| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J M Wierońska, K Stachowicz, P Brański, A Pałucha-Poniewiera, A Pil. On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21855555. |
the blockade of gabaergic system by gaba(a) receptor antagonist flumazenil (10mg/kg) or gaba(b) receptor antagonist cgp55845 (10mg/kg), and the blockade of serotonergic system by 5-ht(1a) receptor antagonist way100635 (0.1 and 1mg/kg) or 5-ht(2a/2c) receptor antagonist ritanserin (0.5mg/kg) had no influence on the anti-hyperthermic effect induced by effective dose of ly379268. |
2012-08-13 |
2023-08-12 |
mouse |
| Stephanie R Fox, Evan S Deneri. Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674259. |
to investigate intrinsic serotonergic functions for en1/2, we generated compound conditional en mutants with floxed alleles and a cre recombinase line that becomes active in postmitotic fetal 5-ht neurons. |
2012-08-09 |
2023-08-12 |
mouse |
| Stephanie R Fox, Evan S Deneri. Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674259. |
furthermore, en1/2 are required for perinatal maintenance of serotonergic identity and postnatal forebrain 5-ht levels. |
2012-08-09 |
2023-08-12 |
mouse |
| Stephanie R Fox, Evan S Deneri. Engrailed is required in maturing serotonin neurons to regulate the cytoarchitecture and survival of the dorsal raphe nucleus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 23. 2012-08-09. PMID:22674259. |
increased numbers of caspase-3-expressing cells and loss of significant numbers of 5-ht neuron cell bodies, indicative of apoptosis, occurred after loss of serotonergic identity. |
2012-08-09 |
2023-08-12 |
mouse |
| Jack J Che. Pharmacologic safety concerns in Parkinson's disease: facts and insights. The International journal of neuroscience. vol 121 Suppl 2. 2012-08-03. PMID:22035029. |
in patients treated with selective mao-b inhibitors, the risk of serotonin toxicity (st) due to a concomitant serotonergic agent (e.g., antidepressants, dextromethorphan, serotonergic analgesics) or hypertensive crisis due to dietary tyramine or sympathomimetic amines appears to be minimal and is based on isolated case reports and overgeneralizations from nonselective mao inhibitor pharmacology. |
2012-08-03 |
2023-08-12 |
Not clear |
| Lisbeth Marne. Communication among neurons. Danish medical journal. vol 59. issue 4. 2012-08-02. PMID:22459725. |
furthermore, a pet study of patients with alzheimer's disease with the serotonin transporter ligand [11c]dasb showed relatively preserved serotonergic projections, despite a marked decrease in 5-ht2a receptor binding. |
2012-08-02 |
2023-08-12 |
human |
| Pierre-Eric Lutz, Amynah A Pradhan, Celia Goeldner, Brigitte L Kieffe. Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 21. issue 11. 2012-08-01. PMID:21402471. |
the serotonergic system and especially the 5-ht(1a) receptor crucially regulate emotional behaviors both in humans and rodents. |
2012-08-01 |
2023-08-12 |
mouse |
| Erica Y Shen, Syed F Ali, Jerrold S Meye. Chronic administration of THC prevents the behavioral effects of intermittent adolescent MDMA administration and attenuates MDMA-induced hyperthermia and neurotoxicity in rats. Neuropharmacology. vol 61. issue 8. 2012-08-01. PMID:21763331. |
therefore, the present study was conducted to investigate the effects of chronic adolescent administration of both thc and mdma on behavior and on regional serotonin transporter (sert) binding and serotonin (5-ht) concentrations as indices of serotonergic system integrity. |
2012-08-01 |
2023-08-12 |
rat |
| Mireille Basselin, Epolia Ramadan, Stanley I Rapopor. Imaging brain signal transduction and metabolism via arachidonic and docosahexaenoic acid in animals and humans. Brain research bulletin. vol 87. issue 2-3. 2012-08-01. PMID:22178644. |
