| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
impacts of brain serotonin deficiency following tph2 inactivation on development and raphe neuron serotonergic specification. |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
to further analyze the importance of brain 5-ht in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-ht deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (tph2). |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
the conserved expression pattern of the 5-ht neuron-specific markers (except tph2 and 5-ht) demonstrates that brain 5-ht synthesis is not a prerequisite for the proliferation, differentiation and survival of raphe neurons subjected to the developmental program of serotonergic specification. |
2013-05-01 |
2023-08-12 |
mouse |
| Jeff S Kruk, Maryam S Vasefi, Hui Liu, John J Heikkila, Michael A Beazel. 5-HT(1A) receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells. Cellular signalling. vol 25. issue 1. 2013-04-30. PMID:23006663. |
this crosstalk between 5-ht and pdgfβ receptors identifies a potentially important signaling link between the serotonergic system and growth factor signaling in neurons. |
2013-04-30 |
2023-08-12 |
Not clear |
| Pau Celada, M Victoria Puig, Francesc Artiga. Serotonin modulation of cortical neurons and networks. Frontiers in integrative neuroscience. vol 7. 2013-04-30. PMID:23626526. |
of all cortical regions, the frontal lobe is the area most enriched in serotonergic axons and 5-ht receptors. |
2013-04-30 |
2023-08-12 |
Not clear |
| Gilda Neves, Camila B Antonio, Andresa H Betti, Mariana A Pranke, Carlos A M Fraga, Eliezer J Barreiro, François Noël, Stela M K Rate. New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia. Behavioural brain research. vol 237. 2013-04-26. PMID:23000351. |
reversed the catalepsy induced by way 100,635, corroborating its action on both dopaminergic and serotonergic neurotransmission and pointing to the contribution of 5-ht(1a) receptor activation to its pharmacological profile. |
2013-04-26 |
2023-08-12 |
Not clear |
| Andrey Sequeira-Cordero, Marianela Masís-Calvo, Andrea Mora-Gallegos, Jaime Fornaguera-Tría. Maternal behavior as an early modulator of neurobehavioral offspring responses by Sprague-Dawley rats. Behavioural brain research. vol 237. 2013-04-26. PMID:23018125. |
this effect seems to be associated with the serotonergic systems in both nucleus accumbens (nac) and hippocampus (hpc), since offspring of low lg mothers showed decreased 5-ht neurotransmission in those brain regions compared with animals of high lg mothers. |
2013-04-26 |
2023-08-12 |
rat |
| Kafui Dzirasa, Sunil Kumar, Benjamin D Sachs, Marc G Caron, Miguel A L Nicoleli. Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467366. |
although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. |
2013-04-26 |
2023-08-12 |
mouse |
| Ivan Skelin, Tomislav Kovačević, Hiroki Sato, Mirko Diksi. The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression. Brain research bulletin. vol 88. issue 5. 2013-04-25. PMID:22542420. |
flinders sensitive line (fsl) rat is as an animal model of depression with altered parameters of the serotonergic (5-ht) system function (5-ht synthesis rates, tissue concentrations, release, receptor density and affinity), as well as an altered sensitivity of these parameters to different 5-ht based antidepressants. |
2013-04-25 |
2023-08-12 |
rat |
| Sonja Sucic, Florian Koban, Ali El-Kasaby, Oliver Kudlacek, Thomas Stockner, Harald H Sitte, Michael Freissmut. Switching the clientele: a lysine residing in the C terminus of the serotonin transporter specifies its preference for the coat protein complex II component SEC24C. The Journal of biological chemistry. vol 288. issue 8. 2013-04-25. PMID:23288844. |
the serotonin transporter (sert) maintains serotonergic neurotransmission via rapid reuptake of serotonin from the synaptic cleft. |
2013-04-25 |
2023-08-12 |
Not clear |
| Sun Jung Bang, Kathryn G Common. Forebrain GABAergic projections from the dorsal raphe nucleus identified by using GAD67-GFP knock-in mice. The Journal of comparative neurology. vol 520. issue 18. 2013-04-18. PMID:22605640. |
the dorsal raphe nucleus (dr) contains serotonergic (5-ht) neurons that project widely throughout the forebrain. |
2013-04-18 |
2023-08-12 |
mouse |
