| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J B Lauridsen, J L Johansen, J C Rekling, K Thirstrup, A Moerk, T N Sage. Regulation of the Bcas1 and Baiap3 transcripts in the subthalamic nucleus in mice recovering from MPTP toxicity. Neuroscience research. vol 70. issue 3. 2012-05-04. PMID:21514331. |
this mouse specific recovery might be linked to transcriptional changes in the basal ganglia enabling mice to maintain normal motor function in spite of low striatal dopamine levels. |
2012-05-04 |
2023-08-12 |
mouse |
| M Giorgi, G Melchiorri, V Nuccetelli, V D'Angelo, A Martorana, R Sorge, V Castelli, G Bernardi, G Sancesari. PDE10A and PDE10A-dependent cAMP catabolism are dysregulated oppositely in striatum and nucleus accumbens after lesion of midbrain dopamine neurons in rat: a key step in parkinsonism physiopathology. Neurobiology of disease. vol 43. issue 1. 2012-04-09. PMID:21515371. |
loss of dopamine neurons in experimental parkinsonism results in altered cyclic nucleotide camp and cgmp levels throughout the basal ganglia. |
2012-04-09 |
2023-08-12 |
rat |
| Seung-Nam Kim, Ah-Reum Doo, Ji-Yeun Park, Hyungjin Bae, Younbyoung Chae, Insop Shim, Hyangsook Lee, Woongjoon Moon, Hyejung Lee, Hi-Joon Par. Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease. PloS one. vol 6. issue 11. 2012-04-02. PMID:22132113. |
moreover, acupuncture treatment mitigated mptp-induced abnormal postsynaptic changes, suggesting that acupuncture treatment may increase postsynaptic dopamine neurotransmission and facilitate the normalization of basal ganglia activity. |
2012-04-02 |
2023-08-12 |
mouse |
| Fabrizio Stocch. Continuous dopaminergic stimulation and novel formulations of dopamine agonists. Journal of neurology. vol 258. issue Suppl 2. 2012-03-25. PMID:21560062. |
there is now accumulating evidence that the combination of progressive pathology of parkinson's disease, the change in drug pharmacodynamics, and the pulsatile manner in which short-acting dopaminergic agents stimulate striatal dopamine receptors are the key contributing factors to the priming of the basal ganglia for induction of motor complications. |
2012-03-25 |
2023-08-12 |
Not clear |
| Steven C Stoner, Amy Berr. Suspected neuroleptic malignant syndrome during quetiapine-clozapine cross-titration. Journal of pharmacy practice. vol 23. issue 1. 2012-03-22. PMID:21507795. |
neuroleptic malignant syndrome (nms) is a physiologic phenomenon that has been associated with the use of both first- and second-generation antipsychotics resultant to their ability to block dopamine blockade in the basal ganglia and hypothalamic regions of the brain. |
2012-03-22 |
2023-08-12 |
Not clear |
| C J Wilson, M D Beva. Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease. Neuroscience. vol 198. 2012-03-22. PMID:21723918. |
furthermore, chronic dopamine depletion in parkinson's disease may modify both synaptic transmission and integration in the subthalamic nucleus, in addition to its effects on other regions of the basal ganglia. |
2012-03-22 |
2023-08-12 |
Not clear |
| P Redgrave, N Vautrelle, J N J Reynold. Functional properties of the basal ganglia's re-entrant loop architecture: selection and reinforcement. Neuroscience. vol 198. 2012-03-22. PMID:21821101. |
considerations of connectional architecture and signal timing suggest that the short-latency, sensory-evoked dopamine response, which can modulate the re-entrant loop structure within the basal ganglia, is ideally suited to reinforce the determination of agency and the discovery of novel actions. |
2012-03-22 |
2023-08-12 |
Not clear |
| M E Rice, J C Patel, S J Crag. Dopamine release in the basal ganglia. Neuroscience. vol 198. 2012-03-22. PMID:21939738. |
dopamine release in the basal ganglia. |
2012-03-22 |
2023-08-12 |
Not clear |
| M E Rice, J C Patel, S J Crag. Dopamine release in the basal ganglia. Neuroscience. vol 198. 2012-03-22. PMID:21939738. |
dopamine (da) is a key transmitter in the basal ganglia, yet da transmission does not conform to several aspects of the classic synaptic doctrine. |
2012-03-22 |
2023-08-12 |
Not clear |
| Anke M W Linssen, Eric F P M Vuurman, Anke Sambeth, Stephane Nave, Will Spooren, Gabriel Vargas, Luca Santarelli, Wim J Riede. Contingent negative variation as a dopaminergic biomarker: evidence from dose-related effects of methylphenidate. Psychopharmacology. vol 218. issue 3. 2012-03-19. PMID:21597989. |
preparation of a motor response has been associated with dopamine release in the basal ganglia, and response readiness may therefore serve as a pharmacodynamic marker of dopamine activity. |
2012-03-19 |
2023-08-12 |
Not clear |