we have employed our method to image and quantify effects of mood stabilizers on brain aa/dha incorporation during neurotransmission by muscarinic m(1,3,5), serotonergic 5-ht(2a/2c), dopaminergic d(2)-like (d(2), d(3), d(4)) or glutamatergic n-methyl-d-aspartic acid (nmda) receptors, and effects of inhibition of acetylcholinesterase, of selective serotonin and dopamine reuptake transporter inhibitors, of neuroinflammation (hiv-1 and lipopolysaccharide) and excitotoxicity, and in genetically modified rodents. |
2012-08-01 |
2023-08-12 |
human |
| R S Fais, G M Reis, J W S Silveira, Q M Dias, A C Rossaneis, W A Prad. Amitriptyline prolongs the antihyperalgesic effect of 2- or 100-Hz electro-acupuncture in a rat model of post-incision pain. European journal of pain (London, England). vol 16. issue 5. 2012-08-01. PMID:22337080. |
the mechanisms through which electro-acupuncture (ea) and tricyclic antidepressants produce analgesia seem to be complementary: ea inhibits the transmission of noxious messages by activating supraspinal serotonergic and noradrenergic neurons that project to the spinal cord, whereas tricyclic antidepressants affect pain transmission by inhibiting the reuptake of norepinephrine and serotonin at the spinal level. |
2012-08-01 |
2023-08-12 |
rat |
| Sayamwong E Hammack, Matthew A Cooper, Kimberly R Leza. Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disorders. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:21396383. |
exposure to traumatic events can increase the risk for major depressive disorder (mdd) as well as posttraumatic stress disorder (ptsd), and pharmacological treatments for these disorders often involve the modulation of serotonergic (5-ht) systems. |
2012-07-27 |
2023-08-12 |
rat |
| Caroline A Browne, Gerard Clarke, Timothy G Dinan, John F Crya. An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour. Neuropharmacology. vol 62. issue 5-6. 2012-07-23. PMID:22212181. |
peripheral and central tryptophan levels and consequently central serotonergic turnover were significantly decreased by the trp(-) diet in both strains, however, no effect of tryptophan supplementation was observed on tryptophan or serotonin levels. |
2012-07-23 |
2023-08-12 |
mouse |
| P Panther, S Nullmeier, H Dobrowolny, H Schwegler, R Wol. CPB-K mice a mouse model of schizophrenia? Differences in dopaminergic, serotonergic and behavioral markers compared to BALB/cJ mice. Behavioural brain research. vol 230. issue 1. 2012-07-23. PMID:22454846. |
our results can be summarized as follows: compared to balb/cj, cpb-k mice showed:(1) significantly reduced traveling distance and number of contacts in social interaction test, (2) differences in the number of serotonin transporter-immunoreactive neurons and volume of raphe nuclei and a lower serotonergic fiber density in the ventral and dorsal hippocampal subfields ca1 and ca3, (3) no alterations of dopaminergic markers like neuron number, neuron density and volume in subregions of substantia nigra and ventral tegmental area, but a significantly higher dopaminergic fiber density in the dorsal hippocampus, the ventral hippocampus of ca1 and gyrus dentatus, (4) no significant differences in serotonergic and dopaminergic fiber densities in the amygdala.based on our results and previous studies, cpb-k mice compared to balb/cj may serve as an important model to understand the interaction of the serotonergic and dopaminergic system and their impact on sensorimotor gating and cognitive function as related to neuropsychiatric disorders like schizophrenia. |
2012-07-23 |
2023-08-12 |
mouse |
| Verônica Contini, Guilherme P Bertuzzi, Evelise R Polina, Tábita Hunemeier, Elisa M Hendler, Mara H Hutz, Claiton H D Ba. A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. Drug and alcohol dependence. vol 122. issue 1-2. 2012-07-20. PMID:22005095. |
