| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ignacio Obeso, Leonora Wilkinson, Marjan Jahanshah. Levodopa medication does not influence motor inhibition or conflict resolution in a conditional stop-signal task in Parkinson's disease. Experimental brain research. vol 213. issue 4. 2012-06-01. PMID:21796541. |
evidence from animal, clinical, and imaging studies suggests that the basal ganglia and their frontal connections mediate motor inhibition, but the role of dopamine remains unclear. |
2012-06-01 |
2023-08-12 |
human |
| Y Iris Chen, Jia-Qian Ren, Ted J Kaptchuk, Kenneth K Kwon. Restoring cerebral dopamine homeostasis by electrical forepaw stimulation: an FMRI study. Synapse (New York, N.Y.). vol 66. issue 4. 2012-05-21. PMID:22170513. |
as dopamine function is tightly regulated within the basal ganglia circuitry, cortical perturbation would lead to modulation of dopaminergic activity in the striatum. |
2012-05-21 |
2023-08-12 |
rat |
| Margaret E Ric. H2O2: a dynamic neuromodulator. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. vol 17. issue 4. 2012-05-17. PMID:21666063. |
this rapid signaling has been examined most thoroughly in the nigrostriatal dopamine (da) pathway, which plays a key role in facilitating movement mediated by the basal ganglia. |
2012-05-17 |
2023-08-12 |
Not clear |
| Ana C Barceló, Bárbara Filippini, Jorge H Paz. The striatum and pain modulation. Cellular and molecular neurobiology. vol 32. issue 1. 2012-05-17. PMID:21789630. |
this analgesic action of the striatum was mediated by activation of its dopamine d(2) receptors and transmitted through the indirect pathways of the basal ganglia and the medullary dorsal reticular nucleus (rvm) to the sensorial nuclei of the trigeminal nerve. |
2012-05-17 |
2023-08-12 |
Not clear |
| Lina Mastrangelo, Ji-Eun Kim, Atsushi Miyanohara, Tae Hyuk Kang, Theodore Friedman. Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 9. 2012-05-08. PMID:22331909. |
lesch-nyhan disease (lnd) is an x-linked genetic disorder caused by mutations of the hypoxanthine guanine phosphoribosyltransferase (hprt) purine biosynthesis gene and characterized by aberrant purine metabolism, deficient basal ganglia dopamine levels, dystonia, and severe neurobehavioral manifestations, including compulsive self-injurious behavior. |
2012-05-08 |
2023-08-12 |
human |
| Véronique Sgambato-Faure, Maria Angela Cenc. Glutamatergic mechanisms in the dyskinesias induced by pharmacological dopamine replacement and deep brain stimulation for the treatment of Parkinson's disease. Progress in neurobiology. vol 96. issue 1. 2012-05-07. PMID:22075179. |
accumulating evidence indicates that dyskinesias induced by stn-hfs and dopamine replacement therapy are linked to dysregulation of glutamate transmission in the basal ganglia. |
2012-05-07 |
2023-08-12 |
rat |
| J B Lauridsen, J L Johansen, J C Rekling, K Thirstrup, A Moerk, T N Sage. Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity. Neuroscience research. vol 70. issue 3. 2012-05-04. PMID:21514331. |
this mouse specific recovery might be linked to transcriptional changes in the basal ganglia enabling mice to maintain normal motor function in spite of low striatal dopamine levels. |
2012-05-04 |
2023-08-12 |
mouse |
| M Giorgi, G Melchiorri, V Nuccetelli, V D'Angelo, A Martorana, R Sorge, V Castelli, G Bernardi, G Sancesari. PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515371. |
loss of dopamine neurons in experimental parkinsonism results in altered cyclic nucleotide camp and cgmp levels throughout the basal ganglia. |
2012-04-09 |
2023-08-12 |
rat |
| Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyungjin Bae, Younbyoung Chae, Insop Shim, Hyangsook Lee, Woongjoon Moon, Hyejung Lee, Hi-Joon Par. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132113. |
moreover, acupuncture treatment mitigated mptp-induced abnormal postsynaptic changes, suggesting that acupuncture treatment may increase postsynaptic dopamine neurotransmission and facilitate the normalization of basal ganglia activity. |
2012-04-02 |
2023-08-12 |
mouse |
| Fabrizio Stocch. Continuous dopaminergic stimulation and novel formulations of dopamine agonists. Journal of neurology. vol 258. issue Suppl 2. 2012-03-25. PMID:21560062. |
