| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Konstantin A Pavlov, Dimitry A Chistiakov, Vladimir P Chekhoni. Genetic determinants of aggression and impulsivity in humans. Journal of applied genetics. vol 53. issue 1. 2012-05-14. PMID:21994088. |
serotonin facilitates prefrontal inhibition, and thus insufficient serotonergic activity can enhance aggression. |
2012-05-14 |
2023-08-12 |
human |
| C Gómez, G G Curto, F C Baltanás, J Valero, E O'Shea, M I Colado, D Díaz, E Weruaga, J R Alons. Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss. Neuroscience. vol 201. 2012-05-14. PMID:22133893. |
the distribution and density of serotonergic centrifugal axons were studied in the mob of control and pcd mice, both before and after the loss of mitral cells, using serotonin (5-ht) and 5-ht transporter immunohistochemistry. |
2012-05-14 |
2023-08-12 |
mouse |
| Hans Jörgen Grabe, Christian Schwahn, Jessie Mahler, Katja Appel, Andrea Schulz, Carsten Spitzer, Kristin Fenske, Sven Barnow, Harald Jürgen Freyberger, Alexander Teumer, Astrid Petersmann, Reiner Biffar, Dieter Rosskopf, Ulrich John, Henry Völzk. Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 2. 2012-05-08. PMID:21996278. |
based on biological interactions between the serotonergic system and the brain-derived neurotrophic factor (bdnf), bdnf is a plausible candidate for a gene-gene-environment interaction moderating the interaction between the s/l- promoter polymorphism of the serotonin transporter (5-httlpr) and childhood abuse. |
2012-05-08 |
2023-08-12 |
Not clear |
| Robert Marseille, Royce Lee, Emil F Coccar. Inter-relationship between different platelet measures of 5-HT and their relationship to aggression in human subjects. Progress in neuro-psychopharmacology & biological psychiatry. vol 36. issue 2. 2012-05-08. PMID:22019855. |
the objective of this study was to explore the inter-relationship of three platelet measures of serotonergic function (5-ht): 5-ht transporter binding, 5-ht-2 receptor binding and 5-ht content and to explore their inter-relationship with measures of aggression and impulsivity. |
2012-05-08 |
2023-08-12 |
human |
| Qi Wu, Michael S Clark, Richard D Palmite. Deciphering a neuronal circuit that mediates appetite. Nature. vol 483. issue 7391. 2012-05-08. PMID:22419158. |
blockade of serotonin (5-ht(3)) receptor signalling in the nts by either the chronic administration of ondansetron or the genetic inactivation of tph2 in caudal serotonergic neurons that project to the nts protects against starvation when agrp neurons are ablated. |
2012-05-08 |
2023-08-12 |
mouse |
| M Picard, J-F Cloix, T K Hevo. Serotonergic neurotransmission plays a major role in the action of the glycogenic convulsant methionine sulfoximine. Neuroscience research. vol 70. issue 3. 2012-05-04. PMID:21396968. |
these results indicate that increased glycogen content and decreased brain levels of 5-ht and tryptophan are hallmarks of mso action in mice, and suggest that defective serotonergic neurotransmission could trigger glycogen increase and seizure genesis. |
2012-05-04 |
2023-08-12 |
mouse |
| Quentin Rainer, Hai T Nguyen, Gaël Quesseveur, Alain M Gardier, Denis J David, Bruno P Guiar. Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration. Molecular pharmacology. vol 81. issue 2. 2012-05-04. PMID:22031471. |
an increase in somatodendritic 5-ht(1a) autoreceptor density in the dorsal raphe (dr) attenuates the therapeutic activity of selective serotonin-reuptake inhibitors (ssris), whereas their functional desensitization promotes activation of brain serotonergic transmission, thereby representing an adaptive change relevant to their therapeutic effect. |
2012-05-04 |
2023-08-12 |
mouse |
| Quentin Rainer, Hai T Nguyen, Gaël Quesseveur, Alain M Gardier, Denis J David, Bruno P Guiar. Functional status of somatodendritic serotonin 1A autoreceptor after long-term treatment with fluoxetine in a mouse model of anxiety/depression based on repeated corticosterone administration. Molecular pharmacology. vol 81. issue 2. 2012-05-04. PMID:22031471. |
this change had an overall effect on serotonergic tone because we found a greater firing rate of 5-ht neurons associated with an enhancement of 5-ht outflow in the dr of corticosterone-pretreated mice in response to fluoxetine compared with the corresponding group of vehicle-pretreated mice. |
2012-05-04 |
2023-08-12 |
mouse |
| Vincent Fournet, Annie Schweitzer, Caroline Chevarin, Jean-Christophe Deloulme, Michel Hamon, Bruno Giros, Annie Andrieux, Marie-Pascale Martre. The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. Journal of neurochemistry. vol 121. issue 1. 2012-05-03. PMID:22146001. |
in stop knockout (ko) compared with wild-type mice, serotonin (5-ht) markers are found to be markedly accumulated in the raphe nuclei and, in contrast, deeply depleted in all serotonergic projection areas. |
2012-05-03 |
2023-08-12 |
mouse |