| Rupert Lanzenberger, Georg S Kranz, Daniela Haeusler, Elena Akimova, Markus Savli, Andreas Hahn, Markus Mitterhauser, Christoph Spindelegger, Cecile Philippe, Martin Fink, Wolfgang Wadsak, Georgios Karanikas, Siegfried Kaspe. Prediction of SSRI treatment response in major depression based on serotonin transporter interplay between median raphe nucleus and projection areas. NeuroImage. vol 63. issue 2. 2013-04-18. PMID:22828162. |
recent mathematical models suggest restored serotonergic burst-firing to underlie the antidepressant effect of selective serotonin reuptake inhibitors (ssri), resulting from down-regulated serotonin transporters (sert) in terminal regions. |
2013-04-18 |
2023-08-12 |
Not clear |
| Arnold E Egger. Extending David Horrobin's membrane phospholipid theory of schizophrenia: overactivity of cytosolic phospholipase A(2) in the brain is caused by overdrive of coupled serotonergic 5HT(2A/2C) receptors in response to stress. Medical hypotheses. vol 79. issue 6. 2013-04-18. PMID:22986004. |
extending david horrobin's membrane phospholipid theory of schizophrenia: overactivity of cytosolic phospholipase a(2) in the brain is caused by overdrive of coupled serotonergic 5ht(2a/2c) receptors in response to stress. |
2013-04-18 |
2023-08-12 |
Not clear |
| Arnold E Egger. Extending David Horrobin's membrane phospholipid theory of schizophrenia: overactivity of cytosolic phospholipase A(2) in the brain is caused by overdrive of coupled serotonergic 5HT(2A/2C) receptors in response to stress. Medical hypotheses. vol 79. issue 6. 2013-04-18. PMID:22986004. |
it is known that serotonergic 5ht(2a/2c) receptors are coupled to pla(2), which hydrolyzes both arachidonic acid (aa) and epa from diacylglycerides at the sn-2 position. |
2013-04-18 |
2023-08-12 |
Not clear |
| N M Maksimova, O P Vertogradov. [The dynamics of anxious depression under the treatment with antidepressants with different mechanisms of action]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 112. issue 11 Pt 2. 2013-04-17. PMID:23257755. |
peculiarities of the dynamics of anxious depression under the treatment with selective serotonergic antidepressants with different mechanisms of action on the serotonin reuptake were investigated. |
2013-04-17 |
2023-08-12 |
Not clear |
| R Hazra, J D Guo, J Dabrowska, D G Rainni. Differential distribution of serotonin receptor subtypes in BNST(ALG) neurons: modulation by unpredictable shock stress. Neuroscience. vol 225. 2013-04-16. PMID:22922122. |
stressors that activate the bnst also activate serotonergic (5-ht) systems. |
2013-04-16 |
2023-08-12 |
Not clear |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
activation of the dynorphin/κ-opioid receptor (kor) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and reinstatement of extinguished cocaine place preference behaviors by stimulation of p38α mapk, which subsequently causes the translocation of the serotonin transporter (sert, slc6a4) to the synaptic terminals of serotonergic neurons. |
2013-04-11 |
2023-08-12 |
mouse |
| William E Wood, Thomas K Roseberry, David J Perke. HTR2 receptors in a songbird premotor cortical-like area modulate spectral characteristics of zebra finch song. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 7. 2013-04-11. PMID:23407949. |
injection of the serotonergic neurotoxin 5,7-dihydroxytryptamine into the third ventricle greatly reduced telencephalic 5-ht and resulted in decreased fundamental frequency of harmonic syllables as well as increased goodness of pitch. |
2013-04-11 |
2023-08-12 |
Not clear |
| Harun N Noristani, Alexei Verkhratsky, José J Rodrígue. High tryptophan diet reduces CA1 intraneuronal β-amyloid in the triple transgenic mouse model of Alzheimer's disease. Aging cell. vol 11. issue 5. 2013-04-10. PMID:22702392. |
here, we analysed the effect of chronic (1 month) food diets containing low (ltrp), normal (ntrp) and high tryptophan (htrp), 0.04, 0.20 and 0.40 g/100 g, respectively, on ca1 serotonin transporter (sert) fibre density, intraneuronal aβ deposition and total number of serotonergic (5-ht) neurons in an ad triple transgenic (3xtg-ad) mouse model. |
2013-04-10 |
2023-08-12 |
mouse |
| Patrick D Ganzer, Karen A Moxon, Eric B Knudsen, Jed S Shumsk. Serotonergic pharmacotherapy promotes cortical reorganization after spinal cord injury. Experimental neurology. vol 241. 2013-04-08. PMID:23262119. |
we use a complete spinal transection model to focus on cortical reorganization in response to serotonergic (5-ht) pharmacotherapy without any confounding effects from spared fibers left after partial lesions. |
2013-04-08 |
2023-08-12 |
rat |