 |
2023-08-12 |
Not clear |
| A Mohajjel Nayebi A, H Sheidae. Buspirone improves haloperidol-induced Parkinson disease in mice through 5-HT(1A) recaptors. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 18. issue 1. 2012-08-23. PMID:22615592. |
the available literatures show that 5-ht(1a) receptors are widely distributed throughout the basal ganglia, and their activation facilitate dopamine release. |
2012-08-23 |
2023-08-12 |
mouse |
| Micaela Morelli, Fabio Blandini, Nicola Simola, Robert A Hause. A(2A) Receptor Antagonism and Dyskinesia in Parkinson's Disease. Parkinson's disease. vol 2012. 2012-08-23. PMID:22754707. |
the unique cellular and regional distribution of adenosine a(2a) receptors in basal ganglia areas that are richly innervated by dopamine, and their antagonistic role towards dopamine receptor stimulation, have positioned a(2a) receptor antagonists as an attractive nondopaminergic target to improve the motor deficits that characterize pd. |
2012-08-23 |
2023-08-12 |
Not clear |
| Melissa L Perreault, Theresa Fan, Mohammed Alijaniaram, Brian F O'Dowd, Susan R Georg. Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. PloS one. vol 7. issue 3. 2012-08-20. PMID:22428025. |
this could have broad implications in understanding how dysregulation of neurotransmission within basal ganglia contributes to dopamine neuronal dysfunction. |
2012-08-20 |
2023-08-12 |
Not clear |
| Masato Kinboshi, Manabu Inoue, Yasuhiro Kojima, Tomokazu Nakagawa, Masutaro Kanda, Hiroshi Shibasak. [Elderly case of moyamoya disease presenting with hemichorea]. Rinsho shinkeigaku = Clinical neurology. vol 52. issue 1. 2012-08-17. PMID:22260975. |
in the present case, increased rcbf in the basal ganglia and remarkable effect of a dopamine d2 blocker suggest functional abnormality of the corresponding striatum as an underlying cause of hemichorea. |
2012-08-17 |
2023-08-12 |
Not clear |