animal and human studies have suggested that the serotonergic system plays an important role in alcohol consumption and abuse, mainly due to the serotonin receptor 1b (5-ht(1b)) function in the mesolimbic reward pathway. |
2012-07-20 |
2023-08-12 |
human |
| S Sırrı Bilge, Ayhan Bozkurt, Fatih Ilkaya, Engin Ciftcioğlu, Yüksel Kesim, Tayfun I Uzba. The antinociceptive effects of intravenous tianeptine in colorectal distension-induced visceral pain in rats: the role of 5-HT₃ receptors. European journal of pharmacology. vol 681. issue 1-3. 2012-07-20. PMID:22348811. |
in this study, we aimed to investigate the antinociceptive effect of tianeptine on visceral pain in rats and to determine whether possible antinociceptive effect of tianeptine is mediated by serotonergic (5-ht(2,3)) and noradrenergic (α(1,2)) receptor subtypes. |
2012-07-20 |
2023-08-12 |
rat |
| Michael Camilleri, David A Katzk. Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Genetic epidemiology and pharmacogenetics in irritable bowel syndrome. American journal of physiology. Gastrointestinal and liver physiology. vol 302. issue 10. 2012-07-20. PMID:22403795. |
the second objective is to review pharmacogenetics in ibs, with the focus on cytochrome p-450 metabolism of drugs used in ibs, modulation of motor and sensory responses to serotonergic agents based on the 5-hydroxytryptamine (5-ht) transporter-linked polymorphic region (5-httlpr) and 5-ht(3) genetic variants, responses to a nonselective cannabinoid agonist (dronabinol) based on cannabinoid receptor (cnr1) and fatty acid amide hydrolase (faah) variation, and responses to a bile acid (sodium chenodeoxycholate) and bile acid binding (colesevelam) based on klothoβ (klb) and fibroblast growth factor receptor 4 (fgfr4) variation. |
2012-07-20 |
2023-08-12 |
Not clear |
| Lucila Kargieman, Maurizio S Riga, Francesc Artigas, Pau Celad. Clozapine Reverses Phencyclidine-Induced Desynchronization of Prefrontal Cortex through a 5-HT(1A) Receptor-Dependent Mechanism. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 3. 2012-07-19. PMID:22012474. |
clozapine (0.5 mg/kg, intraperitoneally) significantly reversed pcp effect in wt and ko-2a mice, but not in ko-1a mice nor in wt mice pretreated with the selective 5-ht(1a)r antagonist way-100635.the pcp-induced disorganization of pfc activity does not appear to depend on serotonergic function. |
2012-07-19 |
2023-08-12 |
mouse |
| D R Loyd, P B Chen, K M Hargreave. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat. Neuroscience. vol 203. 2012-07-19. PMID:22209919. |
the peripheral serotonergic system has been implicated in the modulation of an array of pain states, from migraine to fibromyalgia; however, the mechanism by which serotonin (5ht) induces pain is unclear. |
2012-07-19 |
2023-08-12 |
rat |
| D R Loyd, P B Chen, K M Hargreave. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat. Neuroscience. vol 203. 2012-07-19. PMID:22209919. |
overall, our results provide in vivo evidence supporting an enhancing role of 5ht on trpv1-evoked thermal hyperalgesia, which can be attenuated by peripheral serotonergic intervention. |
2012-07-19 |
2023-08-12 |
rat |
| Kelly C Rowe, Jane S Paulsen, Douglas R Langbehn, Chiachi Wang, James Mills, Leigh J Beglinger, Megan M Smith, Eric A Epping, Jess G Fiedorowicz, Kevin Duff, Adam Ruggle, David J Mose. Patterns of serotonergic antidepressant usage in prodromal Huntington disease. Psychiatry research. vol 196. issue 2-3. 2012-07-19. PMID:22397915. |
of those, the vast majority took serotonergic antidepressants (selective serotonin reuptake inhibitor (ssri) or serotonin/norepinephrine reuptake inhibitor (snri)). |
2012-07-19 |
2023-08-12 |
human |