there is now accumulating evidence that the combination of progressive pathology of parkinson's disease, the change in drug pharmacodynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors are the key contributing factors to the priming of the basal ganglia for induction of motor complications. |
2012-03-25 |
2023-08-12 |
Not clear |
| Steven C Stoner, Amy Berr. Suspected neuroleptic malignant syndrome during quetiapine-clozapine cross-titration. Journal of pharmacy practice. vol 23. issue 1. 2012-03-22. PMID:21507795. |
neuroleptic malignant syndrome (nms) is a physiologic phenomenon that has been associated with the use of both first- and second-generation antipsychotics resultant to their ability to block dopamine blockade in the basal ganglia and hypothalamic regions of the brain. |
2012-03-22 |
2023-08-12 |
Not clear |
| C J Wilson, M D Beva. Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease. Neuroscience. vol 198. 2012-03-22. PMID:21723918. |
furthermore, chronic dopamine depletion in parkinson's disease may modify both synaptic transmission and integration in the subthalamic nucleus, in addition to its effects on other regions of the basal ganglia. |
2012-03-22 |
2023-08-12 |
Not clear |
| P Redgrave, N Vautrelle, J N J Reynold. Functional properties of the basal ganglia's re-entrant loop architecture: selection and reinforcement. Neuroscience. vol 198. 2012-03-22. PMID:21821101. |
considerations of connectional architecture and signal timing suggest that the short-latency, sensory-evoked dopamine response, which can modulate the re-entrant loop structure within the basal ganglia, is ideally suited to reinforce the determination of agency and the discovery of novel actions. |
2012-03-22 |
2023-08-12 |
Not clear |
| M E Rice, J C Patel, S J Crag. Dopamine release in the basal ganglia. Neuroscience. vol 198. 2012-03-22. PMID:21939738. |
dopamine release in the basal ganglia. |
2012-03-22 |
2023-08-12 |
Not clear |
| M E Rice, J C Patel, S J Crag. Dopamine release in the basal ganglia. Neuroscience. vol 198. 2012-03-22. PMID:21939738. |
dopamine (da) is a key transmitter in the basal ganglia, yet da transmission does not conform to several aspects of the classic synaptic doctrine. |
2012-03-22 |
2023-08-12 |
Not clear |
| Anke M W Linssen, Eric F P M Vuurman, Anke Sambeth, Stephane Nave, Will Spooren, Gabriel Vargas, Luca Santarelli, Wim J Riede. Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate. Psychopharmacology. vol 218. issue 3. 2012-03-19. PMID:21597989. |
preparation of a motor response has been associated with dopamine release in the basal ganglia, and response readiness may therefore serve as a pharmacodynamic marker of dopamine activity. |
2012-03-19 |
2023-08-12 |
Not clear |
| Ned Jenkinson, Peter Brow. New insights into the relationship between dopamine, beta oscillations and motor function. Trends in neurosciences. vol 34. issue 12. 2012-03-15. PMID:22018805. |
oscillatory beta activity is in turn modulated by net dopamine levels at sites of cortical input to the basal ganglia. |
2012-03-15 |
2023-08-12 |
human |
| Curt R Freed, Wenbo Zhou, Robert E Breez. Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 8. issue 4. 2012-03-12. PMID:21997523. |
because putamen is the basal ganglia structure most depleted of dopamine in parkinson's disease and because it is the structure most closely mapped to the motor cortex, it has been the primary target for neurotransplantation. |
2012-03-12 |
2023-08-12 |
human |
| Marie Therese Armentero, Annalisa Pinna, Sergi Ferré, José Luis Lanciego, Christa E Müller, Rafael Franc. Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. Pharmacology & therapeutics. vol 132. issue 3. 2012-03-01. PMID:21810444. |
the usefulness of these antagonists has been deduced from studies demonstrating functional interactions between dopamine d₂ and adenosine a(2a) receptors in the basal ganglia. |
2012-03-01 |
2023-08-12 |
Not clear |
| Cristina Miguelez, Asier Aristieta, Maria Angela Cenci, Luisa Uged. The locus coeruleus is directly implicated in L-DOPA-induced dyskinesia in parkinsonian rats: an electrophysiological and behavioural study. PloS one. vol 6. issue 9. 2012-02-28. PMID:21931808. |
l-dopa-induced dyskinesia is attributed to a dysregulated dopamine transmission within the basal ganglia, but serotonergic and noradrenergic systems are believed to play an important modulatory role. |
2012-02-28 |
2023-08-12 |
rat |