| Ned Jenkinson, Peter Brow. New insights into the relationship between dopamine, beta oscillations and motor function. Trends in neurosciences. vol 34. issue 12. 2012-03-15. PMID:22018805. |
oscillatory beta activity is in turn modulated by net dopamine levels at sites of cortical input to the basal ganglia. |
2012-03-15 |
2023-08-12 |
human |
| Curt R Freed, Wenbo Zhou, Robert E Breez. Dopamine cell transplantation for Parkinson's disease: the importance of controlled clinical trials. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. vol 8. issue 4. 2012-03-12. PMID:21997523. |
because putamen is the basal ganglia structure most depleted of dopamine in parkinson's disease and because it is the structure most closely mapped to the motor cortex, it has been the primary target for neurotransplantation. |
2012-03-12 |
2023-08-12 |
human |
| Marie Therese Armentero, Annalisa Pinna, Sergi Ferré, José Luis Lanciego, Christa E Müller, Rafael Franc. Past, present and future of A(2A) adenosine receptor antagonists in the therapy of Parkinson's disease. Pharmacology & therapeutics. vol 132. issue 3. 2012-03-01. PMID:21810444. |
the usefulness of these antagonists has been deduced from studies demonstrating functional interactions between dopamine d₂ and adenosine a(2a) receptors in the basal ganglia. |
2012-03-01 |
2023-08-12 |
Not clear |
| Cristina Miguelez, Asier Aristieta, Maria Angela Cenci, Luisa Uged. The locus coeruleus is directly implicated in L-DOPA-induced dyskinesia in parkinsonian rats: an electrophysiological and behavioural study. PloS one. vol 6. issue 9. 2012-02-28. PMID:21931808. |
l-dopa-induced dyskinesia is attributed to a dysregulated dopamine transmission within the basal ganglia, but serotonergic and noradrenergic systems are believed to play an important modulatory role. |
2012-02-28 |
2023-08-12 |
rat |
| Jeff A Beele. Preservation of function in Parkinson's disease: what's learning got to do with it? Brain research. vol 1423. 2012-02-17. PMID:22000081. |
the 'integrative selective gain' framework proposed here integrates dopaminergic mechanisms known to modulate basal ganglia throughput into a single conceptual framework: (1) synaptic weights, the neural instantiation of accumulated experience and skill modulated by dopamine-dependent plasticity and (2) system gain, the operating parameters of the basal ganglia, modulated by dopamine's on-line effects on cell excitability, glutamatergic transmission and the balance between facilitatory and inhibitory pathways. |
2012-02-17 |
2023-08-12 |
Not clear |
| Jeff A Beele. Preservation of function in Parkinson's disease: what's learning got to do with it? Brain research. vol 1423. 2012-02-17. PMID:22000081. |
within this framework and based on recent work, a hypothesis is presented that prior synaptic weights and established skills can facilitate motor performance and preserve function despite diminished dopamine; however, dopamine denervation induces aberrant corticostriatal plasticity that degrades established synaptic weights and replaces them with inappropriate, inhibitory learning that inverts the function of the basal ganglia resulting in 'anti-optimization' of motor performance. |
2012-02-17 |
2023-08-12 |
Not clear |
| Tanya L Daigle, William C Wetsel, Marc G Caro. Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. The European journal of neuroscience. vol 34. issue 9. 2012-02-17. PMID:22034973. |
it is well established that the cannabinoid and dopamine systems interact at various levels to regulate basal ganglia function. |
2012-02-17 |
2023-08-12 |
mouse |
| Jedediah Tressler, Christine Schwartz, Paul Wellman, Samuel Hughes, Michael Smotherma. Regulation of bat echolocation pulse acoustics by striatal dopamine. The Journal of experimental biology. vol 214. issue Pt 19. 2012-01-03. PMID:21900471. |
the basal ganglia (bg) are a suite of forebrain nuclei centrally involved in sensory-motor control and are characterized by their dependence on dopamine. |
2012-01-03 |
2023-08-12 |
Not clear |
| Tommas J Ellender, Icnelia Huerta-Ocampo, Karl Deisseroth, Marco Capogna, J Paul Bola. Differential modulation of excitatory and inhibitory striatal synaptic transmission by histamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 43. 2011-12-19. PMID:22031880. |
information processing in the striatum is critical for basal ganglia function and strongly influenced by neuromodulators (e.g., dopamine). |
2011-12-19 |
2023-08-12 |
mouse |
| Moran Weinberger, Jonathan O Dostrovsk. A basis for the pathological oscillations in basal ganglia: the crucial role of dopamine. Neuroreport. vol 22. issue 4. 2011-12-12. PMID:21304324. |
a basis for the pathological oscillations in basal ganglia: the crucial role of dopamine. |
2011-12-12 |
2023-08-12 |
Not clear |