| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S S Shim, R E Becke. Effect of monoamine oxidase A and B inhibition on the uptake and metabolism of serotonin within serotonergic neurons of rat brain. Journal of psychopharmacology (Oxford, England). vol 7. issue 2. 2012-10-02. PMID:22290665. |
selectivity of the uptake and subsequent deamination of 5-ht within serotonergic synaptosomes were confirmed using selective and non-selective 5-ht and norepinephrine (ne) uptake inhibitors. |
2012-10-02 |
2023-08-12 |
rat |
| S S Shim, R E Becke. Effect of monoamine oxidase A and B inhibition on the uptake and metabolism of serotonin within serotonergic neurons of rat brain. Journal of psychopharmacology (Oxford, England). vol 7. issue 2. 2012-10-02. PMID:22290665. |
mao inhibitor analysis of 5-ht deamination occurring within serotonergic synaptosomes indicated that, at physiologically relevant concentrations of 5-ht, mao a deaminates 5-ht, maintaining a low cytoplasmic concentration of 5-ht. |
2012-10-02 |
2023-08-12 |
rat |
| D Nut. The anxiety factor in depression. Journal of psychopharmacology (Oxford, England). vol 9. issue 2 Suppl. 2012-10-02. PMID:22297237. |
an increase in serotonergic function is implicated in the pathogenesis of anxiety and there is good evidence that the selective serotonin re-uptake inhibitors (ssris) may be useful in clinical management. |
2012-10-02 |
2023-08-12 |
Not clear |
| H G Series, M le Masurier, S E Gartside, M Franklin, T Shar. Behavioural and neuroendocrine responses to D-fenfluramine in rats treated with neurotoxic amphetamines. Journal of psychopharmacology (Oxford, England). vol 9. issue 3. 2012-10-02. PMID:22297760. |
the amphetamine derivatives p-chloroamphetamine (pca), 3,4-methylenedioxymethamphetamine (mdma, 'ecstasy') and d-fenfluramine can, if given repeatedly in high doses to rats, produce a degeneration of serotonergic nerve terminals which we have previously shown to result in a reduction in d-fenfluramine-evoked release of 5-ht in vivo. |
2012-10-02 |
2023-08-12 |
rat |
| H G Series, M le Masurier, S E Gartside, M Franklin, T Shar. Behavioural and neuroendocrine responses to D-fenfluramine in rats treated with neurotoxic amphetamines. Journal of psychopharmacology (Oxford, England). vol 9. issue 3. 2012-10-02. PMID:22297760. |
the present study examined the effect of pre-treatment with these three agents (pca 12 mg/kg×2; mdma 20 mg/kg×8; d-fenfluramine 12.5 mg/kg×8, 14 days prior to testing) on behavioural (5-ht syndrome) and neuroendocrine [prolactin and adrenocorticotrophin (acth)] responses in rats to acute administration of d-fenfluramine and other serotonergic agonists. |
2012-10-02 |
2023-08-12 |
rat |
| Young-Min Park, Seung-Hwan Lee, Eun Jin Par. Usefulness of LDAEP to predict tolerability to SSRIs in major depressive disorder: a case report. Psychiatry investigation. vol 9. issue 1. 2012-10-02. PMID:22396689. |
we assumed that it was this high serotonergic activity that rendered him unresponsive to ssris, and brought on him the adverse effects, and that the tianeptine was effective due to the lack of serotonin reuptake inhibitory action. |
2012-10-02 |
2023-08-12 |
Not clear |
| Luke E Grzeskowiak, Andrew L Gilbert, Janna L Morriso. Long term impact of prenatal exposure to SSRIs on growth and body weight in childhood: evidence from animal and human studies. Reproductive toxicology (Elmsford, N.Y.). vol 34. issue 1. 2012-10-02. PMID:22433946. |
animal studies demonstrate that changes in 5-ht homeostasis during critical periods of fetal development can lead to sex-specific molecular and functional alterations in the serotonergic and hpa systems, leading to an increased risk of overweight in male, but not female, offspring in later life. |
2012-10-02 |
2023-08-12 |
human |
| Daniel Avesar, Allan T Gulledg. Selective serotonergic excitation of callosal projection neurons. Frontiers in neural circuits. vol 6. 2012-10-02. PMID:22454619. |
we tested the serotonergic responsiveness of layer 5 pyramidal neurons (l5pns) in the mouse medial prefrontal cortex (mpfc), and found three distinct response types: long-lasting 5-ht(1a) (1a) receptor-dependent inhibitory responses (84% of l5pns), 5-ht(2a) (2a) receptor-dependent excitatory responses (9%), and biphasic responses in which 2a-dependent excitation followed brief inhibition (5%). |
2012-10-02 |
2023-08-12 |
mouse |
| Daniel Avesar, Allan T Gulledg. Selective serotonergic excitation of callosal projection neurons. Frontiers in neural circuits. vol 6. 2012-10-02. PMID:22454619. |
selective serotonergic excitation of com neurons was not layer-specific, as com neurons in layer 2/3 were also selectively excited by 5-ht relative to their non-labeled pyramidal neuron neighbors. |
2012-10-02 |
2023-08-12 |
mouse |
| Soo-Hyun Park, Yun-Beom Sim, Yu-Jung Kang, Jin-Koo Lee, Soon-Sung Lim, Hong-Won Su. Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 16. issue 2. 2012-10-02. PMID:22563257. |