| Carla S Lima, André L Nunes-Freitas, Anderson Ribeiro-Carvalho, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21871486. |
considering the association between depression and the serotonergic (5ht) system, in the present study we investigated whether a subchronic exposure to methamidophos affects the serotonergic system of adult mice. |
2012-05-02 |
2023-08-12 |
mouse |
| Carla S Lima, André L Nunes-Freitas, Anderson Ribeiro-Carvalho, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Exposure to methamidophos at adulthood adversely affects serotonergic biomarkers in the mouse brain. Neurotoxicology. vol 32. issue 6. 2012-05-02. PMID:21871486. |
we evaluated three serotonergic biomarkers during (pn89) and after (pn100) the exposure period: 5ht(1a) receptor binding with [(3)h]oh-dpat, 5ht(2) receptor binding with [(3)h]ketanserin and 5ht transporter binding with [(3)h]paroxetine. |
2012-05-02 |
2023-08-12 |
mouse |
| Jill M Butterfield, Kenneth R Lawrence, Arlene Reisman, David B Huang, Charles A Thompson, Thomas P Lodis. Comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: an analysis of Phase III and IV randomized clinical trial data. The Journal of antimicrobial chemotherapy. vol 67. issue 2. 2012-05-01. PMID:22139199. |
comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: an analysis of phase iii and iv randomized clinical trial data. |
2012-05-01 |
2023-08-12 |
Not clear |
| Jill M Butterfield, Kenneth R Lawrence, Arlene Reisman, David B Huang, Charles A Thompson, Thomas P Lodis. Comparison of serotonin toxicity with concomitant use of either linezolid or comparators and serotonergic agents: an analysis of Phase III and IV randomized clinical trial data. The Journal of antimicrobial chemotherapy. vol 67. issue 2. 2012-05-01. PMID:22139199. |
the present study's objective was to evaluate serotonin toxicity with concomitant use of linezolid or comparators and serotonergic agents from 20 phase iii and iv comparator-controlled clinical studies on treatment of various gram-positive infections. |
2012-05-01 |
2023-08-12 |
Not clear |
| Waldemar Kryszkowski, Kinga Bobińska, Monika Talarowska, Agata Orzechowska, Antoni Florkowski, Piotr Gałeck. [Trazodone in the treatment of addiction]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 31. issue 186. 2012-05-01. PMID:22239013. |
counted among the sari (serotonin reuptake inhibitor and antagonist), shows antagonism to serotonergic receptors (5-ht2 receptors), while an inhibitor of serotonin reuptake. |
2012-05-01 |
2023-08-12 |
Not clear |
| M Martínez-Vázquez, R Estrada-Reyes, A G Araujo Escalona, I Ledesma Velázquez, L Martínez-Mota, J Moreno, G Heinz. Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice. Journal of ethnopharmacology. vol 139. issue 1. 2012-04-27. PMID:22101086. |
it has been reported that the alkaloids isolated from some species of the annona have affinity to serotonergic 5-ht(1a) receptors and modulate dopaminergic transmission, which is involved in depressive disorders. |
2012-04-27 |
2023-08-12 |
mouse |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
the region-specific alterations of brain 5-ht1a gene expression and reduced raphe 5-ht content in deaf-1(-/-) mice indicate the importance of deaf-1 in regulation of 5-ht1a gene expression and provide insight into the role of the 5-ht1a g(-1019) allele in reducing serotonergic neurotransmission by derepression of 5-ht1a autoreceptors. |
2012-04-25 |
2023-08-12 |
mouse |
| Takahisa Kawano, Takayuki Kosuge, Shunsuke Takagi, Akira Shimoyama, Nobuyuki Harunari, Yoshio Tahara, Noriyuki Suzuk. [First death case of serotonin syndrome in Japan induced by fluvoxamine and tandospirone]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. vol 24. issue 4. 2012-04-24. PMID:22338341. |
we should aware of the serotonin syndrome a case of overdose on a serotonergic agent. |
2012-04-24 |
2023-08-12 |
Not clear |
| Andreas Hahn, Wolfgang Wadsak, Christian Windischberger, Pia Baldinger, Anna S Höflich, Jan Losak, Lukas Nics, Cécile Philippe, Georg S Kranz, Christoph Kraus, Markus Mitterhauser, Georgios Karanikas, Siegfried Kasper, Rupert Lanzenberge. Differential modulation of the default mode network via serotonin-1A receptors. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 7. 2012-04-20. PMID:22308408. |
our results indicate a modulation of key areas involved in self-referential processing by serotonergic neurotransmission, whereas variations in 5-ht(1a) binding explained a considerable amount of the individual variability in the dmn. |
2012-04-20 |
2023-08-12 |
human |
| C Hempfling, W L Neuhuber, J Wör. Serotonin-immunoreactive neurons and mast cells in the mouse esophagus suggest involvement of serotonin in both motility control and neuroimmune interactions. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 24. issue 1. 2012-04-11. PMID:22029710. |
serotonin is a major transmitter in the gastrointestinal tract, but little is known about the serotonergic system in the esophagus. |
2012-04-11 |
2023-08-12 |
mouse |