however, naloxone (opioid receptor antagonist) or methysergide (5-ht serotonergic receptor antagonist) did not affect antinociception induced by agrimonia pilosa ledeb extract in the writhing test. |
2012-10-02 |
2023-08-12 |
mouse |
| Soo-Hyun Park, Yun-Beom Sim, Yu-Jung Kang, Sung-Su Kim, Chea-Ha Kim, Su-Jin Kim, Jee-Young Seo, Su-Min Lim, Hong-Won Su. Hop extract produces antinociception by acting on opioid system in mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 16. issue 3. 2012-10-02. PMID:22802700. |
however, methysergide (a 5-ht serotonergic receptor antagonist) or yohimbine (an α(2)-adrenergic receptor antagonist) did not affect antinociception induced by hop extract in the writhing test. |
2012-10-02 |
2023-08-12 |
mouse |
| Quentin Perrenoud, Jean Rossier, Isabelle Férézou, Hélène Geoffroy, Thierry Gallopin, Tania Vitalis, Armelle Rancilla. Activation of cortical 5-HT(3) receptor-expressing interneurons induces NO mediated vasodilatations and NPY mediated vasoconstrictions. Frontiers in neural circuits. vol 6. 2012-10-02. PMID:22907992. |
they form a highly diverse population among which the serotonin 5-hydroxytryptamine 3a receptor (5-ht(3a))-expressing interneurons share a common developmental origin, in addition to the responsiveness to serotonergic ascending pathway. |
2012-10-02 |
2023-08-12 |
mouse |
| Laura M Hurley, Megan R Sulliva. From behavioral context to receptors: serotonergic modulatory pathways in the IC. Frontiers in neural circuits. vol 6. 2012-10-02. PMID:22973195. |
serotonergic inputs to the ic originate from centralized raphe nuclei, release serotonin in the ic, and activate serotonin receptors expressed by auditory neurons. |
2012-10-02 |
2023-08-12 |
Not clear |
| Philippe Marin, Carine Becamel, Aline Dumuis, Joel Bockaer. 5-HT receptor-associated protein networks: new targets for drug discovery in psychiatric disorders? Current drug targets. vol 13. issue 1. 2012-10-01. PMID:21777185. |
finally, it reports recent data dealing with the roles of gips in 5-ht-related behaviours and highlights the potential of manipulating 5-ht receptor-gip interactions to design new treatments in psychiatric disorders related to perturbations of serotonergic systems. |
2012-10-01 |
2023-08-12 |
human |
| Lisbeth Marner, Vibe G Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F C Baaré, Gitte M Knudsen, Steen G Hasselbalc. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20510480. |
loss of serotonin 2a receptors exceeds loss of serotonergic projections in early alzheimer's disease: a combined [11c]dasb and [18f]altanserin-pet study. |
2012-09-28 |
2023-08-12 |
human |
| Lisbeth Marner, Vibe G Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F C Baaré, Gitte M Knudsen, Steen G Hasselbalc. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20510480. |
to establish if this was due to a selective disease process of the serotonin system, we investigated the cerebral 5-ht(2a) receptor and the serotonin transporter binding, the latter as a measure of serotonergic projections and neurons. |
2012-09-28 |
2023-08-12 |
human |
| Lisbeth Marner, Vibe G Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F C Baaré, Gitte M Knudsen, Steen G Hasselbalc. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20510480. |
we conclude that the prominent reduction in neocortical 5-ht(2a) receptor binding in early ad is not caused by a primary loss of serotonergic neurons or their projections. |
2012-09-28 |
2023-08-12 |
human |
| Veronika Kuscha, Antón Barreiro-Iglesias, Catherina G Becker, Thomas Becke. Plasticity of tyrosine hydroxylase and serotonergic systems in the regenerating spinal cord of adult zebrafish. The Journal of comparative neurology. vol 520. issue 5. 2012-09-28. PMID:21830219. |
here we performed a quantitative study to determine the plastic changes of tyrosine hydroxylase-positive (th1(+); mainly dopaminergic), and serotonergic (5-ht(+)) terminals and cells during successful spinal cord regeneration in adult zebrafish. |
2012-09-28 |
2023-08-12 |
zebrafish |
| Wendi S Neckameyer, Parag Bhat. Neurotrophic actions of dopamine on the development of a serotonergic feeding circuit in Drosophila melanogaster. BMC neuroscience. vol 13. 2012-09-27. PMID:22413901. |
there is an inverse relationship between neuronal serotonin levels during late embryogenesis and the complexity of the serotonergic fibers projecting from the larval brain to the foregut, which correlate with perturbations in feeding, the functional output of the circuit. |
2012-09-27 |
2023-08-12 |
drosophila_melanogaster |
| Andrea J Rapkin, Alin L Akopian. Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause international. vol 18. issue 2. 2012-09-25. PMID:22611222. |
the lowering of serotonin can give rise to pms-like symptoms and serotonergic functioning seems to be deficient by some methods of estimating serotonergic activity in the brain; agents that augment serotonin are efficacious and are as effective even if administered only in the luteal phase. |
2012-09-25 |
2023-08-12 |
Not clear |